MersV1, PubMed, Checkpoint, bibRecord, 002458

trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.

Identifieur interne : 002458 ( PubMed/Checkpoint ); précédent : 002457; suivant : 002459

trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.

Auteurs : M B Janik [Allemagne] ; B. Lippert

Source :

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [ 0949-8257 ] ; 1999.

RBID : pubmed:10550694

Descripteurs français

English descriptors

KwdEn :
- Cisplatin (chemistry), Cisplatin (pharmacology), Cross-Linking Reagents (chemistry), Cross-Linking Reagents (pharmacology), DNA Replication (drug effects), Hydrolysis, Magnetic Resonance Spectroscopy, Mass Spectrometry, Nucleic Acid Conformation, Nucleic Acid Hybridization, Oligodeoxyribonucleotides, Antisense (chemistry), Oligodeoxyribonucleotides, Antisense (pharmacology), Purines (metabolism), RNA, Messenger (drug effects), Stereoisomerism, Transcription, Genetic (drug effects).
MESH :
- chemical , chemistry : Cisplatin, Cross-Linking Reagents, Oligodeoxyribonucleotides, Antisense.
- chemical , drug effects : RNA, Messenger.
- chemical , metabolism : Purines.
- chemical , pharmacology : Cisplatin, Cross-Linking Reagents, Oligodeoxyribonucleotides, Antisense.
- drug effects : DNA Replication, Transcription, Genetic.
- Hydrolysis, Magnetic Resonance Spectroscopy, Mass Spectrometry, Nucleic Acid Conformation, Nucleic Acid Hybridization, Stereoisomerism.

Abstract

An approach is presented which probes the possible use of trans-[(NH3)(2)PtCl](+)-modified deoxyoligonucleotides in the antisense strategy. It consists of (1) the selective platination of an oligonucleotide containing 11 pyrimidine (T, C) bases as well as a single guanine (G) as a Pt-anchoring group at the 5'-end to give trans-[(NH3)(2)Pt¿5'-d(G(N7)T(2)C(2)T(2)C(2)T(2)C¿Cl](10-) 1 ("antisense strand") and (2) subsequent hybridization with the purine 12-mer 5'-d(GA(2)G(2)A(2)G(2)A(2)G)(11-) ("sense strand"). According to HPLC, three major species 2-4 are formed during reaction (2), all of which are cross-linking adducts between 1 and the sense strand, as confirmed by ESI MS and melting temperature measurements. Only for the major product 3 can a structure be proposed on the basis of 1D and 2D NMR spectra. According to these, G(1) of the antisense strand is cross-linked with G(20) via trans-(NH3)(2)Pt(II). The complementary overhangs of the duplex represent "sticky ends" and are, in principle, capable of associating into multimers of the duplex.

DOI: 10.1007/s007750050388
PubMed: 10550694

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002614
to stream PubMed, to step Curation: 002614

Links to Exploration step

pubmed:10550694

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.</title>
<author><name sortKey="Janik, M B" sort="Janik, M B" uniqKey="Janik M" first="M B" last="Janik">M B Janik</name>
<affiliation wicri:level="3"><nlm:affiliation>Fachbereich Chemie, Universität Dortmund Otto-Hahn-Strasse 6, D-44221 Dortmund, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Fachbereich Chemie, Universität Dortmund Otto-Hahn-Strasse 6, D-44221 Dortmund</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District d'Arnsberg</region>
<settlement type="city">Dortmund</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lippert, B" sort="Lippert, B" uniqKey="Lippert B" first="B" last="Lippert">B. Lippert</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1999">1999</date>
<idno type="RBID">pubmed:10550694</idno>
<idno type="pmid">10550694</idno>
<idno type="doi">10.1007/s007750050388</idno>
<idno type="wicri:Area/PubMed/Corpus">002614</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002614</idno>
<idno type="wicri:Area/PubMed/Curation">002614</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002614</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002458</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002458</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.</title>
<author><name sortKey="Janik, M B" sort="Janik, M B" uniqKey="Janik M" first="M B" last="Janik">M B Janik</name>
<affiliation wicri:level="3"><nlm:affiliation>Fachbereich Chemie, Universität Dortmund Otto-Hahn-Strasse 6, D-44221 Dortmund, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Fachbereich Chemie, Universität Dortmund Otto-Hahn-Strasse 6, D-44221 Dortmund</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District d'Arnsberg</region>
<settlement type="city">Dortmund</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lippert, B" sort="Lippert, B" uniqKey="Lippert B" first="B" last="Lippert">B. Lippert</name>
</author>
</analytic>
<series><title level="j">Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry</title>
<idno type="ISSN">0949-8257</idno>
<imprint><date when="1999" type="published">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cisplatin (chemistry)</term>
<term>Cisplatin (pharmacology)</term>
<term>Cross-Linking Reagents (chemistry)</term>
<term>Cross-Linking Reagents (pharmacology)</term>
<term>DNA Replication (drug effects)</term>
<term>Hydrolysis</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Mass Spectrometry</term>
<term>Nucleic Acid Conformation</term>
<term>Nucleic Acid Hybridization</term>
<term>Oligodeoxyribonucleotides, Antisense (chemistry)</term>
<term>Oligodeoxyribonucleotides, Antisense (pharmacology)</term>
<term>Purines (metabolism)</term>
<term>RNA, Messenger (drug effects)</term>
<term>Stereoisomerism</term>
<term>Transcription, Genetic (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager ()</term>
<term>Cisplatine ()</term>
<term>Cisplatine (pharmacologie)</term>
<term>Conformation d'acide nucléique</term>
<term>Hybridation d'acides nucléiques</term>
<term>Hydrolyse</term>
<term>Oligodésoxyribonucléotides antisens ()</term>
<term>Oligodésoxyribonucléotides antisens (pharmacologie)</term>
<term>Purines (métabolisme)</term>
<term>Réactifs réticulants ()</term>
<term>Réactifs réticulants (pharmacologie)</term>
<term>Réplication de l'ADN ()</term>
<term>Spectrométrie de masse</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Stéréoisomérie</term>
<term>Transcription génétique ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cisplatin</term>
<term>Cross-Linking Reagents</term>
<term>Oligodeoxyribonucleotides, Antisense</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Purines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cisplatin</term>
<term>Cross-Linking Reagents</term>
<term>Oligodeoxyribonucleotides, Antisense</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>DNA Replication</term>
<term>Transcription, Genetic</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Purines</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Cisplatine</term>
<term>Oligodésoxyribonucléotides antisens</term>
<term>Réactifs réticulants</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Hydrolysis</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Mass Spectrometry</term>
<term>Nucleic Acid Conformation</term>
<term>Nucleic Acid Hybridization</term>
<term>Stereoisomerism</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ARN messager</term>
<term>Cisplatine</term>
<term>Conformation d'acide nucléique</term>
<term>Hybridation d'acides nucléiques</term>
<term>Hydrolyse</term>
<term>Oligodésoxyribonucléotides antisens</term>
<term>Réactifs réticulants</term>
<term>Réplication de l'ADN</term>
<term>Spectrométrie de masse</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Stéréoisomérie</term>
<term>Transcription génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">An approach is presented which probes the possible use of trans-[(NH3)(2)PtCl](+)-modified deoxyoligonucleotides in the antisense strategy. It consists of (1) the selective platination of an oligonucleotide containing 11 pyrimidine (T, C) bases as well as a single guanine (G) as a Pt-anchoring group at the 5'-end to give trans-[(NH3)(2)Pt¿5'-d(G(N7)T(2)C(2)T(2)C(2)T(2)C¿Cl](10-) 1 ("antisense strand") and (2) subsequent hybridization with the purine 12-mer 5'-d(GA(2)G(2)A(2)G(2)A(2)G)(11-) ("sense strand"). According to HPLC, three major species 2-4 are formed during reaction (2), all of which are cross-linking adducts between 1 and the sense strand, as confirmed by ESI MS and melting temperature measurements. Only for the major product 3 can a structure be proposed on the basis of 1D and 2D NMR spectra. According to these, G(1) of the antisense strand is cross-linked with G(20) via trans-(NH3)(2)Pt(II). The complementary overhangs of the duplex represent "sticky ends" and are, in principle, capable of associating into multimers of the duplex.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10550694</PMID>
<DateCompleted><Year>1999</Year>
<Month>11</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>11</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0949-8257</ISSN>
<JournalIssue CitedMedium="Print"><Volume>4</Volume>
<Issue>5</Issue>
<PubDate><Year>1999</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry</Title>
<ISOAbbreviation>J. Biol. Inorg. Chem.</ISOAbbreviation>
</Journal>
<ArticleTitle>trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.</ArticleTitle>
<Pagination><MedlinePgn>645-53</MedlinePgn>
</Pagination>
<Abstract><AbstractText>An approach is presented which probes the possible use of trans-[(NH3)(2)PtCl](+)-modified deoxyoligonucleotides in the antisense strategy. It consists of (1) the selective platination of an oligonucleotide containing 11 pyrimidine (T, C) bases as well as a single guanine (G) as a Pt-anchoring group at the 5'-end to give trans-[(NH3)(2)Pt¿5'-d(G(N7)T(2)C(2)T(2)C(2)T(2)C¿Cl](10-) 1 ("antisense strand") and (2) subsequent hybridization with the purine 12-mer 5'-d(GA(2)G(2)A(2)G(2)A(2)G)(11-) ("sense strand"). According to HPLC, three major species 2-4 are formed during reaction (2), all of which are cross-linking adducts between 1 and the sense strand, as confirmed by ESI MS and melting temperature measurements. Only for the major product 3 can a structure be proposed on the basis of 1D and 2D NMR spectra. According to these, G(1) of the antisense strand is cross-linked with G(20) via trans-(NH3)(2)Pt(II). The complementary overhangs of the duplex represent "sticky ends" and are, in principle, capable of associating into multimers of the duplex.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Janik</LastName>
<ForeName>M B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>Fachbereich Chemie, Universität Dortmund Otto-Hahn-Strasse 6, D-44221 Dortmund, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lippert</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>J Biol Inorg Chem</MedlineTA>
<NlmUniqueID>9616326</NlmUniqueID>
<ISSNLinking>0949-8257</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D003432">Cross-Linking Reagents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020319">Oligodeoxyribonucleotides, Antisense</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011687">Purines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>14913-33-8</RegistryNumber>
<NameOfSubstance UI="C034697">transplatin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>Q20Q21Q62J</RegistryNumber>
<NameOfSubstance UI="D002945">Cisplatin</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D002945" MajorTopicYN="N">Cisplatin</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003432" MajorTopicYN="N">Cross-Linking Reagents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004261" MajorTopicYN="N">DNA Replication</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006868" MajorTopicYN="N">Hydrolysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009690" MajorTopicYN="N">Nucleic Acid Conformation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009693" MajorTopicYN="N">Nucleic Acid Hybridization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020319" MajorTopicYN="N">Oligodeoxyribonucleotides, Antisense</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011687" MajorTopicYN="N">Purines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013237" MajorTopicYN="N">Stereoisomerism</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year>
<Month>11</Month>
<Day>7</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1999</Year>
<Month>11</Month>
<Day>7</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1999</Year>
<Month>11</Month>
<Day>7</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">10550694</ArticleId>
<ArticleId IdType="pii">90040645.775</ArticleId>
<ArticleId IdType="doi">10.1007/s007750050388</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>District d'Arnsberg</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Dortmund</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Lippert, B" sort="Lippert, B" uniqKey="Lippert B" first="B" last="Lippert">B. Lippert</name>
</noCountry>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Janik, M B" sort="Janik, M B" uniqKey="Janik M" first="M B" last="Janik">M B Janik</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002458 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002458 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:10550694
   |texte=   trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:10550694" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.

trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki