Remote Laboratory Management: Respiratory Virus Diagnostics.
Identifieur interne : 000560 ( PubMed/Corpus ); précédent : 000559; suivant : 000561Remote Laboratory Management: Respiratory Virus Diagnostics.
Auteurs : Elena V. Petrova ; Vasanthi Avadhanula ; Sarah Michel ; Karen E. Gincoo ; Pedro A. Piedra ; Sharmila AnandasabapathySource :
- Journal of visualized experiments : JoVE [ 1940-087X ] ; 2019.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Influenza, Human.
- genetics : Orthomyxoviridae.
- Humans, Laboratories, Real-Time Polymerase Chain Reaction.
Abstract
An uptick in recent pandemics (Ebola, Zika, MERS, influenza, etc.) underlines the need for a more 'nimble,' coordinated response that addresses a multitude of issues ranging from transportation, access, facilities, equipment, and communication to provider training. To address this need, we have developed an innovative, scalable, logistics-enhanced, mobile, laboratory facility for emergencies and epidemics in resource-constrained global settings. Utilizing a background in clinical operations as an academic medical center, we designed a rapidly-deployable, modular BSL-2 and BSL-3 facility with user-friendly software for tracking and management of drugs and supplies in remote regions during epidemics and outbreaks. Here, we present our intermodal, mobile, expandable shipping-container laboratory units. The design of the laboratory facilitates off-grid usage by minimizing power consumption and allowing alternate water sources. The unit's information communication technology (ICT) platform provides (i) user-friendly tablet-based documentation, (ii) enhanced tracking of patients and supplies, and (iii) integrated communication onsite with built-in telehealth capabilities. To ensure quality in remote environments, we have developed a checklist for a basic laboratory workflow and a protocol for respiratory viral diagnosis using reverse-transcription polymerase chain reaction (RT-PCR). As described, this innovative and comprehensive approach allows for the provision of laboratory capability in resource-limited global environments.
DOI: 10.3791/59188
PubMed: 31009009
Links to Exploration step
pubmed:31009009Le document en format XML
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<author><name sortKey="Michel, Sarah" sort="Michel, Sarah" uniqKey="Michel S" first="Sarah" last="Michel">Sarah Michel</name>
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<author><name sortKey="Anandasabapathy, Sharmila" sort="Anandasabapathy, Sharmila" uniqKey="Anandasabapathy S" first="Sharmila" last="Anandasabapathy">Sharmila Anandasabapathy</name>
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<front><div type="abstract" xml:lang="en">An uptick in recent pandemics (Ebola, Zika, MERS, influenza, etc.) underlines the need for a more 'nimble,' coordinated response that addresses a multitude of issues ranging from transportation, access, facilities, equipment, and communication to provider training. To address this need, we have developed an innovative, scalable, logistics-enhanced, mobile, laboratory facility for emergencies and epidemics in resource-constrained global settings. Utilizing a background in clinical operations as an academic medical center, we designed a rapidly-deployable, modular BSL-2 and BSL-3 facility with user-friendly software for tracking and management of drugs and supplies in remote regions during epidemics and outbreaks. Here, we present our intermodal, mobile, expandable shipping-container laboratory units. The design of the laboratory facilitates off-grid usage by minimizing power consumption and allowing alternate water sources. The unit's information communication technology (ICT) platform provides (i) user-friendly tablet-based documentation, (ii) enhanced tracking of patients and supplies, and (iii) integrated communication onsite with built-in telehealth capabilities. To ensure quality in remote environments, we have developed a checklist for a basic laboratory workflow and a protocol for respiratory viral diagnosis using reverse-transcription polymerase chain reaction (RT-PCR). As described, this innovative and comprehensive approach allows for the provision of laboratory capability in resource-limited global environments.</div>
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