Deployment of convalescent plasma for the prevention and treatment of COVID-19.
Identifieur interne : 000078 ( PubMed/Corpus ); précédent : 000077; suivant : 000079Deployment of convalescent plasma for the prevention and treatment of COVID-19.
Auteurs : Evan M. Bloch ; Shmuel Shoham ; Arturo Casadevall ; Bruce S. Sachais ; Beth Shaz ; Jeffrey L. Winters ; Camille Van Buskirk ; Brenda J. Grossman ; Michael Joyner ; Jeffrey P. Henderson ; Andrew Pekosz ; Bryan Lau ; Amy Wesolowski ; Louis Katz ; Hua Shan ; Paul G. Auwaerter ; David Thomas ; David J. Sullivan ; Nigel Paneth ; Eric Gehrie ; Steven Spitalnik ; Eldad Hod ; Lewis Pollack ; Wayne T. Nicholson ; Liise-Anne Pirofski ; Jeffrey A. Bailey ; Aaron Ar TobianSource :
- The Journal of clinical investigation [ 1558-8238 ] ; 2020.
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. Immune (i.e. "convalescent") plasma refers to plasma that is collected from individuals, following resolution of infection and development of antibodies. Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy to confer immediate immunity to susceptible individuals. There are numerous examples, where convalescent plasma has been used successfully as post-exposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East Respiratory Syndrome [MERS]). Convalescent plasma has also been used in the COVID-19 pandemic; limited data from China suggest clinical benefit, including radiological resolution, reduction in viral loads and improved survival. Globally, blood centers have robust infrastructure to undertake collections and construct inventories of convalescent plasma to meet the growing demand. Nonetheless, there are nuanced challenges, both regulatory and logistical, spanning donor eligibility, donor recruitment, collections and transfusion itself. Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). We provide an overview of convalescent plasma, from evidence of benefit, regulatory considerations, logistical work flow and proposed clinical trials, as scale up is brought underway to mobilize this critical resource. .
DOI: 10.1172/JCI138745
PubMed: 32254064
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deployment of convalescent plasma for the prevention and treatment of COVID-19.</title><author><name sortKey="Bloch, Evan M" sort="Bloch, Evan M" uniqKey="Bloch E" first="Evan M" last="Bloch">Evan M. Bloch</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Shoham, Shmuel" sort="Shoham, Shmuel" uniqKey="Shoham S" first="Shmuel" last="Shoham">Shmuel Shoham</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Casadevall, Arturo" sort="Casadevall, Arturo" uniqKey="Casadevall A" first="Arturo" last="Casadevall">Arturo Casadevall</name><affiliation><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Sachais, Bruce S" sort="Sachais, Bruce S" uniqKey="Sachais B" first="Bruce S" last="Sachais">Bruce S. Sachais</name><affiliation><nlm:affiliation>Hematology, New York Blood Center Enterprises, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Shaz, Beth" sort="Shaz, Beth" uniqKey="Shaz B" first="Beth" last="Shaz">Beth Shaz</name><affiliation><nlm:affiliation>Hematology, New York Blood Center Enterprises, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Winters, Jeffrey L" sort="Winters, Jeffrey L" uniqKey="Winters J" first="Jeffrey L" last="Winters">Jeffrey L. Winters</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Laboratory Medicine and Pat, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Van Buskirk, Camille" sort="Van Buskirk, Camille" uniqKey="Van Buskirk C" first="Camille" last="Van Buskirk">Camille Van Buskirk</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Laboratory Medicine and Pat, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Grossman, Brenda J" sort="Grossman, Brenda J" uniqKey="Grossman B" first="Brenda J" last="Grossman">Brenda J. Grossman</name><affiliation><nlm:affiliation>Department of Pathology, Washington University School of Medicine in St. Louis, St. Louis, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Joyner, Michael" sort="Joyner, Michael" uniqKey="Joyner M" first="Michael" last="Joyner">Michael Joyner</name><affiliation><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Jeffrey P" sort="Henderson, Jeffrey P" uniqKey="Henderson J" first="Jeffrey P" last="Henderson">Jeffrey P. Henderson</name><affiliation><nlm:affiliation>Departments of Medicine and Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Pekosz, Andrew" sort="Pekosz, Andrew" uniqKey="Pekosz A" first="Andrew" last="Pekosz">Andrew Pekosz</name><affiliation><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Lau, Bryan" sort="Lau, Bryan" uniqKey="Lau B" first="Bryan" last="Lau">Bryan Lau</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Wesolowski, Amy" sort="Wesolowski, Amy" uniqKey="Wesolowski A" first="Amy" last="Wesolowski">Amy Wesolowski</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Katz, Louis" sort="Katz, Louis" uniqKey="Katz L" first="Louis" last="Katz">Louis Katz</name><affiliation><nlm:affiliation>Blood Center, Mississippi Valley Regional Blood Center, Davenport, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Shan, Hua" sort="Shan, Hua" uniqKey="Shan H" first="Hua" last="Shan">Hua Shan</name><affiliation><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Palo Alto, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Auwaerter, Paul G" sort="Auwaerter, Paul G" uniqKey="Auwaerter P" first="Paul G" last="Auwaerter">Paul G. Auwaerter</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, David" sort="Thomas, David" uniqKey="Thomas D" first="David" last="Thomas">David Thomas</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Sullivan, David J" sort="Sullivan, David J" uniqKey="Sullivan D" first="David J" last="Sullivan">David J. Sullivan</name><affiliation><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Paneth, Nigel" sort="Paneth, Nigel" uniqKey="Paneth N" first="Nigel" last="Paneth">Nigel Paneth</name><affiliation><nlm:affiliation>Departments of Epidemiology and Biostatistics and Pediatrics, and Human Dev, Michigan State University, East Lansing, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Gehrie, Eric" sort="Gehrie, Eric" uniqKey="Gehrie E" first="Eric" last="Gehrie">Eric Gehrie</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Spitalnik, Steven" sort="Spitalnik, Steven" uniqKey="Spitalnik S" first="Steven" last="Spitalnik">Steven Spitalnik</name><affiliation><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hod, Eldad" sort="Hod, Eldad" uniqKey="Hod E" first="Eldad" last="Hod">Eldad Hod</name><affiliation><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Pollack, Lewis" sort="Pollack, Lewis" uniqKey="Pollack L" first="Lewis" last="Pollack">Lewis Pollack</name><affiliation><nlm:affiliation>Independent Consultant, unknown, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Nicholson, Wayne T" sort="Nicholson, Wayne T" uniqKey="Nicholson W" first="Wayne T" last="Nicholson">Wayne T. Nicholson</name><affiliation><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Pirofski, Liise Anne" sort="Pirofski, Liise Anne" uniqKey="Pirofski L" first="Liise-Anne" last="Pirofski">Liise-Anne Pirofski</name><affiliation><nlm:affiliation>Departments of Infectious Diseases, Albert Einstein College of Medicine, Bronx, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Bailey, Jeffrey A" sort="Bailey, Jeffrey A" uniqKey="Bailey J" first="Jeffrey A" last="Bailey">Jeffrey A. Bailey</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Tobian, Aaron Ar" sort="Tobian, Aaron Ar" uniqKey="Tobian A" first="Aaron Ar" last="Tobian">Aaron Ar Tobian</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32254064</idno><idno type="pmid">32254064</idno><idno type="doi">10.1172/JCI138745</idno><idno type="wicri:Area/PubMed/Corpus">000078</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000078</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deployment of convalescent plasma for the prevention and treatment of COVID-19.</title><author><name sortKey="Bloch, Evan M" sort="Bloch, Evan M" uniqKey="Bloch E" first="Evan M" last="Bloch">Evan M. Bloch</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Shoham, Shmuel" sort="Shoham, Shmuel" uniqKey="Shoham S" first="Shmuel" last="Shoham">Shmuel Shoham</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Casadevall, Arturo" sort="Casadevall, Arturo" uniqKey="Casadevall A" first="Arturo" last="Casadevall">Arturo Casadevall</name><affiliation><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Sachais, Bruce S" sort="Sachais, Bruce S" uniqKey="Sachais B" first="Bruce S" last="Sachais">Bruce S. Sachais</name><affiliation><nlm:affiliation>Hematology, New York Blood Center Enterprises, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Shaz, Beth" sort="Shaz, Beth" uniqKey="Shaz B" first="Beth" last="Shaz">Beth Shaz</name><affiliation><nlm:affiliation>Hematology, New York Blood Center Enterprises, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Winters, Jeffrey L" sort="Winters, Jeffrey L" uniqKey="Winters J" first="Jeffrey L" last="Winters">Jeffrey L. Winters</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Laboratory Medicine and Pat, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Van Buskirk, Camille" sort="Van Buskirk, Camille" uniqKey="Van Buskirk C" first="Camille" last="Van Buskirk">Camille Van Buskirk</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Laboratory Medicine and Pat, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Grossman, Brenda J" sort="Grossman, Brenda J" uniqKey="Grossman B" first="Brenda J" last="Grossman">Brenda J. Grossman</name><affiliation><nlm:affiliation>Department of Pathology, Washington University School of Medicine in St. Louis, St. Louis, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Joyner, Michael" sort="Joyner, Michael" uniqKey="Joyner M" first="Michael" last="Joyner">Michael Joyner</name><affiliation><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Jeffrey P" sort="Henderson, Jeffrey P" uniqKey="Henderson J" first="Jeffrey P" last="Henderson">Jeffrey P. Henderson</name><affiliation><nlm:affiliation>Departments of Medicine and Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Pekosz, Andrew" sort="Pekosz, Andrew" uniqKey="Pekosz A" first="Andrew" last="Pekosz">Andrew Pekosz</name><affiliation><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Lau, Bryan" sort="Lau, Bryan" uniqKey="Lau B" first="Bryan" last="Lau">Bryan Lau</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Wesolowski, Amy" sort="Wesolowski, Amy" uniqKey="Wesolowski A" first="Amy" last="Wesolowski">Amy Wesolowski</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Katz, Louis" sort="Katz, Louis" uniqKey="Katz L" first="Louis" last="Katz">Louis Katz</name><affiliation><nlm:affiliation>Blood Center, Mississippi Valley Regional Blood Center, Davenport, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Shan, Hua" sort="Shan, Hua" uniqKey="Shan H" first="Hua" last="Shan">Hua Shan</name><affiliation><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Palo Alto, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Auwaerter, Paul G" sort="Auwaerter, Paul G" uniqKey="Auwaerter P" first="Paul G" last="Auwaerter">Paul G. Auwaerter</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, David" sort="Thomas, David" uniqKey="Thomas D" first="David" last="Thomas">David Thomas</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Sullivan, David J" sort="Sullivan, David J" uniqKey="Sullivan D" first="David J" last="Sullivan">David J. Sullivan</name><affiliation><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Paneth, Nigel" sort="Paneth, Nigel" uniqKey="Paneth N" first="Nigel" last="Paneth">Nigel Paneth</name><affiliation><nlm:affiliation>Departments of Epidemiology and Biostatistics and Pediatrics, and Human Dev, Michigan State University, East Lansing, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Gehrie, Eric" sort="Gehrie, Eric" uniqKey="Gehrie E" first="Eric" last="Gehrie">Eric Gehrie</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Spitalnik, Steven" sort="Spitalnik, Steven" uniqKey="Spitalnik S" first="Steven" last="Spitalnik">Steven Spitalnik</name><affiliation><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hod, Eldad" sort="Hod, Eldad" uniqKey="Hod E" first="Eldad" last="Hod">Eldad Hod</name><affiliation><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Pollack, Lewis" sort="Pollack, Lewis" uniqKey="Pollack L" first="Lewis" last="Pollack">Lewis Pollack</name><affiliation><nlm:affiliation>Independent Consultant, unknown, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Nicholson, Wayne T" sort="Nicholson, Wayne T" uniqKey="Nicholson W" first="Wayne T" last="Nicholson">Wayne T. Nicholson</name><affiliation><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Pirofski, Liise Anne" sort="Pirofski, Liise Anne" uniqKey="Pirofski L" first="Liise-Anne" last="Pirofski">Liise-Anne Pirofski</name><affiliation><nlm:affiliation>Departments of Infectious Diseases, Albert Einstein College of Medicine, Bronx, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Bailey, Jeffrey A" sort="Bailey, Jeffrey A" uniqKey="Bailey J" first="Jeffrey A" last="Bailey">Jeffrey A. Bailey</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Tobian, Aaron Ar" sort="Tobian, Aaron Ar" uniqKey="Tobian A" first="Aaron Ar" last="Tobian">Aaron Ar Tobian</name><affiliation><nlm:affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of clinical investigation</title><idno type="eISSN">1558-8238</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. Immune (i.e. "convalescent") plasma refers to plasma that is collected from individuals, following resolution of infection and development of antibodies. Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy to confer immediate immunity to susceptible individuals. There are numerous examples, where convalescent plasma has been used successfully as post-exposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East Respiratory Syndrome [MERS]). Convalescent plasma has also been used in the COVID-19 pandemic; limited data from China suggest clinical benefit, including radiological resolution, reduction in viral loads and improved survival. Globally, blood centers have robust infrastructure to undertake collections and construct inventories of convalescent plasma to meet the growing demand. Nonetheless, there are nuanced challenges, both regulatory and logistical, spanning donor eligibility, donor recruitment, collections and transfusion itself. Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). We provide an overview of convalescent plasma, from evidence of benefit, regulatory considerations, logistical work flow and proposed clinical trials, as scale up is brought underway to mobilize this critical resource. .</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32254064</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-8238</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>07</Day></PubDate></JournalIssue><Title>The Journal of clinical investigation</Title><ISOAbbreviation>J. Clin. Invest.</ISOAbbreviation></Journal><ArticleTitle>Deployment of convalescent plasma for the prevention and treatment of COVID-19.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1172/JCI138745</ELocationID><ELocationID EIdType="pii" ValidYN="Y">138745</ELocationID><Abstract><AbstractText>Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. Immune (i.e. "convalescent") plasma refers to plasma that is collected from individuals, following resolution of infection and development of antibodies. Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy to confer immediate immunity to susceptible individuals. There are numerous examples, where convalescent plasma has been used successfully as post-exposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East Respiratory Syndrome [MERS]). Convalescent plasma has also been used in the COVID-19 pandemic; limited data from China suggest clinical benefit, including radiological resolution, reduction in viral loads and improved survival. Globally, blood centers have robust infrastructure to undertake collections and construct inventories of convalescent plasma to meet the growing demand. Nonetheless, there are nuanced challenges, both regulatory and logistical, spanning donor eligibility, donor recruitment, collections and transfusion itself. Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). We provide an overview of convalescent plasma, from evidence of benefit, regulatory considerations, logistical work flow and proposed clinical trials, as scale up is brought underway to mobilize this critical resource. .</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bloch</LastName><ForeName>Evan M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shoham</LastName><ForeName>Shmuel</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casadevall</LastName><ForeName>Arturo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sachais</LastName><ForeName>Bruce S</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Hematology, New York Blood Center Enterprises, New York, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaz</LastName><ForeName>Beth</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Hematology, New York Blood Center Enterprises, New York, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winters</LastName><ForeName>Jeffrey L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Division of Transfusion Medicine, Department of Laboratory Medicine and Pat, Mayo Clinic, Rochester, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Buskirk</LastName><ForeName>Camille</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Transfusion Medicine, Department of Laboratory Medicine and Pat, Mayo Clinic, Rochester, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grossman</LastName><ForeName>Brenda J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Department of Pathology, Washington University School of Medicine in St. Louis, St. Louis, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joyner</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>Jeffrey P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Departments of Medicine and Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pekosz</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>Bryan</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wesolowski</LastName><ForeName>Amy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>Louis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Blood Center, Mississippi Valley Regional Blood Center, Davenport, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shan</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Palo Alto, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auwaerter</LastName><ForeName>Paul G</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sullivan</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paneth</LastName><ForeName>Nigel</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Departments of Epidemiology and Biostatistics and Pediatrics, and Human Dev, Michigan State University, East Lansing, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gehrie</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spitalnik</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hod</LastName><ForeName>Eldad</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pollack</LastName><ForeName>Lewis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Independent Consultant, unknown, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicholson</LastName><ForeName>Wayne T</ForeName><Initials>WT</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pirofski</LastName><ForeName>Liise-Anne</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Departments of Infectious Diseases, Albert Einstein College of Medicine, Bronx, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Jeffrey A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tobian</LastName><ForeName>Aaron Ar</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States of America.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Invest</MedlineTA><NlmUniqueID>7802877</NlmUniqueID><ISSNLinking>0021-9738</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32254064</ArticleId><ArticleId IdType="pii">138745</ArticleId><ArticleId IdType="doi">10.1172/JCI138745</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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