ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.
Identifieur interne : 000644 ( PubMed/Corpus ); précédent : 000643; suivant : 000645ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.
Auteurs : Janine Kemming ; Emma Reeves ; Katja Nitschke ; Vanessa Widmeier ; Florian Emmerich ; Tobias Hermle ; Emma Gostick ; Andreas Walker ; Jörg Timm ; David A. Price ; Maike Hofmann ; Robert Thimme ; Edward James ; Christoph Neumann-HaefelinSource :
- Journal of hepatology [ 1600-0641 ] ; 2019.
Abstract
Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms are linked with human leukocyte antigen (HLA) class I-associated autoinflammatory disorders, including ankylosing spondylitis and Behçet's disease. Disease-associated ERAP1 allotypes exhibit distinct functional properties, but it remains unclear how differential peptide trimming in vivo affects the repertoire of epitopes presented to CD8+ T cells. The aim of this study was to determine the impact of ERAP1 allotypes on the virus-specific CD8+ T cell epitope repertoire in an HLA-B*27:05+ individual with acute hepatitis C virus (HCV) infection.
DOI: 10.1016/j.jhep.2019.01.034
PubMed: 30769005
Links to Exploration step
pubmed:30769005Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ERAP1 allotypes shape the epitope repertoire of virus-specific CD8<sup>+</sup> T cell responses in acute hepatitis C virus infection.</title><author><name sortKey="Kemming, Janine" sort="Kemming, Janine" uniqKey="Kemming J" first="Janine" last="Kemming">Janine Kemming</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Reeves, Emma" sort="Reeves, Emma" uniqKey="Reeves E" first="Emma" last="Reeves">Emma Reeves</name><affiliation><nlm:affiliation>Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Nitschke, Katja" sort="Nitschke, Katja" uniqKey="Nitschke K" first="Katja" last="Nitschke">Katja Nitschke</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Widmeier, Vanessa" sort="Widmeier, Vanessa" uniqKey="Widmeier V" first="Vanessa" last="Widmeier">Vanessa Widmeier</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Emmerich, Florian" sort="Emmerich, Florian" uniqKey="Emmerich F" first="Florian" last="Emmerich">Florian Emmerich</name><affiliation><nlm:affiliation>Institute of Transfusion Medicine and Gene Therapy, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hermle, Tobias" sort="Hermle, Tobias" uniqKey="Hermle T" first="Tobias" last="Hermle">Tobias Hermle</name><affiliation><nlm:affiliation>Renal Division, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gostick, Emma" sort="Gostick, Emma" uniqKey="Gostick E" first="Emma" last="Gostick">Emma Gostick</name><affiliation><nlm:affiliation>Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Walker, Andreas" sort="Walker, Andreas" uniqKey="Walker A" first="Andreas" last="Walker">Andreas Walker</name><affiliation><nlm:affiliation>Institute for Virology, Heinrich Heine University, Düsseldorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Timm, Jorg" sort="Timm, Jorg" uniqKey="Timm J" first="Jörg" last="Timm">Jörg Timm</name><affiliation><nlm:affiliation>Institute for Virology, Heinrich Heine University, Düsseldorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Price, David A" sort="Price, David A" uniqKey="Price D" first="David A" last="Price">David A. Price</name><affiliation><nlm:affiliation>Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmann, Maike" sort="Hofmann, Maike" uniqKey="Hofmann M" first="Maike" last="Hofmann">Maike Hofmann</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Thimme, Robert" sort="Thimme, Robert" uniqKey="Thimme R" first="Robert" last="Thimme">Robert Thimme</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="James, Edward" sort="James, Edward" uniqKey="James E" first="Edward" last="James">Edward James</name><affiliation><nlm:affiliation>Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Neumann Haefelin, Christoph" sort="Neumann Haefelin, Christoph" uniqKey="Neumann Haefelin C" first="Christoph" last="Neumann-Haefelin">Christoph Neumann-Haefelin</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: christoph.neumann-haefelin@uniklinik-freiburg.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30769005</idno><idno type="pmid">30769005</idno><idno type="doi">10.1016/j.jhep.2019.01.034</idno><idno type="wicri:Area/PubMed/Corpus">000644</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000644</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ERAP1 allotypes shape the epitope repertoire of virus-specific CD8<sup>+</sup> T cell responses in acute hepatitis C virus infection.</title><author><name sortKey="Kemming, Janine" sort="Kemming, Janine" uniqKey="Kemming J" first="Janine" last="Kemming">Janine Kemming</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Reeves, Emma" sort="Reeves, Emma" uniqKey="Reeves E" first="Emma" last="Reeves">Emma Reeves</name><affiliation><nlm:affiliation>Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Nitschke, Katja" sort="Nitschke, Katja" uniqKey="Nitschke K" first="Katja" last="Nitschke">Katja Nitschke</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Widmeier, Vanessa" sort="Widmeier, Vanessa" uniqKey="Widmeier V" first="Vanessa" last="Widmeier">Vanessa Widmeier</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Emmerich, Florian" sort="Emmerich, Florian" uniqKey="Emmerich F" first="Florian" last="Emmerich">Florian Emmerich</name><affiliation><nlm:affiliation>Institute of Transfusion Medicine and Gene Therapy, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hermle, Tobias" sort="Hermle, Tobias" uniqKey="Hermle T" first="Tobias" last="Hermle">Tobias Hermle</name><affiliation><nlm:affiliation>Renal Division, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gostick, Emma" sort="Gostick, Emma" uniqKey="Gostick E" first="Emma" last="Gostick">Emma Gostick</name><affiliation><nlm:affiliation>Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Walker, Andreas" sort="Walker, Andreas" uniqKey="Walker A" first="Andreas" last="Walker">Andreas Walker</name><affiliation><nlm:affiliation>Institute for Virology, Heinrich Heine University, Düsseldorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Timm, Jorg" sort="Timm, Jorg" uniqKey="Timm J" first="Jörg" last="Timm">Jörg Timm</name><affiliation><nlm:affiliation>Institute for Virology, Heinrich Heine University, Düsseldorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Price, David A" sort="Price, David A" uniqKey="Price D" first="David A" last="Price">David A. Price</name><affiliation><nlm:affiliation>Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmann, Maike" sort="Hofmann, Maike" uniqKey="Hofmann M" first="Maike" last="Hofmann">Maike Hofmann</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Thimme, Robert" sort="Thimme, Robert" uniqKey="Thimme R" first="Robert" last="Thimme">Robert Thimme</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="James, Edward" sort="James, Edward" uniqKey="James E" first="Edward" last="James">Edward James</name><affiliation><nlm:affiliation>Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Neumann Haefelin, Christoph" sort="Neumann Haefelin, Christoph" uniqKey="Neumann Haefelin C" first="Christoph" last="Neumann-Haefelin">Christoph Neumann-Haefelin</name><affiliation><nlm:affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: christoph.neumann-haefelin@uniklinik-freiburg.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of hepatology</title><idno type="eISSN">1600-0641</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms are linked with human leukocyte antigen (HLA) class I-associated autoinflammatory disorders, including ankylosing spondylitis and Behçet's disease. Disease-associated ERAP1 allotypes exhibit distinct functional properties, but it remains unclear how differential peptide trimming in vivo affects the repertoire of epitopes presented to CD8<sup>+</sup> T cells. The aim of this study was to determine the impact of ERAP1 allotypes on the virus-specific CD8<sup>+</sup> T cell epitope repertoire in an HLA-B*27:05<sup>+</sup> individual with acute hepatitis C virus (HCV) infection.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">30769005</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0641</ISSN><JournalIssue CitedMedium="Internet"><Volume>70</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of hepatology</Title><ISOAbbreviation>J. Hepatol.</ISOAbbreviation></Journal><ArticleTitle>ERAP1 allotypes shape the epitope repertoire of virus-specific CD8<sup>+</sup> T cell responses in acute hepatitis C virus infection.</ArticleTitle><Pagination><MedlinePgn>1072-1081</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0168-8278(19)30111-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhep.2019.01.034</ELocationID><Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms are linked with human leukocyte antigen (HLA) class I-associated autoinflammatory disorders, including ankylosing spondylitis and Behçet's disease. Disease-associated ERAP1 allotypes exhibit distinct functional properties, but it remains unclear how differential peptide trimming in vivo affects the repertoire of epitopes presented to CD8<sup>+</sup> T cells. The aim of this study was to determine the impact of ERAP1 allotypes on the virus-specific CD8<sup>+</sup> T cell epitope repertoire in an HLA-B*27:05<sup>+</sup> individual with acute hepatitis C virus (HCV) infection.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We performed genetic and functional analyses of ERAP1 allotypes and characterized the HCV-specific CD8<sup>+</sup> T cell repertoire at the level of fine epitope specificity and HLA class I restriction, in a patient who had acquired an HCV genotype 1a infection through a needle-stick injury.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Two hypoactive allotypic variants of ERAP1 were identified in an individual with acute HCV infection. The associated repertoire of virus-derived epitopes recognized by CD8<sup>+</sup> T cells was uncommon in a couple of respects. Firstly, reactivity was directed away from classically immunodominant epitopes, preferentially targeting either novel or subdominant epitopes. Secondly, reactivity was biased towards longer epitopes (10-11-mers). Despite the patient exhibiting favorable prognostic indicators, these atypical immune responses failed to clear the virus and the patient developed persistent low-level infection with HCV.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">ERAP1 allotypes modify the virus-specific CD8<sup>+</sup> T cell epitope repertoire in vivo, leading to altered immunodominance patterns that may contribute to the failure of antiviral immunity after infection with HCV.</AbstractText><AbstractText Label="LAY SUMMARY" NlmCategory="UNASSIGNED">Endoplasmic reticulum aminopeptidase 1 (ERAP1) plays a key role in antigen presentation. Genetic variants of ERAP1 (leading to distinct allotypes) are linked with specific autoinflammatory disorders, such as ankylosing spondylitis and Behçet's disease. We found that ERAP1 allotypes modified the repertoire of virus-specific CD8<sup>+</sup> T cell epitopes in a patient with hepatitis C virus, leading to an altered pattern of immunodominance that may have contributed to the failure of antiviral immunity in this patient.</AbstractText><CopyrightInformation>Copyright © 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kemming</LastName><ForeName>Janine</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reeves</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nitschke</LastName><ForeName>Katja</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Widmeier</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emmerich</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute of Transfusion Medicine and Gene Therapy, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hermle</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Renal Division, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gostick</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Virology, Heinrich Heine University, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Timm</LastName><ForeName>Jörg</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Virology, Heinrich Heine University, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofmann</LastName><ForeName>Maike</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thimme</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>James</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neumann-Haefelin</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: christoph.neumann-haefelin@uniklinik-freiburg.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>02</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Hepatol</MedlineTA><NlmUniqueID>8503886</NlmUniqueID><ISSNLinking>0168-8278</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ERAP1</Keyword><Keyword MajorTopicYN="N">Epitope repertoire</Keyword><Keyword MajorTopicYN="N">HLA-B*27</Keyword><Keyword MajorTopicYN="N">Hepatitis C virus</Keyword><Keyword MajorTopicYN="N">T cells</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>06</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30769005</ArticleId><ArticleId IdType="pii">S0168-8278(19)30111-4</ArticleId><ArticleId IdType="doi">10.1016/j.jhep.2019.01.034</ArticleId><ArticleId IdType="pmc">PMC6527866</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Exp Med. 2001 Nov 19;194(10):1395-406</Citation><ArticleIdList><ArticleId IdType="pubmed">11714747</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2002 Aug;110(4):515-26</Citation><ArticleIdList><ArticleId IdType="pubmed">12189246</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15661-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12441397</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterology. 2003 Jul;125(1):80-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12851873</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2004 Jul;40(1):108-14</Citation><ArticleIdList><ArticleId IdType="pubmed">15239092</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterology. 2004 Sep;127(3):924-36</Citation><ArticleIdList><ArticleId IdType="pubmed">15362047</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2004 Dec 20;200(12):1593-604</Citation><ArticleIdList><ArticleId IdType="pubmed">15611288</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2005 Nov 21;202(10):1349-61</Citation><ArticleIdList><ArticleId IdType="pubmed">16287711</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2006 Mar;43(3):563-72</Citation><ArticleIdList><ArticleId IdType="pubmed">16496339</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2006 Oct;25(4):533-43</Citation><ArticleIdList><ArticleId IdType="pubmed">17046682</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(2):945-53</Citation><ArticleIdList><ArticleId IdType="pubmed">17079288</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2007 Jul;88(Pt 7):1986-91</Citation><ArticleIdList><ArticleId IdType="pubmed">17554032</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2007 Nov;39(11):1329-37</Citation><ArticleIdList><ArticleId IdType="pubmed">17952073</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Apr;82(7):3438-51</Citation><ArticleIdList><ArticleId IdType="pubmed">18216107</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2008 Jun;47(6):1824-36</Citation><ArticleIdList><ArticleId IdType="pubmed">18454507</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2009 Feb;119(2):376-86</Citation><ArticleIdList><ArticleId IdType="pubmed">19139562</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2009 Oct 8;461(7265):798-801</Citation><ArticleIdList><ArticleId IdType="pubmed">19759533</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 2010 Dec 1;19(23):4705-14</Citation><ArticleIdList><ArticleId IdType="pubmed">20843824</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2011 Jul 10;43(8):761-7</Citation><ArticleIdList><ArticleId IdType="pubmed">21743469</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2011 Oct;54(4):1157-66</Citation><ArticleIdList><ArticleId IdType="pubmed">22006856</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Proteomics. 2012 Nov;11(11):1416-29</Citation><ArticleIdList><ArticleId IdType="pubmed">22918227</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2013 Feb;45(2):202-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23291587</ArticleId></ArticleIdList></Reference><Reference><Citation>AIDS. 2013 Jul 17;27(11):1697-706</Citation><ArticleIdList><ArticleId IdType="pubmed">23435305</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2013 Jul 1;191(1):35-43</Citation><ArticleIdList><ArticleId IdType="pubmed">23733883</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Immunol. 2014 Jan;57(1):12-21</Citation><ArticleIdList><ArticleId IdType="pubmed">23916068</ArticleId></ArticleIdList></Reference><Reference><Citation>Autoimmunity. 2013 Dec;46(8):497-508</Citation><ArticleIdList><ArticleId IdType="pubmed">24028501</ArticleId></ArticleIdList></Reference><Reference><Citation>Arthritis Rheumatol. 2014 Feb;66(2):284-94</Citation><ArticleIdList><ArticleId IdType="pubmed">24504800</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17594-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25422414</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Res. 2014 Dec;60(2-3):257-69</Citation><ArticleIdList><ArticleId IdType="pubmed">25434650</ArticleId></ArticleIdList></Reference><Reference><Citation>Arthritis Rheumatol. 2015 Mar;67(3):692-701</Citation><ArticleIdList><ArticleId IdType="pubmed">25469497</ArticleId></ArticleIdList></Reference><Reference><Citation>J Innate Immun. 2015;7(3):275-89</Citation><ArticleIdList><ArticleId IdType="pubmed">25591727</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2015 Mar 21;385(9973):1124-35</Citation><ArticleIdList><ArticleId IdType="pubmed">25687730</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Rheumatol. 2015 Jul;27(4):349-56</Citation><ArticleIdList><ArticleId IdType="pubmed">26002026</ArticleId></ArticleIdList></Reference><Reference><Citation>Dig Dis. 2016;34(4):396-409</Citation><ArticleIdList><ArticleId IdType="pubmed">27170395</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2016 Aug;16(8):509-23</Citation><ArticleIdList><ArticleId IdType="pubmed">27374637</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Immunol. 2016 Sep;77:193-204</Citation><ArticleIdList><ArticleId IdType="pubmed">27522479</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2017 Jun 9;292(23):9680-9689</Citation><ArticleIdList><ArticleId IdType="pubmed">28446606</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2017 Dec;190(3):281-290</Citation><ArticleIdList><ArticleId IdType="pubmed">28759104</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Immunol. 2017 Nov;78(11-12):731-738</Citation><ArticleIdList><ArticleId IdType="pubmed">29037997</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 1995 Nov;96(5):2311-21</Citation><ArticleIdList><ArticleId IdType="pubmed">7593618</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000644 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000644 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:30769005
|texte= ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:30769005" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |