Dominant efficiency of nonregular patterns of subthalamic nucleus deep brain stimulation for Parkinson's disease and obsessive-compulsive disorder in a data-driven computational model.
Identifieur interne : 001328 ( PubMed/Corpus ); précédent : 001327; suivant : 001329Dominant efficiency of nonregular patterns of subthalamic nucleus deep brain stimulation for Parkinson's disease and obsessive-compulsive disorder in a data-driven computational model.
Auteurs : Sofia D. Karamintziou ; Nick G. Deligiannis ; Brigitte Piallat ; Mircea Polosan ; Stephan Chabardès ; Olivier David ; Pantelis G. Stathis ; George A. Tagaris ; Efstathios J. Boviatsis ; Damianos E. Sakas ; Georgia E. Polychronaki ; George L. Tsirogiannis ; Konstantina S. NikitaSource :
- Journal of neural engineering [ 1741-2552 ] ; 2016.
English descriptors
- KwdEn :
- Computer Simulation, Deep Brain Stimulation (methods), Humans, Models, Neurological, Obsessive-Compulsive Disorder (physiopathology), Obsessive-Compulsive Disorder (therapy), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Subthalamic Nucleus (physiopathology), Therapy, Computer-Assisted (methods), Treatment Outcome.
- MESH :
- methods : Deep Brain Stimulation, Therapy, Computer-Assisted.
- physiopathology : Obsessive-Compulsive Disorder, Parkinson Disease, Subthalamic Nucleus.
- therapy : Obsessive-Compulsive Disorder, Parkinson Disease.
- Computer Simulation, Humans, Models, Neurological, Treatment Outcome.
Abstract
Almost 30 years after the start of the modern era of deep brain stimulation (DBS), the subthalamic nucleus (STN) still constitutes a standard stimulation target for advanced Parkinson's disease (PD), but the use of STN-DBS is also now supported by level I clinical evidence for treatment-refractory obsessive-compulsive disorder (OCD). Disruption of neural synchronization in the STN has been suggested as one of the possible mechanisms of action of standard and alternative patterns of STN-DBS at a local level. Meanwhile, recent experimental and computational modeling evidence has signified the efficiency of alternative patterns of stimulation; however, no indications exist for treatment-refractory OCD. Here, we comparatively simulate the desynchronizing effect of standard (regular at 130 Hz) versus temporally alternative (in terms of frequency, temporal variability and the existence of bursts or pauses) patterns of STN-DBS for PD and OCD, by means of a stochastic dynamical model and two microelectrode recording (MER) datasets.
DOI: 10.1088/1741-2560/13/1/016013
PubMed: 26695534
Links to Exploration step
pubmed:26695534Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dominant efficiency of nonregular patterns of subthalamic nucleus deep brain stimulation for Parkinson's disease and obsessive-compulsive disorder in a data-driven computational model.</title>
<author><name sortKey="Karamintziou, Sofia D" sort="Karamintziou, Sofia D" uniqKey="Karamintziou S" first="Sofia D" last="Karamintziou">Sofia D. Karamintziou</name>
<affiliation><nlm:affiliation>Biomedical Simulations and Imaging Laboratory (BIOSIM), School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Deligiannis, Nick G" sort="Deligiannis, Nick G" uniqKey="Deligiannis N" first="Nick G" last="Deligiannis">Nick G. Deligiannis</name>
</author>
<author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name>
</author>
<author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name>
</author>
<author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardès">Stephan Chabardès</name>
</author>
<author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name>
</author>
<author><name sortKey="Stathis, Pantelis G" sort="Stathis, Pantelis G" uniqKey="Stathis P" first="Pantelis G" last="Stathis">Pantelis G. Stathis</name>
</author>
<author><name sortKey="Tagaris, George A" sort="Tagaris, George A" uniqKey="Tagaris G" first="George A" last="Tagaris">George A. Tagaris</name>
</author>
<author><name sortKey="Boviatsis, Efstathios J" sort="Boviatsis, Efstathios J" uniqKey="Boviatsis E" first="Efstathios J" last="Boviatsis">Efstathios J. Boviatsis</name>
</author>
<author><name sortKey="Sakas, Damianos E" sort="Sakas, Damianos E" uniqKey="Sakas D" first="Damianos E" last="Sakas">Damianos E. Sakas</name>
</author>
<author><name sortKey="Polychronaki, Georgia E" sort="Polychronaki, Georgia E" uniqKey="Polychronaki G" first="Georgia E" last="Polychronaki">Georgia E. Polychronaki</name>
</author>
<author><name sortKey="Tsirogiannis, George L" sort="Tsirogiannis, George L" uniqKey="Tsirogiannis G" first="George L" last="Tsirogiannis">George L. Tsirogiannis</name>
</author>
<author><name sortKey="Nikita, Konstantina S" sort="Nikita, Konstantina S" uniqKey="Nikita K" first="Konstantina S" last="Nikita">Konstantina S. Nikita</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26695534</idno>
<idno type="pmid">26695534</idno>
<idno type="doi">10.1088/1741-2560/13/1/016013</idno>
<idno type="wicri:Area/PubMed/Corpus">001328</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001328</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Dominant efficiency of nonregular patterns of subthalamic nucleus deep brain stimulation for Parkinson's disease and obsessive-compulsive disorder in a data-driven computational model.</title>
<author><name sortKey="Karamintziou, Sofia D" sort="Karamintziou, Sofia D" uniqKey="Karamintziou S" first="Sofia D" last="Karamintziou">Sofia D. Karamintziou</name>
<affiliation><nlm:affiliation>Biomedical Simulations and Imaging Laboratory (BIOSIM), School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Deligiannis, Nick G" sort="Deligiannis, Nick G" uniqKey="Deligiannis N" first="Nick G" last="Deligiannis">Nick G. Deligiannis</name>
</author>
<author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name>
</author>
<author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name>
</author>
<author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardès">Stephan Chabardès</name>
</author>
<author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name>
</author>
<author><name sortKey="Stathis, Pantelis G" sort="Stathis, Pantelis G" uniqKey="Stathis P" first="Pantelis G" last="Stathis">Pantelis G. Stathis</name>
</author>
<author><name sortKey="Tagaris, George A" sort="Tagaris, George A" uniqKey="Tagaris G" first="George A" last="Tagaris">George A. Tagaris</name>
</author>
<author><name sortKey="Boviatsis, Efstathios J" sort="Boviatsis, Efstathios J" uniqKey="Boviatsis E" first="Efstathios J" last="Boviatsis">Efstathios J. Boviatsis</name>
</author>
<author><name sortKey="Sakas, Damianos E" sort="Sakas, Damianos E" uniqKey="Sakas D" first="Damianos E" last="Sakas">Damianos E. Sakas</name>
</author>
<author><name sortKey="Polychronaki, Georgia E" sort="Polychronaki, Georgia E" uniqKey="Polychronaki G" first="Georgia E" last="Polychronaki">Georgia E. Polychronaki</name>
</author>
<author><name sortKey="Tsirogiannis, George L" sort="Tsirogiannis, George L" uniqKey="Tsirogiannis G" first="George L" last="Tsirogiannis">George L. Tsirogiannis</name>
</author>
<author><name sortKey="Nikita, Konstantina S" sort="Nikita, Konstantina S" uniqKey="Nikita K" first="Konstantina S" last="Nikita">Konstantina S. Nikita</name>
</author>
</analytic>
<series><title level="j">Journal of neural engineering</title>
<idno type="eISSN">1741-2552</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Simulation</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Humans</term>
<term>Models, Neurological</term>
<term>Obsessive-Compulsive Disorder (physiopathology)</term>
<term>Obsessive-Compulsive Disorder (therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Subthalamic Nucleus (physiopathology)</term>
<term>Therapy, Computer-Assisted (methods)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
<term>Therapy, Computer-Assisted</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Obsessive-Compulsive Disorder</term>
<term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Obsessive-Compulsive Disorder</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term>
<term>Humans</term>
<term>Models, Neurological</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Almost 30 years after the start of the modern era of deep brain stimulation (DBS), the subthalamic nucleus (STN) still constitutes a standard stimulation target for advanced Parkinson's disease (PD), but the use of STN-DBS is also now supported by level I clinical evidence for treatment-refractory obsessive-compulsive disorder (OCD). Disruption of neural synchronization in the STN has been suggested as one of the possible mechanisms of action of standard and alternative patterns of STN-DBS at a local level. Meanwhile, recent experimental and computational modeling evidence has signified the efficiency of alternative patterns of stimulation; however, no indications exist for treatment-refractory OCD. Here, we comparatively simulate the desynchronizing effect of standard (regular at 130 Hz) versus temporally alternative (in terms of frequency, temporal variability and the existence of bursts or pauses) patterns of STN-DBS for PD and OCD, by means of a stochastic dynamical model and two microelectrode recording (MER) datasets.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26695534</PMID>
<DateCompleted><Year>2016</Year>
<Month>10</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>12</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1741-2552</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<Issue>1</Issue>
<PubDate><Year>2016</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Journal of neural engineering</Title>
<ISOAbbreviation>J Neural Eng</ISOAbbreviation>
</Journal>
<ArticleTitle>Dominant efficiency of nonregular patterns of subthalamic nucleus deep brain stimulation for Parkinson's disease and obsessive-compulsive disorder in a data-driven computational model.</ArticleTitle>
<Pagination><MedlinePgn>016013</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1088/1741-2560/13/1/016013</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Almost 30 years after the start of the modern era of deep brain stimulation (DBS), the subthalamic nucleus (STN) still constitutes a standard stimulation target for advanced Parkinson's disease (PD), but the use of STN-DBS is also now supported by level I clinical evidence for treatment-refractory obsessive-compulsive disorder (OCD). Disruption of neural synchronization in the STN has been suggested as one of the possible mechanisms of action of standard and alternative patterns of STN-DBS at a local level. Meanwhile, recent experimental and computational modeling evidence has signified the efficiency of alternative patterns of stimulation; however, no indications exist for treatment-refractory OCD. Here, we comparatively simulate the desynchronizing effect of standard (regular at 130 Hz) versus temporally alternative (in terms of frequency, temporal variability and the existence of bursts or pauses) patterns of STN-DBS for PD and OCD, by means of a stochastic dynamical model and two microelectrode recording (MER) datasets.</AbstractText>
<AbstractText Label="APPROACH" NlmCategory="METHODS">The stochastic model is fitted to subthalamic MERs acquired during eight surgical interventions for PD and eight surgical interventions for OCD. For each dynamical system simulated, we comparatively assess the invariant density (steady-state phase distribution) as a measure inversely related to the desynchronizing effect yielded by the applied patterns of stimulation.</AbstractText>
<AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">We demonstrate that high (130 Hz)-and low (80 Hz)-frequency irregular patterns of stimulation, and low-frequency periodic stimulation interrupted by bursts of pulses, yield in both pathologic conditions a significantly stronger desynchronizing effect compared with standard STN-DBS, and distinct alternative patterns of stimulation. In PD, values of the invariant density measure are proven to be optimal at the dorsolateral oscillatory region of the STN including sites with the optimal therapeutic window.</AbstractText>
<AbstractText Label="SIGNIFICANCE" NlmCategory="CONCLUSIONS">In addition to providing novel insights into the efficiency of low-frequency nonregular patterns of STN-DBS for advanced PD and treatment-refractory OCD, this work points to a possible correlation of a model-based outcome measure with clinical effectiveness of stimulation and may have significant implications for an energy- and therapeutically-efficient configuration of a closed-loop neuromodulation system.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Karamintziou</LastName>
<ForeName>Sofia D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Biomedical Simulations and Imaging Laboratory (BIOSIM), School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deligiannis</LastName>
<ForeName>Nick G</ForeName>
<Initials>NG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Piallat</LastName>
<ForeName>Brigitte</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Polosan</LastName>
<ForeName>Mircea</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chabardès</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>David</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
</Author>
<Author ValidYN="Y"><LastName>Stathis</LastName>
<ForeName>Pantelis G</ForeName>
<Initials>PG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tagaris</LastName>
<ForeName>George A</ForeName>
<Initials>GA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Boviatsis</LastName>
<ForeName>Efstathios J</ForeName>
<Initials>EJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sakas</LastName>
<ForeName>Damianos E</ForeName>
<Initials>DE</Initials>
</Author>
<Author ValidYN="Y"><LastName>Polychronaki</LastName>
<ForeName>Georgia E</ForeName>
<Initials>GE</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tsirogiannis</LastName>
<ForeName>George L</ForeName>
<Initials>GL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nikita</LastName>
<ForeName>Konstantina S</ForeName>
<Initials>KS</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>12</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Neural Eng</MedlineTA>
<NlmUniqueID>101217933</NlmUniqueID>
<ISSNLinking>1741-2552</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D003198" MajorTopicYN="N">Computer Simulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046690" MajorTopicYN="N">Deep Brain Stimulation</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008959" MajorTopicYN="Y">Models, Neurological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009771" MajorTopicYN="N">Obsessive-Compulsive Disorder</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013813" MajorTopicYN="N">Therapy, Computer-Assisted</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>12</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>12</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26695534</ArticleId>
<ArticleId IdType="doi">10.1088/1741-2560/13/1/016013</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001328 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001328 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:26695534 |texte= Dominant efficiency of nonregular patterns of subthalamic nucleus deep brain stimulation for Parkinson's disease and obsessive-compulsive disorder in a data-driven computational model. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26695534" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |