Computerized polymorphic marker identification: experimental validation and a predicted human polymorphism catalog.
Identifieur interne : 002547 ( PubMed/Checkpoint ); précédent : 002546; suivant : 002548Computerized polymorphic marker identification: experimental validation and a predicted human polymorphism catalog.
Auteurs : J W Fondon [États-Unis] ; G M Mele ; R I Brezinschek ; D. Cummings ; A. Pande ; J. Wren ; K M O'Brien ; K C Kupfer ; M H Wei ; M. Lerman ; J D Minna ; H R GarnerSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 1998.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
A computational system for the prediction of polymorphic loci directly and efficiently from human genomic sequence was developed and verified. A suite of programs, collectively called POMPOUS (polymorphic marker prediction of ubiquitous simple sequences) detects tandem repeats ranging from dinucleotides up to 250 mers, scores them according to predicted level of polymorphism, and designs appropriate flanking primers for PCR amplification. This approach was validated on an approximately 750-kilobase region of human chromosome 3p21.3, involved in lung and breast carcinoma homozygous deletions. Target DNA from 36 paired B lymphoblastoid and lung cancer lines was amplified and allelotyped for 33 loci predicted by POMPOUS to be variable in repeat size. We found that among those 36 predominately Caucasian individuals 22 of the 33 (67%) predicted loci were polymorphic with an average heterozygosity of 0.42. Allele loss in this region was found in 27/36 (75%) of the tumor lines using these markers. POMPOUS provides the genetic researcher with an additional tool for the rapid and efficient identification of polymorphic markers, and through a World Wide Web site, investigators can use POMPOUS to identify polymorphic markers for their research. A catalog of 13,261 potential polymorphic markers and associated primer sets has been created from the analysis of 141,779,504 base pairs of human genomic sequence in GenBank. This data is available on our Web site (pompous.swmed.edu) and will be updated periodically as GenBank is expanded and algorithm accuracy is improved.
DOI: 10.1073/pnas.95.13.7514
PubMed: 9636181
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:9636181Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Computerized polymorphic marker identification: experimental validation and a predicted human polymorphism catalog.</title><author><name sortKey="Fondon, J W" sort="Fondon, J W" uniqKey="Fondon J" first="J W" last="Fondon">J W Fondon</name><affiliation wicri:level="2"><nlm:affiliation>McDermott Center for Human Growth and Development and the Center for Biomedical Inventions, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>McDermott Center for Human Growth and Development and the Center for Biomedical Inventions, The University of Texas Southwestern Medical Center, Dallas, TX 75235</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mele, G M" sort="Mele, G M" uniqKey="Mele G" first="G M" last="Mele">G M Mele</name></author><author><name sortKey="Brezinschek, R I" sort="Brezinschek, R I" uniqKey="Brezinschek R" first="R I" last="Brezinschek">R I Brezinschek</name></author><author><name sortKey="Cummings, D" sort="Cummings, D" uniqKey="Cummings D" first="D" last="Cummings">D. Cummings</name></author><author><name sortKey="Pande, A" sort="Pande, A" uniqKey="Pande A" first="A" last="Pande">A. Pande</name></author><author><name sortKey="Wren, J" sort="Wren, J" uniqKey="Wren J" first="J" last="Wren">J. Wren</name></author><author><name sortKey="O Brien, K M" sort="O Brien, K M" uniqKey="O Brien K" first="K M" last="O'Brien">K M O'Brien</name></author><author><name sortKey="Kupfer, K C" sort="Kupfer, K C" uniqKey="Kupfer K" first="K C" last="Kupfer">K C Kupfer</name></author><author><name sortKey="Wei, M H" sort="Wei, M H" uniqKey="Wei M" first="M H" last="Wei">M H Wei</name></author><author><name sortKey="Lerman, M" sort="Lerman, M" uniqKey="Lerman M" first="M" last="Lerman">M. Lerman</name></author><author><name sortKey="Minna, J D" sort="Minna, J D" uniqKey="Minna J" first="J D" last="Minna">J D Minna</name></author><author><name sortKey="Garner, H R" sort="Garner, H R" uniqKey="Garner H" first="H R" last="Garner">H R Garner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9636181</idno><idno type="pmid">9636181</idno><idno type="doi">10.1073/pnas.95.13.7514</idno><idno type="wicri:Area/PubMed/Corpus">002682</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002682</idno><idno type="wicri:Area/PubMed/Curation">002682</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002682</idno><idno type="wicri:Area/PubMed/Checkpoint">002547</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002547</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Computerized polymorphic marker identification: experimental validation and a predicted human polymorphism catalog.</title><author><name sortKey="Fondon, J W" sort="Fondon, J W" uniqKey="Fondon J" first="J W" last="Fondon">J W Fondon</name><affiliation wicri:level="2"><nlm:affiliation>McDermott Center for Human Growth and Development and the Center for Biomedical Inventions, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>McDermott Center for Human Growth and Development and the Center for Biomedical Inventions, The University of Texas Southwestern Medical Center, Dallas, TX 75235</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mele, G M" sort="Mele, G M" uniqKey="Mele G" first="G M" last="Mele">G M Mele</name></author><author><name sortKey="Brezinschek, R I" sort="Brezinschek, R I" uniqKey="Brezinschek R" first="R I" last="Brezinschek">R I Brezinschek</name></author><author><name sortKey="Cummings, D" sort="Cummings, D" uniqKey="Cummings D" first="D" last="Cummings">D. Cummings</name></author><author><name sortKey="Pande, A" sort="Pande, A" uniqKey="Pande A" first="A" last="Pande">A. Pande</name></author><author><name sortKey="Wren, J" sort="Wren, J" uniqKey="Wren J" first="J" last="Wren">J. Wren</name></author><author><name sortKey="O Brien, K M" sort="O Brien, K M" uniqKey="O Brien K" first="K M" last="O'Brien">K M O'Brien</name></author><author><name sortKey="Kupfer, K C" sort="Kupfer, K C" uniqKey="Kupfer K" first="K C" last="Kupfer">K C Kupfer</name></author><author><name sortKey="Wei, M H" sort="Wei, M H" uniqKey="Wei M" first="M H" last="Wei">M H Wei</name></author><author><name sortKey="Lerman, M" sort="Lerman, M" uniqKey="Lerman M" first="M" last="Lerman">M. Lerman</name></author><author><name sortKey="Minna, J D" sort="Minna, J D" uniqKey="Minna J" first="J D" last="Minna">J D Minna</name></author><author><name sortKey="Garner, H R" sort="Garner, H R" uniqKey="Garner H" first="H R" last="Garner">H R Garner</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Communication Networks</term><term>Genetic Markers</term><term>Human Genome Project</term><term>Humans</term><term>Numerical Analysis, Computer-Assisted</term><term>Polymorphism, Genetic</term><term>Repetitive Sequences, Nucleic Acid</term><term>Software</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse numérique assistée par ordinateur</term><term>Cellules cancéreuses en culture</term><term>Humains</term><term>Logiciel</term><term>Marqueurs génétiques</term><term>Polymorphisme génétique</term><term>Projet génome humain</term><term>Réseaux de communication entre ordinateurs</term><term>Séquences répétées d'acides nucléiques</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Communication Networks</term><term>Human Genome Project</term><term>Humans</term><term>Numerical Analysis, Computer-Assisted</term><term>Polymorphism, Genetic</term><term>Repetitive Sequences, Nucleic Acid</term><term>Software</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse numérique assistée par ordinateur</term><term>Cellules cancéreuses en culture</term><term>Humains</term><term>Logiciel</term><term>Marqueurs génétiques</term><term>Polymorphisme génétique</term><term>Projet génome humain</term><term>Réseaux de communication entre ordinateurs</term><term>Séquences répétées d'acides nucléiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A computational system for the prediction of polymorphic loci directly and efficiently from human genomic sequence was developed and verified. A suite of programs, collectively called POMPOUS (polymorphic marker prediction of ubiquitous simple sequences) detects tandem repeats ranging from dinucleotides up to 250 mers, scores them according to predicted level of polymorphism, and designs appropriate flanking primers for PCR amplification. This approach was validated on an approximately 750-kilobase region of human chromosome 3p21.3, involved in lung and breast carcinoma homozygous deletions. Target DNA from 36 paired B lymphoblastoid and lung cancer lines was amplified and allelotyped for 33 loci predicted by POMPOUS to be variable in repeat size. We found that among those 36 predominately Caucasian individuals 22 of the 33 (67%) predicted loci were polymorphic with an average heterozygosity of 0.42. Allele loss in this region was found in 27/36 (75%) of the tumor lines using these markers. POMPOUS provides the genetic researcher with an additional tool for the rapid and efficient identification of polymorphic markers, and through a World Wide Web site, investigators can use POMPOUS to identify polymorphic markers for their research. A catalog of 13,261 potential polymorphic markers and associated primer sets has been created from the analysis of 141,779,504 base pairs of human genomic sequence in GenBank. This data is available on our Web site (pompous.swmed.edu) and will be updated periodically as GenBank is expanded and algorithm accuracy is improved.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9636181</PMID><DateCompleted><Year>1998</Year><Month>08</Month><Day>06</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0027-8424</ISSN><JournalIssue CitedMedium="Print"><Volume>95</Volume><Issue>13</Issue><PubDate><Year>1998</Year><Month>Jun</Month><Day>23</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation></Journal><ArticleTitle>Computerized polymorphic marker identification: experimental validation and a predicted human polymorphism catalog.</ArticleTitle><Pagination><MedlinePgn>7514-9</MedlinePgn></Pagination><Abstract><AbstractText>A computational system for the prediction of polymorphic loci directly and efficiently from human genomic sequence was developed and verified. A suite of programs, collectively called POMPOUS (polymorphic marker prediction of ubiquitous simple sequences) detects tandem repeats ranging from dinucleotides up to 250 mers, scores them according to predicted level of polymorphism, and designs appropriate flanking primers for PCR amplification. This approach was validated on an approximately 750-kilobase region of human chromosome 3p21.3, involved in lung and breast carcinoma homozygous deletions. Target DNA from 36 paired B lymphoblastoid and lung cancer lines was amplified and allelotyped for 33 loci predicted by POMPOUS to be variable in repeat size. We found that among those 36 predominately Caucasian individuals 22 of the 33 (67%) predicted loci were polymorphic with an average heterozygosity of 0.42. Allele loss in this region was found in 27/36 (75%) of the tumor lines using these markers. POMPOUS provides the genetic researcher with an additional tool for the rapid and efficient identification of polymorphic markers, and through a World Wide Web site, investigators can use POMPOUS to identify polymorphic markers for their research. A catalog of 13,261 potential polymorphic markers and associated primer sets has been created from the analysis of 141,779,504 base pairs of human genomic sequence in GenBank. This data is available on our Web site (pompous.swmed.edu) and will be updated periodically as GenBank is expanded and algorithm accuracy is improved.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fondon</LastName><ForeName>J W</ForeName><Initials>JW</Initials><Suffix>3rd</Suffix><AffiliationInfo><Affiliation>McDermott Center for Human Growth and Development and the Center for Biomedical Inventions, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mele</LastName><ForeName>G M</ForeName><Initials>GM</Initials></Author><Author ValidYN="Y"><LastName>Brezinschek</LastName><ForeName>R I</ForeName><Initials>RI</Initials></Author><Author ValidYN="Y"><LastName>Cummings</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Pande</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Wren</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>O'Brien</LastName><ForeName>K M</ForeName><Initials>KM</Initials></Author><Author ValidYN="Y"><LastName>Kupfer</LastName><ForeName>K C</ForeName><Initials>KC</Initials></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>M H</ForeName><Initials>MH</Initials></Author><Author ValidYN="Y"><LastName>Lerman</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Minna</LastName><ForeName>J D</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Garner</LastName><ForeName>H R</ForeName><Initials>HR</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P50 CA070907</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA071618</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA 71618</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 CA70907</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005819">Genetic Markers</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D003195" MajorTopicYN="N">Computer Communication Networks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005819" MajorTopicYN="Y">Genetic Markers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016045" MajorTopicYN="N">Human Genome Project</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009716" MajorTopicYN="N">Numerical Analysis, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="Y">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012091" MajorTopicYN="N">Repetitive Sequences, Nucleic Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012984" MajorTopicYN="N">Software</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014407" MajorTopicYN="N">Tumor Cells, Cultured</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>6</Month><Day>24</Day><Hour>2</Hour><Minute>2</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>6</Month><Day>24</Day><Hour>2</Hour><Minute>2</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9636181</ArticleId><ArticleId IdType="pmc">PMC22669</ArticleId><ArticleId IdType="doi">10.1073/pnas.95.13.7514</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Science. 1987 Mar 27;235(4796):1616-22</Citation><ArticleIdList><ArticleId IdType="pubmed">3029872</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1985 Mar 22;227(4693):1435-41</Citation><ArticleIdList><ArticleId IdType="pubmed">2983426</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 1990 Aug;7(4):524-30</Citation><ArticleIdList><ArticleId IdType="pubmed">1974878</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 1990 Oct 5;215(3):403-10</Citation><ArticleIdList><ArticleId IdType="pubmed">2231712</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2002-6</Citation><ArticleIdList><ArticleId IdType="pubmed">1549558</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3419-23</Citation><ArticleIdList><ArticleId IdType="pubmed">1314388</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 1992 Jul;13(3):820-5</Citation><ArticleIdList><ArticleId IdType="pubmed">1386339</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1992 Oct 29;359(6398):794-801</Citation><ArticleIdList><ArticleId IdType="pubmed">1436057</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Genet Dev. 1992 Dec;2(6):850-6</Citation><ArticleIdList><ArticleId IdType="pubmed">1477530</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 1993 Jul;8(7):1721-9</Citation><ArticleIdList><ArticleId IdType="pubmed">8390035</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 1993 Jun;16(3):655-63</Citation><ArticleIdList><ArticleId IdType="pubmed">8100801</ArticleId></ArticleIdList></Reference><Reference><Citation>Genet Anal Tech Appl. 1993 Feb;10(1):2-5</Citation><ArticleIdList><ArticleId IdType="pubmed">8329220</ArticleId></ArticleIdList></Reference><Reference><Citation>Comput Appl Biosci. 1994 Feb;10(1):67-70</Citation><ArticleIdList><ArticleId IdType="pubmed">7514951</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hum Genet. 1994 Jul;55(1):175-89</Citation><ArticleIdList><ArticleId IdType="pubmed">7912887</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 1994 Nov 11;22(22):4828-36</Citation><ArticleIdList><ArticleId IdType="pubmed">7984436</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 1995 Jan 1;25(1):1-8</Citation><ArticleIdList><ArticleId IdType="pubmed">7774906</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 1995 Apr;4(4):727-9</Citation><ArticleIdList><ArticleId IdType="pubmed">7633423</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 1995 Sep;4(9):1485-91</Citation><ArticleIdList><ArticleId IdType="pubmed">8541830</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 1995 Oct 10;29(3):760-5</Citation><ArticleIdList><ArticleId IdType="pubmed">8575771</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 1995 Oct;4(10):1829-36</Citation><ArticleIdList><ArticleId IdType="pubmed">8595403</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 1995 Oct;4(10):1837-44</Citation><ArticleIdList><ArticleId IdType="pubmed">8595404</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 1995 Dec 21;11(12):2591-8</Citation><ArticleIdList><ArticleId IdType="pubmed">8545116</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1996 Mar 14;380(6570):152-4</Citation><ArticleIdList><ArticleId IdType="pubmed">8600387</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1996 Apr 12;272(5259):188-9</Citation><ArticleIdList><ArticleId IdType="pubmed">8602498</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 1996 Apr 1;56(7):1487-92</Citation><ArticleIdList><ArticleId IdType="pubmed">8603390</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hum Genet. 1996 Aug;59(2):360-7</Citation><ArticleIdList><ArticleId IdType="pubmed">8755922</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biotechnol. 1996 Jun;5(3):233-41</Citation><ArticleIdList><ArticleId IdType="pubmed">8837029</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 1997 Mar 15;40(3):476-85</Citation><ArticleIdList><ArticleId IdType="pubmed">9073516</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 1997 Apr 1;57(7):1344-52</Citation><ArticleIdList><ArticleId IdType="pubmed">9102223</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Cancer Res. 1997;71:27-92</Citation><ArticleIdList><ArticleId IdType="pubmed">9111863</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1981 Dec;78(12):7665-9</Citation><ArticleIdList><ArticleId IdType="pubmed">6801656</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1985 Mar 7-13;314(6006):67-73</Citation><ArticleIdList><ArticleId IdType="pubmed">3856104</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1988 Apr;85(8):2444-8</Citation><ArticleIdList><ArticleId IdType="pubmed">3162770</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="Brezinschek, R I" sort="Brezinschek, R I" uniqKey="Brezinschek R" first="R I" last="Brezinschek">R I Brezinschek</name><name sortKey="Cummings, D" sort="Cummings, D" uniqKey="Cummings D" first="D" last="Cummings">D. Cummings</name><name sortKey="Garner, H R" sort="Garner, H R" uniqKey="Garner H" first="H R" last="Garner">H R Garner</name><name sortKey="Kupfer, K C" sort="Kupfer, K C" uniqKey="Kupfer K" first="K C" last="Kupfer">K C Kupfer</name><name sortKey="Lerman, M" sort="Lerman, M" uniqKey="Lerman M" first="M" last="Lerman">M. Lerman</name><name sortKey="Mele, G M" sort="Mele, G M" uniqKey="Mele G" first="G M" last="Mele">G M Mele</name><name sortKey="Minna, J D" sort="Minna, J D" uniqKey="Minna J" first="J D" last="Minna">J D Minna</name><name sortKey="O Brien, K M" sort="O Brien, K M" uniqKey="O Brien K" first="K M" last="O'Brien">K M O'Brien</name><name sortKey="Pande, A" sort="Pande, A" uniqKey="Pande A" first="A" last="Pande">A. Pande</name><name sortKey="Wei, M H" sort="Wei, M H" uniqKey="Wei M" first="M H" last="Wei">M H Wei</name><name sortKey="Wren, J" sort="Wren, J" uniqKey="Wren J" first="J" last="Wren">J. Wren</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Fondon, J W" sort="Fondon, J W" uniqKey="Fondon J" first="J W" last="Fondon">J W Fondon</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002547 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002547 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:9636181
|texte= Computerized polymorphic marker identification: experimental validation and a predicted human polymorphism catalog.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:9636181" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |