MersV1, PubMed, Corpus, bibRecord, 000A81

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

Identifieur interne : 000A81 ( PubMed/Corpus ); précédent : 000A80; suivant : 000A82

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

Auteurs : Kristina Dietert ; Birgitt Gutbier ; Sandra M. Wienhold ; Katrin Reppe ; Xiaohui Jiang ; Ling Yao ; Catherine Chaput ; Jan Naujoks ; Markus Brack ; Alexandra Kupke ; Christin Peteranderl ; Stephan Becker ; Carolin Von Lachner ; Nelli Baal ; Hortense Slevogt ; Andreas C. Hocke ; Martin Witzenrath ; Bastian Opitz ; Susanne Herold ; Holger Hackstein ; Leif E. Sander ; Norbert Suttorp ; Achim D. Gruber

Source :

PloS one [ 1932-6203 ] ; 2017.

RBID : pubmed:29155867

English descriptors

Abstract

Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.

DOI: 10.1371/journal.pone.0188251
PubMed: 29155867

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pubmed:29155867

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<author><name sortKey="Dietert, Kristina" sort="Dietert, Kristina" uniqKey="Dietert K" first="Kristina" last="Dietert">Kristina Dietert</name>
<affiliation><nlm:affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Gutbier, Birgitt" sort="Gutbier, Birgitt" uniqKey="Gutbier B" first="Birgitt" last="Gutbier">Birgitt Gutbier</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Wienhold, Sandra M" sort="Wienhold, Sandra M" uniqKey="Wienhold S" first="Sandra M" last="Wienhold">Sandra M. Wienhold</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
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<author><name sortKey="Reppe, Katrin" sort="Reppe, Katrin" uniqKey="Reppe K" first="Katrin" last="Reppe">Katrin Reppe</name>
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<author><name sortKey="Jiang, Xiaohui" sort="Jiang, Xiaohui" uniqKey="Jiang X" first="Xiaohui" last="Jiang">Xiaohui Jiang</name>
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<author><name sortKey="Yao, Ling" sort="Yao, Ling" uniqKey="Yao L" first="Ling" last="Yao">Ling Yao</name>
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<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
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<author><name sortKey="Peteranderl, Christin" sort="Peteranderl, Christin" uniqKey="Peteranderl C" first="Christin" last="Peteranderl">Christin Peteranderl</name>
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<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
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<author><name sortKey="Von Lachner, Carolin" sort="Von Lachner, Carolin" uniqKey="Von Lachner C" first="Carolin" last="Von Lachner">Carolin Von Lachner</name>
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<author><name sortKey="Baal, Nelli" sort="Baal, Nelli" uniqKey="Baal N" first="Nelli" last="Baal">Nelli Baal</name>
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</affiliation>
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<author><name sortKey="Slevogt, Hortense" sort="Slevogt, Hortense" uniqKey="Slevogt H" first="Hortense" last="Slevogt">Hortense Slevogt</name>
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<author><name sortKey="Hocke, Andreas C" sort="Hocke, Andreas C" uniqKey="Hocke A" first="Andreas C" last="Hocke">Andreas C. Hocke</name>
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<author><name sortKey="Witzenrath, Martin" sort="Witzenrath, Martin" uniqKey="Witzenrath M" first="Martin" last="Witzenrath">Martin Witzenrath</name>
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</affiliation>
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<author><name sortKey="Opitz, Bastian" sort="Opitz, Bastian" uniqKey="Opitz B" first="Bastian" last="Opitz">Bastian Opitz</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herold, Susanne" sort="Herold, Susanne" uniqKey="Herold S" first="Susanne" last="Herold">Susanne Herold</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hackstein, Holger" sort="Hackstein, Holger" uniqKey="Hackstein H" first="Holger" last="Hackstein">Holger Hackstein</name>
<affiliation><nlm:affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sander, Leif E" sort="Sander, Leif E" uniqKey="Sander L" first="Leif E" last="Sander">Leif E. Sander</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Suttorp, Norbert" sort="Suttorp, Norbert" uniqKey="Suttorp N" first="Norbert" last="Suttorp">Norbert Suttorp</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gruber, Achim D" sort="Gruber, Achim D" uniqKey="Gruber A" first="Achim D" last="Gruber">Achim D. Gruber</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.</title>
<author><name sortKey="Dietert, Kristina" sort="Dietert, Kristina" uniqKey="Dietert K" first="Kristina" last="Dietert">Kristina Dietert</name>
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<author><name sortKey="Gutbier, Birgitt" sort="Gutbier, Birgitt" uniqKey="Gutbier B" first="Birgitt" last="Gutbier">Birgitt Gutbier</name>
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</affiliation>
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<author><name sortKey="Wienhold, Sandra M" sort="Wienhold, Sandra M" uniqKey="Wienhold S" first="Sandra M" last="Wienhold">Sandra M. Wienhold</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Reppe, Katrin" sort="Reppe, Katrin" uniqKey="Reppe K" first="Katrin" last="Reppe">Katrin Reppe</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Jiang, Xiaohui" sort="Jiang, Xiaohui" uniqKey="Jiang X" first="Xiaohui" last="Jiang">Xiaohui Jiang</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Yao, Ling" sort="Yao, Ling" uniqKey="Yao L" first="Ling" last="Yao">Ling Yao</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chaput, Catherine" sort="Chaput, Catherine" uniqKey="Chaput C" first="Catherine" last="Chaput">Catherine Chaput</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Naujoks, Jan" sort="Naujoks, Jan" uniqKey="Naujoks J" first="Jan" last="Naujoks">Jan Naujoks</name>
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</affiliation>
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<author><name sortKey="Brack, Markus" sort="Brack, Markus" uniqKey="Brack M" first="Markus" last="Brack">Markus Brack</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peteranderl, Christin" sort="Peteranderl, Christin" uniqKey="Peteranderl C" first="Christin" last="Peteranderl">Christin Peteranderl</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Von Lachner, Carolin" sort="Von Lachner, Carolin" uniqKey="Von Lachner C" first="Carolin" last="Von Lachner">Carolin Von Lachner</name>
<affiliation><nlm:affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Baal, Nelli" sort="Baal, Nelli" uniqKey="Baal N" first="Nelli" last="Baal">Nelli Baal</name>
<affiliation><nlm:affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slevogt, Hortense" sort="Slevogt, Hortense" uniqKey="Slevogt H" first="Hortense" last="Slevogt">Hortense Slevogt</name>
<affiliation><nlm:affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hocke, Andreas C" sort="Hocke, Andreas C" uniqKey="Hocke A" first="Andreas C" last="Hocke">Andreas C. Hocke</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Witzenrath, Martin" sort="Witzenrath, Martin" uniqKey="Witzenrath M" first="Martin" last="Witzenrath">Martin Witzenrath</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Opitz, Bastian" sort="Opitz, Bastian" uniqKey="Opitz B" first="Bastian" last="Opitz">Bastian Opitz</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herold, Susanne" sort="Herold, Susanne" uniqKey="Herold S" first="Susanne" last="Herold">Susanne Herold</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hackstein, Holger" sort="Hackstein, Holger" uniqKey="Hackstein H" first="Holger" last="Hackstein">Holger Hackstein</name>
<affiliation><nlm:affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sander, Leif E" sort="Sander, Leif E" uniqKey="Sander L" first="Leif E" last="Sander">Leif E. Sander</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Suttorp, Norbert" sort="Suttorp, Norbert" uniqKey="Suttorp N" first="Norbert" last="Suttorp">Norbert Suttorp</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gruber, Achim D" sort="Gruber, Achim D" uniqKey="Gruber A" first="Achim D" last="Gruber">Achim D. Gruber</name>
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</affiliation>
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<term>Escherichia coli (pathogenicity)</term>
<term>Escherichia coli (physiology)</term>
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<term>Humans</term>
<term>Immunohistochemistry</term>
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<front><div type="abstract" xml:lang="en">Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.</div>
</front>
</TEI>
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<Month>11</Month>
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<Title>PloS one</Title>
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<ArticleTitle>Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.</ArticleTitle>
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</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0188251</ELocationID>
<Abstract><AbstractText>Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dietert</LastName>
<ForeName>Kristina</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5667-6750</Identifier>
<AffiliationInfo><Affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gutbier</LastName>
<ForeName>Birgitt</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wienhold</LastName>
<ForeName>Sandra M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reppe</LastName>
<ForeName>Katrin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Xiaohui</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yao</LastName>
<ForeName>Ling</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chaput</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Naujoks</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brack</LastName>
<ForeName>Markus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kupke</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Virology, Philipps University of Marburg, German Center for Infection Research (DZIF), TTU Emerging Infections, Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peteranderl</LastName>
<ForeName>Christin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Becker</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Virology, Philipps University of Marburg, German Center for Infection Research (DZIF), TTU Emerging Infections, Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>von Lachner</LastName>
<ForeName>Carolin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baal</LastName>
<ForeName>Nelli</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slevogt</LastName>
<ForeName>Hortense</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Septomics Research Center, Jena University Hospital, Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hocke</LastName>
<ForeName>Andreas C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Witzenrath</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Opitz</LastName>
<ForeName>Bastian</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herold</LastName>
<ForeName>Susanne</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine II, Section for Infectious Diseases, Universities Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hackstein</LastName>
<ForeName>Holger</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), University Hospital Giessen und Marburg, Justus-Liebig-University Giessen, Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sander</LastName>
<ForeName>Leif E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suttorp</LastName>
<ForeName>Norbert</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gruber</LastName>
<ForeName>Achim D</ForeName>
<Initials>AD</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>11</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D040981" MajorTopicYN="N">Acinetobacter baumannii</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058507" MajorTopicYN="Y">Host Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007711" MajorTopicYN="N">Klebsiella pneumoniae</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016952" MajorTopicYN="N">Legionella pneumophila</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018410" MajorTopicYN="N">Pneumonia, Bacterial</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013296" MajorTopicYN="N">Streptococcus pneumoniae</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>07</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>11</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>11</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>11</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>12</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29155867</ArticleId>
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<ArticleId IdType="pii">PONE-D-17-27356</ArticleId>
<ArticleId IdType="pmc">PMC5695780</ArticleId>
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Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

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