Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature.
Identifieur interne : 001104 ( PubMed/Corpus ); précédent : 001103; suivant : 001105Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature.
Auteurs : Hussein Algahtani ; Ahmad Subahi ; Bader ShirahSource :
- Case reports in neurological medicine [ 2090-6668 ] ; 2016.
Abstract
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.
DOI: 10.1155/2016/3502683
PubMed: 27239356
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Box 12723, Jeddah 21483, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Shirah, Bader" sort="Shirah, Bader" uniqKey="Shirah B" first="Bader" last="Shirah">Bader Shirah</name><affiliation><nlm:affiliation>King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27239356</idno><idno type="pmid">27239356</idno><idno type="doi">10.1155/2016/3502683</idno><idno type="wicri:Area/PubMed/Corpus">001104</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature.</title><author><name sortKey="Algahtani, Hussein" sort="Algahtani, Hussein" uniqKey="Algahtani H" first="Hussein" last="Algahtani">Hussein Algahtani</name><affiliation><nlm:affiliation>King Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Subahi, Ahmad" sort="Subahi, Ahmad" uniqKey="Subahi A" first="Ahmad" last="Subahi">Ahmad Subahi</name><affiliation><nlm:affiliation>King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Shirah, Bader" sort="Shirah, Bader" uniqKey="Shirah B" first="Bader" last="Shirah">Bader Shirah</name><affiliation><nlm:affiliation>King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Case reports in neurological medicine</title><idno type="ISSN">2090-6668</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism. </div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27239356</PMID><DateCompleted><Year>2016</Year><Month>05</Month><Day>30</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2090-6668</ISSN><JournalIssue CitedMedium="Print"><Volume>2016</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Case reports in neurological medicine</Title><ISOAbbreviation>Case Rep Neurol Med</ISOAbbreviation></Journal><ArticleTitle>Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature.</ArticleTitle><Pagination><MedlinePgn>3502683</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2016/3502683</ELocationID><Abstract><AbstractText>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Algahtani</LastName><ForeName>Hussein</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0001-9484-9838</Identifier><AffiliationInfo><Affiliation>King Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subahi</LastName><ForeName>Ahmad</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shirah</LastName><ForeName>Bader</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, P.O. 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