Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases.
Identifieur interne : 001897 ( PubMed/Corpus ); précédent : 001896; suivant : 001898Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases.
Auteurs : J. Poissy ; A. Goffard ; E. Parmentier-Decrucq ; R. Favory ; M. Kauv ; E. Kipnis ; D. Mathieu ; S. Van Der Werf ; B. GuerySource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2014.
English descriptors
- KwdEn :
- Blood (virology), Coronavirus Infections (virology), Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), RNA, Viral (analysis), RNA, Viral (genetics), RNA, Viral (isolation & purification), Real-Time Polymerase Chain Reaction, Rectum (virology), Respiratory System (virology), Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Urine (virology), Virus Shedding.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , genetics : RNA, Viral.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus, RNA, Viral.
- virology : Blood, Coronavirus Infections, Rectum, Respiratory System, Urine.
- Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Virus Shedding.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course.
DOI: 10.1016/j.jcv.2014.07.002
PubMed: 25073585
Links to Exploration step
pubmed:25073585Le document en format XML
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course.</div>
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<ArticleTitle>Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Describe the kinetics and pattern of viral excretion in two infected patients.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">After the initial diagnosis, blood, urine, rectal and respiratory samples were collected regularly, aliquoted and stored at -80°C. Real-time reverse transcriptase polymerase chain reaction assay targeted the UpE and Orf1a regions of the MERS-CoV genome.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In patient 1, who died of refractory ARDS and renal failure, MERS-CoV RNA was detected in pharyngeal and tracheal swabs, as well blood samples and urine samples until the 30th day. Rectal swabs were negative. Patient 2 also developed multiple-organ failure, but survived, with persisting renal insufficiency (creatinine clearance at 30 mL/min) and persistent interstitial syndrome albeit weaned off mechanical ventilation and no longer requiring oxygen. Tracheal aspirations were positive until the 33rd day, while nasopharyngeal swabs were negative. All other biological samples were negative.</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Lower respiratory tract excretion of MERS-CoV could be observed for more than one month. The most severely ill patient presented an expression of the virus in blood and urine, consistent with a type-1 interferon mediated immunological response impaired in patient 1, but developed by patient 2. These results suggest that infection control precautions must be adequately evaluated in clinical wards and laboratories exposed to MERS-CoV.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Poissy</LastName>
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