Multihospital Outbreak of a Middle East Respiratory Syndrome Coronavirus Deletion Variant, Jordan: A Molecular, Serologic, and Epidemiologic Investigation.
Identifieur interne : 000761 ( PubMed/Corpus ); précédent : 000760; suivant : 000762Multihospital Outbreak of a Middle East Respiratory Syndrome Coronavirus Deletion Variant, Jordan: A Molecular, Serologic, and Epidemiologic Investigation.
Auteurs : Daniel C. Payne ; Holly M. Biggs ; Mohammad Mousa Al-Abdallat ; Sultan Alqasrawi ; Xiaoyan Lu ; Glen R. Abedi ; Aktham Haddadin ; Ibrahim Iblan ; Tarek Alsanouri ; Mohannad Al Nsour ; Sami Sheikh Ali ; Brian Rha ; Suvang U. Trivedi ; Mohammed Ata Ur Rasheed ; Azaibi Tamin ; Mart M. Lamers ; Bart L. Haagmans ; Dean D. Erdman ; Natalie J. Thornburg ; Susan I. GerberSource :
- Open forum infectious diseases [ 2328-8957 ] ; 2018.
Abstract
An outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Jordan in 2015 involved a variant virus that acquired distinctive deletions in the accessory open reading frames. We conducted a molecular and seroepidemiologic investigation to describe the deletion variant's transmission patterns and epidemiology.
DOI: 10.1093/ofid/ofy095
PubMed: 30294616
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multihospital Outbreak of a Middle East Respiratory Syndrome Coronavirus Deletion Variant, Jordan: A Molecular, Serologic, and Epidemiologic Investigation.</title><author><name sortKey="Payne, Daniel C" sort="Payne, Daniel C" uniqKey="Payne D" first="Daniel C" last="Payne">Daniel C. Payne</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Biggs, Holly M" sort="Biggs, Holly M" uniqKey="Biggs H" first="Holly M" last="Biggs">Holly M. Biggs</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Abdallat, Mohammad Mousa" sort="Al Abdallat, Mohammad Mousa" uniqKey="Al Abdallat M" first="Mohammad Mousa" last="Al-Abdallat">Mohammad Mousa Al-Abdallat</name><affiliation><nlm:affiliation>Communicable Diseases Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Alqasrawi, Sultan" sort="Alqasrawi, Sultan" uniqKey="Alqasrawi S" first="Sultan" last="Alqasrawi">Sultan Alqasrawi</name><affiliation><nlm:affiliation>Communicable Diseases Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Xiaoyan" sort="Lu, Xiaoyan" uniqKey="Lu X" first="Xiaoyan" last="Lu">Xiaoyan Lu</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Abedi, Glen R" sort="Abedi, Glen R" uniqKey="Abedi G" first="Glen R" last="Abedi">Glen R. Abedi</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Haddadin, Aktham" sort="Haddadin, Aktham" uniqKey="Haddadin A" first="Aktham" last="Haddadin">Aktham Haddadin</name><affiliation><nlm:affiliation>Laboratory Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Iblan, Ibrahim" sort="Iblan, Ibrahim" uniqKey="Iblan I" first="Ibrahim" last="Iblan">Ibrahim Iblan</name><affiliation><nlm:affiliation>Field Epidemiology Training Program, Jordan Ministry of Health, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Alsanouri, Tarek" sort="Alsanouri, Tarek" uniqKey="Alsanouri T" first="Tarek" last="Alsanouri">Tarek Alsanouri</name><affiliation><nlm:affiliation>Eastern Mediterranean Public Health Network, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Al Nsour, Mohannad" sort="Al Nsour, Mohannad" uniqKey="Al Nsour M" first="Mohannad" last="Al Nsour">Mohannad Al Nsour</name><affiliation><nlm:affiliation>Eastern Mediterranean Public Health Network, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Sheikh Ali, Sami" sort="Sheikh Ali, Sami" uniqKey="Sheikh Ali S" first="Sami" last="Sheikh Ali">Sami Sheikh Ali</name><affiliation><nlm:affiliation>Communicable Diseases Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Rha, Brian" sort="Rha, Brian" uniqKey="Rha B" first="Brian" last="Rha">Brian Rha</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Trivedi, Suvang U" sort="Trivedi, Suvang U" uniqKey="Trivedi S" first="Suvang U" last="Trivedi">Suvang U. Trivedi</name><affiliation><nlm:affiliation>IHRC, Inc, contracting agency for the Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Rasheed, Mohammed Ata Ur" sort="Rasheed, Mohammed Ata Ur" uniqKey="Rasheed M" first="Mohammed Ata Ur" last="Rasheed">Mohammed Ata Ur Rasheed</name><affiliation><nlm:affiliation>IHRC, Inc, contracting agency for the Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M" last="Lamers">Mart M. Lamers</name><affiliation><nlm:affiliation>Viroscience Department, Erasmus University Medical Center, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><affiliation><nlm:affiliation>Viroscience Department, Erasmus University Medical Center, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Erdman, Dean D" sort="Erdman, Dean D" uniqKey="Erdman D" first="Dean D" last="Erdman">Dean D. Erdman</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Thornburg, Natalie J" sort="Thornburg, Natalie J" uniqKey="Thornburg N" first="Natalie J" last="Thornburg">Natalie J. Thornburg</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I" last="Gerber">Susan I. Gerber</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30294616</idno><idno type="pmid">30294616</idno><idno type="doi">10.1093/ofid/ofy095</idno><idno type="wicri:Area/PubMed/Corpus">000761</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000761</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multihospital Outbreak of a Middle East Respiratory Syndrome Coronavirus Deletion Variant, Jordan: A Molecular, Serologic, and Epidemiologic Investigation.</title><author><name sortKey="Payne, Daniel C" sort="Payne, Daniel C" uniqKey="Payne D" first="Daniel C" last="Payne">Daniel C. Payne</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Biggs, Holly M" sort="Biggs, Holly M" uniqKey="Biggs H" first="Holly M" last="Biggs">Holly M. Biggs</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Abdallat, Mohammad Mousa" sort="Al Abdallat, Mohammad Mousa" uniqKey="Al Abdallat M" first="Mohammad Mousa" last="Al-Abdallat">Mohammad Mousa Al-Abdallat</name><affiliation><nlm:affiliation>Communicable Diseases Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Alqasrawi, Sultan" sort="Alqasrawi, Sultan" uniqKey="Alqasrawi S" first="Sultan" last="Alqasrawi">Sultan Alqasrawi</name><affiliation><nlm:affiliation>Communicable Diseases Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Xiaoyan" sort="Lu, Xiaoyan" uniqKey="Lu X" first="Xiaoyan" last="Lu">Xiaoyan Lu</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Abedi, Glen R" sort="Abedi, Glen R" uniqKey="Abedi G" first="Glen R" last="Abedi">Glen R. Abedi</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Haddadin, Aktham" sort="Haddadin, Aktham" uniqKey="Haddadin A" first="Aktham" last="Haddadin">Aktham Haddadin</name><affiliation><nlm:affiliation>Laboratory Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Iblan, Ibrahim" sort="Iblan, Ibrahim" uniqKey="Iblan I" first="Ibrahim" last="Iblan">Ibrahim Iblan</name><affiliation><nlm:affiliation>Field Epidemiology Training Program, Jordan Ministry of Health, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Alsanouri, Tarek" sort="Alsanouri, Tarek" uniqKey="Alsanouri T" first="Tarek" last="Alsanouri">Tarek Alsanouri</name><affiliation><nlm:affiliation>Eastern Mediterranean Public Health Network, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Al Nsour, Mohannad" sort="Al Nsour, Mohannad" uniqKey="Al Nsour M" first="Mohannad" last="Al Nsour">Mohannad Al Nsour</name><affiliation><nlm:affiliation>Eastern Mediterranean Public Health Network, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Sheikh Ali, Sami" sort="Sheikh Ali, Sami" uniqKey="Sheikh Ali S" first="Sami" last="Sheikh Ali">Sami Sheikh Ali</name><affiliation><nlm:affiliation>Communicable Diseases Directorate, Amman, Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Rha, Brian" sort="Rha, Brian" uniqKey="Rha B" first="Brian" last="Rha">Brian Rha</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Trivedi, Suvang U" sort="Trivedi, Suvang U" uniqKey="Trivedi S" first="Suvang U" last="Trivedi">Suvang U. Trivedi</name><affiliation><nlm:affiliation>IHRC, Inc, contracting agency for the Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Rasheed, Mohammed Ata Ur" sort="Rasheed, Mohammed Ata Ur" uniqKey="Rasheed M" first="Mohammed Ata Ur" last="Rasheed">Mohammed Ata Ur Rasheed</name><affiliation><nlm:affiliation>IHRC, Inc, contracting agency for the Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M" last="Lamers">Mart M. Lamers</name><affiliation><nlm:affiliation>Viroscience Department, Erasmus University Medical Center, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><affiliation><nlm:affiliation>Viroscience Department, Erasmus University Medical Center, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Erdman, Dean D" sort="Erdman, Dean D" uniqKey="Erdman D" first="Dean D" last="Erdman">Dean D. Erdman</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Thornburg, Natalie J" sort="Thornburg, Natalie J" uniqKey="Thornburg N" first="Natalie J" last="Thornburg">Natalie J. Thornburg</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I" last="Gerber">Susan I. Gerber</name><affiliation><nlm:affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Open forum infectious diseases</title><idno type="ISSN">2328-8957</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Jordan in 2015 involved a variant virus that acquired distinctive deletions in the accessory open reading frames. We conducted a molecular and seroepidemiologic investigation to describe the deletion variant's transmission patterns and epidemiology.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30294616</PMID><DateRevised><Year>2019</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2328-8957</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>5</Issue><PubDate><Year>2018</Year><Month>May</Month></PubDate></JournalIssue><Title>Open forum infectious diseases</Title><ISOAbbreviation>Open Forum Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Multihospital Outbreak of a Middle East Respiratory Syndrome Coronavirus Deletion Variant, Jordan: A Molecular, Serologic, and Epidemiologic Investigation.</ArticleTitle><Pagination><MedlinePgn>ofy095</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ofid/ofy095</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">An outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Jordan in 2015 involved a variant virus that acquired distinctive deletions in the accessory open reading frames. We conducted a molecular and seroepidemiologic investigation to describe the deletion variant's transmission patterns and epidemiology.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">We reviewed epidemiologic and medical chart data and analyzed viral genome sequences from respiratory specimens of MERS-CoV cases. In early 2016, sera and standardized interviews were obtained from MERS-CoV cases and their contacts. Sera were evaluated by nucleocapsid and spike protein enzyme immunoassays and microneutralization.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Among 16 cases, 11 (69%) had health care exposure and 5 (31%) were relatives of a known case; 13 (81%) were symptomatic, and 7 (44%) died. Genome sequencing of MERS-CoV from 13 cases revealed 3 transmissible deletions associated with clinical illness during the outbreak. Deletion variant sequences were epidemiologically clustered and linked to a common transmission chain. Interviews and sera were collected from 2 surviving cases, 23 household contacts, and 278 health care contacts; 1 (50%) case, 2 (9%) household contacts, and 3 (1%) health care contacts tested seropositive.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">The MERS-CoV deletion variants retained human-to-human transmissibility and caused clinical illness in infected persons despite accumulated mutations. Serology suggested limited transmission beyond that detected during the initial outbreak investigation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Payne</LastName><ForeName>Daniel C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biggs</LastName><ForeName>Holly M</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Abdallat</LastName><ForeName>Mohammad Mousa</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Communicable Diseases Directorate, Amman, Jordan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alqasrawi</LastName><ForeName>Sultan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Communicable Diseases Directorate, Amman, Jordan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Xiaoyan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abedi</LastName><ForeName>Glen R</ForeName><Initials>GR</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haddadin</LastName><ForeName>Aktham</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory Directorate, Amman, Jordan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iblan</LastName><ForeName>Ibrahim</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Field Epidemiology Training Program, Jordan Ministry of Health, Amman, Jordan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alsanouri</LastName><ForeName>Tarek</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Eastern Mediterranean Public Health Network, Amman, Jordan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al Nsour</LastName><ForeName>Mohannad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Eastern Mediterranean Public Health Network, Amman, Jordan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sheikh Ali</LastName><ForeName>Sami</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Communicable Diseases Directorate, Amman, Jordan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rha</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trivedi</LastName><ForeName>Suvang U</ForeName><Initials>SU</Initials><AffiliationInfo><Affiliation>IHRC, Inc, contracting agency for the Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rasheed</LastName><ForeName>Mohammed Ata Ur</ForeName><Initials>MAU</Initials><AffiliationInfo><Affiliation>IHRC, Inc, contracting agency for the Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamin</LastName><ForeName>Azaibi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lamers</LastName><ForeName>Mart M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Viroscience Department, Erasmus University Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haagmans</LastName><ForeName>Bart L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Viroscience Department, Erasmus University Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erdman</LastName><ForeName>Dean D</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thornburg</LastName><ForeName>Natalie J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gerber</LastName><ForeName>Susan I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>04</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Open Forum Infect Dis</MedlineTA><NlmUniqueID>101637045</NlmUniqueID><ISSNLinking>2328-8957</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Jordan</Keyword><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">Middle East respiratory syndrome</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword><Keyword MajorTopicYN="N">emerging infectious disease</Keyword><Keyword MajorTopicYN="N">genome deletion</Keyword><Keyword MajorTopicYN="N">outbreak investigation</Keyword><Keyword MajorTopicYN="N">sero-epidemiology</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>03</Month><Day>30</Day></PubMedPubDate><PubMedPubDate 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