Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.
Identifieur interne : 001649 ( PubMed/Corpus ); précédent : 001648; suivant : 001650Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.
Auteurs : Marcel A. Müller ; Benjamin Meyer ; Victor M. Corman ; Malak Al-Masri ; Abdulhafeez Turkestani ; Daniel Ritz ; Andrea Sieberg ; Souhaib Aldabbagh ; Berend-J Bosch ; Erik Lattwein ; Raafat F. Alhakeem ; Abdullah M. Assiri ; Ali M. Albarrak ; Ali M. Al-Shangiti ; Jaffar A. Al-Tawfiq ; Paul Wikramaratna ; Abdullah A. Alrabeeah ; Christian Drosten ; Ziad A. MemishSource :
- The Lancet. Infectious diseases [ 1474-4457 ] ; 2015.
English descriptors
- KwdEn :
- Abattoirs, Adolescent, Adult, Aged, Animal Husbandry, Animals, Antibodies, Viral (blood), Camelus (virology), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (transmission), Coronavirus Infections (virology), Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (immunology), Occupations, Prevalence, Saudi Arabia (epidemiology), Seroepidemiologic Studies.
- MESH :
- chemical , blood : Antibodies, Viral.
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Saudi Arabia.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- virology : Camelus, Coronavirus Infections.
- Abattoirs, Adolescent, Adult, Aged, Animal Husbandry, Animals, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Occupations, Prevalence, Seroepidemiologic Studies.
Abstract
Scientific evidence suggests that dromedary camels are the intermediary host for the Middle East respiratory syndrome coronavirus (MERS-CoV). However, the actual number of infections in people who have had contact with camels is unknown and most index patients cannot recall any such contact. We aimed to do a nationwide serosurvey in Saudi Arabia to establish the prevalence of MERS-CoV antibodies, both in the general population and in populations of individuals who have maximum exposure to camels.
DOI: 10.1016/S1473-3099(15)70090-3
PubMed: 25863564
Links to Exploration step
pubmed:25863564Le document en format XML
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Corman</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Al Masri, Malak" sort="Al Masri, Malak" uniqKey="Al Masri M" first="Malak" last="Al-Masri">Malak Al-Masri</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Turkestani, Abdulhafeez" sort="Turkestani, Abdulhafeez" uniqKey="Turkestani A" first="Abdulhafeez" last="Turkestani">Abdulhafeez Turkestani</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia; Makkah Regional Health Affairs, Ministry of Health, Makkah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ritz, Daniel" sort="Ritz, Daniel" uniqKey="Ritz D" first="Daniel" last="Ritz">Daniel Ritz</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Sieberg, Andrea" sort="Sieberg, Andrea" uniqKey="Sieberg A" first="Andrea" last="Sieberg">Andrea Sieberg</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aldabbagh, Souhaib" sort="Aldabbagh, Souhaib" uniqKey="Aldabbagh S" first="Souhaib" last="Aldabbagh">Souhaib Aldabbagh</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bosch, Berend J" sort="Bosch, Berend J" uniqKey="Bosch B" first="Berend-J" last="Bosch">Berend-J Bosch</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lattwein, Erik" sort="Lattwein, Erik" uniqKey="Lattwein E" first="Erik" last="Lattwein">Erik Lattwein</name><affiliation><nlm:affiliation>Euroimmun AG, Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Alhakeem, Raafat F" sort="Alhakeem, Raafat F" uniqKey="Alhakeem R" first="Raafat F" last="Alhakeem">Raafat F. Alhakeem</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M" last="Assiri">Abdullah M. Assiri</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M" last="Albarrak">Ali M. Albarrak</name><affiliation><nlm:affiliation>Saudi Center for Disease Control, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Shangiti, Ali M" sort="Al Shangiti, Ali M" uniqKey="Al Shangiti A" first="Ali M" last="Al-Shangiti">Ali M. Al-Shangiti</name><affiliation><nlm:affiliation>National Health Laboratory, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:affiliation>Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wikramaratna, Paul" sort="Wikramaratna, Paul" uniqKey="Wikramaratna P" first="Paul" last="Wikramaratna">Paul Wikramaratna</name><affiliation><nlm:affiliation>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Alrabeeah, Abdullah A" sort="Alrabeeah, Abdullah A" uniqKey="Alrabeeah A" first="Abdullah A" last="Alrabeeah">Abdullah A. Alrabeeah</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Bonn, Germany. Electronic address: drosten@virology-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia; Alfaisal University, Riyadh, Saudi Arabia. Electronic address: zmemish@yahoo.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25863564</idno><idno type="pmid">25863564</idno><idno type="doi">10.1016/S1473-3099(15)70090-3</idno><idno type="wicri:Area/PubMed/Corpus">001649</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001649</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.</title><author><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A" last="Müller">Marcel A. Müller</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, Benjamin" sort="Meyer, Benjamin" uniqKey="Meyer B" first="Benjamin" last="Meyer">Benjamin Meyer</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M" last="Corman">Victor M. Corman</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Al Masri, Malak" sort="Al Masri, Malak" uniqKey="Al Masri M" first="Malak" last="Al-Masri">Malak Al-Masri</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Turkestani, Abdulhafeez" sort="Turkestani, Abdulhafeez" uniqKey="Turkestani A" first="Abdulhafeez" last="Turkestani">Abdulhafeez Turkestani</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia; Makkah Regional Health Affairs, Ministry of Health, Makkah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ritz, Daniel" sort="Ritz, Daniel" uniqKey="Ritz D" first="Daniel" last="Ritz">Daniel Ritz</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Sieberg, Andrea" sort="Sieberg, Andrea" uniqKey="Sieberg A" first="Andrea" last="Sieberg">Andrea Sieberg</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aldabbagh, Souhaib" sort="Aldabbagh, Souhaib" uniqKey="Aldabbagh S" first="Souhaib" last="Aldabbagh">Souhaib Aldabbagh</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bosch, Berend J" sort="Bosch, Berend J" uniqKey="Bosch B" first="Berend-J" last="Bosch">Berend-J Bosch</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lattwein, Erik" sort="Lattwein, Erik" uniqKey="Lattwein E" first="Erik" last="Lattwein">Erik Lattwein</name><affiliation><nlm:affiliation>Euroimmun AG, Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Alhakeem, Raafat F" sort="Alhakeem, Raafat F" uniqKey="Alhakeem R" first="Raafat F" last="Alhakeem">Raafat F. Alhakeem</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M" last="Assiri">Abdullah M. Assiri</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M" last="Albarrak">Ali M. Albarrak</name><affiliation><nlm:affiliation>Saudi Center for Disease Control, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Shangiti, Ali M" sort="Al Shangiti, Ali M" uniqKey="Al Shangiti A" first="Ali M" last="Al-Shangiti">Ali M. Al-Shangiti</name><affiliation><nlm:affiliation>National Health Laboratory, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:affiliation>Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wikramaratna, Paul" sort="Wikramaratna, Paul" uniqKey="Wikramaratna P" first="Paul" last="Wikramaratna">Paul Wikramaratna</name><affiliation><nlm:affiliation>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Alrabeeah, Abdullah A" sort="Alrabeeah, Abdullah A" uniqKey="Alrabeeah A" first="Abdullah A" last="Alrabeeah">Abdullah A. Alrabeeah</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Bonn, Germany. Electronic address: drosten@virology-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name><affiliation><nlm:affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia; Alfaisal University, Riyadh, Saudi Arabia. Electronic address: zmemish@yahoo.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Lancet. Infectious diseases</title><idno type="eISSN">1474-4457</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abattoirs</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animal Husbandry</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Camelus (virology)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (virology)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Occupations</term><term>Prevalence</term><term>Saudi Arabia (epidemiology)</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Abattoirs</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animal Husbandry</term><term>Animals</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Occupations</term><term>Prevalence</term><term>Seroepidemiologic Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Scientific evidence suggests that dromedary camels are the intermediary host for the Middle East respiratory syndrome coronavirus (MERS-CoV). However, the actual number of infections in people who have had contact with camels is unknown and most index patients cannot recall any such contact. We aimed to do a nationwide serosurvey in Saudi Arabia to establish the prevalence of MERS-CoV antibodies, both in the general population and in populations of individuals who have maximum exposure to camels.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25863564</PMID><DateCompleted><Year>2015</Year><Month>07</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-4457</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>The Lancet. Infectious diseases</Title><ISOAbbreviation>Lancet Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.</ArticleTitle><Pagination><MedlinePgn>559-64</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1473-3099(15)70090-3</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1473-3099(15)70090-3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Scientific evidence suggests that dromedary camels are the intermediary host for the Middle East respiratory syndrome coronavirus (MERS-CoV). However, the actual number of infections in people who have had contact with camels is unknown and most index patients cannot recall any such contact. We aimed to do a nationwide serosurvey in Saudi Arabia to establish the prevalence of MERS-CoV antibodies, both in the general population and in populations of individuals who have maximum exposure to camels.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In the cross-sectional serosurvey, we tested human serum samples obtained from healthy individuals older than 15 years who attended primary health-care centres or participated in a national burden-of-disease study in all 13 provinces of Saudi Arabia. Additionally, we tested serum samples from shepherds and abattoir workers with occupational exposure to camels. Samples were screened by recombinant ELISA and MERS-CoV seropositivity was confirmed by recombinant immunofluorescence and plaque reduction neutralisation tests. We used two-tailed Mann Whitney U exact tests, χ(2), and Fisher's exact tests to analyse the data.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Between Dec 1, 2012, and Dec 1, 2013, we obtained individual serum samples from 10,009 individuals. Anti-MERS-CoV antibodies were confirmed in 15 (0·15%; 95% CI 0·09-0·24) of 10,009 people in six of the 13 provinces. The mean age of seropositive individuals was significantly younger than that of patients with reported, laboratory-confirmed, primary Middle Eastern respiratory syndrome (43·5 years [SD 17·3] vs 53·8 years [17·5]; p=0·008). Men had a higher antibody prevalence than did women (11 [0·25%] of 4341 vs two [0·05%] of 4378; p=0·028) and antibody prevalence was significantly higher in central versus coastal provinces (14 [0·26%] of 5479 vs one [0·02%] of 4529; p=0·003). Compared with the general population, seroprevalence of MERS-CoV antibodies was significantly increased by 15 times in shepherds (two [2·3%] of 87, p=0·0004) and by 23 times in slaughterhouse workers (five [3·6%] of 140; p<0·0001).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Seroprevalence of MERS-CoV antibodies was significantly higher in camel-exposed individuals than in the general population. By simple multiplication, a projected 44,951 (95% CI 26,971-71,922) individuals older than 15 years might be seropositive for MERS-CoV in Saudi Arabia. These individuals might be the source of infection for patients with confirmed MERS who had no previous exposure to camels.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">European Union, German Centre for Infection Research, Federal Ministry of Education and Research, German Research Council, and Ministry of Health of Saudi Arabia.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Marcel A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corman</LastName><ForeName>Victor M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Masri</LastName><ForeName>Malak</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turkestani</LastName><ForeName>Abdulhafeez</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia; Makkah Regional Health Affairs, Ministry of Health, Makkah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritz</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sieberg</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aldabbagh</LastName><ForeName>Souhaib</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bosch</LastName><ForeName>Berend-J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lattwein</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Euroimmun AG, Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alhakeem</LastName><ForeName>Raafat F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assiri</LastName><ForeName>Abdullah M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albarrak</LastName><ForeName>Ali M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Saudi Center for Disease Control, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Shangiti</LastName><ForeName>Ali M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>National Health Laboratory, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Tawfiq</LastName><ForeName>Jaffar A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wikramaratna</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alrabeeah</LastName><ForeName>Abdullah A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drosten</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Bonn, Germany. Electronic address: drosten@virology-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Memish</LastName><ForeName>Ziad A</ForeName><Initials>ZA</Initials><AffiliationInfo><Affiliation>King Abdulaziz Medical City & Advisor Royal Court, Riyadh, Saudi Arabia; Alfaisal University, Riyadh, Saudi Arabia. Electronic address: zmemish@yahoo.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lancet Infect Dis</MedlineTA><NlmUniqueID>101130150</NlmUniqueID><ISSNLinking>1473-3099</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Lancet Infect Dis. 2015 May;15(5):495-7</RefSource><PMID Version="1">25863563</PMID></CommentsCorrections><CommentsCorrections RefType="ErratumIn"><RefSource>Lancet Infect Dis. 2015 Jun;15(6):629</RefSource><PMID Version="1">26008827</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000003" MajorTopicYN="N">Abattoirs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000822" MajorTopicYN="N">Animal Husbandry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002162" MajorTopicYN="N">Camelus</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009790" MajorTopicYN="N">Occupations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012529" MajorTopicYN="N">Saudi Arabia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016036" MajorTopicYN="N">Seroepidemiologic Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25863564</ArticleId><ArticleId IdType="pii">S1473-3099(15)70090-3</ArticleId><ArticleId IdType="doi">10.1016/S1473-3099(15)70090-3</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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