A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.
Identifieur interne : 001247 ( PubMed/Corpus ); précédent : 001246; suivant : 001248A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.
Auteurs : Hanjun Zhao ; Jie Zhou ; Ke Zhang ; Hin Chu ; Dabin Liu ; Vincent Kwok-Man Poon ; Chris Chung-Sing Chan ; Ho-Chuen Leung ; Ng Fai ; Yong-Ping Lin ; Anna Jin-Xia Zhang ; Dong-Yan Jin ; Kwok-Yung Yuen ; Bo-Jian ZhengSource :
- Scientific reports [ 2045-2322 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Endosomes (drug effects), Endosomes (metabolism), Endosomes (virology), Influenza A virus (drug effects), Influenza A virus (physiology), Inhibitory Concentration 50, Mice, Microbial Sensitivity Tests, Middle East Respiratory Syndrome Coronavirus (drug effects), Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (virology), Peptide Fragments (pharmacology), Peptides (chemistry), Peptides (metabolism), Peptides (pharmacology), Protein Binding, SARS Virus (drug effects), Viral Envelope Proteins (metabolism), Viral Load, beta-Defensins (chemistry).
- MESH :
- chemical , chemistry : Peptides, beta-Defensins.
- chemical , metabolism : Peptides, Viral Envelope Proteins.
- chemical , pharmacology : Antiviral Agents, Peptide Fragments, Peptides.
- drug effects : Endosomes, Influenza A virus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- drug therapy : Orthomyxoviridae Infections.
- metabolism : Endosomes.
- mortality : Orthomyxoviridae Infections.
- pathology : Orthomyxoviridae Infections.
- physiology : Influenza A virus.
- virology : Endosomes, Orthomyxoviridae Infections.
- Animals, Inhibitory Concentration 50, Mice, Microbial Sensitivity Tests, Protein Binding, Viral Load.
Abstract
A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities.
DOI: 10.1038/srep22008
PubMed: 26911565
Links to Exploration step
pubmed:26911565Le document en format XML
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<front><div type="abstract" xml:lang="en">A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities. </div>
</front>
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<Abstract><AbstractText>A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities. </AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Hanjun</ForeName>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>11</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>02</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>2</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>2</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>12</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
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<ArticleIdList><ArticleId IdType="pubmed">26911565</ArticleId>
<ArticleId IdType="pii">srep22008</ArticleId>
<ArticleId IdType="doi">10.1038/srep22008</ArticleId>
<ArticleId IdType="pmc">PMC4766503</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>N Engl J Med. 2013 May 16;368(20):1888-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23577628</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Cell Biol. 1989 Apr;108(4):1291-300</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2925786</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nucleic Acids Res. 2007 Jul;35(Web Server issue):W126-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17439967</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 Oct 10;302(5643):276-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12958366</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2011 Apr 15;186(8):4794-804</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21398612</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Virol. 2010 Apr;155(4):491-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20195655</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2004 Apr 9;304(5668):237-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15073366</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Immunol. 2005 Oct;6(10):995-1001</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16155572</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Oct 25;362(9393):1353-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14585636</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Virol. 2000;145(11):2233-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11205114</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9280-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12883000</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2008 Aug 15;283(33):22417-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18567888</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Trends Microbiol. 2014 Nov;22(11):623-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25264312</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2006 Jul 15;177(2):782-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16818731</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Nov;79(22):14318-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16254366</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2009 May 1;58(16):433-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19407738</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Microbiol. 2009 Mar;7(3):226-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19198616</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Invest. 1998 Sep 1;102(5):874-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9727055</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Exp Biol Med (Maywood). 2010 Aug;235(8):981-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20660098</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Innate Immun. 2009;1(5):413-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20375599</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Microbiol. 2005 Aug;3(8):591-600</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16064053</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Invest. 1998 Apr 15;101(8):1633-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9541493</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Cell Biol. 1981 Dec;91(3 Pt 1):601-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7328111</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2009 May 22;4(5):e5671</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19479060</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol Methods. 1988 Aug;20(4):309-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2460479</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2004 Jul 8;430(6996):209-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15241415</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>AIDS. 2003 Nov 7;17(16):F39-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14571200</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 1994 Oct;75 ( Pt 10):2595-606</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7931146</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Infect Dis. 2000 Aug;31(2):578-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10987724</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2008 Jan 15;180(2):948-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18178835</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 1995 Oct 17;34(41):13663-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7577957</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Leukoc Biol. 2011 Aug;90(2):343-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21551252</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2002 Jan 24;415(6870):389-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11807545</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2015 Sep 5;386(9997):995-1007</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26049252</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8091-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18523003</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 2009 Aug 4;48(30):7229-39</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19580334</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Struct Mol Biol. 2010 May;17(5):530-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20383144</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Immunol. 2006 Jun;6(6):447-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16724099</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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