Structural insights into coronavirus entry.
Identifieur interne : 000420 ( PubMed/Corpus ); précédent : 000419; suivant : 000421Structural insights into coronavirus entry.
Auteurs : M Alejandra Tortorici ; David VeeslerSource :
- Advances in virus research [ 1557-8399 ] ; 2019.
English descriptors
- KwdEn :
- MESH :
- physiology : Coronavirus.
- ultrastructure : Coronavirus, Virion.
- Animals, Host-Pathogen Interactions, Humans, Virus Internalization.
Abstract
Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbreaks in humans with a fatality rate of 35%. SARS-CoV and MERS-CoV are zoonotic viruses that crossed the species barrier using bats/palm civets and dromedary camels, respectively. No specific treatments or vaccines have been approved against any of the six human coronaviruses, highlighting the need to investigate the principles governing viral entry and cross-species transmission as well as to prepare for zoonotic outbreaks which are likely to occur due to the large reservoir of CoVs found in mammals and birds. Here, we review our understanding of the infection mechanism used by coronaviruses derived from recent structural and biochemical studies.
DOI: 10.1016/bs.aivir.2019.08.002
PubMed: 31522710
Links to Exploration step
pubmed:31522710Le document en format XML
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Electronic address: dveesler@uw.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Advances in virus research</title><idno type="eISSN">1557-8399</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (physiology)</term><term>Coronavirus (ultrastructure)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Virion (ultrastructure)</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Coronavirus</term><term>Virion</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Virus Internalization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbreaks in humans with a fatality rate of 35%. SARS-CoV and MERS-CoV are zoonotic viruses that crossed the species barrier using bats/palm civets and dromedary camels, respectively. No specific treatments or vaccines have been approved against any of the six human coronaviruses, highlighting the need to investigate the principles governing viral entry and cross-species transmission as well as to prepare for zoonotic outbreaks which are likely to occur due to the large reservoir of CoVs found in mammals and birds. Here, we review our understanding of the infection mechanism used by coronaviruses derived from recent structural and biochemical studies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31522710</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8399</ISSN><JournalIssue CitedMedium="Internet"><Volume>105</Volume><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Advances in virus research</Title><ISOAbbreviation>Adv. Virus Res.</ISOAbbreviation></Journal><ArticleTitle>Structural insights into coronavirus entry.</ArticleTitle><Pagination><MedlinePgn>93-116</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0065-3527(19)30028-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/bs.aivir.2019.08.002</ELocationID><Abstract><AbstractText>Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbreaks in humans with a fatality rate of 35%. SARS-CoV and MERS-CoV are zoonotic viruses that crossed the species barrier using bats/palm civets and dromedary camels, respectively. No specific treatments or vaccines have been approved against any of the six human coronaviruses, highlighting the need to investigate the principles governing viral entry and cross-species transmission as well as to prepare for zoonotic outbreaks which are likely to occur due to the large reservoir of CoVs found in mammals and birds. Here, we review our understanding of the infection mechanism used by coronaviruses derived from recent structural and biochemical studies.</AbstractText><CopyrightInformation>© 2019 Elsevier Inc. 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