Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis.
Identifieur interne : 000928 ( PubMed/Corpus ); précédent : 000927; suivant : 000929Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis.
Auteurs : Mostafa Ebraheem Morra ; Le Van Thanh ; Mohamed Gomaa Kamel ; Ahmed Abdelmotaleb Ghazy ; Ahmed M A. Altibi ; Lu Minh Dat ; Tran Ngoc Xuan Thy ; Nguyen Lam Vuong ; Mostafa Reda Mostafa ; Sarah Ibrahim Ahmed ; Sahar Samy Elabd ; Samreen Fathima ; Tran Le Huy Vu ; Ali S. Omrani ; Ziad A. Memish ; Kenji Hirayama ; Nguyen Tien HuySource :
- Reviews in medical virology [ 1099-1654 ] ; 2018.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Coronavirus Infections (virology), Female, Humans, Interferons (pharmacology), Interferons (therapeutic use), Male, Middle East Respiratory Syndrome Coronavirus, Risk Factors, Treatment Outcome.
- MESH :
- chemical , pharmacology : Antiviral Agents, Interferons.
- chemical , therapeutic use : Antiviral Agents, Interferons.
- drug therapy : Coronavirus Infections.
- mortality : Coronavirus Infections.
- virology : Coronavirus Infections.
- Female, Humans, Male, Middle East Respiratory Syndrome Coronavirus, Risk Factors, Treatment Outcome.
Abstract
Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS coronavirus. Because of lack of vaccination, various studies investigated the therapeutic efficacy of antiviral drugs and supportive remedies. A systematic literature search from 10 databases was conducted and screened for relevant articles. Studies reporting information about the treatment of MERS coronavirus infection were extracted and analyzed. Despite receiving treatment with ribavirin plus IFN, the case fatality rate was as high as 71% in the IFN-treatment group and exactly the same in patients who received supportive treatment only. Having chronic renal disease, diabetes mellitus and hypertension increased the risk of mortality (P < .05), and chronic renal disease is the best parameter to predict the mortality. The mean of survival days from onset of illness to death was 46.6 (95% CI, 30.5-62.6) for the IFN group compared with 18.8 (95% CI, 10.3-27.4) for the supportive-only group (P = .001). Delay in starting treatment, older age group, and preexisting comorbidities are associated with worse outcomes. In conclusion, there is no difference between IFN treatment and supportive treatment for MERS patients in terms of mortality. However, ribavirin and IFN combination might have efficacious effects with timely administration and monitoring of adverse events. Large-scale prospective randomized studies are required to assess the role of antiviral drugs for the treatment of this high mortality infection.
DOI: 10.1002/rmv.1977
PubMed: 29664167
Links to Exploration step
pubmed:29664167Le document en format XML
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<author><name sortKey="Thy, Tran Ngoc Xuan" sort="Thy, Tran Ngoc Xuan" uniqKey="Thy T" first="Tran Ngoc Xuan" last="Thy">Tran Ngoc Xuan Thy</name>
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<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name>
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<term>Coronavirus Infections (virology)</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS coronavirus. Because of lack of vaccination, various studies investigated the therapeutic efficacy of antiviral drugs and supportive remedies. A systematic literature search from 10 databases was conducted and screened for relevant articles. Studies reporting information about the treatment of MERS coronavirus infection were extracted and analyzed. Despite receiving treatment with ribavirin plus IFN, the case fatality rate was as high as 71% in the IFN-treatment group and exactly the same in patients who received supportive treatment only. Having chronic renal disease, diabetes mellitus and hypertension increased the risk of mortality (P < .05), and chronic renal disease is the best parameter to predict the mortality. The mean of survival days from onset of illness to death was 46.6 (95% CI, 30.5-62.6) for the IFN group compared with 18.8 (95% CI, 10.3-27.4) for the supportive-only group (P = .001). Delay in starting treatment, older age group, and preexisting comorbidities are associated with worse outcomes. In conclusion, there is no difference between IFN treatment and supportive treatment for MERS patients in terms of mortality. However, ribavirin and IFN combination might have efficacious effects with timely administration and monitoring of adverse events. Large-scale prospective randomized studies are required to assess the role of antiviral drugs for the treatment of this high mortality infection.</div>
</front>
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<Abstract><AbstractText>Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS coronavirus. Because of lack of vaccination, various studies investigated the therapeutic efficacy of antiviral drugs and supportive remedies. A systematic literature search from 10 databases was conducted and screened for relevant articles. Studies reporting information about the treatment of MERS coronavirus infection were extracted and analyzed. Despite receiving treatment with ribavirin plus IFN, the case fatality rate was as high as 71% in the IFN-treatment group and exactly the same in patients who received supportive treatment only. Having chronic renal disease, diabetes mellitus and hypertension increased the risk of mortality (P < .05), and chronic renal disease is the best parameter to predict the mortality. The mean of survival days from onset of illness to death was 46.6 (95% CI, 30.5-62.6) for the IFN group compared with 18.8 (95% CI, 10.3-27.4) for the supportive-only group (P = .001). Delay in starting treatment, older age group, and preexisting comorbidities are associated with worse outcomes. In conclusion, there is no difference between IFN treatment and supportive treatment for MERS patients in terms of mortality. However, ribavirin and IFN combination might have efficacious effects with timely administration and monitoring of adverse events. Large-scale prospective randomized studies are required to assess the role of antiviral drugs for the treatment of this high mortality infection.</AbstractText>
<CopyrightInformation>Copyright © 2018 John Wiley & Sons, Ltd.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Morra</LastName>
<ForeName>Mostafa Ebraheem</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Faculty of Medicine, Alazhar University, Cairo, Egypt.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Online Research Club (http://www.onlineresearchclub.org/).</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Van Thanh</LastName>
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<Initials>L</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Kamel</LastName>
<ForeName>Mohamed Gomaa</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Online Research Club (http://www.onlineresearchclub.org/).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, Minia University, Minya, Egypt.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Ghazy</LastName>
<ForeName>Ahmed Abdelmotaleb</ForeName>
<Initials>AA</Initials>
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<AffiliationInfo><Affiliation>Department of Cardiology, Shebin El-Kom Teaching Hospital, Shibin El Kom, Egypt.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Altibi</LastName>
<ForeName>Ahmed M A</ForeName>
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<AffiliationInfo><Affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Dat</LastName>
<ForeName>Lu Minh</ForeName>
<Initials>LM</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.</Affiliation>
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<Author ValidYN="Y"><LastName>Thy</LastName>
<ForeName>Tran Ngoc Xuan</ForeName>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vuong</LastName>
<ForeName>Nguyen Lam</ForeName>
<Initials>NL</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mostafa</LastName>
<ForeName>Mostafa Reda</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Online Research Club (http://www.onlineresearchclub.org/).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, Tanta University, Tanta, Egypt.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Ahmed</LastName>
<ForeName>Sarah Ibrahim</ForeName>
<Initials>SI</Initials>
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<Author ValidYN="Y"><LastName>Elabd</LastName>
<ForeName>Sahar Samy</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Faculty of Medicine, Benha University, Benha, Egypt.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Fathima</LastName>
<ForeName>Samreen</ForeName>
<Initials>S</Initials>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Huy Vu</LastName>
<ForeName>Tran</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>University of California, Los Angeles, California, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Omrani</LastName>
<ForeName>Ali S</ForeName>
<Initials>AS</Initials>
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<ForeName>Kenji</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Huy</LastName>
<ForeName>Nguyen Tien</ForeName>
<Initials>NT</Initials>
<Identifier Source="ORCID">0000-0002-9543-9440</Identifier>
<AffiliationInfo><Affiliation>Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.</Affiliation>
</AffiliationInfo>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="Y">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
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</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">MERS-CoV</Keyword>
<Keyword MajorTopicYN="Y">Middle East respiratory syndrome</Keyword>
<Keyword MajorTopicYN="Y">interferon</Keyword>
<Keyword MajorTopicYN="Y">systematic review</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>01</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>02</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>02</Month>
<Day>12</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>4</Month>
<Day>18</Day>
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<PubMedPubDate PubStatus="medline"><Year>2018</Year>
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<Day>20</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29664167</ArticleId>
<ArticleId IdType="doi">10.1002/rmv.1977</ArticleId>
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