MersV1, PubMed, Corpus, bibRecord, 000207

Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review.

Identifieur interne : 000207 ( PubMed/Corpus ); précédent : 000206; suivant : 000208

Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review.

Auteurs : Junxiong Pang ; Min Xian Wang ; Ian Yi Han Ang ; Sharon Hui Xuan Tan ; Ruth Frances Lewis ; Jacinta I-Pei Chen ; Ramona A. Gutierrez ; Sylvia Xiao Wei Gwee ; Pearleen Ee Yong Chua ; Qian Yang ; Xian Yi Ng ; Rowena Ks Yap ; Hao Yi Tan ; Yik Ying Teo ; Chorh Chuan Tan ; Alex R. Cook ; Jason Chin-Huat Yap ; Li Yang Hsu

Source :

Journal of clinical medicine [ 2077-0383 ] ; 2020.

RBID : pubmed:32110875

Abstract

Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published. A commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia. However, serological assays as well as point-of-care testing kits have not been developed but are likely in the near future. Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. However, there are currently no effective specific antivirals or drug combinations supported by high-level evidence.

DOI: 10.3390/jcm9030623
PubMed: 32110875

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pubmed:32110875

Le document en format XML

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<front><div type="abstract" xml:lang="en">Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published. A commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia. However, serological assays as well as point-of-care testing kits have not been developed but are likely in the near future. Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. However, there are currently no effective specific antivirals or drug combinations supported by high-level evidence.</div>
</front>
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<Title>Journal of clinical medicine</Title>
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<Abstract><AbstractText>Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published. A commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia. However, serological assays as well as point-of-care testing kits have not been developed but are likely in the near future. Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. However, there are currently no effective specific antivirals or drug combinations supported by high-level evidence.</AbstractText>
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<AffiliationInfo><Affiliation>Centre for Infectious Disease Epidemiology and Research, National University of Singapore, Singapore 117549, Singapore.</Affiliation>
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<Author ValidYN="Y"><LastName>Wang</LastName>
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<AffiliationInfo><Affiliation>Centre for Infectious Disease Epidemiology and Research, National University of Singapore, Singapore 117549, Singapore.</Affiliation>
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<Initials>AR</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Yap</LastName>
<ForeName>Jason Chin-Huat</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsu</LastName>
<ForeName>Li Yang</ForeName>
<Initials>LY</Initials>
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</AffiliationInfo>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>N-608-000-065-001</GrantID>
<Agency>Ministry of Defence</Agency>
<Country></Country>
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<Agency>Ministry of Health</Agency>
<Country></Country>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>02</Month>
<Day>26</Day>
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<NlmUniqueID>101606588</NlmUniqueID>
<ISSNLinking>2077-0383</ISSNLinking>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MERS-CoV</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV</Keyword>
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<Keyword MajorTopicYN="N">global health</Keyword>
<Keyword MajorTopicYN="N">novel coronavirus</Keyword>
<Keyword MajorTopicYN="N">outbreak</Keyword>
<Keyword MajorTopicYN="N">treatments</Keyword>
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Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review.

Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review.

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