Immune Responses to Middle East Respiratory Syndrome Coronavirus During the Acute and Convalescent Phases of Human Infection.
Identifieur interne : 000826 ( PubMed/Corpus ); précédent : 000825; suivant : 000827Immune Responses to Middle East Respiratory Syndrome Coronavirus During the Acute and Convalescent Phases of Human Infection.
Auteurs : Hyoung-Shik Shin ; Yeonjae Kim ; Gayeon Kim ; Ji Yeon Lee ; Ina Jeong ; Joon-Sung Joh ; Hana Kim ; Eunjin Chang ; Soo Yeon Sim ; Jun-Sun Park ; Dong-Gyun LimSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2019.
Abstract
An understanding of immune responses against the Middle East respiratory syndrome (MERS) is important for the development of treatments and preventive measures. Here, we investigated the spectrum of immune responses occurring in patients with MERS during the early period of infection.
DOI: 10.1093/cid/ciy595
PubMed: 30060038
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sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Jeong, Ina" sort="Jeong, Ina" uniqKey="Jeong I" first="Ina" last="Jeong">Ina Jeong</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Joh, Joon Sung" sort="Joh, Joon Sung" uniqKey="Joh J" first="Joon-Sung" last="Joh">Joon-Sung Joh</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hana" sort="Kim, Hana" uniqKey="Kim H" first="Hana" last="Kim">Hana Kim</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Eunjin" sort="Chang, Eunjin" uniqKey="Chang E" first="Eunjin" last="Chang">Eunjin Chang</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Sim, Soo Yeon" sort="Sim, Soo Yeon" uniqKey="Sim S" first="Soo Yeon" last="Sim">Soo Yeon Sim</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name><affiliation><nlm:affiliation>Center for Infectious Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30060038</idno><idno type="pmid">30060038</idno><idno type="doi">10.1093/cid/ciy595</idno><idno type="wicri:Area/PubMed/Corpus">000826</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000826</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immune Responses to Middle East Respiratory Syndrome Coronavirus During the Acute and Convalescent Phases of Human Infection.</title><author><name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name><affiliation><nlm:affiliation>Center for Infectious Diseases, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation><nlm:affiliation>Center for Infectious Diseases, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Gayeon" sort="Kim, Gayeon" uniqKey="Kim G" first="Gayeon" last="Kim">Gayeon Kim</name><affiliation><nlm:affiliation>Center for Infectious Diseases, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Jeong, Ina" sort="Jeong, Ina" uniqKey="Jeong I" first="Ina" last="Jeong">Ina Jeong</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Joh, Joon Sung" sort="Joh, Joon Sung" uniqKey="Joh J" first="Joon-Sung" last="Joh">Joon-Sung Joh</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hana" sort="Kim, Hana" uniqKey="Kim H" first="Hana" last="Kim">Hana Kim</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Eunjin" sort="Chang, Eunjin" uniqKey="Chang E" first="Eunjin" last="Chang">Eunjin Chang</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Sim, Soo Yeon" sort="Sim, Soo Yeon" uniqKey="Sim S" first="Soo Yeon" last="Sim">Soo Yeon Sim</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name><affiliation><nlm:affiliation>Center for Infectious Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name><affiliation><nlm:affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An understanding of immune responses against the Middle East respiratory syndrome (MERS) is important for the development of treatments and preventive measures. Here, we investigated the spectrum of immune responses occurring in patients with MERS during the early period of infection.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">30060038</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>03</Month><Day>05</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Immune Responses to Middle East Respiratory Syndrome Coronavirus During the Acute and Convalescent Phases of Human Infection.</ArticleTitle><Pagination><MedlinePgn>984-992</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciy595</ELocationID><Abstract><AbstractText Label="BACKGROUND">An understanding of immune responses against the Middle East respiratory syndrome (MERS) is important for the development of treatments and preventive measures. Here, we investigated the spectrum of immune responses occurring in patients with MERS during the early period of infection.</AbstractText><AbstractText Label="METHODS">We obtained peripheral blood samples from 27 hospitalized patients recruited during the epidemic that occurred in 2015 in South Korea. Plasma cytokines/chemokines and antibodies were quantified. Virus-specific T cells were examined by intracellular cytokine staining after stimulation of peripheral blood mononuclear cells with overlapping peptides spanning whole virus structural proteins.</AbstractText><AbstractText Label="RESULTS">At the acute phase of infection, elevated levels of plasma proinflammatory cytokines/chemokines were detected in proportion to the severity of the disease. Distinctively high frequencies of MERS coronavirus-reactive CD8+ T cells were also observed in patients with severe/moderate illness, whereas antibody and CD4+ T-cell responses were minimally detected at this stage. At the convalescent phase, disease severity-dependent antibody responses emerged and antigen-reactive cells were identified in both T-cell subsets. These T cells belonged to the T-helper 1 or type 1 cytotoxic T cell subtypes. While CD8+ T cells responded preferentially to the viral S protein compared with E/M/N proteins, especially at the acute stage, slightly more CD4+ T cells recognized E/M/N proteins compared with S protein at the convalescent phase.</AbstractText><AbstractText Label="CONCLUSIONS">Our findings show an association between the early CD8+ T-cell response and the severity of the infection, and also provide basic information that may help to prepare effective control strategies for MERS in humans.</AbstractText><CopyrightInformation>© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Hyoung-Shik</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Center for Infectious Diseases, Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yeonjae</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Center for Infectious Diseases, Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Gayeon</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Center for Infectious Diseases, Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ji Yeon</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeong</LastName><ForeName>Ina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joh</LastName><ForeName>Joon-Sung</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hana</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Eunjin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sim</LastName><ForeName>Soo Yeon</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Jun-Sun</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Center for Infectious Diseases, Research Institute, National Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Dong-Gyun</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>Center for Chronic Diseases, Research Institute, National Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, 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