Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
Identifieur interne : 000210 ( PubMed/Corpus ); précédent : 000209; suivant : 000211Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
Auteurs : Manojit Bhattacharya ; Ashish R. Sharma ; Prasanta Patra ; Pratik Ghosh ; Garima Sharma ; Bidhan C. Patra ; Sang-Soo Lee ; Chiranjib ChakrabortySource :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
DOI: 10.1002/jmv.25736
PubMed: 32108359
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Sharma</name><affiliation><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Patra, Prasanta" sort="Patra, Prasanta" uniqKey="Patra P" first="Prasanta" last="Patra">Prasanta Patra</name><affiliation><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation></affiliation></author><author><name sortKey="Ghosh, Pratik" sort="Ghosh, Pratik" uniqKey="Ghosh P" first="Pratik" last="Ghosh">Pratik Ghosh</name><affiliation><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Garima" sort="Sharma, Garima" uniqKey="Sharma G" first="Garima" last="Sharma">Garima Sharma</name><affiliation><nlm:affiliation>Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Patra, Bidhan C" sort="Patra, Bidhan C" uniqKey="Patra B" first="Bidhan C" last="Patra">Bidhan C. Patra</name><affiliation><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Sang Soo" sort="Lee, Sang Soo" uniqKey="Lee S" first="Sang-Soo" last="Lee">Sang-Soo Lee</name><affiliation><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chakraborty, Chiranjib" sort="Chakraborty, Chiranjib" uniqKey="Chakraborty C" first="Chiranjib" last="Chakraborty">Chiranjib Chakraborty</name><affiliation><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32108359</idno><idno type="pmid">32108359</idno><idno type="doi">10.1002/jmv.25736</idno><idno type="wicri:Area/PubMed/Corpus">000210</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.</title><author><name sortKey="Bhattacharya, Manojit" sort="Bhattacharya, Manojit" uniqKey="Bhattacharya M" first="Manojit" last="Bhattacharya">Manojit Bhattacharya</name><affiliation><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Ashish R" sort="Sharma, Ashish R" uniqKey="Sharma A" first="Ashish R" last="Sharma">Ashish R. Sharma</name><affiliation><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Patra, Prasanta" sort="Patra, Prasanta" uniqKey="Patra P" first="Prasanta" last="Patra">Prasanta Patra</name><affiliation><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation></affiliation></author><author><name sortKey="Ghosh, Pratik" sort="Ghosh, Pratik" uniqKey="Ghosh P" first="Pratik" last="Ghosh">Pratik Ghosh</name><affiliation><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Garima" sort="Sharma, Garima" uniqKey="Sharma G" first="Garima" last="Sharma">Garima Sharma</name><affiliation><nlm:affiliation>Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Patra, Bidhan C" sort="Patra, Bidhan C" uniqKey="Patra B" first="Bidhan C" last="Patra">Bidhan C. Patra</name><affiliation><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Sang Soo" sort="Lee, Sang Soo" uniqKey="Lee S" first="Sang-Soo" last="Lee">Sang-Soo Lee</name><affiliation><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chakraborty, Chiranjib" sort="Chakraborty, Chiranjib" uniqKey="Chakraborty C" first="Chiranjib" last="Chakraborty">Chiranjib Chakraborty</name><affiliation><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32108359</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Feb</Month><Day>28</Day></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J. Med. Virol.</ISOAbbreviation></Journal><ArticleTitle>Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.25736</ELocationID><Abstract><AbstractText>Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.</AbstractText><CopyrightInformation>© 2020 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bhattacharya</LastName><ForeName>Manojit</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9669-1835</Identifier><AffiliationInfo><Affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Ashish R</ForeName><Initials>AR</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3973-6755</Identifier><AffiliationInfo><Affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patra</LastName><ForeName>Prasanta</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3901-8569</Identifier><AffiliationInfo><Affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghosh</LastName><ForeName>Pratik</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8117-7681</Identifier><AffiliationInfo><Affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Garima</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1763-0730</Identifier><AffiliationInfo><Affiliation>Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patra</LastName><ForeName>Bidhan C</ForeName><Initials>BC</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9188-7457</Identifier><AffiliationInfo><Affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Sang-Soo</ForeName><Initials>SS</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5074-7581</Identifier><AffiliationInfo><Affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chakraborty</LastName><ForeName>Chiranjib</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3958-239X</Identifier><AffiliationInfo><Affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Hallym University Research Fund</Agency><Country></Country></Grant><Grant><GrantID>NRF-2017R1A2B4012944</GrantID><Agency>National Research Foundation of Korea (NRF)</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Virol</MedlineTA><NlmUniqueID>7705876</NlmUniqueID><ISSNLinking>0146-6615</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARS-COV-2</Keyword><Keyword MajorTopicYN="N">epitopes</Keyword><Keyword MajorTopicYN="N">immunoinformatics</Keyword><Keyword MajorTopicYN="N">vaccine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32108359</ArticleId><ArticleId IdType="doi">10.1002/jmv.25736</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Wang C, Horby PW, Hayden FG, Gao GF. 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