Gel electrophoresis in combination with laser ablation-inductively coupled plasma mass spectrometry to quantify the interaction of cisplatin with human serum albumin.
Identifieur interne : 000540 ( PubMed/Corpus ); précédent : 000539; suivant : 000541Gel electrophoresis in combination with laser ablation-inductively coupled plasma mass spectrometry to quantify the interaction of cisplatin with human serum albumin.
Auteurs : Matthew P. Sullivan ; Stuart J. Morrow ; David C. Goldstone ; Christian G. HartingerSource :
- Electrophoresis [ 1522-2683 ] ; 2019.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antineoplastic Agents, Cisplatin.
- chemical , chemistry : Antineoplastic Agents, Cisplatin, Serum Albumin, Human.
- chemical , metabolism : Antineoplastic Agents, Cisplatin, Serum Albumin, Human.
- methods : Mass Spectrometry.
- Humans, Lasers.
Abstract
Cisplatin and its second and third generation analogues are widely used in the treatment of cancer. To study their reactions with proteins, we present a method based on SDS-PAGE separation and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) for platinum detection in the reaction between human serum albumin (HSA) and cisplatin. We developed matrix-matched standards of HSA/cisplatin mixtures and used them to quantify the amount of adducts formed at different HSA:cisplatin ratios. We noted that cisplatin incubation with HSA resulted in the formation of higher order HSA n-mers, depending on the amount of cisplatin added. This caused a depletion of the HSA dimer bands, while the majority of HSA was present as the monomer. Inducing the formation of such higher molecular weight species may have an impact on the mode of action of metallodrugs.
DOI: 10.1002/elps.201900070
PubMed: 31087392
Links to Exploration step
pubmed:31087392Le document en format XML
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Goldstone</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Hartinger, Christian G" sort="Hartinger, Christian G" uniqKey="Hartinger C" first="Christian G" last="Hartinger">Christian G. Hartinger</name><affiliation><nlm:affiliation>School of Chemical Sciences, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31087392</idno><idno type="pmid">31087392</idno><idno type="doi">10.1002/elps.201900070</idno><idno type="wicri:Area/PubMed/Corpus">000540</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000540</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gel electrophoresis in combination with laser ablation-inductively coupled plasma mass spectrometry to quantify the interaction of cisplatin with human serum albumin.</title><author><name sortKey="Sullivan, Matthew P" sort="Sullivan, Matthew P" uniqKey="Sullivan M" first="Matthew P" last="Sullivan">Matthew P. Sullivan</name><affiliation><nlm:affiliation>School of Chemical Sciences, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Morrow, Stuart J" sort="Morrow, Stuart J" uniqKey="Morrow S" first="Stuart J" last="Morrow">Stuart J. Morrow</name><affiliation><nlm:affiliation>School of Chemical Sciences, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Goldstone, David C" sort="Goldstone, David C" uniqKey="Goldstone D" first="David C" last="Goldstone">David C. Goldstone</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Hartinger, Christian G" sort="Hartinger, Christian G" uniqKey="Hartinger C" first="Christian G" last="Hartinger">Christian G. Hartinger</name><affiliation><nlm:affiliation>School of Chemical Sciences, University of Auckland, Auckland, New Zealand.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Electrophoresis</title><idno type="eISSN">1522-2683</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (analysis)</term><term>Antineoplastic Agents (chemistry)</term><term>Antineoplastic Agents (metabolism)</term><term>Cisplatin (analysis)</term><term>Cisplatin (chemistry)</term><term>Cisplatin (metabolism)</term><term>Humans</term><term>Lasers</term><term>Mass Spectrometry (methods)</term><term>Serum Albumin, Human (chemistry)</term><term>Serum Albumin, Human (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antineoplastic Agents</term><term>Cisplatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antineoplastic Agents</term><term>Cisplatin</term><term>Serum Albumin, Human</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antineoplastic Agents</term><term>Cisplatin</term><term>Serum Albumin, Human</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mass Spectrometry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Lasers</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cisplatin and its second and third generation analogues are widely used in the treatment of cancer. To study their reactions with proteins, we present a method based on SDS-PAGE separation and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) for platinum detection in the reaction between human serum albumin (HSA) and cisplatin. We developed matrix-matched standards of HSA/cisplatin mixtures and used them to quantify the amount of adducts formed at different HSA:cisplatin ratios. We noted that cisplatin incubation with HSA resulted in the formation of higher order HSA n-mers, depending on the amount of cisplatin added. This caused a depletion of the HSA dimer bands, while the majority of HSA was present as the monomer. Inducing the formation of such higher molecular weight species may have an impact on the mode of action of metallodrugs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31087392</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>04</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-2683</ISSN><JournalIssue CitedMedium="Internet"><Volume>40</Volume><Issue>18-19</Issue><PubDate><Year>2019</Year><Month>09</Month></PubDate></JournalIssue><Title>Electrophoresis</Title><ISOAbbreviation>Electrophoresis</ISOAbbreviation></Journal><ArticleTitle>Gel electrophoresis in combination with laser ablation-inductively coupled plasma mass spectrometry to quantify the interaction of cisplatin with human serum albumin.</ArticleTitle><Pagination><MedlinePgn>2329-2335</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/elps.201900070</ELocationID><Abstract><AbstractText>Cisplatin and its second and third generation analogues are widely used in the treatment of cancer. To study their reactions with proteins, we present a method based on SDS-PAGE separation and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) for platinum detection in the reaction between human serum albumin (HSA) and cisplatin. We developed matrix-matched standards of HSA/cisplatin mixtures and used them to quantify the amount of adducts formed at different HSA:cisplatin ratios. We noted that cisplatin incubation with HSA resulted in the formation of higher order HSA n-mers, depending on the amount of cisplatin added. This caused a depletion of the HSA dimer bands, while the majority of HSA was present as the monomer. Inducing the formation of such higher molecular weight species may have an impact on the mode of action of metallodrugs.</AbstractText><CopyrightInformation>© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sullivan</LastName><ForeName>Matthew P</ForeName><Initials>MP</Initials><Identifier Source="ORCID">0000-0003-4181-4249</Identifier><AffiliationInfo><Affiliation>School of Chemical Sciences, University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Biological Sciences, University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrow</LastName><ForeName>Stuart J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>School of Chemical Sciences, University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldstone</LastName><ForeName>David C</ForeName><Initials>DC</Initials><Identifier Source="ORCID">0000-0003-0069-9408</Identifier><AffiliationInfo><Affiliation>School of Biological Sciences, University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartinger</LastName><ForeName>Christian G</ForeName><Initials>CG</Initials><Identifier Source="ORCID">0000-0001-9806-0893</Identifier><AffiliationInfo><Affiliation>School of Chemical Sciences, University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>University of Auckland</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>05</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Electrophoresis</MedlineTA><NlmUniqueID>8204476</NlmUniqueID><ISSNLinking>0173-0835</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q20Q21Q62J</RegistryNumber><NameOfSubstance UI="D002945">Cisplatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>ZIF514RVZR</RegistryNumber><NameOfSubstance UI="D000075462">Serum Albumin, Human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002945" MajorTopicYN="N">Cisplatin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007834" MajorTopicYN="N">Lasers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000075462" MajorTopicYN="N">Serum Albumin, Human</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Anticancer agents</Keyword><Keyword MajorTopicYN="Y">Gel electrophoresis</Keyword><Keyword MajorTopicYN="Y">Human Serum albumin</Keyword><Keyword MajorTopicYN="Y">Laser ablation-inductively coupled plasma-mass spectrometry</Keyword><Keyword MajorTopicYN="Y">Metal complexes</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>05</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>5</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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