Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
Identifieur interne : 000A81 ( PubMed/Corpus ); précédent : 000A80; suivant : 000A82Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
Auteurs : Kristina Dietert ; Birgitt Gutbier ; Sandra M. Wienhold ; Katrin Reppe ; Xiaohui Jiang ; Ling Yao ; Catherine Chaput ; Jan Naujoks ; Markus Brack ; Alexandra Kupke ; Christin Peteranderl ; Stephan Becker ; Carolin Von Lachner ; Nelli Baal ; Hortense Slevogt ; Andreas C. Hocke ; Martin Witzenrath ; Bastian Opitz ; Susanne Herold ; Holger Hackstein ; Leif E. Sander ; Norbert Suttorp ; Achim D. GruberSource :
- PloS one [ 1932-6203 ] ; 2017.
English descriptors
- KwdEn :
- Acinetobacter baumannii (pathogenicity), Acinetobacter baumannii (physiology), Animals, Disease Models, Animal, Escherichia coli (pathogenicity), Escherichia coli (physiology), Female, Host Specificity, Humans, Immunohistochemistry, Influenza A virus (pathogenicity), Influenza A virus (physiology), Klebsiella pneumoniae (pathogenicity), Klebsiella pneumoniae (physiology), Legionella pneumophila (pathogenicity), Legionella pneumophila (physiology), Lung (microbiology), Lung (pathology), Lung (virology), Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Middle East Respiratory Syndrome Coronavirus (physiology), Pneumonia, Bacterial (genetics), Pneumonia, Bacterial (microbiology), Pneumonia, Bacterial (pathology), Pneumonia, Bacterial (physiopathology), Pneumonia, Viral (genetics), Pneumonia, Viral (pathology), Pneumonia, Viral (physiopathology), Pneumonia, Viral (virology), Species Specificity, Staphylococcus aureus (pathogenicity), Staphylococcus aureus (physiology), Streptococcus pneumoniae (pathogenicity), Streptococcus pneumoniae (physiology).
- MESH :
- genetics : Pneumonia, Bacterial, Pneumonia, Viral.
- microbiology : Lung, Pneumonia, Bacterial.
- pathogenicity : Acinetobacter baumannii, Escherichia coli, Influenza A virus, Klebsiella pneumoniae, Legionella pneumophila, Middle East Respiratory Syndrome Coronavirus, Staphylococcus aureus, Streptococcus pneumoniae.
- pathology : Lung, Pneumonia, Bacterial, Pneumonia, Viral.
- physiology : Acinetobacter baumannii, Escherichia coli, Influenza A virus, Klebsiella pneumoniae, Legionella pneumophila, Middle East Respiratory Syndrome Coronavirus, Staphylococcus aureus, Streptococcus pneumoniae.
- physiopathology : Pneumonia, Bacterial, Pneumonia, Viral.
- virology : Lung, Pneumonia, Viral.
- Animals, Disease Models, Animal, Female, Host Specificity, Humans, Immunohistochemistry, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Species Specificity.
Abstract
Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.
DOI: 10.1371/journal.pone.0188251
PubMed: 29155867
Links to Exploration step
pubmed:29155867Le document en format XML
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<author><name sortKey="Dietert, Kristina" sort="Dietert, Kristina" uniqKey="Dietert K" first="Kristina" last="Dietert">Kristina Dietert</name>
<affiliation><nlm:affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Gutbier, Birgitt" sort="Gutbier, Birgitt" uniqKey="Gutbier B" first="Birgitt" last="Gutbier">Birgitt Gutbier</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Wienhold, Sandra M" sort="Wienhold, Sandra M" uniqKey="Wienhold S" first="Sandra M" last="Wienhold">Sandra M. Wienhold</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Reppe, Katrin" sort="Reppe, Katrin" uniqKey="Reppe K" first="Katrin" last="Reppe">Katrin Reppe</name>
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<author><name sortKey="Jiang, Xiaohui" sort="Jiang, Xiaohui" uniqKey="Jiang X" first="Xiaohui" last="Jiang">Xiaohui Jiang</name>
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<author><name sortKey="Yao, Ling" sort="Yao, Ling" uniqKey="Yao L" first="Ling" last="Yao">Ling Yao</name>
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<author><name sortKey="Chaput, Catherine" sort="Chaput, Catherine" uniqKey="Chaput C" first="Catherine" last="Chaput">Catherine Chaput</name>
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<author><name sortKey="Naujoks, Jan" sort="Naujoks, Jan" uniqKey="Naujoks J" first="Jan" last="Naujoks">Jan Naujoks</name>
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<author><name sortKey="Brack, Markus" sort="Brack, Markus" uniqKey="Brack M" first="Markus" last="Brack">Markus Brack</name>
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<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
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</affiliation>
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<author><name sortKey="Peteranderl, Christin" sort="Peteranderl, Christin" uniqKey="Peteranderl C" first="Christin" last="Peteranderl">Christin Peteranderl</name>
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</affiliation>
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<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
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</affiliation>
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<author><name sortKey="Von Lachner, Carolin" sort="Von Lachner, Carolin" uniqKey="Von Lachner C" first="Carolin" last="Von Lachner">Carolin Von Lachner</name>
<affiliation><nlm:affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Baal, Nelli" sort="Baal, Nelli" uniqKey="Baal N" first="Nelli" last="Baal">Nelli Baal</name>
<affiliation><nlm:affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Slevogt, Hortense" sort="Slevogt, Hortense" uniqKey="Slevogt H" first="Hortense" last="Slevogt">Hortense Slevogt</name>
<affiliation><nlm:affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Hocke, Andreas C" sort="Hocke, Andreas C" uniqKey="Hocke A" first="Andreas C" last="Hocke">Andreas C. Hocke</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Witzenrath, Martin" sort="Witzenrath, Martin" uniqKey="Witzenrath M" first="Martin" last="Witzenrath">Martin Witzenrath</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Opitz, Bastian" sort="Opitz, Bastian" uniqKey="Opitz B" first="Bastian" last="Opitz">Bastian Opitz</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herold, Susanne" sort="Herold, Susanne" uniqKey="Herold S" first="Susanne" last="Herold">Susanne Herold</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hackstein, Holger" sort="Hackstein, Holger" uniqKey="Hackstein H" first="Holger" last="Hackstein">Holger Hackstein</name>
<affiliation><nlm:affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sander, Leif E" sort="Sander, Leif E" uniqKey="Sander L" first="Leif E" last="Sander">Leif E. Sander</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Suttorp, Norbert" sort="Suttorp, Norbert" uniqKey="Suttorp N" first="Norbert" last="Suttorp">Norbert Suttorp</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gruber, Achim D" sort="Gruber, Achim D" uniqKey="Gruber A" first="Achim D" last="Gruber">Achim D. Gruber</name>
<affiliation><nlm:affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.</title>
<author><name sortKey="Dietert, Kristina" sort="Dietert, Kristina" uniqKey="Dietert K" first="Kristina" last="Dietert">Kristina Dietert</name>
<affiliation><nlm:affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Gutbier, Birgitt" sort="Gutbier, Birgitt" uniqKey="Gutbier B" first="Birgitt" last="Gutbier">Birgitt Gutbier</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wienhold, Sandra M" sort="Wienhold, Sandra M" uniqKey="Wienhold S" first="Sandra M" last="Wienhold">Sandra M. Wienhold</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reppe, Katrin" sort="Reppe, Katrin" uniqKey="Reppe K" first="Katrin" last="Reppe">Katrin Reppe</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jiang, Xiaohui" sort="Jiang, Xiaohui" uniqKey="Jiang X" first="Xiaohui" last="Jiang">Xiaohui Jiang</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yao, Ling" sort="Yao, Ling" uniqKey="Yao L" first="Ling" last="Yao">Ling Yao</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chaput, Catherine" sort="Chaput, Catherine" uniqKey="Chaput C" first="Catherine" last="Chaput">Catherine Chaput</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Naujoks, Jan" sort="Naujoks, Jan" uniqKey="Naujoks J" first="Jan" last="Naujoks">Jan Naujoks</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brack, Markus" sort="Brack, Markus" uniqKey="Brack M" first="Markus" last="Brack">Markus Brack</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peteranderl, Christin" sort="Peteranderl, Christin" uniqKey="Peteranderl C" first="Christin" last="Peteranderl">Christin Peteranderl</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Von Lachner, Carolin" sort="Von Lachner, Carolin" uniqKey="Von Lachner C" first="Carolin" last="Von Lachner">Carolin Von Lachner</name>
<affiliation><nlm:affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Baal, Nelli" sort="Baal, Nelli" uniqKey="Baal N" first="Nelli" last="Baal">Nelli Baal</name>
<affiliation><nlm:affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slevogt, Hortense" sort="Slevogt, Hortense" uniqKey="Slevogt H" first="Hortense" last="Slevogt">Hortense Slevogt</name>
<affiliation><nlm:affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hocke, Andreas C" sort="Hocke, Andreas C" uniqKey="Hocke A" first="Andreas C" last="Hocke">Andreas C. Hocke</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Witzenrath, Martin" sort="Witzenrath, Martin" uniqKey="Witzenrath M" first="Martin" last="Witzenrath">Martin Witzenrath</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Opitz, Bastian" sort="Opitz, Bastian" uniqKey="Opitz B" first="Bastian" last="Opitz">Bastian Opitz</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herold, Susanne" sort="Herold, Susanne" uniqKey="Herold S" first="Susanne" last="Herold">Susanne Herold</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hackstein, Holger" sort="Hackstein, Holger" uniqKey="Hackstein H" first="Holger" last="Hackstein">Holger Hackstein</name>
<affiliation><nlm:affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sander, Leif E" sort="Sander, Leif E" uniqKey="Sander L" first="Leif E" last="Sander">Leif E. Sander</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Suttorp, Norbert" sort="Suttorp, Norbert" uniqKey="Suttorp N" first="Norbert" last="Suttorp">Norbert Suttorp</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gruber, Achim D" sort="Gruber, Achim D" uniqKey="Gruber A" first="Achim D" last="Gruber">Achim D. Gruber</name>
<affiliation><nlm:affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
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<term>Acinetobacter baumannii (physiology)</term>
<term>Animals</term>
<term>Disease Models, Animal</term>
<term>Escherichia coli (pathogenicity)</term>
<term>Escherichia coli (physiology)</term>
<term>Female</term>
<term>Host Specificity</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Influenza A virus (physiology)</term>
<term>Klebsiella pneumoniae (pathogenicity)</term>
<term>Klebsiella pneumoniae (physiology)</term>
<term>Legionella pneumophila (pathogenicity)</term>
<term>Legionella pneumophila (physiology)</term>
<term>Lung (microbiology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Pneumonia, Bacterial (genetics)</term>
<term>Pneumonia, Bacterial (microbiology)</term>
<term>Pneumonia, Bacterial (pathology)</term>
<term>Pneumonia, Bacterial (physiopathology)</term>
<term>Pneumonia, Viral (genetics)</term>
<term>Pneumonia, Viral (pathology)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Species Specificity</term>
<term>Staphylococcus aureus (pathogenicity)</term>
<term>Staphylococcus aureus (physiology)</term>
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<term>Pneumonia, Bacterial</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Acinetobacter baumannii</term>
<term>Escherichia coli</term>
<term>Influenza A virus</term>
<term>Klebsiella pneumoniae</term>
<term>Legionella pneumophila</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Staphylococcus aureus</term>
<term>Streptococcus pneumoniae</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Pneumonia, Bacterial</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Acinetobacter baumannii</term>
<term>Escherichia coli</term>
<term>Influenza A virus</term>
<term>Klebsiella pneumoniae</term>
<term>Legionella pneumophila</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
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<term>Pneumonia, Viral</term>
</keywords>
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<term>Disease Models, Animal</term>
<term>Female</term>
<term>Host Specificity</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<front><div type="abstract" xml:lang="en">Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.</div>
</front>
</TEI>
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<DateCompleted><Year>2017</Year>
<Month>12</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>11</Issue>
<PubDate><Year>2017</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.</ArticleTitle>
<Pagination><MedlinePgn>e0188251</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0188251</ELocationID>
<Abstract><AbstractText>Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dietert</LastName>
<ForeName>Kristina</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5667-6750</Identifier>
<AffiliationInfo><Affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gutbier</LastName>
<ForeName>Birgitt</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wienhold</LastName>
<ForeName>Sandra M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reppe</LastName>
<ForeName>Katrin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Xiaohui</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yao</LastName>
<ForeName>Ling</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chaput</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Naujoks</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brack</LastName>
<ForeName>Markus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kupke</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Virology, Philipps University of Marburg, German Center for Infection Research (DZIF), TTU Emerging Infections, Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peteranderl</LastName>
<ForeName>Christin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Becker</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Virology, Philipps University of Marburg, German Center for Infection Research (DZIF), TTU Emerging Infections, Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>von Lachner</LastName>
<ForeName>Carolin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baal</LastName>
<ForeName>Nelli</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slevogt</LastName>
<ForeName>Hortense</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hocke</LastName>
<ForeName>Andreas C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Witzenrath</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Opitz</LastName>
<ForeName>Bastian</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herold</LastName>
<ForeName>Susanne</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hackstein</LastName>
<ForeName>Holger</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sander</LastName>
<ForeName>Leif E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suttorp</LastName>
<ForeName>Norbert</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gruber</LastName>
<ForeName>Achim D</ForeName>
<Initials>AD</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>11</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D040981" MajorTopicYN="N">Acinetobacter baumannii</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058507" MajorTopicYN="Y">Host Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007711" MajorTopicYN="N">Klebsiella pneumoniae</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016952" MajorTopicYN="N">Legionella pneumophila</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018410" MajorTopicYN="N">Pneumonia, Bacterial</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013296" MajorTopicYN="N">Streptococcus pneumoniae</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>07</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>11</Month>
<Day>05</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>11</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>11</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>12</Month>
<Day>20</Day>
<Hour>6</Hour>
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<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29155867</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0188251</ArticleId>
<ArticleId IdType="pii">PONE-D-17-27356</ArticleId>
<ArticleId IdType="pmc">PMC5695780</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Am J Respir Cell Mol Biol. 2009 Apr;40(4):474-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18931326</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2012 Mar 23;30(14):2411-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22100884</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Microbiol. 2011 Nov;13(11):1668-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21790939</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Infect. 2005 Nov;11(11):868-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16216100</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2002 Apr 1;165(7):867-903</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11934711</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cytokine. 2007 May;38(2):61-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17611121</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Immunol. 2017 Aug 4;2(14 ):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28778905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Infect Dis. 2015 Jul;36:54-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26072036</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1935-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19815859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367 (19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Vet Res. 2013 Jun 21;9:123</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23800279</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16210672</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2002 Mar 2;359(9308):753-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11888586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2017 Jun 27;35(30):3780-3788</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28579232</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2010 Feb 15;181(4):394-418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20130146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vet Med Educ. 2007 Fall;34(4):473-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18287475</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2016 Apr 14;90(9):4838-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26889022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J. 2007 Dec;30(6):1193-207</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18055704</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Korean J Intern Med. 2012 Jun;27(2):128-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22707882</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Genomics. 2016 Feb 27;17:143</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26921172</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Infect Dis. 2012 Jun 21;12:139</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22721450</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Rev. 1995 Dec;59(4):591-603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8531887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Cell Mol Biol. 2011 May;44(5):725-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21531958</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2016 Feb 01;12(2):e1005408</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26829557</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Regul Toxicol Pharmacol. 2012 Jul;63(2):286-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22475931</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J. 2015 May;45(5):1463-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25792631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2002 Mar;2(3):171-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11944187</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>F1000Prime Rep. 2014 Sep 04;6:82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25343039</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomed Pharmacother. 2017 Feb;86:715-724</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28063402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2001 Mar 1;166(5):3355-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11207291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nat Sci Biol Med. 2017 Jan-Jun;8(1):46-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28250674</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect. 2010 Feb;60(2):154-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19748521</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Dec 17;279(51):53241-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15485852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Rev Oncol Hematol. 2017 Apr;112:80-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28325268</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Novartis Found Symp. 2007;280:21-7; discussion 27-36, 160-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17380786</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L379-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18621912</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbes Infect. 2010 Sep;12(10):759-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20493961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Respir Med. 2014 Sep;2(9):764-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25151022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Microbiol. 2014 Oct;22(10):573-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25178651</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Wkly Epidemiol Rec. 2007 Mar 23;82(12):93-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17380597</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vet Med Educ. 2007 Fall;34(4):485-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18287477</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Res. 2013 Sep 17;14:91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24044871</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 1984 Sep;74(3):771-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6470140</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Antimicrob Chemother. 2015 Mar;70(3):830-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25406299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2015 Aug;89(16):8651-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26018172</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pneumologie. 2012 Aug;66(8):470-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22875730</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2010 Aug 1;51 Suppl 1:S48-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20597672</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Control. 1985 Feb;6(2):68-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3882593</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 May;88(10):5209-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24600003</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24960575</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 2007 Feb;75(2):1040-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17101657</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Med. 2007 Sep;101(9):1864-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17548187</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2006 Mar 23;440(7083):435-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16554799</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26047639</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Microbiol. 2014;68:81-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24819367</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Zhonghua Er Ke Za Zhi. 2004 Sep;42(9):644-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15482661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Infect Dis. 2012 May;16(5):e321-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22387143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Semin Pediatr Infect Dis. 2002 Oct;13(4):273-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12491233</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2014 Apr 10;(4):CD008965</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24718923</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Clin Microbiol Infect Dis. 2007 Dec;26(12):857-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17701432</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Res. 2015 Oct 06;16:123</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26438075</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Toxicol Pathol. 2017 Jan;45(1):161-171</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28068894</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Semin Respir Crit Care Med. 2000;21(4):295-304</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16088740</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24083868</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2014 Feb;14 (2):140-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pulm Pharmacol Ther. 2010 Aug;23(4):334-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20362688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Med. 2003;2(3):235-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14720005</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 2015 Sep;83(9):3418-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26056382</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Public Health. 2000 Feb;90(2):223-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10667183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Rev Clin Lab Sci. 2003 Jun;40(3):209-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12892317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Jul 16;9(7):e100970</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25029240</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vis Exp. 2014 Nov 17;(93):e52261</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25490457</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Jul 17;9(7):e102606</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25033194</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Shock. 2014 Sep;42(3):246-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24978886</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24599590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Innate Immun. 2017;9(4):403-418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28601872</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2015 Nov;89(22):11654-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26355094</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Sep 09;9(9):e107394</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25203254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pediatr. 2001 Sep;8 Suppl 4:742s-746s</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11582921</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):189-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10575129</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Microbiol. 2009 Jan;11(1):21-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18782351</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 2015 Dec;83(12):4617-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26371127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dev Ctries. 2009 Dec 15;3(10):771-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20009278</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dtsch Med Wochenschr. 2011 Apr;136(15):775-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21469047</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2006 Mar;2(3):e18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16552444</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
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