Hole Migration in Telomere-Based Oligonucleotide Anions and G-Quadruplexes.
Identifieur interne : 000397 ( PubMed/Corpus ); précédent : 000396; suivant : 000398Hole Migration in Telomere-Based Oligonucleotide Anions and G-Quadruplexes.
Auteurs : Wen Li ; Edita Mjekiqi ; Wessel Douma ; Xin Wang ; Oksana Kavatsyuk ; Ronnie Hoekstra ; Jean-Christophe Poully ; Thomas SchlathölterSource :
- Chemistry (Weinheim an der Bergstrasse, Germany) [ 1521-3765 ] ; 2019.
Abstract
Vacuum ultraviolet photoionization of a gas-phase oligonucleotide anion leads to the formation of a valence hole. This hole migrates towards an energetically favorable site where it can weaken bonds and ultimately lead to bond cleavage. We have studied Vacuum UV photoionization of deprotonated oligonucleotides containing the human telomere sequence dTTAGGG and G-quadruplex structures consisting of four dTGGGGT single strands, stabilized by NH4+ counter ions. The oligonucleotide and G-quadruplex anions were confined in a radiofrequency ion trap, interfaced with a synchrotron beamline and the photofragmentation was studied using time-of-flight mass spectrometry. Oligonucleotide 12-mers containing the 5'-TTAGGG sequence were found to predominantly break in the GGG region, whereas no selective bond cleavage region was observed for the reversed 5'-GGGATT sequence. For G-quadruplex structures, fragmentation was quenched and mostly non-dissociative single and double electron removal was observed.
DOI: 10.1002/chem.201904105
PubMed: 31614016
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Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xin" sort="Wang, Xin" uniqKey="Wang X" first="Xin" last="Wang">Xin Wang</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kavatsyuk, Oksana" sort="Kavatsyuk, Oksana" uniqKey="Kavatsyuk O" first="Oksana" last="Kavatsyuk">Oksana Kavatsyuk</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hoekstra, Ronnie" sort="Hoekstra, Ronnie" uniqKey="Hoekstra R" first="Ronnie" last="Hoekstra">Ronnie Hoekstra</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Poully, Jean Christophe" sort="Poully, Jean Christophe" uniqKey="Poully J" first="Jean-Christophe" last="Poully">Jean-Christophe Poully</name><affiliation><nlm:affiliation>CIMAP laboratory UMR 6252, Université de Caen Normandie/CEA/CNRS/ENSICAEN, Bd Becquerel, 14070, CAEN Cedex 5, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schlatholter, Thomas" sort="Schlatholter, Thomas" uniqKey="Schlatholter T" first="Thomas" last="Schlathölter">Thomas Schlathölter</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31614016</idno><idno type="pmid">31614016</idno><idno type="doi">10.1002/chem.201904105</idno><idno 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last="Douma">Wessel Douma</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xin" sort="Wang, Xin" uniqKey="Wang X" first="Xin" last="Wang">Xin Wang</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kavatsyuk, Oksana" sort="Kavatsyuk, Oksana" uniqKey="Kavatsyuk O" first="Oksana" last="Kavatsyuk">Oksana Kavatsyuk</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hoekstra, Ronnie" sort="Hoekstra, Ronnie" uniqKey="Hoekstra R" first="Ronnie" last="Hoekstra">Ronnie Hoekstra</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Poully, Jean Christophe" sort="Poully, Jean Christophe" uniqKey="Poully J" first="Jean-Christophe" last="Poully">Jean-Christophe Poully</name><affiliation><nlm:affiliation>CIMAP laboratory UMR 6252, Université de Caen Normandie/CEA/CNRS/ENSICAEN, Bd Becquerel, 14070, CAEN Cedex 5, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schlatholter, Thomas" sort="Schlatholter, Thomas" uniqKey="Schlatholter T" first="Thomas" last="Schlathölter">Thomas Schlathölter</name><affiliation><nlm:affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Chemistry (Weinheim an der Bergstrasse, Germany)</title><idno type="eISSN">1521-3765</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vacuum ultraviolet photoionization of a gas-phase oligonucleotide anion leads to the formation of a valence hole. This hole migrates towards an energetically favorable site where it can weaken bonds and ultimately lead to bond cleavage. We have studied Vacuum UV photoionization of deprotonated oligonucleotides containing the human telomere sequence dTTAGGG and G-quadruplex structures consisting of four dTGGGGT single strands, stabilized by NH<sub>4</sub><sup>+</sup> counter ions. The oligonucleotide and G-quadruplex anions were confined in a radiofrequency ion trap, interfaced with a synchrotron beamline and the photofragmentation was studied using time-of-flight mass spectrometry. Oligonucleotide 12-mers containing the 5'-TTAGGG sequence were found to predominantly break in the GGG region, whereas no selective bond cleavage region was observed for the reversed 5'-GGGATT sequence. For G-quadruplex structures, fragmentation was quenched and mostly non-dissociative single and double electron removal was observed.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">31614016</PMID><DateRevised><Year>2020</Year><Month>01</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-3765</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2019</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Chemistry (Weinheim an der Bergstrasse, Germany)</Title><ISOAbbreviation>Chemistry</ISOAbbreviation></Journal><ArticleTitle>Hole Migration in Telomere-Based Oligonucleotide Anions and G-Quadruplexes.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1002/chem.201904105</ELocationID><Abstract><AbstractText>Vacuum ultraviolet photoionization of a gas-phase oligonucleotide anion leads to the formation of a valence hole. This hole migrates towards an energetically favorable site where it can weaken bonds and ultimately lead to bond cleavage. We have studied Vacuum UV photoionization of deprotonated oligonucleotides containing the human telomere sequence dTTAGGG and G-quadruplex structures consisting of four dTGGGGT single strands, stabilized by NH<sub>4</sub><sup>+</sup> counter ions. The oligonucleotide and G-quadruplex anions were confined in a radiofrequency ion trap, interfaced with a synchrotron beamline and the photofragmentation was studied using time-of-flight mass spectrometry. Oligonucleotide 12-mers containing the 5'-TTAGGG sequence were found to predominantly break in the GGG region, whereas no selective bond cleavage region was observed for the reversed 5'-GGGATT sequence. For G-quadruplex structures, fragmentation was quenched and mostly non-dissociative single and double electron removal was observed.</AbstractText><CopyrightInformation>© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Wen</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mjekiqi</LastName><ForeName>Edita</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Douma</LastName><ForeName>Wessel</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kavatsyuk</LastName><ForeName>Oksana</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University College Groningen, University of Groningen, Hoendiepskade 23/24, 9718 BG, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoekstra</LastName><ForeName>Ronnie</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poully</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>CIMAP laboratory UMR 6252, Université de Caen Normandie/CEA/CNRS/ENSICAEN, Bd Becquerel, 14070, CAEN Cedex 5, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlathölter</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9923-172X</Identifier><AffiliationInfo><Affiliation>Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>a</GrantID><Agency>Chinese Government Scholarship</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal 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