Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases.
Identifieur interne : 001897 ( PubMed/Corpus ); précédent : 001896; suivant : 001898Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases.
Auteurs : J. Poissy ; A. Goffard ; E. Parmentier-Decrucq ; R. Favory ; M. Kauv ; E. Kipnis ; D. Mathieu ; S. Van Der Werf ; B. GuerySource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2014.
English descriptors
- KwdEn :
- Blood (virology), Coronavirus Infections (virology), Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), RNA, Viral (analysis), RNA, Viral (genetics), RNA, Viral (isolation & purification), Real-Time Polymerase Chain Reaction, Rectum (virology), Respiratory System (virology), Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Urine (virology), Virus Shedding.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , genetics : RNA, Viral.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus, RNA, Viral.
- virology : Blood, Coronavirus Infections, Rectum, Respiratory System, Urine.
- Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Virus Shedding.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course.
DOI: 10.1016/j.jcv.2014.07.002
PubMed: 25073585
Links to Exploration step
pubmed:25073585Le document en format XML
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Poissy</name><affiliation><nlm:affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France. Electronic address: julien_poissy@hotmail.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Goffard, A" sort="Goffard, A" uniqKey="Goffard A" first="A" last="Goffard">A. Goffard</name><affiliation><nlm:affiliation>Laboratoire de Virologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France; Molecular & Cellular Virology of Hepatitis C, Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Université Lille Nord de France, F-59000 Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Parmentier Decrucq, E" sort="Parmentier Decrucq, E" uniqKey="Parmentier Decrucq E" first="E" last="Parmentier-Decrucq">E. Parmentier-Decrucq</name><affiliation><nlm:affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Favory, R" sort="Favory, R" uniqKey="Favory R" first="R" last="Favory">R. Favory</name><affiliation><nlm:affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kauv, M" sort="Kauv, M" uniqKey="Kauv M" first="M" last="Kauv">M. Kauv</name><affiliation><nlm:affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kipnis, E" sort="Kipnis, E" uniqKey="Kipnis E" first="E" last="Kipnis">E. Kipnis</name><affiliation><nlm:affiliation>Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille, France; Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France; Département d'anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mathieu, D" sort="Mathieu, D" uniqKey="Mathieu D" first="D" last="Mathieu">D. Mathieu</name><affiliation><nlm:affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Werf, S" sort="Van Der Werf, S" uniqKey="Van Der Werf S" first="S" last="Van Der Werf">S. Van Der Werf</name></author><author><name sortKey="Guery, B" sort="Guery, B" uniqKey="Guery B" first="B" last="Guery">B. Guery</name><affiliation><nlm:affiliation>Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille, France; Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France; Département d'anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France; Service de maladies infectieuses, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title><idno type="eISSN">1873-5967</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood (virology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>RNA, Viral (analysis)</term><term>RNA, Viral (genetics)</term><term>RNA, Viral (isolation & purification)</term><term>Real-Time Polymerase Chain Reaction</term><term>Rectum (virology)</term><term>Respiratory System (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Time Factors</term><term>Urine (virology)</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Blood</term><term>Coronavirus Infections</term><term>Rectum</term><term>Respiratory System</term><term>Urine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Time Factors</term><term>Virus Shedding</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25073585</PMID><DateCompleted><Year>2015</Year><Month>05</Month><Day>20</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation></Journal><ArticleTitle>Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases.</ArticleTitle><Pagination><MedlinePgn>275-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2014.07.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1386-6532(14)00265-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Describe the kinetics and pattern of viral excretion in two infected patients.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">After the initial diagnosis, blood, urine, rectal and respiratory samples were collected regularly, aliquoted and stored at -80°C. Real-time reverse transcriptase polymerase chain reaction assay targeted the UpE and Orf1a regions of the MERS-CoV genome.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In patient 1, who died of refractory ARDS and renal failure, MERS-CoV RNA was detected in pharyngeal and tracheal swabs, as well blood samples and urine samples until the 30th day. Rectal swabs were negative. Patient 2 also developed multiple-organ failure, but survived, with persisting renal insufficiency (creatinine clearance at 30 mL/min) and persistent interstitial syndrome albeit weaned off mechanical ventilation and no longer requiring oxygen. Tracheal aspirations were positive until the 33rd day, while nasopharyngeal swabs were negative. All other biological samples were negative.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Lower respiratory tract excretion of MERS-CoV could be observed for more than one month. The most severely ill patient presented an expression of the virus in blood and urine, consistent with a type-1 interferon mediated immunological response impaired in patient 1, but developed by patient 2. These results suggest that infection control precautions must be adequately evaluated in clinical wards and laboratories exposed to MERS-CoV.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Poissy</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France. Electronic address: julien_poissy@hotmail.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goffard</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratoire de Virologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France; Molecular & Cellular Virology of Hepatitis C, Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Université Lille Nord de France, F-59000 Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parmentier-Decrucq</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Favory</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kauv</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kipnis</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille, France; Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France; Département d'anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathieu</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Werf</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Guery</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Host-Pathogen Translational Research Group, Université de Lille 2, Lille Cedex, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8204, F-59021 Lille, France; Institut National de la Santé et de la Recherche Médicale, U1019, F-59019 Lille, France; Département d'anesthésie-réanimation, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France; Service de maladies infectieuses, Centre Hospitalier Régional et Universitaire de Lille, Lille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>MERS-CoV Biology Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>07</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>J Clin Virol. 2015 Feb,63:94</RefSource><Note>van der Werf, S [added]</Note></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D001769" MajorTopicYN="N">Blood</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" 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