Immunogenicity of Different Forms of Middle East Respiratory Syndrome S Glycoprotein.
Identifieur interne : 000555 ( PubMed/Corpus ); précédent : 000554; suivant : 000556Immunogenicity of Different Forms of Middle East Respiratory Syndrome S Glycoprotein.
Auteurs : T A Ozharovskaia ; O V Zubkova ; I V Dolzhikova ; A S Gromova ; D M Grousova ; A I Tukhvatulin ; O. Popova ; D V Shcheblyakov ; D N Scherbinin ; A S Dzharullaeva ; A S Erokhova ; M M Shmarov ; S Y Loginova ; S V Borisevich ; B S Naroditsky ; D Y Logunov ; A L GintsburgSource :
- Acta naturae [ 2075-8251 ]
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in 2012 during the first Middle East respiratory syndrome (MERS) outbreaks. MERS-CoV causes an acute lower-respiratory infection in humans, with a fatality rate of ~35.5%. Currently, there are no registered vaccines or means of therapeutic protection against MERS in the world. The MERS-CoV S glycoprotein plays the most important role in the viral life cycle (virus internalization). The S protein is an immunodominant antigen and the main target for neutralizing antibodies. In the present study, the immunogenicities of five different forms of the MERS-CoV S glycoprotein were compared: the full-length S glycoprotein, the full-length S glycoprotein with the transmembrane domain of the G glycoprotein of VSV (S-G), the receptor-binding domain (RBD) of the S glycoprotein, the membrane-fused RBD (the RBD fused with the transmembrane domain of the VSV G glycoprotein (RBD-G)), and the RBD fused with Fc of human IgG1 (RBD-Fc). Recombinant vectors based on human adenoviruses type 5 (rAd5) were used as delivery vehicles. Vaccination with all of the developed rAd5 vectors elicited a balanced Th1/Th2 response in mice. The most robust humoral immune response was induced after the animal had been vaccinated with the membrane-fused RBD (rAd5-RBD-G). Only immunization with membrane forms of the glycoprotein (rAd5-S, rAd5-S-G, and rAd5-RBD-G) elicited neutralizing antibodies among all vaccinated animals. The most significant cellular immune response was induced after vaccination of the animals with the full-length S (rAd5-S). These investigations suggest that the full-length S and the membrane form of the RBD (RBD-G) are the most promising vaccine candidates among all the studied forms of S glycoprotein.
PubMed: 31024747
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<author><name sortKey="Shcheblyakov, D V" sort="Shcheblyakov, D V" uniqKey="Shcheblyakov D" first="D V" last="Shcheblyakov">D V Shcheblyakov</name>
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<author><name sortKey="Borisevich, S V" sort="Borisevich, S V" uniqKey="Borisevich S" first="S V" last="Borisevich">S V Borisevich</name>
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<author><name sortKey="Logunov, D Y" sort="Logunov, D Y" uniqKey="Logunov D" first="D Y" last="Logunov">D Y Logunov</name>
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<front><div type="abstract" xml:lang="en">The Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in 2012 during the first Middle East respiratory syndrome (MERS) outbreaks. MERS-CoV causes an acute lower-respiratory infection in humans, with a fatality rate of ~35.5%. Currently, there are no registered vaccines or means of therapeutic protection against MERS in the world. The MERS-CoV S glycoprotein plays the most important role in the viral life cycle (virus internalization). The S protein is an immunodominant antigen and the main target for neutralizing antibodies. In the present study, the immunogenicities of five different forms of the MERS-CoV S glycoprotein were compared: the full-length S glycoprotein, the full-length S glycoprotein with the transmembrane domain of the G glycoprotein of VSV (S-G), the receptor-binding domain (RBD) of the S glycoprotein, the membrane-fused RBD (the RBD fused with the transmembrane domain of the VSV G glycoprotein (RBD-G)), and the RBD fused with Fc of human IgG1 (RBD-Fc). Recombinant vectors based on human adenoviruses type 5 (rAd5) were used as delivery vehicles. Vaccination with all of the developed rAd5 vectors elicited a balanced Th1/Th2 response in mice. The most robust humoral immune response was induced after the animal had been vaccinated with the membrane-fused RBD (rAd5-RBD-G). Only immunization with membrane forms of the glycoprotein (rAd5-S, rAd5-S-G, and rAd5-RBD-G) elicited neutralizing antibodies among all vaccinated animals. The most significant cellular immune response was induced after vaccination of the animals with the full-length S (rAd5-S). These investigations suggest that the full-length S and the membrane form of the RBD (RBD-G) are the most promising vaccine candidates among all the studied forms of S glycoprotein.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31024747</PMID>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">2075-8251</ISSN>
<JournalIssue CitedMedium="Print"><Volume>11</Volume>
<Issue>1</Issue>
<PubDate><MedlineDate>2019 Jan-Mar</MedlineDate>
</PubDate>
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<Title>Acta naturae</Title>
<ISOAbbreviation>Acta Naturae</ISOAbbreviation>
</Journal>
<ArticleTitle>Immunogenicity of Different Forms of Middle East Respiratory Syndrome S Glycoprotein.</ArticleTitle>
<Pagination><MedlinePgn>38-47</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in 2012 during the first Middle East respiratory syndrome (MERS) outbreaks. MERS-CoV causes an acute lower-respiratory infection in humans, with a fatality rate of ~35.5%. Currently, there are no registered vaccines or means of therapeutic protection against MERS in the world. The MERS-CoV S glycoprotein plays the most important role in the viral life cycle (virus internalization). The S protein is an immunodominant antigen and the main target for neutralizing antibodies. In the present study, the immunogenicities of five different forms of the MERS-CoV S glycoprotein were compared: the full-length S glycoprotein, the full-length S glycoprotein with the transmembrane domain of the G glycoprotein of VSV (S-G), the receptor-binding domain (RBD) of the S glycoprotein, the membrane-fused RBD (the RBD fused with the transmembrane domain of the VSV G glycoprotein (RBD-G)), and the RBD fused with Fc of human IgG1 (RBD-Fc). Recombinant vectors based on human adenoviruses type 5 (rAd5) were used as delivery vehicles. Vaccination with all of the developed rAd5 vectors elicited a balanced Th1/Th2 response in mice. The most robust humoral immune response was induced after the animal had been vaccinated with the membrane-fused RBD (rAd5-RBD-G). Only immunization with membrane forms of the glycoprotein (rAd5-S, rAd5-S-G, and rAd5-RBD-G) elicited neutralizing antibodies among all vaccinated animals. The most significant cellular immune response was induced after vaccination of the animals with the full-length S (rAd5-S). These investigations suggest that the full-length S and the membrane form of the RBD (RBD-G) are the most promising vaccine candidates among all the studied forms of S glycoprotein.</AbstractText>
</Abstract>
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<ForeName>T A</ForeName>
<Initials>TA</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zubkova</LastName>
<ForeName>O V</ForeName>
<Initials>OV</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Dolzhikova</LastName>
<ForeName>I V</ForeName>
<Initials>IV</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Gromova</LastName>
<ForeName>A S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grousova</LastName>
<ForeName>D M</ForeName>
<Initials>DM</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Tukhvatulin</LastName>
<ForeName>A I</ForeName>
<Initials>AI</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Popova</LastName>
<ForeName>O</ForeName>
<Initials>O</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Shcheblyakov</LastName>
<ForeName>D V</ForeName>
<Initials>DV</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Scherbinin</LastName>
<ForeName>D N</ForeName>
<Initials>DN</Initials>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dzharullaeva</LastName>
<ForeName>A S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Erokhova</LastName>
<ForeName>A S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shmarov</LastName>
<ForeName>M M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loginova</LastName>
<ForeName>S Y</ForeName>
<Initials>SY</Initials>
<AffiliationInfo><Affiliation>«48 Central Research Institute», Ministry of Defense of Russian Federation, Oktyabrskaya Str. 11, 141306 , Sergiev Posad, Russia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borisevich</LastName>
<ForeName>S V</ForeName>
<Initials>SV</Initials>
<AffiliationInfo><Affiliation>«48 Central Research Institute», Ministry of Defense of Russian Federation, Oktyabrskaya Str. 11, 141306 , Sergiev Posad, Russia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Naroditsky</LastName>
<ForeName>B S</ForeName>
<Initials>BS</Initials>
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<Author ValidYN="Y"><LastName>Logunov</LastName>
<ForeName>D Y</ForeName>
<Initials>DY</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Gintsburg</LastName>
<ForeName>A L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of Russian Federation, Gamaleya Str. 18, 123098, Moscow, Russia.</Affiliation>
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<MedlineTA>Acta Naturae</MedlineTA>
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<Keyword MajorTopicYN="N">MERS-CoV</Keyword>
<Keyword MajorTopicYN="N">Middle East respiratory syndrome</Keyword>
<Keyword MajorTopicYN="N">adenoviral vector</Keyword>
<Keyword MajorTopicYN="N">glycoprotein</Keyword>
<Keyword MajorTopicYN="N">immunity</Keyword>
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<Day>27</Day>
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