Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).
Identifieur interne : 000D32 ( PubMed/Corpus ); précédent : 000D31; suivant : 000D33Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).
Auteurs : Chang-Jiang-Sheng Lai ; Yuan Yuan ; Da-Hui Liu ; Chuan-Zhi Kang ; Yu Zhang ; Liangping Zha ; Liping Kang ; Tong Chen ; Tie-Gui Nan ; Qing-Xiu Hao ; Lu-Qi HuangSource :
- Journal of pharmaceutical and biomedical analysis [ 1873-264X ] ; 2017.
English descriptors
- KwdEn :
- MESH :
Abstract
In order to comprehensively elucidate the chemical biosynthesis process of the beige-scape Gastrodia elata Blume (Wutianma) as a traditional herbal medicines, the untargeted analysis-based UHPLC-PDA-ESI-Q-TOF-MS reveals the metabolites ranging from the skeletons to novel dimers of citric acids in fresh and dried immature/mature stem tubers. Interestingly, two novel types of dimers for citric acids with the anhydride groups at sn-1 and/or sn-5 were discovered in fresh samples. Moreover, the classical mono- versus novel di-mers, and the aglycons versus the glycosides could be easily discriminated by signature fragmentation patterns and some novel adduct ions. The heat map of contents demonstrated more p-hydroxybenzyl metabolites than gastroxyl ones were determined in fresh Wutianma revealing a significant specificity with the lack of the sufficient gastrodin and gastroxyl products in biosynthetic pathway.
DOI: 10.1016/j.jpba.2017.03.055
PubMed: 28380386
Links to Exploration step
pubmed:28380386Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).</title><author><name sortKey="Lai, Chang Jiang Sheng" sort="Lai, Chang Jiang Sheng" uniqKey="Lai C" first="Chang-Jiang-Sheng" last="Lai">Chang-Jiang-Sheng Lai</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China. Electronic address: laichangjiang44@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Da Hui" sort="Liu, Da Hui" uniqKey="Liu D" first="Da-Hui" last="Liu">Da-Hui Liu</name><affiliation><nlm:affiliation>College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Chuan Zhi" sort="Kang, Chuan Zhi" uniqKey="Kang C" first="Chuan-Zhi" last="Kang">Chuan-Zhi Kang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Zha, Liangping" sort="Zha, Liangping" uniqKey="Zha L" first="Liangping" last="Zha">Liangping Zha</name><affiliation><nlm:affiliation>College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Liping" sort="Kang, Liping" uniqKey="Kang L" first="Liping" last="Kang">Liping Kang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Tong" sort="Chen, Tong" uniqKey="Chen T" first="Tong" last="Chen">Tong Chen</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Nan, Tie Gui" sort="Nan, Tie Gui" uniqKey="Nan T" first="Tie-Gui" last="Nan">Tie-Gui Nan</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Hao, Qing Xiu" sort="Hao, Qing Xiu" uniqKey="Hao Q" first="Qing-Xiu" last="Hao">Qing-Xiu Hao</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Lu Qi" sort="Huang, Lu Qi" uniqKey="Huang L" first="Lu-Qi" last="Huang">Lu-Qi Huang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China. Electronic address: huangluqi01@126.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28380386</idno><idno type="pmid">28380386</idno><idno type="doi">10.1016/j.jpba.2017.03.055</idno><idno type="wicri:Area/PubMed/Corpus">000D32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).</title><author><name sortKey="Lai, Chang Jiang Sheng" sort="Lai, Chang Jiang Sheng" uniqKey="Lai C" first="Chang-Jiang-Sheng" last="Lai">Chang-Jiang-Sheng Lai</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China. Electronic address: laichangjiang44@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Da Hui" sort="Liu, Da Hui" uniqKey="Liu D" first="Da-Hui" last="Liu">Da-Hui Liu</name><affiliation><nlm:affiliation>College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Chuan Zhi" sort="Kang, Chuan Zhi" uniqKey="Kang C" first="Chuan-Zhi" last="Kang">Chuan-Zhi Kang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Zha, Liangping" sort="Zha, Liangping" uniqKey="Zha L" first="Liangping" last="Zha">Liangping Zha</name><affiliation><nlm:affiliation>College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Liping" sort="Kang, Liping" uniqKey="Kang L" first="Liping" last="Kang">Liping Kang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Tong" sort="Chen, Tong" uniqKey="Chen T" first="Tong" last="Chen">Tong Chen</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Nan, Tie Gui" sort="Nan, Tie Gui" uniqKey="Nan T" first="Tie-Gui" last="Nan">Tie-Gui Nan</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Hao, Qing Xiu" sort="Hao, Qing Xiu" uniqKey="Hao Q" first="Qing-Xiu" last="Hao">Qing-Xiu Hao</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Lu Qi" sort="Huang, Lu Qi" uniqKey="Huang L" first="Lu-Qi" last="Huang">Lu-Qi Huang</name><affiliation><nlm:affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China. Electronic address: huangluqi01@126.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of pharmaceutical and biomedical analysis</title><idno type="eISSN">1873-264X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>Citric Acid</term><term>Dimerization</term><term>Gastrodia</term><term>Mass Spectrometry</term><term>Plant Extracts</term><term>Plant Tubers</term><term>Plants, Medicinal</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Citric Acid</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>Dimerization</term><term>Gastrodia</term><term>Mass Spectrometry</term><term>Plant Tubers</term><term>Plants, Medicinal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to comprehensively elucidate the chemical biosynthesis process of the beige-scape Gastrodia elata Blume (Wutianma) as a traditional herbal medicines, the untargeted analysis-based UHPLC-PDA-ESI-Q-TOF-MS reveals the metabolites ranging from the skeletons to novel dimers of citric acids in fresh and dried immature/mature stem tubers. Interestingly, two novel types of dimers for citric acids with the anhydride groups at sn-1 and/or sn-5 were discovered in fresh samples. Moreover, the classical mono- versus novel di-mers, and the aglycons versus the glycosides could be easily discriminated by signature fragmentation patterns and some novel adduct ions. The heat map of contents demonstrated more p-hydroxybenzyl metabolites than gastroxyl ones were determined in fresh Wutianma revealing a significant specificity with the lack of the sufficient gastrodin and gastroxyl products in biosynthetic pathway.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">28380386</PMID><DateCompleted><Year>2018</Year><Month>01</Month><Day>24</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-264X</ISSN><JournalIssue CitedMedium="Internet"><Volume>140</Volume><PubDate><Year>2017</Year><Month>Jun</Month><Day>05</Day></PubDate></JournalIssue><Title>Journal of pharmaceutical and biomedical analysis</Title><ISOAbbreviation>J Pharm Biomed Anal</ISOAbbreviation></Journal><ArticleTitle>Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).</ArticleTitle><Pagination><MedlinePgn>287-294</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0731-7085(17)30482-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jpba.2017.03.055</ELocationID><Abstract><AbstractText>In order to comprehensively elucidate the chemical biosynthesis process of the beige-scape Gastrodia elata Blume (Wutianma) as a traditional herbal medicines, the untargeted analysis-based UHPLC-PDA-ESI-Q-TOF-MS reveals the metabolites ranging from the skeletons to novel dimers of citric acids in fresh and dried immature/mature stem tubers. Interestingly, two novel types of dimers for citric acids with the anhydride groups at sn-1 and/or sn-5 were discovered in fresh samples. Moreover, the classical mono- versus novel di-mers, and the aglycons versus the glycosides could be easily discriminated by signature fragmentation patterns and some novel adduct ions. The heat map of contents demonstrated more p-hydroxybenzyl metabolites than gastroxyl ones were determined in fresh Wutianma revealing a significant specificity with the lack of the sufficient gastrodin and gastroxyl products in biosynthetic pathway.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Chang-Jiang-Sheng</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China. Electronic address: laichangjiang44@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Da-Hui</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Chuan-Zhi</ForeName><Initials>CZ</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zha</LastName><ForeName>Liangping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Liping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Tong</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nan</LastName><ForeName>Tie-Gui</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hao</LastName><ForeName>Qing-Xiu</ForeName><Initials>QX</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Lu-Qi</ForeName><Initials>LQ</Initials><AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China. Electronic address: huangluqi01@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Pharm Biomed Anal</MedlineTA><NlmUniqueID>8309336</NlmUniqueID><ISSNLinking>0731-7085</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>2968PHW8QP</RegistryNumber><NameOfSubstance UI="D019343">Citric Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019343" MajorTopicYN="N">Citric Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019281" MajorTopicYN="N">Dimerization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031668" MajorTopicYN="Y">Gastrodia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035281" MajorTopicYN="N">Plant Tubers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010946" MajorTopicYN="N">Plants, Medicinal</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Citric acids</Keyword><Keyword MajorTopicYN="N">Gastrodia elata</Keyword><Keyword MajorTopicYN="N">Gastrodin</Keyword><Keyword MajorTopicYN="N">Parishins</Keyword><Keyword MajorTopicYN="N">UHPLC-PDA-ESI-Q-TOF-MS</Keyword><Keyword MajorTopicYN="N">p-Hydroxybenzyl alcohol</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>4</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28380386</ArticleId><ArticleId IdType="pii">S0731-7085(17)30482-X</ArticleId><ArticleId IdType="doi">10.1016/j.jpba.2017.03.055</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D32 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000D32 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:28380386
|texte= Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:28380386" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |