3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.
Identifieur interne : 001279 ( PubMed/Corpus ); précédent : 001278; suivant : 0012803B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.
Auteurs : Reed F. Johnson ; Ulas Bagci ; Lauren Keith ; Xianchun Tang ; Daniel J. Mollura ; Larry Zeitlin ; Jing Qin ; Louis Huzella ; Christopher J. Bartos ; Natasha Bohorova ; Ognian Bohorov ; Charles Goodman ; Do H. Kim ; Michael H. Paulty ; Jesus Velasco ; Kevin J. Whaley ; Joshua C. Johnson ; James Pettitt ; Britini L. Ork ; Jeffrey Solomon ; Nicholas Oberlander ; Quan Zhu ; Jiusong Sun ; Michael R. Holbrook ; Gene G. Olinger ; Ralph S. Baric ; Lisa E. Hensley ; Peter B. Jahrling ; Wayne A. MarascoSource :
- Virology [ 1096-0341 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (administration & dosage), Antibodies, Viral (administration & dosage), Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Coronavirus Infections (virology), Disease Models, Animal, Humans, Lung (pathology), Lung (virology), Macaca mulatta, Male, Middle East Respiratory Syndrome Coronavirus (physiology).
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Antibodies, Viral.
- drug therapy : Coronavirus Infections.
- pathology : Coronavirus Infections, Lung.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Lung.
- Animals, Disease Models, Animal, Humans, Macaca mulatta, Male.
Abstract
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment.
DOI: 10.1016/j.virol.2016.01.004
PubMed: 26828465
Links to Exploration step
pubmed:26828465Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.</title><author><name sortKey="Johnson, Reed F" sort="Johnson, Reed F" uniqKey="Johnson R" first="Reed F" last="Johnson">Reed F. Johnson</name><affiliation><nlm:affiliation>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA. Electronic address: johnsonreed@mail.nih.gov.</nlm:affiliation></affiliation></author><author><name sortKey="Bagci, Ulas" sort="Bagci, Ulas" uniqKey="Bagci U" first="Ulas" last="Bagci">Ulas Bagci</name><affiliation><nlm:affiliation>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA; Center for Research in Computer Vision (CRCV), Department of Electrics Electronics and Computer Science, University of Central Florida, Orlando, FL 32816, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keith, Lauren" sort="Keith, Lauren" uniqKey="Keith L" first="Lauren" last="Keith">Lauren Keith</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Xianchun" sort="Tang, Xianchun" uniqKey="Tang X" first="Xianchun" last="Tang">Xianchun Tang</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mollura, Daniel J" sort="Mollura, Daniel J" uniqKey="Mollura D" first="Daniel J" last="Mollura">Daniel J. Mollura</name><affiliation><nlm:affiliation>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zeitlin, Larry" sort="Zeitlin, Larry" uniqKey="Zeitlin L" first="Larry" last="Zeitlin">Larry Zeitlin</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Jing" sort="Qin, Jing" uniqKey="Qin J" first="Jing" last="Qin">Jing Qin</name><affiliation><nlm:affiliation>Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huzella, Louis" sort="Huzella, Louis" uniqKey="Huzella L" first="Louis" last="Huzella">Louis Huzella</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bartos, Christopher J" sort="Bartos, Christopher J" uniqKey="Bartos C" first="Christopher J" last="Bartos">Christopher J. Bartos</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bohorova, Natasha" sort="Bohorova, Natasha" uniqKey="Bohorova N" first="Natasha" last="Bohorova">Natasha Bohorova</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bohorov, Ognian" sort="Bohorov, Ognian" uniqKey="Bohorov O" first="Ognian" last="Bohorov">Ognian Bohorov</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goodman, Charles" sort="Goodman, Charles" uniqKey="Goodman C" first="Charles" last="Goodman">Charles Goodman</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Do H" sort="Kim, Do H" uniqKey="Kim D" first="Do H" last="Kim">Do H. Kim</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Paulty, Michael H" sort="Paulty, Michael H" uniqKey="Paulty M" first="Michael H" last="Paulty">Michael H. Paulty</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Velasco, Jesus" sort="Velasco, Jesus" uniqKey="Velasco J" first="Jesus" last="Velasco">Jesus Velasco</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Whaley, Kevin J" sort="Whaley, Kevin J" uniqKey="Whaley K" first="Kevin J" last="Whaley">Kevin J. Whaley</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Joshua C" sort="Johnson, Joshua C" uniqKey="Johnson J" first="Joshua C" last="Johnson">Joshua C. Johnson</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pettitt, James" sort="Pettitt, James" uniqKey="Pettitt J" first="James" last="Pettitt">James Pettitt</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ork, Britini L" sort="Ork, Britini L" uniqKey="Ork B" first="Britini L" last="Ork">Britini L. Ork</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Solomon, Jeffrey" sort="Solomon, Jeffrey" uniqKey="Solomon J" first="Jeffrey" last="Solomon">Jeffrey Solomon</name><affiliation><nlm:affiliation>Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,Frederick, MD 21702-USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oberlander, Nicholas" sort="Oberlander, Nicholas" uniqKey="Oberlander N" first="Nicholas" last="Oberlander">Nicholas Oberlander</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Quan" sort="Zhu, Quan" uniqKey="Zhu Q" first="Quan" last="Zhu">Quan Zhu</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Jiusong" sort="Sun, Jiusong" uniqKey="Sun J" first="Jiusong" last="Sun">Jiusong Sun</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holbrook, Michael R" sort="Holbrook, Michael R" uniqKey="Holbrook M" first="Michael R" last="Holbrook">Michael R. Holbrook</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Olinger, Gene G" sort="Olinger, Gene G" uniqKey="Olinger G" first="Gene G" last="Olinger">Gene G. Olinger</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hensley, Lisa E" sort="Hensley, Lisa E" uniqKey="Hensley L" first="Lisa E" last="Hensley">Lisa E. Hensley</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jahrling, Peter B" sort="Jahrling, Peter B" uniqKey="Jahrling P" first="Peter B" last="Jahrling">Peter B. Jahrling</name><affiliation><nlm:affiliation>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26828465</idno><idno type="pmid">26828465</idno><idno type="doi">10.1016/j.virol.2016.01.004</idno><idno type="wicri:Area/PubMed/Corpus">001279</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001279</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.</title><author><name sortKey="Johnson, Reed F" sort="Johnson, Reed F" uniqKey="Johnson R" first="Reed F" last="Johnson">Reed F. Johnson</name><affiliation><nlm:affiliation>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA. Electronic address: johnsonreed@mail.nih.gov.</nlm:affiliation></affiliation></author><author><name sortKey="Bagci, Ulas" sort="Bagci, Ulas" uniqKey="Bagci U" first="Ulas" last="Bagci">Ulas Bagci</name><affiliation><nlm:affiliation>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA; Center for Research in Computer Vision (CRCV), Department of Electrics Electronics and Computer Science, University of Central Florida, Orlando, FL 32816, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keith, Lauren" sort="Keith, Lauren" uniqKey="Keith L" first="Lauren" last="Keith">Lauren Keith</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Xianchun" sort="Tang, Xianchun" uniqKey="Tang X" first="Xianchun" last="Tang">Xianchun Tang</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mollura, Daniel J" sort="Mollura, Daniel J" uniqKey="Mollura D" first="Daniel J" last="Mollura">Daniel J. Mollura</name><affiliation><nlm:affiliation>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zeitlin, Larry" sort="Zeitlin, Larry" uniqKey="Zeitlin L" first="Larry" last="Zeitlin">Larry Zeitlin</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Jing" sort="Qin, Jing" uniqKey="Qin J" first="Jing" last="Qin">Jing Qin</name><affiliation><nlm:affiliation>Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huzella, Louis" sort="Huzella, Louis" uniqKey="Huzella L" first="Louis" last="Huzella">Louis Huzella</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bartos, Christopher J" sort="Bartos, Christopher J" uniqKey="Bartos C" first="Christopher J" last="Bartos">Christopher J. Bartos</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bohorova, Natasha" sort="Bohorova, Natasha" uniqKey="Bohorova N" first="Natasha" last="Bohorova">Natasha Bohorova</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bohorov, Ognian" sort="Bohorov, Ognian" uniqKey="Bohorov O" first="Ognian" last="Bohorov">Ognian Bohorov</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goodman, Charles" sort="Goodman, Charles" uniqKey="Goodman C" first="Charles" last="Goodman">Charles Goodman</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Do H" sort="Kim, Do H" uniqKey="Kim D" first="Do H" last="Kim">Do H. Kim</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Paulty, Michael H" sort="Paulty, Michael H" uniqKey="Paulty M" first="Michael H" last="Paulty">Michael H. Paulty</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Velasco, Jesus" sort="Velasco, Jesus" uniqKey="Velasco J" first="Jesus" last="Velasco">Jesus Velasco</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Whaley, Kevin J" sort="Whaley, Kevin J" uniqKey="Whaley K" first="Kevin J" last="Whaley">Kevin J. Whaley</name><affiliation><nlm:affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Joshua C" sort="Johnson, Joshua C" uniqKey="Johnson J" first="Joshua C" last="Johnson">Joshua C. Johnson</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pettitt, James" sort="Pettitt, James" uniqKey="Pettitt J" first="James" last="Pettitt">James Pettitt</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ork, Britini L" sort="Ork, Britini L" uniqKey="Ork B" first="Britini L" last="Ork">Britini L. Ork</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Solomon, Jeffrey" sort="Solomon, Jeffrey" uniqKey="Solomon J" first="Jeffrey" last="Solomon">Jeffrey Solomon</name><affiliation><nlm:affiliation>Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,Frederick, MD 21702-USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oberlander, Nicholas" sort="Oberlander, Nicholas" uniqKey="Oberlander N" first="Nicholas" last="Oberlander">Nicholas Oberlander</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Quan" sort="Zhu, Quan" uniqKey="Zhu Q" first="Quan" last="Zhu">Quan Zhu</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Jiusong" sort="Sun, Jiusong" uniqKey="Sun J" first="Jiusong" last="Sun">Jiusong Sun</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holbrook, Michael R" sort="Holbrook, Michael R" uniqKey="Holbrook M" first="Michael R" last="Holbrook">Michael R. Holbrook</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Olinger, Gene G" sort="Olinger, Gene G" uniqKey="Olinger G" first="Gene G" last="Olinger">Gene G. Olinger</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hensley, Lisa E" sort="Hensley, Lisa E" uniqKey="Hensley L" first="Lisa E" last="Hensley">Lisa E. Hensley</name><affiliation><nlm:affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jahrling, Peter B" sort="Jahrling, Peter B" uniqKey="Jahrling P" first="Peter B" last="Jahrling">Peter B. Jahrling</name><affiliation><nlm:affiliation>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name><affiliation><nlm:affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Virology</title><idno type="eISSN">1096-0341</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (administration & dosage)</term><term>Antibodies, Viral (administration & dosage)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Disease Models, Animal</term><term>Humans</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Macaca mulatta</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Macaca mulatta</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26828465</PMID><DateCompleted><Year>2016</Year><Month>08</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0341</ISSN><JournalIssue CitedMedium="Internet"><Volume>490</Volume><PubDate><Year>2016</Year><Month>03</Month></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.</ArticleTitle><Pagination><MedlinePgn>49-58</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.virol.2016.01.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0042-6822(16)00007-6</ELocationID><Abstract><AbstractText>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment.</AbstractText><CopyrightInformation>Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Reed F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA. Electronic address: johnsonreed@mail.nih.gov.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bagci</LastName><ForeName>Ulas</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA; Center for Research in Computer Vision (CRCV), Department of Electrics Electronics and Computer Science, University of Central Florida, Orlando, FL 32816, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keith</LastName><ForeName>Lauren</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Xianchun</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mollura</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeitlin</LastName><ForeName>Larry</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huzella</LastName><ForeName>Louis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartos</LastName><ForeName>Christopher J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bohorova</LastName><ForeName>Natasha</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bohorov</LastName><ForeName>Ognian</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goodman</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Do H</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paulty</LastName><ForeName>Michael H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velasco</LastName><ForeName>Jesus</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whaley</LastName><ForeName>Kevin J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Joshua C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pettitt</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ork</LastName><ForeName>Britini L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Solomon</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,Frederick, MD 21702-USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oberlander</LastName><ForeName>Nicholas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Quan</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Jiusong</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holbrook</LastName><ForeName>Michael R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olinger</LastName><ForeName>Gene G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baric</LastName><ForeName>Ralph S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hensley</LastName><ForeName>Lisa E</ForeName><Initials>LE</Initials><AffiliationInfo><Affiliation>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahrling</LastName><ForeName>Peter B</ForeName><Initials>PB</Initials><AffiliationInfo><Affiliation>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marasco</LastName><ForeName>Wayne A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI085524</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AI085524</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261200800001C</GrantID><Acronym>RC</Acronym><Agency>CCR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN272200700016I</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>Z99 AI999999</GrantID><Acronym>ImNIH</Acronym><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261200800001E</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>ZIA AI001025-08</GrantID><Acronym>ImNIH</Acronym><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Virology</MedlineTA><NlmUniqueID>0110674</NlmUniqueID><ISSNLinking>0042-6822</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East 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