Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.
Identifieur interne : 000437 ( PubMed/Corpus ); précédent : 000436; suivant : 000438Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.
Auteurs : Mary K. Yates ; Payel Chatterjee ; Mike Flint ; Yafet Arefeayne ; Damjan Makuc ; Janez Plavec ; Christina F. Spiropoulou ; Katherine L. Seley-RadtkeSource :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2019.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cell Line, Tumor, Ebolavirus (drug effects), Humans, Indicators and Reagents, Lipids (chemistry), Molecular Conformation, Proton Magnetic Resonance Spectroscopy, Pyrimidines (chemistry), Pyrimidines (pharmacology), Structure-Activity Relationship.
- MESH :
- chemical , chemistry : Antiviral Agents, Lipids, Pyrimidines.
- chemical , pharmacology : Antiviral Agents, Pyrimidines.
- drug effects : Ebolavirus.
- Cell Line, Tumor, Humans, Indicators and Reagents, Molecular Conformation, Proton Magnetic Resonance Spectroscopy, Structure-Activity Relationship.
Abstract
Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance. In that regard, flexible nucleoside analogues known as "fleximers" have garnered attention over the years due to their ability to survey different amino acids in enzyme binding sites, thus overcoming the potential development of antiviral resistance. Acyclic fleximers have previously demonstrated antiviral activity against numerous viruses including Middle East Respiratory Syndrome coronavirus (MERS-CoV), Ebola virus (EBOV), and, most recently, flaviviruses such as Dengue (DENV) and Yellow Fever Virus (YFV). Due to these interesting results, a Structure Activity Relationship (SAR) study was pursued in order to analyze the effect of the pyrimidine functional group and acyl protecting group on antiviral activity, cytotoxicity, and conformation. The results of those studies are presented herein.
DOI: 10.3390/molecules24173184
PubMed: 31480658
Links to Exploration step
pubmed:31480658Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.</title><author><name sortKey="Yates, Mary K" sort="Yates, Mary K" uniqKey="Yates M" first="Mary K" last="Yates">Mary K. Yates</name><affiliation><nlm:affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chatterjee, Payel" sort="Chatterjee, Payel" uniqKey="Chatterjee P" first="Payel" last="Chatterjee">Payel Chatterjee</name><affiliation><nlm:affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Flint, Mike" sort="Flint, Mike" uniqKey="Flint M" first="Mike" last="Flint">Mike Flint</name><affiliation><nlm:affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arefeayne, Yafet" sort="Arefeayne, Yafet" uniqKey="Arefeayne Y" first="Yafet" last="Arefeayne">Yafet Arefeayne</name><affiliation><nlm:affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Makuc, Damjan" sort="Makuc, Damjan" uniqKey="Makuc D" first="Damjan" last="Makuc">Damjan Makuc</name><affiliation><nlm:affiliation>Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Plavec, Janez" sort="Plavec, Janez" uniqKey="Plavec J" first="Janez" last="Plavec">Janez Plavec</name><affiliation><nlm:affiliation>Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Spiropoulou, Christina F" sort="Spiropoulou, Christina F" uniqKey="Spiropoulou C" first="Christina F" last="Spiropoulou">Christina F. Spiropoulou</name><affiliation><nlm:affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seley Radtke, Katherine L" sort="Seley Radtke, Katherine L" uniqKey="Seley Radtke K" first="Katherine L" last="Seley-Radtke">Katherine L. Seley-Radtke</name><affiliation><nlm:affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. kseley@umbc.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31480658</idno><idno type="pmid">31480658</idno><idno type="doi">10.3390/molecules24173184</idno><idno type="wicri:Area/PubMed/Corpus">000437</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000437</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.</title><author><name sortKey="Yates, Mary K" sort="Yates, Mary K" uniqKey="Yates M" first="Mary K" last="Yates">Mary K. Yates</name><affiliation><nlm:affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chatterjee, Payel" sort="Chatterjee, Payel" uniqKey="Chatterjee P" first="Payel" last="Chatterjee">Payel Chatterjee</name><affiliation><nlm:affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Flint, Mike" sort="Flint, Mike" uniqKey="Flint M" first="Mike" last="Flint">Mike Flint</name><affiliation><nlm:affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arefeayne, Yafet" sort="Arefeayne, Yafet" uniqKey="Arefeayne Y" first="Yafet" last="Arefeayne">Yafet Arefeayne</name><affiliation><nlm:affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Makuc, Damjan" sort="Makuc, Damjan" uniqKey="Makuc D" first="Damjan" last="Makuc">Damjan Makuc</name><affiliation><nlm:affiliation>Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Plavec, Janez" sort="Plavec, Janez" uniqKey="Plavec J" first="Janez" last="Plavec">Janez Plavec</name><affiliation><nlm:affiliation>Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Spiropoulou, Christina F" sort="Spiropoulou, Christina F" uniqKey="Spiropoulou C" first="Christina F" last="Spiropoulou">Christina F. Spiropoulou</name><affiliation><nlm:affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seley Radtke, Katherine L" sort="Seley Radtke, Katherine L" uniqKey="Seley Radtke K" first="Katherine L" last="Seley-Radtke">Katherine L. Seley-Radtke</name><affiliation><nlm:affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. kseley@umbc.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Cell Line, Tumor</term><term>Ebolavirus (drug effects)</term><term>Humans</term><term>Indicators and Reagents</term><term>Lipids (chemistry)</term><term>Molecular Conformation</term><term>Proton Magnetic Resonance Spectroscopy</term><term>Pyrimidines (chemistry)</term><term>Pyrimidines (pharmacology)</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Lipids</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Ebolavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Humans</term><term>Indicators and Reagents</term><term>Molecular Conformation</term><term>Proton Magnetic Resonance Spectroscopy</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance. In that regard, flexible nucleoside analogues known as "fleximers" have garnered attention over the years due to their ability to survey different amino acids in enzyme binding sites, thus overcoming the potential development of antiviral resistance. Acyclic fleximers have previously demonstrated antiviral activity against numerous viruses including Middle East Respiratory Syndrome coronavirus (MERS-CoV), Ebola virus (EBOV), and, most recently, flaviviruses such as Dengue (DENV) and Yellow Fever Virus (YFV). Due to these interesting results, a Structure Activity Relationship (SAR) study was pursued in order to analyze the effect of the pyrimidine functional group and acyl protecting group on antiviral activity, cytotoxicity, and conformation. The results of those studies are presented herein.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31480658</PMID><DateCompleted><Year>2020</Year><Month>01</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>17</Issue><PubDate><Year>2019</Year><Month>Sep</Month><Day>02</Day></PubDate></JournalIssue><Title>Molecules (Basel, Switzerland)</Title><ISOAbbreviation>Molecules</ISOAbbreviation></Journal><ArticleTitle>Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E3184</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules24173184</ELocationID><Abstract><AbstractText>Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance. In that regard, flexible nucleoside analogues known as "fleximers" have garnered attention over the years due to their ability to survey different amino acids in enzyme binding sites, thus overcoming the potential development of antiviral resistance. Acyclic fleximers have previously demonstrated antiviral activity against numerous viruses including Middle East Respiratory Syndrome coronavirus (MERS-CoV), Ebola virus (EBOV), and, most recently, flaviviruses such as Dengue (DENV) and Yellow Fever Virus (YFV). Due to these interesting results, a Structure Activity Relationship (SAR) study was pursued in order to analyze the effect of the pyrimidine functional group and acyl protecting group on antiviral activity, cytotoxicity, and conformation. The results of those studies are presented herein.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yates</LastName><ForeName>Mary K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatterjee</LastName><ForeName>Payel</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flint</LastName><ForeName>Mike</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-5373-787X</Identifier><AffiliationInfo><Affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arefeayne</LastName><ForeName>Yafet</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makuc</LastName><ForeName>Damjan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plavec</LastName><ForeName>Janez</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-1570-8602</Identifier><AffiliationInfo><Affiliation>Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spiropoulou</LastName><ForeName>Christina F</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seley-Radtke</LastName><ForeName>Katherine L</ForeName><Initials>KL</Initials><Identifier Source="ORCID">0000-0002-0154-3459</Identifier><AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. kseley@umbc.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>T32 GM066706</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI135252</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>09</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Molecules</MedlineTA><NlmUniqueID>100964009</NlmUniqueID><ISSNLinking>1420-3049</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007202">Indicators and Reagents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008055">Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011743">Pyrimidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>K8CXK5Q32L</RegistryNumber><NameOfSubstance UI="C030986">pyrimidine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029043" MajorTopicYN="N">Ebolavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007202" MajorTopicYN="N">Indicators and Reagents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008968" MajorTopicYN="N">Molecular Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066244" MajorTopicYN="N">Proton Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011743" MajorTopicYN="N">Pyrimidines</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SAR</Keyword><Keyword MajorTopicYN="N">filovirus</Keyword><Keyword MajorTopicYN="N">flavivirus</Keyword><Keyword MajorTopicYN="N">fleximers</Keyword><Keyword MajorTopicYN="N">nucleoside</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>08</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>08</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>08</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>9</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>9</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31480658</ArticleId><ArticleId IdType="pii">molecules24173184</ArticleId><ArticleId IdType="doi">10.3390/molecules24173184</ArticleId><ArticleId IdType="pmc">PMC6749450</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Org Lett. 2001 Oct 4;3(20):3209-10</Citation><ArticleIdList><ArticleId IdType="pubmed">11574032</ArticleId></ArticleIdList></Reference><Reference><Citation>J Org Chem. 2002 May 17;67(10):3365-73</Citation><ArticleIdList><ArticleId IdType="pubmed">12003548</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem Lett. 2003 Jun 16;13(12):1985-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12781179</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Chem Soc. 2004 Jul 7;126(26):8159-66</Citation><ArticleIdList><ArticleId IdType="pubmed">15225057</ArticleId></ArticleIdList></Reference><Reference><Citation>J Org Chem. 2005 Mar 4;70(5):1612-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15730279</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochemistry. 2005 Aug 16;44(32):10854-63</Citation><ArticleIdList><ArticleId IdType="pubmed">16086588</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochemistry. 2005 Oct 4;44(39):13172-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16185085</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2008 Dec;26(3):283-92</Citation><ArticleIdList><ArticleId IdType="pubmed">18808194</ArticleId></ArticleIdList></Reference><Reference><Citation>Tetrahedron. 2008 Nov 24;64(48):10791-10797</Citation><ArticleIdList><ArticleId IdType="pubmed">19946353</ArticleId></ArticleIdList></Reference><Reference><Citation>Org Lett. 2010 Oct 15;12(20):4466-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20845910</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem. 2012 May 1;20(9):3009-15</Citation><ArticleIdList><ArticleId IdType="pubmed">22464686</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleosides Nucleotides Nucleic Acids. 2013;32(3):137-54</Citation><ArticleIdList><ArticleId IdType="pubmed">23473101</ArticleId></ArticleIdList></Reference><Reference><Citation>Medchemcomm. 2011 Jul 1;2(7):null</Citation><ArticleIdList><ArticleId IdType="pubmed">24312722</ArticleId></ArticleIdList></Reference><Reference><Citation>Synthesis (Stuttg). 2012;44(22):3496-3504</Citation><ArticleIdList><ArticleId IdType="pubmed">24465059</ArticleId></ArticleIdList></Reference><Reference><Citation>Molecules. 2014 Dec 16;19(12):21200-14</Citation><ArticleIdList><ArticleId IdType="pubmed">25521119</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem Lett. 2015 Aug 1;25(15):2923-6</Citation><ArticleIdList><ArticleId IdType="pubmed">26048809</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2015 Oct;484:259-64</Citation><ArticleIdList><ArticleId IdType="pubmed">26122472</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem Lett. 2015 Oct 1;25(19):4274-6</Citation><ArticleIdList><ArticleId IdType="pubmed">26316465</ArticleId></ArticleIdList></Reference><Reference><Citation>ACS Infect Dis. 2015 Aug 14;1(8):357-66</Citation><ArticleIdList><ArticleId IdType="pubmed">27624884</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2016 Dec;136:9-18</Citation><ArticleIdList><ArticleId IdType="pubmed">27771389</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem Lett. 2017 Jun 15;27(12):2800-2802</Citation><ArticleIdList><ArticleId IdType="pubmed">28465098</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2018 Jun;154:66-86</Citation><ArticleIdList><ArticleId IdType="pubmed">29649496</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2019 Feb;162:5-21</Citation><ArticleIdList><ArticleId IdType="pubmed">30529089</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem. 2019 Jul 1;27(13):2883-2892</Citation><ArticleIdList><ArticleId IdType="pubmed">31126822</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000437 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000437 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:31480658
|texte= Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:31480658" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |