Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia.
Identifieur interne : 000326 ( PubMed/Corpus ); précédent : 000325; suivant : 000327Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia.
Auteurs : Rajaa M. Al-Raddadi ; Omaima I. Shabouni ; Zeyad M. Alraddadi ; Abdulmohsen H. Alzalabani ; Ahmad M. Al-Asmari ; Adel Ibrahim ; Abdullatif Almarashi ; Tariq A. MadaniSource :
- Journal of infection and public health [ 1876-035X ] ; 2019.
Abstract
MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31months period from June 6, 2012 to January 5, 2015. The total number of patients was 835; 528 (63.2%) patients were male, 771 (92.3%) patients were ≥25 years of age, and 210 (25.1%) patients were healthcare workers. A total of 751 (89.9%) patients required hospitalization. The median duration between onset of illness and hospitalization was 2 days (interquartile range, 0-5). The median length of hospital stay was 14 days (IQR, 6-27). The overall case fatality rate was 43.1%. Basic reproductive number was 0.9. Being Saudi, non-healthcare workers, and age ≥65 years were significantly associated with higher mortality. In conclusion, MERS-CoV infection caused a substantial health burden in Saudi Arabia.
DOI: 10.1016/j.jiph.2019.11.016
PubMed: 31843650
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia.</title><author><name sortKey="Al Raddadi, Rajaa M" sort="Al Raddadi, Rajaa M" uniqKey="Al Raddadi R" first="Rajaa M" last="Al-Raddadi">Rajaa M. Al-Raddadi</name><affiliation><nlm:affiliation>Department of Community Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: rmsalhari@kau.edu.sa.</nlm:affiliation></affiliation></author><author><name sortKey="Shabouni, Omaima I" sort="Shabouni, Omaima I" uniqKey="Shabouni O" first="Omaima I" last="Shabouni">Omaima I. Shabouni</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Alraddadi, Zeyad M" sort="Alraddadi, Zeyad M" uniqKey="Alraddadi Z" first="Zeyad M" last="Alraddadi">Zeyad M. Alraddadi</name><affiliation><nlm:affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Alzalabani, Abdulmohsen H" sort="Alzalabani, Abdulmohsen H" uniqKey="Alzalabani A" first="Abdulmohsen H" last="Alzalabani">Abdulmohsen H. Alzalabani</name><affiliation><nlm:affiliation>Department of Family and Community Medicine, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Asmari, Ahmad M" sort="Al Asmari, Ahmad M" uniqKey="Al Asmari A" first="Ahmad M" last="Al-Asmari">Ahmad M. Al-Asmari</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia; King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ibrahim, Adel" sort="Ibrahim, Adel" uniqKey="Ibrahim A" first="Adel" last="Ibrahim">Adel Ibrahim</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Almarashi, Abdullatif" sort="Almarashi, Abdullatif" uniqKey="Almarashi A" first="Abdullatif" last="Almarashi">Abdullatif Almarashi</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A" last="Madani">Tariq A. Madani</name><affiliation><nlm:affiliation>Department of Medicine, Faulty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31843650</idno><idno type="pmid">31843650</idno><idno type="doi">10.1016/j.jiph.2019.11.016</idno><idno type="wicri:Area/PubMed/Corpus">000326</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000326</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia.</title><author><name sortKey="Al Raddadi, Rajaa M" sort="Al Raddadi, Rajaa M" uniqKey="Al Raddadi R" first="Rajaa M" last="Al-Raddadi">Rajaa M. Al-Raddadi</name><affiliation><nlm:affiliation>Department of Community Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: rmsalhari@kau.edu.sa.</nlm:affiliation></affiliation></author><author><name sortKey="Shabouni, Omaima I" sort="Shabouni, Omaima I" uniqKey="Shabouni O" first="Omaima I" last="Shabouni">Omaima I. Shabouni</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Alraddadi, Zeyad M" sort="Alraddadi, Zeyad M" uniqKey="Alraddadi Z" first="Zeyad M" last="Alraddadi">Zeyad M. Alraddadi</name><affiliation><nlm:affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Alzalabani, Abdulmohsen H" sort="Alzalabani, Abdulmohsen H" uniqKey="Alzalabani A" first="Abdulmohsen H" last="Alzalabani">Abdulmohsen H. Alzalabani</name><affiliation><nlm:affiliation>Department of Family and Community Medicine, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Al Asmari, Ahmad M" sort="Al Asmari, Ahmad M" uniqKey="Al Asmari A" first="Ahmad M" last="Al-Asmari">Ahmad M. Al-Asmari</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia; King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ibrahim, Adel" sort="Ibrahim, Adel" uniqKey="Ibrahim A" first="Adel" last="Ibrahim">Adel Ibrahim</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Almarashi, Abdullatif" sort="Almarashi, Abdullatif" uniqKey="Almarashi A" first="Abdullatif" last="Almarashi">Abdullatif Almarashi</name><affiliation><nlm:affiliation>Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A" last="Madani">Tariq A. Madani</name><affiliation><nlm:affiliation>Department of Medicine, Faulty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of infection and public health</title><idno type="eISSN">1876-035X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31months period from June 6, 2012 to January 5, 2015. The total number of patients was 835; 528 (63.2%) patients were male, 771 (92.3%) patients were ≥25 years of age, and 210 (25.1%) patients were healthcare workers. A total of 751 (89.9%) patients required hospitalization. The median duration between onset of illness and hospitalization was 2 days (interquartile range, 0-5). The median length of hospital stay was 14 days (IQR, 6-27). The overall case fatality rate was 43.1%. Basic reproductive number was 0.9. Being Saudi, non-healthcare workers, and age ≥65 years were significantly associated with higher mortality. In conclusion, MERS-CoV infection caused a substantial health burden in Saudi Arabia.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">31843650</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1876-035X</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2019</Year><Month>Dec</Month><Day>13</Day></PubDate></JournalIssue><Title>Journal of infection and public health</Title><ISOAbbreviation>J Infect Public Health</ISOAbbreviation></Journal><ArticleTitle>Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1876-0341(19)30357-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jiph.2019.11.016</ELocationID><Abstract><AbstractText>MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31months period from June 6, 2012 to January 5, 2015. The total number of patients was 835; 528 (63.2%) patients were male, 771 (92.3%) patients were ≥25 years of age, and 210 (25.1%) patients were healthcare workers. A total of 751 (89.9%) patients required hospitalization. The median duration between onset of illness and hospitalization was 2 days (interquartile range, 0-5). The median length of hospital stay was 14 days (IQR, 6-27). The overall case fatality rate was 43.1%. Basic reproductive number was 0.9. Being Saudi, non-healthcare workers, and age ≥65 years were significantly associated with higher mortality. In conclusion, MERS-CoV infection caused a substantial health burden in Saudi Arabia.</AbstractText><CopyrightInformation>Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Al-Raddadi</LastName><ForeName>Rajaa M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Community Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: rmsalhari@kau.edu.sa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shabouni</LastName><ForeName>Omaima I</ForeName><Initials>OI</Initials><AffiliationInfo><Affiliation>Ministry of Health, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alraddadi</LastName><ForeName>Zeyad M</ForeName><Initials>ZM</Initials><AffiliationInfo><Affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alzalabani</LastName><ForeName>Abdulmohsen H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Department of Family and Community Medicine, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Asmari</LastName><ForeName>Ahmad M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Ministry of Health, Jeddah, Saudi Arabia; King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ibrahim</LastName><ForeName>Adel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Ministry of Health, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Almarashi</LastName><ForeName>Abdullatif</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Ministry of Health, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madani</LastName><ForeName>Tariq A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Faulty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>12</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Infect Public Health</MedlineTA><NlmUniqueID>101487384</NlmUniqueID><ISSNLinking>1876-0341</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Burden</Keyword><Keyword MajorTopicYN="N">Case fatality rate</Keyword><Keyword MajorTopicYN="N">Health care workers</Keyword><Keyword MajorTopicYN="N">MERS-Coronavirus</Keyword><Keyword MajorTopicYN="N">Saudi Arabia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>06</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>08</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate 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