RNase III enzymes and the initiation of gene silencing.
Identifieur interne : 002242 ( PubMed/Checkpoint ); précédent : 002241; suivant : 002243RNase III enzymes and the initiation of gene silencing.
Auteurs : Michelle A. Carmell [États-Unis] ; Gregory J. HannonSource :
- Nature structural & molecular biology [ 1545-9993 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Petit ARN interférent, microARN.
- métabolisme : Petit ARN interférent, Ribonuclease III, microARN.
- physiologie : Ribonuclease III.
- Extinction de l'expression des gènes, Interférence par ARN, Modèles génétiques.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : MicroRNAs, RNA, Small Interfering.
- chemical , metabolism : MicroRNAs, RNA, Small Interfering, Ribonuclease III.
- chemical , physiology : Ribonuclease III.
- Gene Silencing, Models, Genetic, RNA Interference.
Abstract
Our understanding of RNA interference has been enhanced by new data concerning RNase III molecules. The role of Dicer has previously been established in RNAi as the originator of 22-mers characteristic of silencing phenomena. Recently, a related RNAse III enzyme, Drosha, has surfaced as another component of the RNAi pathway. In addition to biochemistry, protein structures have proven to be helpful in deciphering the enzymology of RNase III molecules.
DOI: 10.1038/nsmb729
PubMed: 14983173
Affiliations:
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pubmed:14983173Le document en format XML
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Hannon</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Carmell, Michelle A" sort="Carmell, Michelle A" uniqKey="Carmell M" first="Michelle A" last="Carmell">Michelle A. Carmell</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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