MersV1, PubMed, Checkpoint, bibRecord, 002309

Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.

Identifieur interne : 002309 ( PubMed/Checkpoint ); précédent : 002308; suivant : 002310

Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.

Auteurs : Rachel Schneerson [États-Unis] ; Joanna Kubler-Kielb ; Teh-Yung Liu ; Zhong-Dong Dai ; Stephen H. Leppla ; Alfred Yergey ; Peter Backlund ; Joseph Shiloach ; Fathy Majadly ; John B. Robbins

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2003.

RBID : pubmed:12857944

Descripteurs français

English descriptors

KwdEn :
- Animals, Anthrax (immunology), Anthrax (prevention & control), Anthrax Vaccines (administration & dosage), Anthrax Vaccines (chemistry), Antibodies, Bacterial (biosynthesis), Antigens, Bacterial (administration & dosage), Antigens, Bacterial (chemistry), Bacillus anthracis (immunology), Bacterial Toxins (administration & dosage), Bacterial Toxins (chemistry), Bacterial Toxins (immunology), Female, Immunoglobulin G (biosynthesis), Mice, Polyglutamic Acid (administration & dosage), Polyglutamic Acid (chemistry), Polyglutamic Acid (immunology), Vaccines, Conjugate (administration & dosage), Vaccines, Conjugate (chemistry).
MESH :
- chemical , administration & dosage : Anthrax Vaccines, Antigens, Bacterial, Bacterial Toxins, Polyglutamic Acid, Vaccines, Conjugate.
- chemical , biosynthesis : Antibodies, Bacterial, Immunoglobulin G.
- chemical , chemistry : Anthrax Vaccines, Antigens, Bacterial, Bacterial Toxins, Polyglutamic Acid, Vaccines, Conjugate.
- immunology : Anthrax, Bacillus anthracis, Bacterial Toxins, Polyglutamic Acid.
- prevention & control : Anthrax.
- Animals, Female, Mice.

Abstract

Both the protective antigen (PA) and the poly(gamma-d-glutamic acid) capsule (gamma dPGA) are essential for the virulence of Bacillus anthracis. A critical level of vaccine-induced IgG anti-PA confers immunity to anthrax, but there is no information about the protective action of IgG anti-gamma dPGA. Because the number of spores presented by bioterrorists might be greater than encountered in nature, we sought to induce capsular antibodies to expand the immunity conferred by available anthrax vaccines. The nonimmunogenic gamma dPGA or corresponding synthetic peptides were bound to BSA, recombinant B. anthracis PA (rPA), or recombinant Pseudomonas aeruginosa exotoxin A (rEPA). To identify the optimal construct, conjugates of B. anthracis gamma dPGA, Bacillus pumilus gamma dLPGA, and peptides of varying lengths (5-, 10-, or 20-mers), of the d or l configuration with active groups at the N or C termini, were bound at 5-32 mol per protein. The conjugates were characterized by physico-chemical and immunological assays, including GLC-MS and matrix-assisted laser desorption ionization time-of-flight spectrometry, and immunogenicity in 5- to 6-week-old mice. IgG anti-gamma dPGA and antiprotein were measured by ELISA. The highest levels of IgG anti-gamma dPGA were elicited by decamers of gamma dPGA at 10 -20 mol per protein bound to the N- or C-terminal end. High IgG anti-gamma dPGA levels were elicited by two injections of 2.5 microg of gamma dPGA per mouse, whereas three injections were needed to achieve high levels of protein antibodies. rPA was the most effective carrier. Anti-gamma dPGA induced opsonophagocytic killing of B. anthracis tox-, cap+. gamma dPGA conjugates may enhance the protection conferred by PA alone. gamma dPGA-rPA conjugates induced both anti-PA and anti-gamma dPGA.

DOI: 10.1073/pnas.1633512100
PubMed: 12857944

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002445
to stream PubMed, to step Curation: 002445

Links to Exploration step

pubmed:12857944

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.</title>
<author><name sortKey="Schneerson, Rachel" sort="Schneerson, Rachel" uniqKey="Schneerson R" first="Rachel" last="Schneerson">Rachel Schneerson</name>
<affiliation wicri:level="2"><nlm:affiliation>National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. schneerr@mail.nih.gov</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kubler Kielb, Joanna" sort="Kubler Kielb, Joanna" uniqKey="Kubler Kielb J" first="Joanna" last="Kubler-Kielb">Joanna Kubler-Kielb</name>
</author>
<author><name sortKey="Liu, Teh Yung" sort="Liu, Teh Yung" uniqKey="Liu T" first="Teh-Yung" last="Liu">Teh-Yung Liu</name>
</author>
<author><name sortKey="Dai, Zhong Dong" sort="Dai, Zhong Dong" uniqKey="Dai Z" first="Zhong-Dong" last="Dai">Zhong-Dong Dai</name>
</author>
<author><name sortKey="Leppla, Stephen H" sort="Leppla, Stephen H" uniqKey="Leppla S" first="Stephen H" last="Leppla">Stephen H. Leppla</name>
</author>
<author><name sortKey="Yergey, Alfred" sort="Yergey, Alfred" uniqKey="Yergey A" first="Alfred" last="Yergey">Alfred Yergey</name>
</author>
<author><name sortKey="Backlund, Peter" sort="Backlund, Peter" uniqKey="Backlund P" first="Peter" last="Backlund">Peter Backlund</name>
</author>
<author><name sortKey="Shiloach, Joseph" sort="Shiloach, Joseph" uniqKey="Shiloach J" first="Joseph" last="Shiloach">Joseph Shiloach</name>
</author>
<author><name sortKey="Majadly, Fathy" sort="Majadly, Fathy" uniqKey="Majadly F" first="Fathy" last="Majadly">Fathy Majadly</name>
</author>
<author><name sortKey="Robbins, John B" sort="Robbins, John B" uniqKey="Robbins J" first="John B" last="Robbins">John B. Robbins</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2003">2003</date>
<idno type="RBID">pubmed:12857944</idno>
<idno type="pmid">12857944</idno>
<idno type="doi">10.1073/pnas.1633512100</idno>
<idno type="wicri:Area/PubMed/Corpus">002445</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002445</idno>
<idno type="wicri:Area/PubMed/Curation">002445</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002445</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002309</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002309</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.</title>
<author><name sortKey="Schneerson, Rachel" sort="Schneerson, Rachel" uniqKey="Schneerson R" first="Rachel" last="Schneerson">Rachel Schneerson</name>
<affiliation wicri:level="2"><nlm:affiliation>National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. schneerr@mail.nih.gov</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kubler Kielb, Joanna" sort="Kubler Kielb, Joanna" uniqKey="Kubler Kielb J" first="Joanna" last="Kubler-Kielb">Joanna Kubler-Kielb</name>
</author>
<author><name sortKey="Liu, Teh Yung" sort="Liu, Teh Yung" uniqKey="Liu T" first="Teh-Yung" last="Liu">Teh-Yung Liu</name>
</author>
<author><name sortKey="Dai, Zhong Dong" sort="Dai, Zhong Dong" uniqKey="Dai Z" first="Zhong-Dong" last="Dai">Zhong-Dong Dai</name>
</author>
<author><name sortKey="Leppla, Stephen H" sort="Leppla, Stephen H" uniqKey="Leppla S" first="Stephen H" last="Leppla">Stephen H. Leppla</name>
</author>
<author><name sortKey="Yergey, Alfred" sort="Yergey, Alfred" uniqKey="Yergey A" first="Alfred" last="Yergey">Alfred Yergey</name>
</author>
<author><name sortKey="Backlund, Peter" sort="Backlund, Peter" uniqKey="Backlund P" first="Peter" last="Backlund">Peter Backlund</name>
</author>
<author><name sortKey="Shiloach, Joseph" sort="Shiloach, Joseph" uniqKey="Shiloach J" first="Joseph" last="Shiloach">Joseph Shiloach</name>
</author>
<author><name sortKey="Majadly, Fathy" sort="Majadly, Fathy" uniqKey="Majadly F" first="Fathy" last="Majadly">Fathy Majadly</name>
</author>
<author><name sortKey="Robbins, John B" sort="Robbins, John B" uniqKey="Robbins J" first="John B" last="Robbins">John B. Robbins</name>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<imprint><date when="2003" type="published">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Anthrax (immunology)</term>
<term>Anthrax (prevention & control)</term>
<term>Anthrax Vaccines (administration & dosage)</term>
<term>Anthrax Vaccines (chemistry)</term>
<term>Antibodies, Bacterial (biosynthesis)</term>
<term>Antigens, Bacterial (administration & dosage)</term>
<term>Antigens, Bacterial (chemistry)</term>
<term>Bacillus anthracis (immunology)</term>
<term>Bacterial Toxins (administration & dosage)</term>
<term>Bacterial Toxins (chemistry)</term>
<term>Bacterial Toxins (immunology)</term>
<term>Female</term>
<term>Immunoglobulin G (biosynthesis)</term>
<term>Mice</term>
<term>Polyglutamic Acid (administration & dosage)</term>
<term>Polyglutamic Acid (chemistry)</term>
<term>Polyglutamic Acid (immunology)</term>
<term>Vaccines, Conjugate (administration & dosage)</term>
<term>Vaccines, Conjugate (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide polyglutamique ()</term>
<term>Acide polyglutamique (administration et posologie)</term>
<term>Acide polyglutamique (immunologie)</term>
<term>Animaux</term>
<term>Anticorps antibactériens (biosynthèse)</term>
<term>Antigènes bactériens ()</term>
<term>Antigènes bactériens (administration et posologie)</term>
<term>Bacillus anthracis (immunologie)</term>
<term>Femelle</term>
<term>Immunoglobuline G (biosynthèse)</term>
<term>Maladie du charbon ()</term>
<term>Maladie du charbon (immunologie)</term>
<term>Souris</term>
<term>Toxines bactériennes ()</term>
<term>Toxines bactériennes (administration et posologie)</term>
<term>Toxines bactériennes (immunologie)</term>
<term>Vaccins anticharbonneux ()</term>
<term>Vaccins anticharbonneux (administration et posologie)</term>
<term>Vaccins conjugués ()</term>
<term>Vaccins conjugués (administration et posologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anthrax Vaccines</term>
<term>Antigens, Bacterial</term>
<term>Bacterial Toxins</term>
<term>Polyglutamic Acid</term>
<term>Vaccines, Conjugate</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Bacterial</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anthrax Vaccines</term>
<term>Antigens, Bacterial</term>
<term>Bacterial Toxins</term>
<term>Polyglutamic Acid</term>
<term>Vaccines, Conjugate</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acide polyglutamique</term>
<term>Antigènes bactériens</term>
<term>Toxines bactériennes</term>
<term>Vaccins anticharbonneux</term>
<term>Vaccins conjugués</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antibactériens</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Acide polyglutamique</term>
<term>Bacillus anthracis</term>
<term>Maladie du charbon</term>
<term>Toxines bactériennes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Anthrax</term>
<term>Bacillus anthracis</term>
<term>Bacterial Toxins</term>
<term>Polyglutamic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Anthrax</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Acide polyglutamique</term>
<term>Animaux</term>
<term>Antigènes bactériens</term>
<term>Femelle</term>
<term>Maladie du charbon</term>
<term>Souris</term>
<term>Toxines bactériennes</term>
<term>Vaccins anticharbonneux</term>
<term>Vaccins conjugués</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Both the protective antigen (PA) and the poly(gamma-d-glutamic acid) capsule (gamma dPGA) are essential for the virulence of Bacillus anthracis. A critical level of vaccine-induced IgG anti-PA confers immunity to anthrax, but there is no information about the protective action of IgG anti-gamma dPGA. Because the number of spores presented by bioterrorists might be greater than encountered in nature, we sought to induce capsular antibodies to expand the immunity conferred by available anthrax vaccines. The nonimmunogenic gamma dPGA or corresponding synthetic peptides were bound to BSA, recombinant B. anthracis PA (rPA), or recombinant Pseudomonas aeruginosa exotoxin A (rEPA). To identify the optimal construct, conjugates of B. anthracis gamma dPGA, Bacillus pumilus gamma dLPGA, and peptides of varying lengths (5-, 10-, or 20-mers), of the d or l configuration with active groups at the N or C termini, were bound at 5-32 mol per protein. The conjugates were characterized by physico-chemical and immunological assays, including GLC-MS and matrix-assisted laser desorption ionization time-of-flight spectrometry, and immunogenicity in 5- to 6-week-old mice. IgG anti-gamma dPGA and antiprotein were measured by ELISA. The highest levels of IgG anti-gamma dPGA were elicited by decamers of gamma dPGA at 10 -20 mol per protein bound to the N- or C-terminal end. High IgG anti-gamma dPGA levels were elicited by two injections of 2.5 microg of gamma dPGA per mouse, whereas three injections were needed to achieve high levels of protein antibodies. rPA was the most effective carrier. Anti-gamma dPGA induced opsonophagocytic killing of B. anthracis tox-, cap+. gamma dPGA conjugates may enhance the protection conferred by PA alone. gamma dPGA-rPA conjugates induced both anti-PA and anti-gamma dPGA.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12857944</PMID>
<DateCompleted><Year>2003</Year>
<Month>09</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0027-8424</ISSN>
<JournalIssue CitedMedium="Print"><Volume>100</Volume>
<Issue>15</Issue>
<PubDate><Year>2003</Year>
<Month>Jul</Month>
<Day>22</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation>
</Journal>
<ArticleTitle>Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.</ArticleTitle>
<Pagination><MedlinePgn>8945-50</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Both the protective antigen (PA) and the poly(gamma-d-glutamic acid) capsule (gamma dPGA) are essential for the virulence of Bacillus anthracis. A critical level of vaccine-induced IgG anti-PA confers immunity to anthrax, but there is no information about the protective action of IgG anti-gamma dPGA. Because the number of spores presented by bioterrorists might be greater than encountered in nature, we sought to induce capsular antibodies to expand the immunity conferred by available anthrax vaccines. The nonimmunogenic gamma dPGA or corresponding synthetic peptides were bound to BSA, recombinant B. anthracis PA (rPA), or recombinant Pseudomonas aeruginosa exotoxin A (rEPA). To identify the optimal construct, conjugates of B. anthracis gamma dPGA, Bacillus pumilus gamma dLPGA, and peptides of varying lengths (5-, 10-, or 20-mers), of the d or l configuration with active groups at the N or C termini, were bound at 5-32 mol per protein. The conjugates were characterized by physico-chemical and immunological assays, including GLC-MS and matrix-assisted laser desorption ionization time-of-flight spectrometry, and immunogenicity in 5- to 6-week-old mice. IgG anti-gamma dPGA and antiprotein were measured by ELISA. The highest levels of IgG anti-gamma dPGA were elicited by decamers of gamma dPGA at 10 -20 mol per protein bound to the N- or C-terminal end. High IgG anti-gamma dPGA levels were elicited by two injections of 2.5 microg of gamma dPGA per mouse, whereas three injections were needed to achieve high levels of protein antibodies. rPA was the most effective carrier. Anti-gamma dPGA induced opsonophagocytic killing of B. anthracis tox-, cap+. gamma dPGA conjugates may enhance the protection conferred by PA alone. gamma dPGA-rPA conjugates induced both anti-PA and anti-gamma dPGA.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schneerson</LastName>
<ForeName>Rachel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. schneerr@mail.nih.gov</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kubler-Kielb</LastName>
<ForeName>Joanna</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Teh-Yung</ForeName>
<Initials>TY</Initials>
</Author>
<Author ValidYN="Y"><LastName>Dai</LastName>
<ForeName>Zhong-Dong</ForeName>
<Initials>ZD</Initials>
</Author>
<Author ValidYN="Y"><LastName>Leppla</LastName>
<ForeName>Stephen H</ForeName>
<Initials>SH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yergey</LastName>
<ForeName>Alfred</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Backlund</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Shiloach</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Majadly</LastName>
<ForeName>Fathy</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Robbins</LastName>
<ForeName>John B</ForeName>
<Initials>JB</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2003</Year>
<Month>07</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Proc Natl Acad Sci U S A</MedlineTA>
<NlmUniqueID>7505876</NlmUniqueID>
<ISSNLinking>0027-8424</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D022122">Anthrax Vaccines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000907">Antibodies, Bacterial</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000942">Antigens, Bacterial</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001427">Bacterial Toxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018074">Vaccines, Conjugate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C030325">anthrax toxin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>25513-46-6</RegistryNumber>
<NameOfSubstance UI="D011099">Polyglutamic Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000881" MajorTopicYN="N">Anthrax</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D022122" MajorTopicYN="N">Anthrax Vaccines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000907" MajorTopicYN="N">Antibodies, Bacterial</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000942" MajorTopicYN="N">Antigens, Bacterial</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001408" MajorTopicYN="N">Bacillus anthracis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001427" MajorTopicYN="N">Bacterial Toxins</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011099" MajorTopicYN="N">Polyglutamic Acid</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018074" MajorTopicYN="N">Vaccines, Conjugate</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year>
<Month>7</Month>
<Day>15</Day>
<Hour>5</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2003</Year>
<Month>9</Month>
<Day>3</Day>
<Hour>5</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2003</Year>
<Month>7</Month>
<Day>15</Day>
<Hour>5</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">12857944</ArticleId>
<ArticleId IdType="doi">10.1073/pnas.1633512100</ArticleId>
<ArticleId IdType="pii">1633512100</ArticleId>
<ArticleId IdType="pmc">PMC166418</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Biochem J. 1956 Jul;63(3):437-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13341899</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 1990 Feb;28(2):223-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2107201</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biotechnol. 1996 Jul 18;48(1-2):9-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8818269</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 1973 Dec;8(6):896-900</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4150383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1976 Jun;116(6):1711-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">58048</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 1971 Sep;124(3):581-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5135243</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br Med J. 1965 Sep 25;2(5464):717-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5825408</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioconjug Chem. 1991 Nov-Dec;2(6):458-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1805944</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Schweiz Z Pathol Bakteriol. 1959;22(2):129-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13646612</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1973 Jan 10;248(1):305-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4692836</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Diagn Lab Immunol. 1997 Jul;4(4):415-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9220157</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Soc Exp Biol Med. 1958 Nov;99(2):345-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13601865</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunochemistry. 1964 Jun;1:133-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14249321</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Public Health Nations Health. 1962 Apr;52(4):632-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18017912</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1980 Aug 1;152(2):361-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6967514</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1962 Dec 21;138(3547):1331-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14033353</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Trop Med Hyg. 1988 Dec;39(6):575-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3144920</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1955 Aug;75(2):129-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13242812</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1963 Jan;85:230-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13972632</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Assoc Off Anal Chem. 1987 Jan-Feb;70(1):151-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3558269</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Exp Pathol. 1946 Dec;27(6):394-418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20284522</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1976 Oct;73(10):3671-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">62364</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1989 Apr 1;142(7):2464-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2784464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 1985 Aug;49(2):291-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3926644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 1988 Jul;56(7):1807-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3384478</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Ind Microbiol Biotechnol. 2002 Apr;28(4):232-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11986925</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 1983 Jan;39(1):371-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6401695</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 1993 Sep;61(9):3678-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8359890</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5194-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10220442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1968 Feb;7(2):706-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4966931</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 1978 Sep 1;173(3):723-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">708370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Microbiol. 1988 May;2(3):371-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2456447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proteins. 1993 Jul;16(3):306-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8346194</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><noCountry><name sortKey="Backlund, Peter" sort="Backlund, Peter" uniqKey="Backlund P" first="Peter" last="Backlund">Peter Backlund</name>
<name sortKey="Dai, Zhong Dong" sort="Dai, Zhong Dong" uniqKey="Dai Z" first="Zhong-Dong" last="Dai">Zhong-Dong Dai</name>
<name sortKey="Kubler Kielb, Joanna" sort="Kubler Kielb, Joanna" uniqKey="Kubler Kielb J" first="Joanna" last="Kubler-Kielb">Joanna Kubler-Kielb</name>
<name sortKey="Leppla, Stephen H" sort="Leppla, Stephen H" uniqKey="Leppla S" first="Stephen H" last="Leppla">Stephen H. Leppla</name>
<name sortKey="Liu, Teh Yung" sort="Liu, Teh Yung" uniqKey="Liu T" first="Teh-Yung" last="Liu">Teh-Yung Liu</name>
<name sortKey="Majadly, Fathy" sort="Majadly, Fathy" uniqKey="Majadly F" first="Fathy" last="Majadly">Fathy Majadly</name>
<name sortKey="Robbins, John B" sort="Robbins, John B" uniqKey="Robbins J" first="John B" last="Robbins">John B. Robbins</name>
<name sortKey="Shiloach, Joseph" sort="Shiloach, Joseph" uniqKey="Shiloach J" first="Joseph" last="Shiloach">Joseph Shiloach</name>
<name sortKey="Yergey, Alfred" sort="Yergey, Alfred" uniqKey="Yergey A" first="Alfred" last="Yergey">Alfred Yergey</name>
</noCountry>
<country name="États-Unis"><region name="Maryland"><name sortKey="Schneerson, Rachel" sort="Schneerson, Rachel" uniqKey="Schneerson R" first="Rachel" last="Schneerson">Rachel Schneerson</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002309 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002309 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:12857944
   |texte=   Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:12857944" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.

Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki