A review of treatment modalities for Middle East Respiratory Syndrome.
Identifieur interne : 000F80 ( PubMed/Corpus ); précédent : 000F79; suivant : 000F81A review of treatment modalities for Middle East Respiratory Syndrome.
Auteurs : Yin Mo ; Dale FisherSource :
- The Journal of antimicrobial chemotherapy [ 1460-2091 ] ; 2016.
English descriptors
- KwdEn :
- Antibodies, Viral (therapeutic use), Antiviral Agents (therapeutic use), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Global Health, Humans, Immunologic Factors (therapeutic use), Interferon-beta (therapeutic use), Lopinavir (therapeutic use), Ribavirin (therapeutic use).
- MESH :
- chemical , therapeutic use : Antibodies, Viral, Antiviral Agents, Immunologic Factors, Interferon-beta, Lopinavir, Ribavirin.
- epidemiology : Coronavirus Infections.
- therapy : Coronavirus Infections.
- Global Health, Humans.
Abstract
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been a focus of international attention since its identification in 2012. Epidemiologically it is characterized by sporadic community cases, which are amplified by hospital-based outbreaks. Healthcare facilities in 27 countries from most continents have experienced imported cases, with the most significant outbreak involving 186 cases in Korea. The mortality internationally is 36% and guidance for clinical management has yet to be developed. Most facilities and healthcare providers outside of the Middle East receiving patients have no or little experience in the clinical management of MERS. When a case does occur there is likely little time for a critical appraisal of the literature and putative pharmacological options. We identified published literature on the management of both MERS-CoV and the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) through searches of PubMed and WHO and the US CDC websites up to 30 April 2016. A total of 101 publications were retrieved for critical appraisal. Most published literature on therapeutics for MERS are in vitro experiments, animal studies and case reports. Current treatment options for MERS can be categorized as: immunotherapy with virus-specific antibodies in convalescent plasma; polyclonal and monoclonal antibodies produced in vitro or in genetically modified animals; and antiviral agents. The use of any therapeutics in MERS-CoV remains investigational. The therapeutic agents with potential benefits and warranting further investigation include convalescent plasma, interferon-β/ribavirin combination therapy and lopinavir. Corticosteroids, ribavirin monotherapy and mycophenolic acid likely have toxicities that exceed potential benefits.
DOI: 10.1093/jac/dkw338
PubMed: 27585965
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pubmed:27585965Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A review of treatment modalities for Middle East Respiratory Syndrome.</title><author><name sortKey="Mo, Yin" sort="Mo, Yin" uniqKey="Mo Y" first="Yin" last="Mo">Yin Mo</name><affiliation><nlm:affiliation>Ministry of Health Holdings, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Fisher, Dale" sort="Fisher, Dale" uniqKey="Fisher D" first="Dale" last="Fisher">Dale Fisher</name><affiliation><nlm:affiliation>Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore mdcfda@nus.edu.sg.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27585965</idno><idno type="pmid">27585965</idno><idno type="doi">10.1093/jac/dkw338</idno><idno type="wicri:Area/PubMed/Corpus">000F80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A review of treatment modalities for Middle East Respiratory Syndrome.</title><author><name sortKey="Mo, Yin" sort="Mo, Yin" uniqKey="Mo Y" first="Yin" last="Mo">Yin Mo</name><affiliation><nlm:affiliation>Ministry of Health Holdings, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Fisher, Dale" sort="Fisher, Dale" uniqKey="Fisher D" first="Dale" last="Fisher">Dale Fisher</name><affiliation><nlm:affiliation>Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore mdcfda@nus.edu.sg.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of antimicrobial chemotherapy</title><idno type="eISSN">1460-2091</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (therapeutic use)</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (therapy)</term><term>Global Health</term><term>Humans</term><term>Immunologic Factors (therapeutic use)</term><term>Interferon-beta (therapeutic use)</term><term>Lopinavir (therapeutic use)</term><term>Ribavirin (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Viral</term><term>Antiviral Agents</term><term>Immunologic Factors</term><term>Interferon-beta</term><term>Lopinavir</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Global Health</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been a focus of international attention since its identification in 2012. Epidemiologically it is characterized by sporadic community cases, which are amplified by hospital-based outbreaks. Healthcare facilities in 27 countries from most continents have experienced imported cases, with the most significant outbreak involving 186 cases in Korea. The mortality internationally is 36% and guidance for clinical management has yet to be developed. Most facilities and healthcare providers outside of the Middle East receiving patients have no or little experience in the clinical management of MERS. When a case does occur there is likely little time for a critical appraisal of the literature and putative pharmacological options. We identified published literature on the management of both MERS-CoV and the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) through searches of PubMed and WHO and the US CDC websites up to 30 April 2016. A total of 101 publications were retrieved for critical appraisal. Most published literature on therapeutics for MERS are in vitro experiments, animal studies and case reports. Current treatment options for MERS can be categorized as: immunotherapy with virus-specific antibodies in convalescent plasma; polyclonal and monoclonal antibodies produced in vitro or in genetically modified animals; and antiviral agents. The use of any therapeutics in MERS-CoV remains investigational. The therapeutic agents with potential benefits and warranting further investigation include convalescent plasma, interferon-β/ribavirin combination therapy and lopinavir. Corticosteroids, ribavirin monotherapy and mycophenolic acid likely have toxicities that exceed potential benefits.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27585965</PMID><DateCompleted><Year>2017</Year><Month>07</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2091</ISSN><JournalIssue CitedMedium="Internet"><Volume>71</Volume><Issue>12</Issue><PubDate><Year>2016</Year><Month>12</Month></PubDate></JournalIssue><Title>The Journal of antimicrobial chemotherapy</Title><ISOAbbreviation>J. Antimicrob. Chemother.</ISOAbbreviation></Journal><ArticleTitle>A review of treatment modalities for Middle East Respiratory Syndrome.</ArticleTitle><Pagination><MedlinePgn>3340-3350</MedlinePgn></Pagination><Abstract><AbstractText>The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been a focus of international attention since its identification in 2012. Epidemiologically it is characterized by sporadic community cases, which are amplified by hospital-based outbreaks. Healthcare facilities in 27 countries from most continents have experienced imported cases, with the most significant outbreak involving 186 cases in Korea. The mortality internationally is 36% and guidance for clinical management has yet to be developed. Most facilities and healthcare providers outside of the Middle East receiving patients have no or little experience in the clinical management of MERS. When a case does occur there is likely little time for a critical appraisal of the literature and putative pharmacological options. We identified published literature on the management of both MERS-CoV and the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) through searches of PubMed and WHO and the US CDC websites up to 30 April 2016. A total of 101 publications were retrieved for critical appraisal. Most published literature on therapeutics for MERS are in vitro experiments, animal studies and case reports. Current treatment options for MERS can be categorized as: immunotherapy with virus-specific antibodies in convalescent plasma; polyclonal and monoclonal antibodies produced in vitro or in genetically modified animals; and antiviral agents. The use of any therapeutics in MERS-CoV remains investigational. The therapeutic agents with potential benefits and warranting further investigation include convalescent plasma, interferon-β/ribavirin combination therapy and lopinavir. Corticosteroids, ribavirin monotherapy and mycophenolic acid likely have toxicities that exceed potential benefits.</AbstractText><CopyrightInformation>© The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. 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