Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia.
Identifieur interne : 001156 ( PubMed/Corpus ); précédent : 001155; suivant : 001157Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia.
Auteurs : Mohammed Al Ghamdi ; Khalid M. Alghamdi ; Yasmeen Ghandoora ; Ameera Alzahrani ; Fatmah Salah ; Abdulmoatani Alsulami ; Mayada F. Bawayan ; Dhananjay Vaidya ; Trish M. Perl ; Geeta SoodSource :
- BMC infectious diseases [ 1471-2334 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Alanine Transaminase (metabolism), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Coronavirus Infections (virology), Female, Health Personnel, Humans, Immunosuppressive Agents (therapeutic use), Logistic Models, Lung (enzymology), Lung (virology), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Multivariate Analysis, Mycophenolic Acid (analogs & derivatives), Mycophenolic Acid (therapeutic use), Polymerase Chain Reaction, Retrospective Studies, Saudi Arabia, Severity of Illness Index, Tertiary Care Centers, Treatment Outcome.
- MESH :
- chemical , analogs & derivatives : Mycophenolic Acid.
- chemical , metabolism : Alanine Transaminase.
- drug therapy : Coronavirus Infections.
- enzymology : Lung.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- mortality : Coronavirus Infections.
- chemical , therapeutic use : Immunosuppressive Agents, Mycophenolic Acid.
- virology : Coronavirus Infections, Lung.
- Aged, Female, Health Personnel, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Polymerase Chain Reaction, Retrospective Studies, Saudi Arabia, Severity of Illness Index, Tertiary Care Centers, Treatment Outcome.
Abstract
Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) is a poorly understood disease with no known treatments. We describe the clinical features and treatment outcomes of patients with laboratory confirmed MERS-CoV at a regional referral center in the Kingdom of Saudi Arabia.
DOI: 10.1186/s12879-016-1492-4
PubMed: 27097824
Links to Exploration step
pubmed:27097824Le document en format XML
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Alghamdi</name><affiliation><nlm:affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ghandoora, Yasmeen" sort="Ghandoora, Yasmeen" uniqKey="Ghandoora Y" first="Yasmeen" last="Ghandoora">Yasmeen Ghandoora</name><affiliation><nlm:affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Alzahrani, Ameera" sort="Alzahrani, Ameera" uniqKey="Alzahrani A" first="Ameera" last="Alzahrani">Ameera Alzahrani</name><affiliation><nlm:affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Salah, Fatmah" sort="Salah, Fatmah" uniqKey="Salah F" first="Fatmah" last="Salah">Fatmah Salah</name><affiliation><nlm:affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Alsulami, Abdulmoatani" sort="Alsulami, Abdulmoatani" uniqKey="Alsulami A" first="Abdulmoatani" last="Alsulami">Abdulmoatani Alsulami</name><affiliation><nlm:affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Bawayan, Mayada F" sort="Bawayan, Mayada F" uniqKey="Bawayan M" first="Mayada F" last="Bawayan">Mayada F. 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We describe the clinical features and treatment outcomes of patients with laboratory confirmed MERS-CoV at a regional referral center in the Kingdom of Saudi Arabia.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">27097824</PMID><DateCompleted><Year>2016</Year><Month>11</Month><Day>09</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2334</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><PubDate><Year>2016</Year><Month>Apr</Month><Day>21</Day></PubDate></JournalIssue><Title>BMC infectious diseases</Title><ISOAbbreviation>BMC Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia.</ArticleTitle><Pagination><MedlinePgn>174</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12879-016-1492-4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) is a poorly understood disease with no known treatments. We describe the clinical features and treatment outcomes of patients with laboratory confirmed MERS-CoV at a regional referral center in the Kingdom of Saudi Arabia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In 2014, a retrospective chart review was performed on patients with a laboratory confirmed diagnosis of MERS-CoV to determine clinical and treatment characteristics associated with death. Confounding was evaluated and a multivariate logistic regression was performed to assess the independent effect of treatments administered.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Fifty-one patients had an overall mortality of 37 %. Most patients were male (78 %) with a mean age of 54 years. Almost a quarter of the patients were healthcare workers (23.5 %) and 41 % had a known exposure to another person with MERS-CoV. Survival was associated with male gender, working as a healthcare worker, history of hypertension, vomiting on admission, elevated respiratory rate, abnormal lung exam, elevated alanine transaminase (ALT), clearance of MERS-CoV on repeat PCR polymerase chain reaction (PCR) testing, and mycophenolate mofetil treatment. Survival was reduced in the presence of coronary artery disease, hypotension, hypoxemia, CXR (chest X-ray) abnormalities, leukocytosis, creatinine >1 · 5 mg/dL, thrombocytopenia, anemia, and renal failure. In a multivariate analysis of treatments administered, severity of illness was the greatest predictor of reduced survival.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Care for patients with MERS-CoV remains a challenge. In this retrospective cohort, interferon beta and mycophenolate mofetil treatment were predictors of increased survival in the univariate analysis. Severity of illness was the greatest predictor of reduced survival in the multivariate analysis. Larger randomized trials are needed to better evaluate the efficacy of these treatment regimens for MERS-CoV.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Al Ghamdi</LastName><ForeName>Mohammed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alghamdi</LastName><ForeName>Khalid M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghandoora</LastName><ForeName>Yasmeen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alzahrani</LastName><ForeName>Ameera</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salah</LastName><ForeName>Fatmah</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alsulami</LastName><ForeName>Abdulmoatani</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bawayan</LastName><ForeName>Mayada F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaidya</LastName><ForeName>Dhananjay</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of General Internal Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perl</LastName><ForeName>Trish M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Infectious Diseases, The Johns Hopkins University, School of Medicine, Baltimore, 21224, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sood</LastName><ForeName>Geeta</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Infectious Diseases, The Johns Hopkins University, School of Medicine, Baltimore, 21224, Maryland, USA. gsood1@jhmi.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Infect Dis</MedlineTA><NlmUniqueID>100968551</NlmUniqueID><ISSNLinking>1471-2334</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.2</RegistryNumber><NameOfSubstance UI="D000410">Alanine Transaminase</NameOfSubstance></Chemical><Chemical><RegistryNumber>HU9DX48N0T</RegistryNumber><NameOfSubstance UI="D009173">Mycophenolic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000410" MajorTopicYN="N">Alanine Transaminase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006282" MajorTopicYN="N">Health Personnel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009173" MajorTopicYN="N">Mycophenolic Acid</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012529" MajorTopicYN="N">Saudi Arabia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062606" MajorTopicYN="N">Tertiary Care Centers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">MERS CoV</Keyword><Keyword MajorTopicYN="N">Middle Eastern Respiratory 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