Atypical presentations of MERS-CoV infection in immunocompromised hosts.
Identifieur interne : 000C81 ( PubMed/Corpus ); précédent : 000C80; suivant : 000C82Atypical presentations of MERS-CoV infection in immunocompromised hosts.
Auteurs : Si-Ho Kim ; Jae-Hoon Ko ; Ga Eun Park ; Sun Young Cho ; Young Eun Ha ; Ji-Man Kang ; Yae-Jean Kim ; Hee Jae Huh ; Chang-Seok Ki ; Byeong-Ho Jeong ; Jinkyeong Park ; Jun Ho Jang ; Won Seog Kim ; Cheol-In Kang ; Doo Ryeon Chung ; Jae-Hoon Song ; Kyong Ran PeckSource :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [ 1437-7780 ] ; 2017.
English descriptors
- KwdEn :
- Adult, Antiviral Agents (therapeutic use), Blood Component Transfusion, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Coronavirus Infections (virology), Disease Outbreaks (prevention & control), Fatal Outcome, Female, Glucocorticoids (therapeutic use), Hematologic Neoplasms (therapy), Humans, Immunocompromised Host, Immunosuppression (adverse effects), Infectious Disease Incubation Period, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (physiology), Peripheral Blood Stem Cell Transplantation (adverse effects), Republic of Korea (epidemiology), Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Tomography, X-Ray Computed, Virus Shedding.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Glucocorticoids.
- adverse effects : Immunosuppression, Peripheral Blood Stem Cell Transplantation.
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Republic of Korea.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Disease Outbreaks.
- therapy : Coronavirus Infections, Hematologic Neoplasms.
- virology : Coronavirus Infections.
- Adult, Blood Component Transfusion, Fatal Outcome, Female, Humans, Immunocompromised Host, Infectious Disease Incubation Period, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Tomography, X-Ray Computed, Virus Shedding.
Abstract
During the 2015 Korean MERS outbreak, we experienced atypical presentations of MERS-CoV infections in three immunocompromised hosts that warranted exceptional management. Case 1 showed delayed symptom development after a four-day asymptomatic period, Case 2 experienced a 20-day incubation period, and Case 3 exhibited persistent viral shedding without clinical deterioration. Recognizing these exceptions is extremely important in the management of MERS-CoV-exposed or -infected patients and for control of potential MERS outbreaks.
DOI: 10.1016/j.jiac.2017.04.004
PubMed: 28545936
Links to Exploration step
pubmed:28545936Le document en format XML
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<author><name sortKey="Chung, Doo Ryeon" sort="Chung, Doo Ryeon" uniqKey="Chung D" first="Doo Ryeon" last="Chung">Doo Ryeon Chung</name>
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<front><div type="abstract" xml:lang="en">During the 2015 Korean MERS outbreak, we experienced atypical presentations of MERS-CoV infections in three immunocompromised hosts that warranted exceptional management. Case 1 showed delayed symptom development after a four-day asymptomatic period, Case 2 experienced a 20-day incubation period, and Case 3 exhibited persistent viral shedding without clinical deterioration. Recognizing these exceptions is extremely important in the management of MERS-CoV-exposed or -infected patients and for control of potential MERS outbreaks.</div>
</front>
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<Month>06</Month>
<Day>12</Day>
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<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1437-7780</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<Issue>11</Issue>
<PubDate><Year>2017</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</Title>
<ISOAbbreviation>J. Infect. Chemother.</ISOAbbreviation>
</Journal>
<ArticleTitle>Atypical presentations of MERS-CoV infection in immunocompromised hosts.</ArticleTitle>
<Pagination><MedlinePgn>769-773</MedlinePgn>
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<Abstract><AbstractText>During the 2015 Korean MERS outbreak, we experienced atypical presentations of MERS-CoV infections in three immunocompromised hosts that warranted exceptional management. Case 1 showed delayed symptom development after a four-day asymptomatic period, Case 2 experienced a 20-day incubation period, and Case 3 exhibited persistent viral shedding without clinical deterioration. Recognizing these exceptions is extremely important in the management of MERS-CoV-exposed or -infected patients and for control of potential MERS outbreaks.</AbstractText>
<CopyrightInformation>Copyright © 2017. Published by Elsevier Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Si-Ho</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Ko</LastName>
<ForeName>Jae-Hoon</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Ga Eun</ForeName>
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<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Cho</LastName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Ha</LastName>
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<Author ValidYN="Y"><LastName>Kang</LastName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Kim</LastName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Park</LastName>
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<ForeName>Doo Ryeon</ForeName>
<Initials>DR</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Jae-Hoon</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peck</LastName>
<ForeName>Kyong Ran</ForeName>
<Initials>KR</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea. Electronic address: krpeck@skku.edu.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<PublicationType UI="D016428">Journal Article</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>05</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Infect Chemother</MedlineTA>
<NlmUniqueID>9608375</NlmUniqueID>
<ISSNLinking>1341-321X</ISSNLinking>
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<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D016913" MajorTopicYN="N">Blood Component Transfusion</DescriptorName>
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<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
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<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
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<MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName>
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<MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
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<MeshHeading><DescriptorName UI="D055256" MajorTopicYN="N">Infectious Disease Incubation Period</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D036102" MajorTopicYN="N">Peripheral Blood Stem Cell Transplantation</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056910" MajorTopicYN="N">Republic of Korea</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017201" MajorTopicYN="N">Virus Shedding</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Asymptomatic period</Keyword>
<Keyword MajorTopicYN="N">Corticosteroid</Keyword>
<Keyword MajorTopicYN="N">Immunocompromised host</Keyword>
<Keyword MajorTopicYN="N">Incubation period</Keyword>
<Keyword MajorTopicYN="N">Middle East respiratory syndrome coronavirus</Keyword>
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<Day>03</Day>
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<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>03</Month>
<Day>09</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>04</Month>
<Day>04</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>5</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>6</Month>
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<Hour>6</Hour>
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<ArticleId IdType="doi">10.1016/j.jiac.2017.04.004</ArticleId>
<ArticleId IdType="pmc">PMC7129274</ArticleId>
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