Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.
Identifieur interne : 000392 ( PubMed/Corpus ); précédent : 000391; suivant : 000393Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.
Auteurs : Ji Hye Yoon ; Jun Young Lee ; Jihye Lee ; Young Sup Shin ; Sangeun Jeon ; Dong Eon Kim ; Jung Sun Min ; Jong Hwan Song ; Seungtaek Kim ; Sunoh Kwon ; Young-Hee Jin ; Min Seong Jang ; Hyoung Rae Kim ; Chul Min ParkSource :
- Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2019.
Abstract
3-Acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives were synthesized and evaluated to show high anti-MERS-CoV inhibitory activities. Among them, 6,8-difluoro-3-isobutyryl-2-((2,3,4-trifluorophenyl)amino)quinolin-4(1H)-one (6u) exhibits high inhibitory effect (IC50 = 86 nM) and low toxicity (CC50 > 25 μM). Moreover, it shows good metabolic stability, low hERG binding affinity, no cytotoxicity, and good in vivo PK properties.
DOI: 10.1016/j.bmcl.2019.126727
PubMed: 31624041
Links to Exploration step
pubmed:31624041Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.</title><author><name sortKey="Yoon, Ji Hye" sort="Yoon, Ji Hye" uniqKey="Yoon J" first="Ji Hye" last="Yoon">Ji Hye Yoon</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jun Young" sort="Lee, Jun Young" uniqKey="Lee J" first="Jun Young" last="Lee">Jun Young Lee</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jihye" sort="Lee, Jihye" uniqKey="Lee J" first="Jihye" last="Lee">Jihye Lee</name><affiliation><nlm:affiliation>Respiratory Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Shin, Young Sup" sort="Shin, Young Sup" uniqKey="Shin Y" first="Young Sup" last="Shin">Young Sup Shin</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jeon, Sangeun" sort="Jeon, Sangeun" uniqKey="Jeon S" first="Sangeun" last="Jeon">Sangeun Jeon</name><affiliation><nlm:affiliation>Respiratory Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Dong Eon" sort="Kim, Dong Eon" uniqKey="Kim D" first="Dong Eon" last="Kim">Dong Eon Kim</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Min, Jung Sun" sort="Min, Jung Sun" uniqKey="Min J" first="Jung Sun" last="Min">Jung Sun Min</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Jong Hwan" sort="Song, Jong Hwan" uniqKey="Song J" first="Jong Hwan" last="Song">Jong Hwan Song</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Seungtaek" sort="Kim, Seungtaek" uniqKey="Kim S" first="Seungtaek" last="Kim">Seungtaek Kim</name><affiliation><nlm:affiliation>Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kwon, Sunoh" sort="Kwon, Sunoh" uniqKey="Kwon S" first="Sunoh" last="Kwon">Sunoh Kwon</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jin, Young Hee" sort="Jin, Young Hee" uniqKey="Jin Y" first="Young-Hee" last="Jin">Young-Hee Jin</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jang, Min Seong" sort="Jang, Min Seong" uniqKey="Jang M" first="Min Seong" last="Jang">Min Seong Jang</name><affiliation><nlm:affiliation>Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hyoung Rae" sort="Kim, Hyoung Rae" uniqKey="Kim H" first="Hyoung Rae" last="Kim">Hyoung Rae Kim</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Chul Min" sort="Park, Chul Min" uniqKey="Park C" first="Chul Min" last="Park">Chul Min Park</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31624041</idno><idno type="pmid">31624041</idno><idno type="doi">10.1016/j.bmcl.2019.126727</idno><idno type="wicri:Area/PubMed/Corpus">000392</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000392</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.</title><author><name sortKey="Yoon, Ji Hye" sort="Yoon, Ji Hye" uniqKey="Yoon J" first="Ji Hye" last="Yoon">Ji Hye Yoon</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jun Young" sort="Lee, Jun Young" uniqKey="Lee J" first="Jun Young" last="Lee">Jun Young Lee</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jihye" sort="Lee, Jihye" uniqKey="Lee J" first="Jihye" last="Lee">Jihye Lee</name><affiliation><nlm:affiliation>Respiratory Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Shin, Young Sup" sort="Shin, Young Sup" uniqKey="Shin Y" first="Young Sup" last="Shin">Young Sup Shin</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jeon, Sangeun" sort="Jeon, Sangeun" uniqKey="Jeon S" first="Sangeun" last="Jeon">Sangeun Jeon</name><affiliation><nlm:affiliation>Respiratory Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Dong Eon" sort="Kim, Dong Eon" uniqKey="Kim D" first="Dong Eon" last="Kim">Dong Eon Kim</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Min, Jung Sun" sort="Min, Jung Sun" uniqKey="Min J" first="Jung Sun" last="Min">Jung Sun Min</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Jong Hwan" sort="Song, Jong Hwan" uniqKey="Song J" first="Jong Hwan" last="Song">Jong Hwan Song</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Seungtaek" sort="Kim, Seungtaek" uniqKey="Kim S" first="Seungtaek" last="Kim">Seungtaek Kim</name><affiliation><nlm:affiliation>Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kwon, Sunoh" sort="Kwon, Sunoh" uniqKey="Kwon S" first="Sunoh" last="Kwon">Sunoh Kwon</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jin, Young Hee" sort="Jin, Young Hee" uniqKey="Jin Y" first="Young-Hee" last="Jin">Young-Hee Jin</name><affiliation><nlm:affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jang, Min Seong" sort="Jang, Min Seong" uniqKey="Jang M" first="Min Seong" last="Jang">Min Seong Jang</name><affiliation><nlm:affiliation>Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hyoung Rae" sort="Kim, Hyoung Rae" uniqKey="Kim H" first="Hyoung Rae" last="Kim">Hyoung Rae Kim</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Chul Min" sort="Park, Chul Min" uniqKey="Park C" first="Chul Min" last="Park">Chul Min Park</name><affiliation><nlm:affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Bioorganic & medicinal chemistry letters</title><idno type="eISSN">1464-3405</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">3-Acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives were synthesized and evaluated to show high anti-MERS-CoV inhibitory activities. Among them, 6,8-difluoro-3-isobutyryl-2-((2,3,4-trifluorophenyl)amino)quinolin-4(1H)-one (6u) exhibits high inhibitory effect (IC<sub>50</sub> = 86 nM) and low toxicity (CC<sub>50</sub> > 25 μM). Moreover, it shows good metabolic stability, low hERG binding affinity, no cytotoxicity, and good in vivo PK properties.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">31624041</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1464-3405</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>23</Issue><PubDate><Year>2019</Year><Month>Dec</Month><Day>01</Day></PubDate></JournalIssue><Title>Bioorganic & medicinal chemistry letters</Title><ISOAbbreviation>Bioorg. Med. Chem. Lett.</ISOAbbreviation></Journal><ArticleTitle>Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.</ArticleTitle><Pagination><MedlinePgn>126727</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0960-894X(19)30685-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bmcl.2019.126727</ELocationID><Abstract><AbstractText>3-Acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives were synthesized and evaluated to show high anti-MERS-CoV inhibitory activities. Among them, 6,8-difluoro-3-isobutyryl-2-((2,3,4-trifluorophenyl)amino)quinolin-4(1H)-one (6u) exhibits high inhibitory effect (IC<sub>50</sub> = 86 nM) and low toxicity (CC<sub>50</sub> > 25 μM). Moreover, it shows good metabolic stability, low hERG binding affinity, no cytotoxicity, and good in vivo PK properties.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yoon</LastName><ForeName>Ji Hye</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jun Young</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jihye</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Respiratory Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Young Sup</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Sangeun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Respiratory Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Dong Eon</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Min</LastName><ForeName>Jung Sun</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Jong Hwan</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Seungtaek</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Sunoh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Young-Hee</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jang</LastName><ForeName>Min Seong</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hyoung Rae</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Chul Min</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Bioorg Med Chem Lett</MedlineTA><NlmUniqueID>9107377</NlmUniqueID><ISSNLinking>0960-894X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">3-Acyl-2-amino-1,4-dihydroquinolin-4(1H)-ones</Keyword><Keyword MajorTopicYN="N">Inhibitor</Keyword><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">RNA virus</Keyword><Keyword MajorTopicYN="N">SAR optimization</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>09</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31624041</ArticleId><ArticleId IdType="pii">S0960-894X(19)30685-7</ArticleId><ArticleId IdType="doi">10.1016/j.bmcl.2019.126727</ArticleId><ArticleId IdType="pmc">PMC7126094</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93</Citation><ArticleIdList><ArticleId IdType="pubmed">24841273</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Clin Microbiol Rev. 2015 Apr;28(2):465-522</Citation><ArticleIdList><ArticleId IdType="pubmed">25810418</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>mBio. 2014 Feb 18;5(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">24549846</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Med Chem. 2009 May 14;52(9):3093-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19419206</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Assay Drug Dev Technol. 2017 Jul;15(5):198-209</Citation><ArticleIdList><ArticleId IdType="pubmed">28723269</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Microbiol. 2016 Aug;14(8):523-34</Citation><ArticleIdList><ArticleId IdType="pubmed">27344959</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84</Citation><ArticleIdList><ArticleId IdType="pubmed">24841269</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>PLoS Negl Trop Dis. 2013 Oct 31;7(10):e2471</Citation><ArticleIdList><ArticleId IdType="pubmed">24205414</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000392 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000392 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:31624041
|texte= Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:31624041" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |