Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.
Identifieur interne : 000F88 ( PubMed/Corpus ); précédent : 000F87; suivant : 000F89Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.
Auteurs : Anthony R. Fehr ; Rudragouda Channappanavar ; Stanley PerlmanSource :
- Annual review of medicine [ 1545-326X ] ; 2017.
English descriptors
- KwdEn :
- Animals, Camelus, Chiroptera, Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Coronavirus Infections (transmission), Coronavirus Infections (virology), Cytokines (blood), Disease Outbreaks, Humans, Immunity, Cellular, Infection Control, Middle East (epidemiology), Middle East Respiratory Syndrome Coronavirus, Zoonoses (transmission), Zoonoses (virology).
- MESH :
- chemical , blood : Cytokines.
- epidemiology : Coronavirus Infections, Middle East.
- therapy : Coronavirus Infections.
- transmission : Coronavirus Infections, Zoonoses.
- virology : Coronavirus Infections, Zoonoses.
- Animals, Camelus, Chiroptera, Disease Outbreaks, Humans, Immunity, Cellular, Infection Control, Middle East Respiratory Syndrome Coronavirus.
Abstract
In 2012, a zoonotic coronavirus was identified as the causative agent of Middle East respiratory syndrome and was named MERS coronavirus (MERS-CoV). As of August 11, 2016, the virus has infected 1,791 patients, with a mortality rate of 35.6%. Although MERS-CoV generally causes subclinical or mild disease, infection can result in serious outcomes, including acute respiratory distress syndrome and multi-organ failure in patients with comorbidities. The virus is endemic in camels in the Arabian Peninsula and Africa and thus poses a consistent threat of frequent reintroduction into human populations. Disease prevalence will increase substantially if the virus mutates to increase human-to-human transmissibility. No therapeutics or vaccines are approved for MERS; thus, development of novel therapies is needed. Further, since many MERS cases are acquired in healthcare settings, public health measures and scrupulous attention to infection control are required to prevent additional MERS outbreaks.
DOI: 10.1146/annurev-med-051215-031152
PubMed: 27576010
Links to Exploration step
pubmed:27576010Le document en format XML
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Fehr</name></author><author><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa 52242; email: stanley-perlman@uiowa.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27576010</idno><idno type="pmid">27576010</idno><idno type="doi">10.1146/annurev-med-051215-031152</idno><idno type="wicri:Area/PubMed/Corpus">000F88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.</title><author><name sortKey="Fehr, Anthony R" sort="Fehr, Anthony R" uniqKey="Fehr A" first="Anthony R" last="Fehr">Anthony R. Fehr</name></author><author><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa 52242; email: stanley-perlman@uiowa.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annual review of medicine</title><idno type="eISSN">1545-326X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Chiroptera</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (virology)</term><term>Cytokines (blood)</term><term>Disease Outbreaks</term><term>Humans</term><term>Immunity, Cellular</term><term>Infection Control</term><term>Middle East (epidemiology)</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Zoonoses (transmission)</term><term>Zoonoses (virology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Middle East</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Chiroptera</term><term>Disease Outbreaks</term><term>Humans</term><term>Immunity, Cellular</term><term>Infection Control</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2012, a zoonotic coronavirus was identified as the causative agent of Middle East respiratory syndrome and was named MERS coronavirus (MERS-CoV). As of August 11, 2016, the virus has infected 1,791 patients, with a mortality rate of 35.6%. Although MERS-CoV generally causes subclinical or mild disease, infection can result in serious outcomes, including acute respiratory distress syndrome and multi-organ failure in patients with comorbidities. The virus is endemic in camels in the Arabian Peninsula and Africa and thus poses a consistent threat of frequent reintroduction into human populations. Disease prevalence will increase substantially if the virus mutates to increase human-to-human transmissibility. No therapeutics or vaccines are approved for MERS; thus, development of novel therapies is needed. Further, since many MERS cases are acquired in healthcare settings, public health measures and scrupulous attention to infection control are required to prevent additional MERS outbreaks.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27576010</PMID><DateCompleted><Year>2018</Year><Month>01</Month><Day>01</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1545-326X</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><PubDate><Year>2017</Year><Month>01</Month><Day>14</Day></PubDate></JournalIssue><Title>Annual review of medicine</Title><ISOAbbreviation>Annu. Rev. 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Disease prevalence will increase substantially if the virus mutates to increase human-to-human transmissibility. No therapeutics or vaccines are approved for MERS; thus, development of novel therapies is needed. 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