Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells.
Identifieur interne : 001F01 ( PubMed/Checkpoint ); précédent : 001F00; suivant : 001F02Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells.
Auteurs : Yow-Jiun Jeng [États-Unis] ; Mikhail Y. Kochukov ; Cheryl S. WatsonSource :
- Journal of molecular signaling [ 1750-2187 ] ; 2009.
Abstract
Estradiol (E2) mediates various intracellular signaling cascades from the plasma membrane via several estrogen receptors (ERs). The pituitary is an estrogen-responsive tissue, and we have previously reported that E2 can activate mitogen-activated protein kinases (MAPKs) such as ERK1/2 and JNK1/2/3 in the membrane ERalpha (mERalpha)-enriched GH3/B6/F10 rat pituitary tumor cell line. Phytoestrogens are compounds found in plants and foods such as soybeans, alfalfa sprouts, and red grapes. They are structurally similar to E2 and share a similar mechanism of action through their binding to ERs. Phytoestrogens bind to nuclear ERs with a much lower affinity and therefore are less potent in mediating genomic responses. However, little is known about their ability to act via mERs to mediate nongenomic effects.
DOI: 10.1186/1750-2187-4-2
PubMed: 19400946
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:19400946Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells.</title><author><name sortKey="Jeng, Yow Jiun" sort="Jeng, Yow Jiun" uniqKey="Jeng Y" first="Yow-Jiun" last="Jeng">Yow-Jiun Jeng</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA. cswatson@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kochukov, Mikhail Y" sort="Kochukov, Mikhail Y" uniqKey="Kochukov M" first="Mikhail Y" last="Kochukov">Mikhail Y. Kochukov</name></author><author><name sortKey="Watson, Cheryl S" sort="Watson, Cheryl S" uniqKey="Watson C" first="Cheryl S" last="Watson">Cheryl S. Watson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19400946</idno><idno type="pmid">19400946</idno><idno type="doi">10.1186/1750-2187-4-2</idno><idno type="wicri:Area/PubMed/Corpus">002017</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002017</idno><idno type="wicri:Area/PubMed/Curation">002017</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002017</idno><idno type="wicri:Area/PubMed/Checkpoint">001F01</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F01</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells.</title><author><name sortKey="Jeng, Yow Jiun" sort="Jeng, Yow Jiun" uniqKey="Jeng Y" first="Yow-Jiun" last="Jeng">Yow-Jiun Jeng</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA. cswatson@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kochukov, Mikhail Y" sort="Kochukov, Mikhail Y" uniqKey="Kochukov M" first="Mikhail Y" last="Kochukov">Mikhail Y. Kochukov</name></author><author><name sortKey="Watson, Cheryl S" sort="Watson, Cheryl S" uniqKey="Watson C" first="Cheryl S" last="Watson">Cheryl S. Watson</name></author></analytic><series><title level="j">Journal of molecular signaling</title><idno type="eISSN">1750-2187</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Estradiol (E2) mediates various intracellular signaling cascades from the plasma membrane via several estrogen receptors (ERs). The pituitary is an estrogen-responsive tissue, and we have previously reported that E2 can activate mitogen-activated protein kinases (MAPKs) such as ERK1/2 and JNK1/2/3 in the membrane ERalpha (mERalpha)-enriched GH3/B6/F10 rat pituitary tumor cell line. Phytoestrogens are compounds found in plants and foods such as soybeans, alfalfa sprouts, and red grapes. They are structurally similar to E2 and share a similar mechanism of action through their binding to ERs. Phytoestrogens bind to nuclear ERs with a much lower affinity and therefore are less potent in mediating genomic responses. However, little is known about their ability to act via mERs to mediate nongenomic effects.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">19400946</PMID><DateCompleted><Year>2011</Year><Month>07</Month><Day>14</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1750-2187</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><PubDate><Year>2009</Year><Month>Apr</Month><Day>28</Day></PubDate></JournalIssue><Title>Journal of molecular signaling</Title><ISOAbbreviation>J Mol Signal</ISOAbbreviation></Journal><ArticleTitle>Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells.</ArticleTitle><Pagination><MedlinePgn>2</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1750-2187-4-2</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Estradiol (E2) mediates various intracellular signaling cascades from the plasma membrane via several estrogen receptors (ERs). The pituitary is an estrogen-responsive tissue, and we have previously reported that E2 can activate mitogen-activated protein kinases (MAPKs) such as ERK1/2 and JNK1/2/3 in the membrane ERalpha (mERalpha)-enriched GH3/B6/F10 rat pituitary tumor cell line. Phytoestrogens are compounds found in plants and foods such as soybeans, alfalfa sprouts, and red grapes. They are structurally similar to E2 and share a similar mechanism of action through their binding to ERs. Phytoestrogens bind to nuclear ERs with a much lower affinity and therefore are less potent in mediating genomic responses. However, little is known about their ability to act via mERs to mediate nongenomic effects.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">To investigate the activation of different nongenomic pathways, and determine the involvement of mERalpha, we measured prolactin (PRL) release by radio-immunoassay, MAPK activations (ERK1/2 and JNK1/2/3) via a quantitative plate immunoassay, and intracellular [Ca2+] by Fura-2 fluorescence imaging in cells treated with E2 or four different phytoestrogens (coumestrol, daidzein, genistein, and trans-resveratrol).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Coumesterol and daidzein increased PRL release similar to E2 in GH3/B6/F10 cells, while genistein and trans-resveratrol had no effect. All of these compounds except genistein activated ERK1/2 signaling at 1-10 picomolar concentrations; JNK 1/2/3 was activated by all compounds at a 100 nanomolar concentration. All compounds also caused rapid Ca2+ uptake, though in unique dose-dependent Ca2+ response patterns for several aspects of this response. A subclone of GH3 cells expressing low levels of mERalpha (GH3/B6/D9) did not respond to any phytoestrogen treatments for any of these responses, suggesting that these nongenomic effects were mediated via mERalpha.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Phytoestrogens were much more potent in mediating these nongenomic responses (activation of MAPKs, PRL release, and increased intracellular [Ca2+]) via mERalpha than was previously reported for genomic responses. The unique non-monotonic dose responses and variant signaling patterns caused by E2 and all tested phytoestrogens suggest that complex and multiple signaling pathways or binding partners could be involved. By activating these different nongenomic signaling pathways, phytoestrogens could have significant physiological consequences for pituitary cell functions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jeng</LastName><ForeName>Yow-Jiun</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA. cswatson@utmb.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kochukov</LastName><ForeName>Mikhail Y</ForeName><Initials>MY</Initials></Author><Author ValidYN="Y"><LastName>Watson</LastName><ForeName>Cheryl S</ForeName><Initials>CS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>04</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Mol Signal</MedlineTA><NlmUniqueID>101271526</NlmUniqueID><ISSNLinking>1750-2187</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>01</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2009</Year><Month>04</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>4</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>4</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>4</Month><Day>30</Day><Hour>9</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19400946</ArticleId><ArticleId IdType="pii">1750-2187-4-2</ArticleId><ArticleId IdType="doi">10.1186/1750-2187-4-2</ArticleId><ArticleId IdType="pmc">PMC2679742</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nutr Cancer. 1997;27(1):31-40</Citation><ArticleIdList><ArticleId IdType="pubmed">8970179</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci STKE. 2002 Jun 25;2002(138):re9</Citation><ArticleIdList><ArticleId IdType="pubmed">12084906</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocr Rev. 1999 Jun;20(3):279-307</Citation><ArticleIdList><ArticleId IdType="pubmed">10368772</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2000 Jan 7;275(1):479-86</Citation><ArticleIdList><ArticleId IdType="pubmed">10617642</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocrinology. 1998 Oct;139(10):4252-63</Citation><ArticleIdList><ArticleId IdType="pubmed">9751507</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocrinology. 1999 Aug;140(8):3805-14</Citation><ArticleIdList><ArticleId IdType="pubmed">10433242</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1984 Jul;81(14):4549-53</Citation><ArticleIdList><ArticleId IdType="pubmed">6589610</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 1996 Jan 15;16(2):595-604</Citation><ArticleIdList><ArticleId IdType="pubmed">8551343</ArticleId></ArticleIdList></Reference><Reference><Citation>Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):1952-61</Citation><ArticleIdList><ArticleId IdType="pubmed">12482819</ArticleId></ArticleIdList></Reference><Reference><Citation>Prostate. 1997 Jul 1;32(2):122-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9215400</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2004 Jun 25;279(26):27008-16</Citation><ArticleIdList><ArticleId IdType="pubmed">15090535</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Endocrinol Metab. 1998 Nov;83(11):3965-72</Citation><ArticleIdList><ArticleId IdType="pubmed">9814476</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7217-22</Citation><ArticleIdList><ArticleId IdType="pubmed">17438283</ArticleId></ArticleIdList></Reference><Reference><Citation>Steroids. 1999 Jan-Feb;64(1-2):28-34</Citation><ArticleIdList><ArticleId IdType="pubmed">10323670</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E388-97</Citation><ArticleIdList><ArticleId IdType="pubmed">15494610</ArticleId></ArticleIdList></Reference><Reference><Citation>Toxicol Appl Pharmacol. 2000 Apr 15;164(2):206-15</Citation><ArticleIdList><ArticleId IdType="pubmed">10764634</ArticleId></ArticleIdList></Reference><Reference><Citation>Steroids. 1999 Jan-Feb;64(1-2):5-13</Citation><ArticleIdList><ArticleId IdType="pubmed">10323667</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Endocrinol. 2002 Jan;16(1):100-15</Citation><ArticleIdList><ArticleId IdType="pubmed">11773442</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Soc Exp Biol Med. 1995 Jan;208(1):82-6</Citation><ArticleIdList><ArticleId IdType="pubmed">7892301</ArticleId></ArticleIdList></Reference><Reference><Citation>Steroids. 2007 Oct;72(11-12):765-77</Citation><ArticleIdList><ArticleId IdType="pubmed">17714751</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocr Rev. 1994 Jun;15(3):275-300</Citation><ArticleIdList><ArticleId IdType="pubmed">8076582</ArticleId></ArticleIdList></Reference><Reference><Citation>Prog Clin Biol Res. 1997;396:233-43</Citation><ArticleIdList><ArticleId IdType="pubmed">9108601</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Metab Dispos. 2004 Dec;32(12):1377-82</Citation><ArticleIdList><ArticleId IdType="pubmed">15333514</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pharmacol Exp Ther. 2001 Nov;299(2):408-14</Citation><ArticleIdList><ArticleId IdType="pubmed">11602649</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 1995 Oct;103 Suppl 7:103-12</Citation><ArticleIdList><ArticleId IdType="pubmed">8593855</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Biol Med (Maywood). 2005 Sep;230(8):558-68</Citation><ArticleIdList><ArticleId IdType="pubmed">16118406</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Biosci. 1998 Aug 6;3:d934-43</Citation><ArticleIdList><ArticleId IdType="pubmed">9696884</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann N Y Acad Sci. 2003 Dec;1007:6-16</Citation><ArticleIdList><ArticleId IdType="pubmed">14993035</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytother Res. 2003 Sep;17(8):845-69</Citation><ArticleIdList><ArticleId IdType="pubmed">13680814</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2005 Apr;113(4):431-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15811834</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1957 Nov 8;126(3280):969-70</Citation><ArticleIdList><ArticleId IdType="pubmed">13486041</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Soc Exp Biol Med. 1999 Jan;220(1):9-19</Citation><ArticleIdList><ArticleId IdType="pubmed">9893163</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Drug Discov. 2006 Jun;5(6):493-506</Citation><ArticleIdList><ArticleId IdType="pubmed">16732220</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2001 Mar;109 Suppl 1:5-20</Citation><ArticleIdList><ArticleId IdType="pubmed">11250801</ArticleId></ArticleIdList></Reference><Reference><Citation>J Endocrinol. 1972 Feb;52(2):299-310</Citation><ArticleIdList><ArticleId IdType="pubmed">5015385</ArticleId></ArticleIdList></Reference><Reference><Citation>Steroids. 2004 Mar;69(3):181-92</Citation><ArticleIdList><ArticleId IdType="pubmed">15072920</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14138-43</Citation><ArticleIdList><ArticleId IdType="pubmed">9391166</ArticleId></ArticleIdList></Reference><Reference><Citation>Steroids. 2001 Oct;66(10):727-36</Citation><ArticleIdList><ArticleId IdType="pubmed">11522334</ArticleId></ArticleIdList></Reference><Reference><Citation>Transgenic Res. 2007 Jun;16(3):281-314</Citation><ArticleIdList><ArticleId IdType="pubmed">17219248</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2004 Nov;112(15):1481-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15531431</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14783-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12415108</ArticleId></ArticleIdList></Reference><Reference><Citation>Scand J Clin Lab Invest Suppl. 1993;215:5-18</Citation><ArticleIdList><ArticleId IdType="pubmed">8392221</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Mar 4;280(9):7460-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15615701</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocr Rev. 2001 Apr;22(2):153-83</Citation><ArticleIdList><ArticleId IdType="pubmed">11294822</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 1999 Feb;103(3):401-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9927501</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Endocrinol Metab. 1999 Nov;10(9):374-377</Citation><ArticleIdList><ArticleId IdType="pubmed">10511697</ArticleId></ArticleIdList></Reference><Reference><Citation>Toxicol Appl Pharmacol. 2007 Jul 1;222(1):25-32</Citation><ArticleIdList><ArticleId IdType="pubmed">17490695</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 1992 Nov 1;52(21):5926-32</Citation><ArticleIdList><ArticleId IdType="pubmed">1327520</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Pharmacol. 1995 Feb;114(4):872-80</Citation><ArticleIdList><ArticleId IdType="pubmed">7773549</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Pharmacol Physiol. 2007 Jul;34(7):672-6</Citation><ArticleIdList><ArticleId IdType="pubmed">17581228</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="Kochukov, Mikhail Y" sort="Kochukov, Mikhail Y" uniqKey="Kochukov M" first="Mikhail Y" last="Kochukov">Mikhail Y. Kochukov</name><name sortKey="Watson, Cheryl S" sort="Watson, Cheryl S" uniqKey="Watson C" first="Cheryl S" last="Watson">Cheryl S. Watson</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Jeng, Yow Jiun" sort="Jeng, Yow Jiun" uniqKey="Jeng Y" first="Yow-Jiun" last="Jeng">Yow-Jiun Jeng</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F01 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001F01 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:19400946
|texte= Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:19400946" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |