SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview
Identifieur interne : 002971 ( PubMed/Checkpoint ); précédent : 002970; suivant : 002972SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview
Auteurs : Ali A. Rabaan [Arabie saoudite] ; Shamsah H. Al-Ahmed [Arabie saoudite] ; Shafiul Haque [Arabie saoudite] ; Ranjit Sah [Népal] ; Ruchi Tiwari [Inde] ; Yashpal Singh Malik [Inde] ; Kuldeep Dhama [Inde] ; M Iqbal Yatoo [Inde] ; D Katterine Bonilla-Aldana ; Alfonso J. Rodriguez-Morales [Colombie]Source :
- Le infezioni in medicina [ 1124-9390 ]
Descripteurs français
- KwdFr :
- Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Pandémies, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- épidémiologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Humains, Pandémies.
English descriptors
- KwdEn :
- Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Betacoronavirus (pathogenicity), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Pandemics, SARS Virus (genetics), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- epidemiology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- genetics : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- isolation & purification : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- pathogenicity : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Humans, Pandemics.
Abstract
The recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV.
PubMed: 32275259
Affiliations:
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pubmed:32275259Le document en format XML
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<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
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<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
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<term>Pandemics</term>
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<front><div type="abstract" xml:lang="en">The recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>15</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>28</Volume>
<Issue>2</Issue>
<PubDate><MedlineDate>2020 Ahead Of Print Jun 1</MedlineDate>
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<Title>Le infezioni in medicina</Title>
<ISOAbbreviation>Infez Med</ISOAbbreviation>
</Journal>
<ArticleTitle>SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview</ArticleTitle>
<Pagination><MedlinePgn>174-184</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rabaan</LastName>
<ForeName>Ali A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Ahmed</LastName>
<ForeName>Shamsah H</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Paediatric Medicine, Qatif Central Hospital, Qatif, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haque</LastName>
<ForeName>Shafiul</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sah</LastName>
<ForeName>Ranjit</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tiwari</LastName>
<ForeName>Ruchi</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Malik</LastName>
<ForeName>Yashpal Singh</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dhama</LastName>
<ForeName>Kuldeep</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yatoo</LastName>
<ForeName>M Iqbal</ForeName>
<Initials>MI</Initials>
<AffiliationInfo><Affiliation>Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar,Srinagar, Jammu and Kashmir, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bonilla-Aldana</LastName>
<ForeName>D Katterine</ForeName>
<Initials>DK</Initials>
<AffiliationInfo><Affiliation>Semillero de Zoonosis, Grupo de Investigacion BIOECOS, Fundacion Universitaria Autonoma de las Americas, Sede Pereira, Pereira, Risaralda, Colombia; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodriguez-Morales</LastName>
<ForeName>Alfonso J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Colombia; Grupo de Investigacion Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Americas, Pereira, Risaralda, Colombia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Italy</Country>
<MedlineTA>Infez Med</MedlineTA>
<NlmUniqueID>9613961</NlmUniqueID>
<ISSNLinking>1124-9390</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>4</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>4</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>4</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32275259</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Arabie saoudite</li>
<li>Colombie</li>
<li>Inde</li>
<li>Népal</li>
</country>
</list>
<tree><noCountry><name sortKey="Bonilla Aldana, D Katterine" sort="Bonilla Aldana, D Katterine" uniqKey="Bonilla Aldana D" first="D Katterine" last="Bonilla-Aldana">D Katterine Bonilla-Aldana</name>
</noCountry>
<country name="Arabie saoudite"><noRegion><name sortKey="Rabaan, Ali A" sort="Rabaan, Ali A" uniqKey="Rabaan A" first="Ali A" last="Rabaan">Ali A. Rabaan</name>
</noRegion>
<name sortKey="Al Ahmed, Shamsah H" sort="Al Ahmed, Shamsah H" uniqKey="Al Ahmed S" first="Shamsah H" last="Al-Ahmed">Shamsah H. Al-Ahmed</name>
<name sortKey="Haque, Shafiul" sort="Haque, Shafiul" uniqKey="Haque S" first="Shafiul" last="Haque">Shafiul Haque</name>
</country>
<country name="Népal"><noRegion><name sortKey="Sah, Ranjit" sort="Sah, Ranjit" uniqKey="Sah R" first="Ranjit" last="Sah">Ranjit Sah</name>
</noRegion>
</country>
<country name="Inde"><noRegion><name sortKey="Tiwari, Ruchi" sort="Tiwari, Ruchi" uniqKey="Tiwari R" first="Ruchi" last="Tiwari">Ruchi Tiwari</name>
</noRegion>
<name sortKey="Dhama, Kuldeep" sort="Dhama, Kuldeep" uniqKey="Dhama K" first="Kuldeep" last="Dhama">Kuldeep Dhama</name>
<name sortKey="Malik, Yashpal Singh" sort="Malik, Yashpal Singh" uniqKey="Malik Y" first="Yashpal Singh" last="Malik">Yashpal Singh Malik</name>
<name sortKey="Yatoo, M Iqbal" sort="Yatoo, M Iqbal" uniqKey="Yatoo M" first="M Iqbal" last="Yatoo">M Iqbal Yatoo</name>
</country>
<country name="Colombie"><noRegion><name sortKey="Rodriguez Morales, Alfonso J" sort="Rodriguez Morales, Alfonso J" uniqKey="Rodriguez Morales A" first="Alfonso J" last="Rodriguez-Morales">Alfonso J. Rodriguez-Morales</name>
</noRegion>
</country>
</tree>
</affiliations>
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