Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection.
Identifieur interne : 001224 ( PubMed/Corpus ); précédent : 001223; suivant : 001225Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection.
Auteurs : Katherine V. Houser ; Lisa Gretebeck ; Tianlei Ying ; Yanping Wang ; Leatrice Vogel ; Elaine W. Lamirande ; Kevin W. Bock ; Ian N. Moore ; Dimiter S. Dimitrov ; Kanta SubbaraoSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2016.
English descriptors
- KwdEn :
- Administration, Intranasal, Administration, Intravenous, Animals, Antibodies, Monoclonal, Humanized (therapeutic use), Antibodies, Neutralizing (blood), Antibodies, Neutralizing (therapeutic use), Antibodies, Viral (blood), Antibodies, Viral (therapeutic use), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Disease Models, Animal, Female, Humans, Immunoglobulins, Intravenous, Lung (virology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), RNA, Viral (analysis), Rabbits.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Antibodies, Viral.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- virology : Lung.
- Administration, Intranasal, Administration, Intravenous, Animals, Disease Models, Animal, Female, Humans, Immunoglobulins, Intravenous, Rabbits.
Abstract
With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40-9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.
DOI: 10.1093/infdis/jiw080
PubMed: 26941283
Links to Exploration step
pubmed:26941283Le document en format XML
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<front><div type="abstract" xml:lang="en">With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40-9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336. </div>
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