MersV1, PubMed, Corpus, bibRecord, 001480

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.

Identifieur interne : 001480 ( PubMed/Corpus ); précédent : 001479; suivant : 001481

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.

Auteurs : Reed F. Johnson ; Laura E. Via ; Mia R. Kumar ; Joseph P. Cornish ; Srikanth Yellayi ; Louis Huzella ; Elena Postnikova ; Nicholas Oberlander ; Christopher Bartos ; Britini L. Ork ; Steven Mazur ; Cindy Allan ; Michael R. Holbrook ; Jeffrey Solomon ; Joshua C. Johnson ; James Pickel ; Lisa E. Hensley ; Peter B. Jahrling

Source :

Virology [ 1096-0341 ] ; 2015.

RBID : pubmed:26342468

English descriptors

KwdEn :
- Animals, Antibodies, Viral (immunology), Biopsy, Callithrix, Chlorocebus aethiops, Coronavirus Infections (veterinary), Disease Models, Animal, Kidney (pathology), Kidney (virology), Lung (pathology), Lung (virology), Middle East Respiratory Syndrome Coronavirus (physiology), Monkey Diseases (diagnosis), Monkey Diseases (immunology), Monkey Diseases (mortality), Monkey Diseases (virology), RNA, Viral (genetics), Severity of Illness Index, Tomography, X-Ray Computed, Vero Cells.
MESH :
- chemical , genetics : RNA, Viral.
- chemical , immunology : Antibodies, Viral.
- diagnosis : Monkey Diseases.
- immunology : Monkey Diseases.
- mortality : Monkey Diseases.
- pathology : Kidney, Lung.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Kidney, Lung, Monkey Diseases.
- Animals, Biopsy, Callithrix, Chlorocebus aethiops, Disease Models, Animal, Severity of Illness Index, Tomography, X-Ray Computed, Vero Cells.

Abstract

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication.

DOI: 10.1016/j.virol.2015.07.013
PubMed: 26342468

Links to Exploration step

pubmed:26342468

Le document en format XML

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<term>Chlorocebus aethiops</term>
<term>Coronavirus Infections (veterinary)</term>
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<term>Kidney (pathology)</term>
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<front><div type="abstract" xml:lang="en">Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication. </div>
</front>
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<ArticleTitle>Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.</ArticleTitle>
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<Abstract><AbstractText>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication. </AbstractText>
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<Author ValidYN="Y"><LastName>Kumar</LastName>
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<ForeName>Jeffrey</ForeName>
<Initials>J</Initials>
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   |texte=   Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.
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Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.

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