Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity.
Identifieur interne : 000440 ( PubMed/Corpus ); précédent : 000439; suivant : 000441Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity.
Auteurs : Bryan A. Johnson ; Adam Hage ; Birte Kalveram ; Megan Mears ; Jessica A. Plante ; Sergio E. Rodriguez ; Zhixia Ding ; Xuemei Luo ; Dennis Bente ; Shelton S. Bradrick ; Alexander N. Freiberg ; Vsevolod Popov ; Ricardo Rajsbaum ; Shannan Rossi ; William K. Russell ; Vineet D. MenacherySource :
- Journal of virology [ 1098-5514 ] ; 2019.
Abstract
Enteric viruses exploit bacterial components, including lipopolysaccharides (LPS) and peptidoglycan (PG), to facilitate infection in humans. Because of their origin in the bat enteric system, we wondered if severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle East respiratory syndrome CoV (MERS-CoV) also use bacterial components to modulate infectivity. To test this question, we incubated CoVs with LPS and PG and evaluated infectivity, finding no change following LPS treatment. However, PG from Bacillus subtilis reduced infection >10,000-fold, while PG from other bacterial species failed to recapitulate this. Treatment with an alcohol solvent transferred inhibitory activity to the wash, and mass spectrometry revealed surfactin, a cyclic lipopeptide antibiotic, as the inhibitory compound. This antibiotic had robust dose- and temperature-dependent inhibition of CoV infectivity. Mechanistic studies indicated that surfactin disrupts CoV virion integrity, and surfactin treatment of the virus inoculum ablated infection in vivo Finally, similar cyclic lipopeptides had no effect on CoV infectivity, and the inhibitory effect of surfactin extended broadly to enveloped viruses, including influenza, Ebola, Zika, Nipah, chikungunya, Una, Mayaro, Dugbe, and Crimean-Congo hemorrhagic fever viruses. Overall, our results indicate that peptidoglycan-associated surfactin has broad viricidal activity and suggest that bacteria by-products may negatively modulate virus infection.IMPORTANCE In this article, we consider a role for bacteria in shaping coronavirus infection. Taking cues from studies of enteric viruses, we initially investigated how bacterial surface components might improve CoV infection. Instead, we found that peptidoglycan-associated surfactin is a potent viricidal compound that disrupts virion integrity with broad activity against enveloped viruses. Our results indicate that interactions with commensal bacterial may improve or disrupt viral infections, highlighting the importance of understanding these microbial interactions and their implications for viral pathogenesis and treatment.
DOI: 10.1128/JVI.01282-19
PubMed: 31462558
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity.</title><author><name sortKey="Johnson, Bryan A" sort="Johnson, Bryan A" uniqKey="Johnson B" first="Bryan A" last="Johnson">Bryan A. Johnson</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hage, Adam" sort="Hage, Adam" uniqKey="Hage A" first="Adam" last="Hage">Adam Hage</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kalveram, Birte" sort="Kalveram, Birte" uniqKey="Kalveram B" first="Birte" last="Kalveram">Birte Kalveram</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mears, Megan" sort="Mears, Megan" uniqKey="Mears M" first="Megan" last="Mears">Megan Mears</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Plante, Jessica A" sort="Plante, Jessica A" uniqKey="Plante J" first="Jessica A" last="Plante">Jessica A. Plante</name><affiliation><nlm:affiliation>World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Sergio E" sort="Rodriguez, Sergio E" uniqKey="Rodriguez S" first="Sergio E" last="Rodriguez">Sergio E. Rodriguez</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ding, Zhixia" sort="Ding, Zhixia" uniqKey="Ding Z" first="Zhixia" last="Ding">Zhixia Ding</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Xuemei" sort="Luo, Xuemei" uniqKey="Luo X" first="Xuemei" last="Luo">Xuemei Luo</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bente, Dennis" sort="Bente, Dennis" uniqKey="Bente D" first="Dennis" last="Bente">Dennis Bente</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bradrick, Shelton S" sort="Bradrick, Shelton S" uniqKey="Bradrick S" first="Shelton S" last="Bradrick">Shelton S. Bradrick</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Freiberg, Alexander N" sort="Freiberg, Alexander N" uniqKey="Freiberg A" first="Alexander N" last="Freiberg">Alexander N. Freiberg</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Popov, Vsevolod" sort="Popov, Vsevolod" uniqKey="Popov V" first="Vsevolod" last="Popov">Vsevolod Popov</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rajsbaum, Ricardo" sort="Rajsbaum, Ricardo" uniqKey="Rajsbaum R" first="Ricardo" last="Rajsbaum">Ricardo Rajsbaum</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rossi, Shannan" sort="Rossi, Shannan" uniqKey="Rossi S" first="Shannan" last="Rossi">Shannan Rossi</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Russell, William K" sort="Russell, William K" uniqKey="Russell W" first="William K" last="Russell">William K. Russell</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Vimenach@utmb.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31462558</idno><idno type="pmid">31462558</idno><idno type="doi">10.1128/JVI.01282-19</idno><idno type="wicri:Area/PubMed/Corpus">000440</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000440</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity.</title><author><name sortKey="Johnson, Bryan A" sort="Johnson, Bryan A" uniqKey="Johnson B" first="Bryan A" last="Johnson">Bryan A. Johnson</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hage, Adam" sort="Hage, Adam" uniqKey="Hage A" first="Adam" last="Hage">Adam Hage</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kalveram, Birte" sort="Kalveram, Birte" uniqKey="Kalveram B" first="Birte" last="Kalveram">Birte Kalveram</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mears, Megan" sort="Mears, Megan" uniqKey="Mears M" first="Megan" last="Mears">Megan Mears</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Plante, Jessica A" sort="Plante, Jessica A" uniqKey="Plante J" first="Jessica A" last="Plante">Jessica A. Plante</name><affiliation><nlm:affiliation>World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Sergio E" sort="Rodriguez, Sergio E" uniqKey="Rodriguez S" first="Sergio E" last="Rodriguez">Sergio E. Rodriguez</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ding, Zhixia" sort="Ding, Zhixia" uniqKey="Ding Z" first="Zhixia" last="Ding">Zhixia Ding</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Xuemei" sort="Luo, Xuemei" uniqKey="Luo X" first="Xuemei" last="Luo">Xuemei Luo</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bente, Dennis" sort="Bente, Dennis" uniqKey="Bente D" first="Dennis" last="Bente">Dennis Bente</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bradrick, Shelton S" sort="Bradrick, Shelton S" uniqKey="Bradrick S" first="Shelton S" last="Bradrick">Shelton S. Bradrick</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Freiberg, Alexander N" sort="Freiberg, Alexander N" uniqKey="Freiberg A" first="Alexander N" last="Freiberg">Alexander N. Freiberg</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Popov, Vsevolod" sort="Popov, Vsevolod" uniqKey="Popov V" first="Vsevolod" last="Popov">Vsevolod Popov</name><affiliation><nlm:affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rajsbaum, Ricardo" sort="Rajsbaum, Ricardo" uniqKey="Rajsbaum R" first="Ricardo" last="Rajsbaum">Ricardo Rajsbaum</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rossi, Shannan" sort="Rossi, Shannan" uniqKey="Rossi S" first="Shannan" last="Rossi">Shannan Rossi</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Russell, William K" sort="Russell, William K" uniqKey="Russell W" first="William K" last="Russell">William K. Russell</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Vimenach@utmb.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Enteric viruses exploit bacterial components, including lipopolysaccharides (LPS) and peptidoglycan (PG), to facilitate infection in humans. Because of their origin in the bat enteric system, we wondered if severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle East respiratory syndrome CoV (MERS-CoV) also use bacterial components to modulate infectivity. To test this question, we incubated CoVs with LPS and PG and evaluated infectivity, finding no change following LPS treatment. However, PG from <i>Bacillus subtilis</i> reduced infection >10,000-fold, while PG from other bacterial species failed to recapitulate this. Treatment with an alcohol solvent transferred inhibitory activity to the wash, and mass spectrometry revealed surfactin, a cyclic lipopeptide antibiotic, as the inhibitory compound. This antibiotic had robust dose- and temperature-dependent inhibition of CoV infectivity. Mechanistic studies indicated that surfactin disrupts CoV virion integrity, and surfactin treatment of the virus inoculum ablated infection <i>in vivo</i> Finally, similar cyclic lipopeptides had no effect on CoV infectivity, and the inhibitory effect of surfactin extended broadly to enveloped viruses, including influenza, Ebola, Zika, Nipah, chikungunya, Una, Mayaro, Dugbe, and Crimean-Congo hemorrhagic fever viruses. Overall, our results indicate that peptidoglycan-associated surfactin has broad viricidal activity and suggest that bacteria by-products may negatively modulate virus infection.<b>IMPORTANCE</b> In this article, we consider a role for bacteria in shaping coronavirus infection. Taking cues from studies of enteric viruses, we initially investigated how bacterial surface components might improve CoV infection. Instead, we found that peptidoglycan-associated surfactin is a potent viricidal compound that disrupts virion integrity with broad activity against enveloped viruses. Our results indicate that interactions with commensal bacterial may improve or disrupt viral infections, highlighting the importance of understanding these microbial interactions and their implications for viral pathogenesis and treatment.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">31462558</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>93</Volume><Issue>22</Issue><PubDate><Year>2019</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">e01282-19</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.01282-19</ELocationID><Abstract><AbstractText>Enteric viruses exploit bacterial components, including lipopolysaccharides (LPS) and peptidoglycan (PG), to facilitate infection in humans. Because of their origin in the bat enteric system, we wondered if severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle East respiratory syndrome CoV (MERS-CoV) also use bacterial components to modulate infectivity. To test this question, we incubated CoVs with LPS and PG and evaluated infectivity, finding no change following LPS treatment. However, PG from <i>Bacillus subtilis</i> reduced infection >10,000-fold, while PG from other bacterial species failed to recapitulate this. Treatment with an alcohol solvent transferred inhibitory activity to the wash, and mass spectrometry revealed surfactin, a cyclic lipopeptide antibiotic, as the inhibitory compound. This antibiotic had robust dose- and temperature-dependent inhibition of CoV infectivity. Mechanistic studies indicated that surfactin disrupts CoV virion integrity, and surfactin treatment of the virus inoculum ablated infection <i>in vivo</i> Finally, similar cyclic lipopeptides had no effect on CoV infectivity, and the inhibitory effect of surfactin extended broadly to enveloped viruses, including influenza, Ebola, Zika, Nipah, chikungunya, Una, Mayaro, Dugbe, and Crimean-Congo hemorrhagic fever viruses. Overall, our results indicate that peptidoglycan-associated surfactin has broad viricidal activity and suggest that bacteria by-products may negatively modulate virus infection.<b>IMPORTANCE</b> In this article, we consider a role for bacteria in shaping coronavirus infection. Taking cues from studies of enteric viruses, we initially investigated how bacterial surface components might improve CoV infection. Instead, we found that peptidoglycan-associated surfactin is a potent viricidal compound that disrupts virion integrity with broad activity against enveloped viruses. Our results indicate that interactions with commensal bacterial may improve or disrupt viral infections, highlighting the importance of understanding these microbial interactions and their implications for viral pathogenesis and treatment.</AbstractText><CopyrightInformation>Copyright © 2019 American Society for Microbiology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Bryan A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hage</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kalveram</LastName><ForeName>Birte</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mears</LastName><ForeName>Megan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plante</LastName><ForeName>Jessica A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez</LastName><ForeName>Sergio E</ForeName><Initials>SE</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4149-7458</Identifier><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>Zhixia</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UTMB Electron Microscopy Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Xuemei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UTMB Mass Spectrometry Facility, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bente</LastName><ForeName>Dennis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bradrick</LastName><ForeName>Shelton S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freiberg</LastName><ForeName>Alexander N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Popov</LastName><ForeName>Vsevolod</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UTMB Electron Microscopy Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajsbaum</LastName><ForeName>Ricardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rossi</LastName><ForeName>Shannan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>William K</ForeName><Initials>WK</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UTMB Mass Spectrometry Facility, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Menachery</LastName><ForeName>Vineet D</ForeName><Initials>VD</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Vimenach@utmb.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R21 AI132479</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI134907</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R00 AG049092</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AI126012</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R24 AI120942</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI100625</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">SARS-CoV</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword><Keyword MajorTopicYN="N">cyclic lipopeptide</Keyword><Keyword MajorTopicYN="N">microbiome</Keyword><Keyword MajorTopicYN="N">surfactin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>08</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2020</Year><Month>04</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31462558</ArticleId><ArticleId 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