MersV1, PubMed, Corpus, bibRecord, 000328

Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.

Identifieur interne : 000328 ( PubMed/Corpus ); précédent : 000327; suivant : 000329

Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.

Auteurs : Olujide O. Olubiyi ; Maryam O. Olagunju ; Birgit Strodel

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2019.

RBID : pubmed:31842406

Abstract

Sickle cell disease (SCD) is a group of inherited disorders affecting red blood cells, which is caused by a single mutation that results in substitution of the amino acid valine for glutamic acid in the sixth position of the β-globin chain of hemoglobin. These mutant hemoglobin molecules, called hemoglobin S, can polymerize upon deoxygenation, causing erythrocytes to adopt a sickled form and to suffer hemolysis and vaso-occlusion. Until recently, only two drug therapies for SCD, which do not even fully address the manifestations of SCD, were approved by the United States (US) Food and Drug Administration. A third treatment was newly approved, while a monoclonal antibody preventing vaso-occlusive crises is also now available. The complex nature of SCD manifestations provides multiple critical points where drug discovery efforts can be and have been directed. These notwithstanding, the need for new therapeutic approaches remains high and one of the recent efforts includes developments aimed at inhibiting the polymerization of hemoglobin S. This review focuses on anti-sickling approaches using peptide-based inhibitors, ranging from individual amino acid dipeptides investigated 30-40 years ago up to more promising 12- and 15-mers under consideration in recent years.

DOI: 10.3390/molecules24244551
PubMed: 31842406

Links to Exploration step

pubmed:31842406

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.</title>
<author><name sortKey="Olubiyi, Olujide O" sort="Olubiyi, Olujide O" uniqKey="Olubiyi O" first="Olujide O" last="Olubiyi">Olujide O. Olubiyi</name>
<affiliation><nlm:affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Olagunju, Maryam O" sort="Olagunju, Maryam O" uniqKey="Olagunju M" first="Maryam O" last="Olagunju">Maryam O. Olagunju</name>
<affiliation><nlm:affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Strodel, Birgit" sort="Strodel, Birgit" uniqKey="Strodel B" first="Birgit" last="Strodel">Birgit Strodel</name>
<affiliation><nlm:affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:31842406</idno>
<idno type="pmid">31842406</idno>
<idno type="doi">10.3390/molecules24244551</idno>
<idno type="wicri:Area/PubMed/Corpus">000328</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000328</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.</title>
<author><name sortKey="Olubiyi, Olujide O" sort="Olubiyi, Olujide O" uniqKey="Olubiyi O" first="Olujide O" last="Olubiyi">Olujide O. Olubiyi</name>
<affiliation><nlm:affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Olagunju, Maryam O" sort="Olagunju, Maryam O" uniqKey="Olagunju M" first="Maryam O" last="Olagunju">Maryam O. Olagunju</name>
<affiliation><nlm:affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Strodel, Birgit" sort="Strodel, Birgit" uniqKey="Strodel B" first="Birgit" last="Strodel">Birgit Strodel</name>
<affiliation><nlm:affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecules (Basel, Switzerland)</title>
<idno type="eISSN">1420-3049</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Sickle cell disease (SCD) is a group of inherited disorders affecting red blood cells, which is caused by a single mutation that results in substitution of the amino acid valine for glutamic acid in the sixth position of the β-globin chain of hemoglobin. These mutant hemoglobin molecules, called hemoglobin S, can polymerize upon deoxygenation, causing erythrocytes to adopt a sickled form and to suffer hemolysis and vaso-occlusion. Until recently, only two drug therapies for SCD, which do not even fully address the manifestations of SCD, were approved by the United States (US) Food and Drug Administration. A third treatment was newly approved, while a monoclonal antibody preventing vaso-occlusive crises is also now available. The complex nature of SCD manifestations provides multiple critical points where drug discovery efforts can be and have been directed. These notwithstanding, the need for new therapeutic approaches remains high and one of the recent efforts includes developments aimed at inhibiting the polymerization of hemoglobin S. This review focuses on anti-sickling approaches using peptide-based inhibitors, ranging from individual amino acid dipeptides investigated 30-40 years ago up to more promising 12- and 15-mers under consideration in recent years.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31842406</PMID>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>24</Issue>
<PubDate><Year>2019</Year>
<Month>Dec</Month>
<Day>12</Day>
</PubDate>
</JournalIssue>
<Title>Molecules (Basel, Switzerland)</Title>
<ISOAbbreviation>Molecules</ISOAbbreviation>
</Journal>
<ArticleTitle>Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E4551</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules24244551</ELocationID>
<Abstract><AbstractText>Sickle cell disease (SCD) is a group of inherited disorders affecting red blood cells, which is caused by a single mutation that results in substitution of the amino acid valine for glutamic acid in the sixth position of the β-globin chain of hemoglobin. These mutant hemoglobin molecules, called hemoglobin S, can polymerize upon deoxygenation, causing erythrocytes to adopt a sickled form and to suffer hemolysis and vaso-occlusion. Until recently, only two drug therapies for SCD, which do not even fully address the manifestations of SCD, were approved by the United States (US) Food and Drug Administration. A third treatment was newly approved, while a monoclonal antibody preventing vaso-occlusive crises is also now available. The complex nature of SCD manifestations provides multiple critical points where drug discovery efforts can be and have been directed. These notwithstanding, the need for new therapeutic approaches remains high and one of the recent efforts includes developments aimed at inhibiting the polymerization of hemoglobin S. This review focuses on anti-sickling approaches using peptide-based inhibitors, ranging from individual amino acid dipeptides investigated 30-40 years ago up to more promising 12- and 15-mers under consideration in recent years.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Olubiyi</LastName>
<ForeName>Olujide O</ForeName>
<Initials>OO</Initials>
<Identifier Source="ORCID">0000-0002-9412-6776</Identifier>
<AffiliationInfo><Affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220282, Nigeria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Olagunju</LastName>
<ForeName>Maryam O</ForeName>
<Initials>MO</Initials>
<AffiliationInfo><Affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Strodel</LastName>
<ForeName>Birgit</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">0000-0002-8734-7765</Identifier>
<AffiliationInfo><Affiliation>Institute of Complex Systems: Structural Biochemistry, Forschungszentrum Jülich, 52425 Jülich, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Theoretical and Computational Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>12</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Molecules</MedlineTA>
<NlmUniqueID>100964009</NlmUniqueID>
<ISSNLinking>1420-3049</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">hemoglobin</Keyword>
<Keyword MajorTopicYN="N">hemoglobin modifiers</Keyword>
<Keyword MajorTopicYN="N">polymerization inhibitors</Keyword>
<Keyword MajorTopicYN="N">sickle cell treatment</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>09</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>12</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>12</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>12</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>12</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>12</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31842406</ArticleId>
<ArticleId IdType="pii">molecules24244551</ArticleId>
<ArticleId IdType="doi">10.3390/molecules24244551</ArticleId>
<ArticleId IdType="pmc">PMC6943517</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Blood Cells Mol Dis. 2018 Mar;69:65-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28951038</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1979 Dec 25;254(24):12273-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">500713</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Pharm Des. 2012;18(6):755-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22236121</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Invest. 1993 Jul;92(1):520-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8326017</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ochsner J. 2018 Winter;18(4):377-389</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30559624</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Hematol. 2017 Sep;92(9):E520-E528</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28589652</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Hematol. 2013 Nov;88(11):932-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23861242</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Drug Discov. 2010 Mar;9(3):237-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20190788</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 1995 Nov 21;34(46):15006-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7578114</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pediatr Blood Cancer. 2011 Jan;56(1):90-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20922765</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Chem. 2012 Jun 28;55(12):5859-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22680612</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Adv Protein Chem. 1990;40:63-279</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2195851</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1983 Jan;80(1):278-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6572002</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 1985 Jun 25;183(4):611-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4020873</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biophys J. 2000 Aug;79(2):1016-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10920031</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 1988 Feb;71(2):512-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3337912</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 1983 Feb 28;111(1):8-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6681956</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Hemorheol Microcirc. 2018;70(1):95-105</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29660913</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 2003 Apr 22;42(15):4476-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12693943</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Drug Discov Today. 2010 Jan;15(1-2):40-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19879957</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 1975 Jan;45(1):45-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">803109</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Haematol. 2018 May;181(4):460-475</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29732531</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 1973 Nov 5;80(3):445-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4762563</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Haematol. 2011 Apr;153(1):92-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21323872</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Adv. 2019 Mar 13;5(3):eaau1086</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30891490</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Med Chem. 2001 Feb;8(2):79-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11172667</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Life Sci. 1993;53(6):517-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8341138</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mayo Clin Proc. 2018 Dec;93(12):1810-1824</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30414734</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAMA. 2003 Apr 2;289(13):1645-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12672732</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Haematol. 2016 Oct;175(1):141-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27378309</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Hematol. 2010 Jun;85(6):403-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20513116</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H328-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23125208</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Lab Clin Med. 1997 Jul;130(1):83-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9242370</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>iScience. 2019 Jul 26;17:87-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31255986</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pharmacogn Rev. 2013 Jan;7(13):53-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23922457</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Haematologica. 2019 May 30;:null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31147439</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Indian J Hematol Blood Transfus. 2014 Jun;30(2):91-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24839362</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Med. 2014 Oct 22;12:200</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25604462</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Hematology Am Soc Hematol Educ Program. 2015;2015:436-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26637755</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Microcirculation. 2004 Mar;11(2):115-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15280087</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1980 Feb 28;283(5750):832-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7360228</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pediatr Blood Cancer. 2012 Aug;59(2):254-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22012708</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 1982 Mar 16;21(6):1400-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7074094</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Hematol J. 2000;1(4):243-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11920197</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Haematol. 2013 Jun;90(6):519-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23489171</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Pediatr Hematol Oncol. 1994 Feb;16(1):27-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8311169</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2014 Dec 18;124(26):3850-7; quiz 4004</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25287707</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biomed Sci. 2017 Mar 21;24(1):21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28320393</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1987 Sep 25;262(27):12920-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2888754</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biophys J. 2013 Nov 5;105(9):2149-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24209860</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Hematol. 2011 Nov;86(11):958-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21948113</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bone Marrow Transplant. 1998 Jul;22(1):1-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9678788</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Med Chem. 2014;21(12):1448-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24304283</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Acta Haematol. 2011;125(3):145-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21196716</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 1984 Jul;64(1):282-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6733278</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2017 Mar 16;129(11):1548-1556</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27965196</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chemistry. 2017 Jan 12;23(3):605-613</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27808442</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2011 Aug 19;146(4):582-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21854983</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2003 Mar 15;101(6):2412-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12433690</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Neurobiol. 2019 Mar;56(3):2211-2223</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30003517</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Drug Deliv. 2018 Nov;25(1):1996-2006</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30799658</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 1977 Sep 15;115(2):111-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22759</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2018 Jul 19;379(3):226-235</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30021096</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Haematol. 2013 Jun;161(6):852-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23590693</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood Cells. 1982;8(2):345-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7159757</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Drug Discov. 2008 Jan;7(1):21-39</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18097458</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Adv. 2019 Aug 21;5(8):eaax3905</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31457104</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 1996 Dec 15;88(12):4701-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8977264</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Acta Haematol. 1992;88(2-3):67-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1281601</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Haematol. 2016 Oct;175(1):24-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27605087</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Molecules. 2019 Mar 07;24(5):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30866424</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Blood Med. 2015 Jul 10;6:229-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26203293</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 1997 Sep 26;272(3):398-407</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9325099</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 1980 Dec 25;144(4):467-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7253024</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Struct Biol. 2016 Jun;194(3):446-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27085422</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1984 Aug 25;259(16):10238-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6469962</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Trends Biotechnol. 1998 Apr;16(4):152-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9586237</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 1990 Sep 1;76(5):1028-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2393711</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biomech. 2017 Jan 4;50:34-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27876368</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 2006 Jul 11;45(27):8358-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16819835</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biophys J. 1997 Jan;72(1):343-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8994619</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1983 Jan;80(2):324-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6572894</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1982 Sep 16;299(5880):231-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7110343</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2011 May 14;377(9778):1663-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21571150</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pediatrics. 2008 Dec;122(6):1332-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19047254</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proteins. 2004 Apr 1;55(1):169-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14997550</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chem Biodivers. 2008 Sep;5(9):1762-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18816529</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Hemoglobin. 1980;4(3-4):335-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7419427</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta. 1980 Aug 21;624(2):372-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7417483</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2017 May 18;129(20):2719-2726</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28385699</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>ACS Med Chem Lett. 2017 Jan 23;8(3):321-326</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28337324</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Haematol. 1991 Sep;79(1):93-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1716963</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>ACS Chem Biol. 2014 Oct 17;9(10):2318-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25061917</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Pharmacol. 1983 Jan;23(1):100-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6865893</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chembiochem. 2003 Aug 4;4(8):748-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12898626</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Opin Struct Biol. 2017 Jun;44:59-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28063303</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biol Blood Marrow Transplant. 2013 May;19(5):820-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23416852</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2019 Apr 12;294(15):6130-6141</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30733338</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):920-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22101818</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Chem. 1983 Apr;26(4):549-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6834388</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 1977 Aug 22;77(4):1217-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">901531</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biophys J. 2004 Dec;87(6):4113-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15465861</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1977 Dec;74(12):5431-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">271966</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Haematologica. 2017 Sep;102(9):1477-1485</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28596281</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Opin Biotechnol. 2006 Dec;17(6):638-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17049837</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1974 Dec;71(12):4693-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4531009</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Haematol. 2017 Jan;98(1):75-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27471124</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Med. 2013;10(7):e1001484</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23874164</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Invest. 1970 Apr;49(4):623-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5443167</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E689-E696</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28096387</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2007 Oct 1;110(7):2749-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17606762</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Chem. 1995 Jan 6;38(1):161-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7837227</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2018 Aug 16;132(7):689-693</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29895661</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2012 Nov 22;120(22):4304-10; quiz 4448</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22915643</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta. 1958 Jun;28(3):539-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13560404</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2008 Jan 1;111(1):402-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17848621</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Complement Altern Med. 2015 Nov 23;15:414</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26597857</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Hematol. 1994 Oct;47(2):106-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8092124</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes Obes Metab. 2010 May;12(5):393-402</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20415687</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 1983 Aug 15;168(3):659-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6887250</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta. 1981 May 29;668(3):397-405</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7236716</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Transl Med. 2012 Sep 19;10 Suppl 1:S1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23046982</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Molecules. 2019 Jan 19;24(2):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30669445</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 1995 Jun 1;85(11):3289-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7756662</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>F1000Res. 2018 Sep 4;7:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30228870</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2019 Aug 8;381(6):509-519</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31199090</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Prog Clin Biol Res. 1981;55:123-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6170070</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pharmacogn Mag. 2011 Apr;7(26):126-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21716622</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1979 Sep 10;254(17):8169-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">468817</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Comput Aided Drug Des. 2018;14(2):106-116</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29380703</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 1977 Jan 24;74(2):637-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">836316</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bioorg Med Chem. 2018 May 15;26(9):2530-2538</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29655608</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Pharm. 2017 Oct 2;14(10):3499-3511</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28858508</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2010 Dec 11;376(9757):2018-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21131035</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Amino Acids. 2006 Jun;30(4):351-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16622600</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Drug Discov. 2019 Feb;18(2):139-158</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30514970</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16157-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19805273</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Struct. 2015 Nov 5;1099:99-107</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26207073</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biophys J. 2016 May 10;110(9):2085-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27166816</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 1991 Mar 15;77(6):1334-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2001455</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1981 Feb 25;256(4):1824-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7462225</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2010 Mar 25;115(12):2354-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19903897</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochim Biophys Acta. 1982 Jul 12;705(1):76-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7115734</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 1980 Apr 15;19(8):1564-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7378365</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Int Med Res. 1976;4(6):375-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1027632</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood Cells. 1982;8(2):213-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6186320</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Alzheimers Dis. 2016;51(1):165-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26836184</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Physiol. 2019 Jul 24;10:931</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31396101</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Tex Rep Biol Med. 1980-1981;40:251-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7034271</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Hematol Oncol Clin North Am. 2016 Apr;30(2):343-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27040958</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Haematol. 2002 Jul;118(1):337-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12100171</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chemphyschem. 2013 Jul 22;14(10):2143-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23703945</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 1977 Jun 10;196(4295):1216-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">870976</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 1978 Dec 12;17(25):5455-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">728408</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Res Notes. 2012 Aug 01;5:396</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22849350</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000328 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000328 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:31842406
   |texte=   Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:31842406" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.

Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki