Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.
Identifieur interne : 001049 ( PubMed/Corpus ); précédent : 001048; suivant : 001050Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.
Auteurs : Yaseen M. Arabi ; Farhan Al-Enezi ; Kajsa-Stina Longuere ; Hanan H. Balkhy ; Mohamed Al-Sultan ; Awad Al-Omari ; Fahad M. Al-Hameed ; Gail Carson ; Nahoko Shindo ; Robert FowlerSource :
- BMC anesthesiology [ 1471-2253 ] ; 2016.
English descriptors
- KwdEn :
- Attitude of Health Personnel, Coronavirus Infections (blood), Coronavirus Infections (therapy), Coronavirus Infections (virology), Critical Care (statistics & numerical data), Feasibility Studies, Humans, Middle East Respiratory Syndrome Coronavirus, Physicians (psychology), Plasma Exchange, Randomized Controlled Trials as Topic (methods), Saudi Arabia, Surveys and Questionnaires.
- MESH :
- blood : Coronavirus Infections.
- methods : Randomized Controlled Trials as Topic.
- psychology : Physicians.
- statistics & numerical data : Critical Care.
- therapy : Coronavirus Infections.
- virology : Coronavirus Infections.
- Attitude of Health Personnel, Feasibility Studies, Humans, Middle East Respiratory Syndrome Coronavirus, Plasma Exchange, Saudi Arabia, Surveys and Questionnaires.
Abstract
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging respiratory pathogen with a high mortality rate and no specific treatments available to date. The purpose of this study was to determine the feasibility of conducting a randomized controlled trial (RCT) of convalescent plasma therapy for MERS-CoV-infected patients by using MERS-CoV-specific convalescent plasma obtained from previously recovered patients.
DOI: 10.1186/s12871-016-0198-x
PubMed: 27405596
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Arabi</name><affiliation><nlm:affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia. arabi@ngha.med.sa.</nlm:affiliation></affiliation></author><author><name sortKey="Al Enezi, Farhan" sort="Al Enezi, Farhan" uniqKey="Al Enezi F" first="Farhan" last="Al-Enezi">Farhan Al-Enezi</name><affiliation><nlm:affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Longuere, Kajsa Stina" sort="Longuere, Kajsa Stina" uniqKey="Longuere K" first="Kajsa-Stina" last="Longuere">Kajsa-Stina Longuere</name><affiliation><nlm:affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name><affiliation><nlm:affiliation>Infection Control Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Sultan, Mohamed" sort="Al Sultan, Mohamed" uniqKey="Al Sultan M" first="Mohamed" last="Al-Sultan">Mohamed Al-Sultan</name><affiliation><nlm:affiliation>Emergency & Critical Care Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation><nlm:affiliation>AlFaisal University, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Hameed, Fahad M" sort="Al Hameed, Fahad M" uniqKey="Al Hameed F" first="Fahad M" last="Al-Hameed">Fahad M. Al-Hameed</name><affiliation><nlm:affiliation>Critical Care & Pulmonary Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name><affiliation><nlm:affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Shindo, Nahoko" sort="Shindo, Nahoko" uniqKey="Shindo N" first="Nahoko" last="Shindo">Nahoko Shindo</name><affiliation><nlm:affiliation>Pandemic and Epidemic Diseases Department, World Health Organization, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Fowler, Robert" sort="Fowler, Robert" uniqKey="Fowler R" first="Robert" last="Fowler">Robert Fowler</name><affiliation><nlm:affiliation>Department of Medicine and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27405596</idno><idno type="pmid">27405596</idno><idno type="doi">10.1186/s12871-016-0198-x</idno><idno type="wicri:Area/PubMed/Corpus">001049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.</title><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><affiliation><nlm:affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia. arabi@ngha.med.sa.</nlm:affiliation></affiliation></author><author><name sortKey="Al Enezi, Farhan" sort="Al Enezi, Farhan" uniqKey="Al Enezi F" first="Farhan" last="Al-Enezi">Farhan Al-Enezi</name><affiliation><nlm:affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Longuere, Kajsa Stina" sort="Longuere, Kajsa Stina" uniqKey="Longuere K" first="Kajsa-Stina" last="Longuere">Kajsa-Stina Longuere</name><affiliation><nlm:affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name><affiliation><nlm:affiliation>Infection Control Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Sultan, Mohamed" sort="Al Sultan, Mohamed" uniqKey="Al Sultan M" first="Mohamed" last="Al-Sultan">Mohamed Al-Sultan</name><affiliation><nlm:affiliation>Emergency & Critical Care Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation><nlm:affiliation>AlFaisal University, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Hameed, Fahad M" sort="Al Hameed, Fahad M" uniqKey="Al Hameed F" first="Fahad M" last="Al-Hameed">Fahad M. Al-Hameed</name><affiliation><nlm:affiliation>Critical Care & Pulmonary Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name><affiliation><nlm:affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Shindo, Nahoko" sort="Shindo, Nahoko" uniqKey="Shindo N" first="Nahoko" last="Shindo">Nahoko Shindo</name><affiliation><nlm:affiliation>Pandemic and Epidemic Diseases Department, World Health Organization, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Fowler, Robert" sort="Fowler, Robert" uniqKey="Fowler R" first="Robert" last="Fowler">Robert Fowler</name><affiliation><nlm:affiliation>Department of Medicine and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMC anesthesiology</title><idno type="eISSN">1471-2253</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attitude of Health Personnel</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (virology)</term><term>Critical Care (statistics & numerical data)</term><term>Feasibility Studies</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Physicians (psychology)</term><term>Plasma Exchange</term><term>Randomized Controlled Trials as Topic (methods)</term><term>Saudi Arabia</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Physicians</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Critical Care</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Attitude of Health Personnel</term><term>Feasibility Studies</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Plasma Exchange</term><term>Saudi Arabia</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging respiratory pathogen with a high mortality rate and no specific treatments available to date. The purpose of this study was to determine the feasibility of conducting a randomized controlled trial (RCT) of convalescent plasma therapy for MERS-CoV-infected patients by using MERS-CoV-specific convalescent plasma obtained from previously recovered patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27405596</PMID><DateCompleted><Year>2017</Year><Month>10</Month><Day>06</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2253</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>07</Month><Day>12</Day></PubDate></JournalIssue><Title>BMC anesthesiology</Title><ISOAbbreviation>BMC Anesthesiol</ISOAbbreviation></Journal><ArticleTitle>Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.</ArticleTitle><Pagination><MedlinePgn>36</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12871-016-0198-x</ELocationID><Abstract><AbstractText Label="BACKGROUND">The Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging respiratory pathogen with a high mortality rate and no specific treatments available to date. The purpose of this study was to determine the feasibility of conducting a randomized controlled trial (RCT) of convalescent plasma therapy for MERS-CoV-infected patients by using MERS-CoV-specific convalescent plasma obtained from previously recovered patients.</AbstractText><AbstractText Label="METHODS">A survey was adapted from validated questionnaire originally aimed to measure network capacities and capabilities within the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC). The questionnaire was modified for this study to include 26 items that were divided into three main domains of interest: (1) the ability to care for critically ill MERS-CoV patients; (2) laboratory capacity to diagnose MERS-CoV and blood bank ability to prepare convalescent plasma; and (3), research capacity to conduct randomized controlled trials. The questionnaire was emailed to physicians.</AbstractText><AbstractText Label="RESULTS">Of 582 physicians who were invited to the survey, 327 responded (56.2 %). The professional focus of the majority of respondents was critical care (106/249 (43 %)), pediatrics (59/249, (24 %)) or internal medicine (52/249 (21 %)) but none was blood banking. Nearly all respondents (251/263 (95 %)) reported to have access to ICU facilities within their institutions. Most respondents (219/270 (81 %)) reported that intensivists were the most physician group responsible for treatment decisions about critically ill SARI patients. While 125/165 respondents (76 %) reported that they conduct research in ICUs, and 80/161 (49.7 %) had been involved in the conduct of RCTs, including using a placebo comparison (60/161 (37 %)), only 49/226 (21 %) of respondents regularly participated in research networks.</AbstractText><AbstractText Label="CONCLUSIONS">Our survey indicated that in the Kingdom of Saudi Arabia (KSA), ICUs are the most likely clinical locations for conducting a clinical trial of convalescent plasma therapy for MERS-CoV, and that most ICUs have experience with such research designs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arabi</LastName><ForeName>Yaseen M</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia. arabi@ngha.med.sa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Enezi</LastName><ForeName>Farhan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Longuere</LastName><ForeName>Kajsa-Stina</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>International Severe Acute Respiratory & emerging Infection Consortium (ISARIC), Old Road Campus, Headington, OX3 7FZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balkhy</LastName><ForeName>Hanan H</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>Infection Control Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Sultan</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Emergency & Critical Care Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Omari</LastName><ForeName>Awad</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>AlFaisal University, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Hameed</LastName><ForeName>Fahad M</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Critical Care & Pulmonary Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carson</LastName><ForeName>Gail</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>International Severe Acute Respiratory & emerging Infection Consortium (ISARIC), Old Road Campus, Headington, OX3 7FZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shindo</LastName><ForeName>Nahoko</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Pandemic and Epidemic Diseases Department, World Health Organization, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fowler</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medicine and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine and Interdepartmental Division of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>001</GrantID><Agency>World Health Organization</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Anesthesiol</MedlineTA><NlmUniqueID>100968535</NlmUniqueID><ISSNLinking>1471-2253</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001291" MajorTopicYN="Y">Attitude of Health Personnel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003422" MajorTopicYN="N">Critical Care</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005240" MajorTopicYN="N">Feasibility Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010820" MajorTopicYN="N">Physicians</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010951" MajorTopicYN="Y">Plasma Exchange</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012529" MajorTopicYN="N">Saudi Arabia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="Y">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Convalescent plasma</Keyword><Keyword MajorTopicYN="Y">Middle East respiratory syndrome coronavirus (MERS-CoV)</Keyword><Keyword MajorTopicYN="Y">Randomized controlled trial</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate 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