MersV1, PubMed, Corpus, bibRecord, 001204

Vaccines for the prevention against the threat of MERS-CoV.

Identifieur interne : 001204 ( PubMed/Corpus ); précédent : 001203; suivant : 001205

Vaccines for the prevention against the threat of MERS-CoV.

Auteurs : Lanying Du ; Wanbo Tai ; Yusen Zhou ; Shibo Jiang

Source :

Expert review of vaccines [ 1744-8395 ] ; 2016.

RBID : pubmed:26985862

English descriptors

KwdEn :
- Animals, Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Disease Models, Animal, Drug Discovery (trends), Humans, Middle East Respiratory Syndrome Coronavirus (immunology), Viral Vaccines (immunology), Viral Vaccines (isolation & purification).
MESH :
- chemical , immunology : Viral Vaccines.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- chemical , isolation & purification : Viral Vaccines.
- prevention & control : Coronavirus Infections.
- trends : Drug Discovery.
- Animals, Disease Models, Animal, Humans.

Abstract

First identified in 2012, Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is listed as a new Category C Priority Pathogen. While the high mortality of MERS-CoV infection is further intensified by potential human-to-human transmissibility, no MERS vaccines are available for human use. This review explains immune responses resulting from MERS-CoV infection, describes MERS vaccine criteria, and presents available small animal models to evaluate the efficacy of MERS vaccines. Current advances in vaccine development are summarized, focusing on specific applications and limitations of each vaccine category. Taken together, this review provides valuable guidelines toward the development of an effective and safe MERS vaccine. This article is written for a Special Focus Issue of Expert Review of Vaccines on 'Vaccines for Biodefence'.

DOI: 10.1586/14760584.2016.1167603
PubMed: 26985862

Links to Exploration step

pubmed:26985862

Le document en format XML

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<front><div type="abstract" xml:lang="en">First identified in 2012, Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is listed as a new Category C Priority Pathogen. While the high mortality of MERS-CoV infection is further intensified by potential human-to-human transmissibility, no MERS vaccines are available for human use. This review explains immune responses resulting from MERS-CoV infection, describes MERS vaccine criteria, and presents available small animal models to evaluate the efficacy of MERS vaccines. Current advances in vaccine development are summarized, focusing on specific applications and limitations of each vaccine category. Taken together, this review provides valuable guidelines toward the development of an effective and safe MERS vaccine. This article is written for a Special Focus Issue of Expert Review of Vaccines on 'Vaccines for Biodefence'.</div>
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<CoiStatement>Declaration of Interests The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.</CoiStatement>
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Vaccines for the prevention against the threat of MERS-CoV.

Vaccines for the prevention against the threat of MERS-CoV.

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