Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy.
Identifieur interne : 001C47 ( PubMed/Checkpoint ); précédent : 001C46; suivant : 001C48Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy.
Auteurs : M. Rossi [Italie] ; A. Lugo ; P. Lagiou ; A. Zucchetto ; J. Polesel ; D. Serraino ; E. Negri ; D. Trichopoulos ; C. La VecchiaSource :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Enquêtes et questionnaires, Femelle, Flavonoïdes (administration et posologie), Flavonoïdes (pharmacologie), Fruit, Humains, Intervalles de confiance, Italie, Légumes, Modèles logistiques, Mâle, Odds ratio, Proanthocyanidines (administration et posologie), Proanthocyanidines (pharmacologie), Risque, Régime alimentaire, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du pancréas (), Études cas-témoins.
- MESH :
- administration et posologie : Flavonoïdes, Proanthocyanidines.
- pharmacologie : Flavonoïdes, Proanthocyanidines.
- Adulte, Adulte d'âge moyen, Enquêtes et questionnaires, Femelle, Fruit, Humains, Intervalles de confiance, Italie, Légumes, Modèles logistiques, Mâle, Odds ratio, Risque, Régime alimentaire, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du pancréas, Études cas-témoins.
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Confidence Intervals, Diet, Female, Flavonoids (administration & dosage), Flavonoids (pharmacology), Fruit, Humans, Italy, Logistic Models, Male, Middle Aged, Odds Ratio, Pancreatic Neoplasms (prevention & control), Proanthocyanidins (administration & dosage), Proanthocyanidins (pharmacology), Risk, Surveys and Questionnaires, Vegetables.
- MESH :
- chemical , administration & dosage : Flavonoids, Proanthocyanidins.
- chemical , pharmacology : Flavonoids, Proanthocyanidins.
- geographic : Italy.
- prevention & control : Pancreatic Neoplasms.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Confidence Intervals, Diet, Female, Fruit, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk, Surveys and Questionnaires, Vegetables.
Abstract
Four cohort studies have examined the relation between flavonoids and pancreatic cancer risk providing inconsistent results.
DOI: 10.1093/annonc/mdr475
PubMed: 22052986
Affiliations:
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pubmed:22052986Le document en format XML
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Lagiou</name></author><author><name sortKey="Zucchetto, A" sort="Zucchetto, A" uniqKey="Zucchetto A" first="A" last="Zucchetto">A. Zucchetto</name></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J" last="Polesel">J. Polesel</name></author><author><name sortKey="Serraino, D" sort="Serraino, D" uniqKey="Serraino D" first="D" last="Serraino">D. Serraino</name></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E" last="Negri">E. Negri</name></author><author><name sortKey="Trichopoulos, D" sort="Trichopoulos, D" uniqKey="Trichopoulos D" first="D" last="Trichopoulos">D. Trichopoulos</name></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C" last="La Vecchia">C. 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Rossi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy. marta.rossi@marionegri.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lugo, A" sort="Lugo, A" uniqKey="Lugo A" first="A" last="Lugo">A. Lugo</name></author><author><name sortKey="Lagiou, P" sort="Lagiou, P" uniqKey="Lagiou P" first="P" last="Lagiou">P. Lagiou</name></author><author><name sortKey="Zucchetto, A" sort="Zucchetto, A" uniqKey="Zucchetto A" first="A" last="Zucchetto">A. Zucchetto</name></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J" last="Polesel">J. Polesel</name></author><author><name sortKey="Serraino, D" sort="Serraino, D" uniqKey="Serraino D" first="D" last="Serraino">D. Serraino</name></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E" last="Negri">E. Negri</name></author><author><name sortKey="Trichopoulos, D" sort="Trichopoulos, D" uniqKey="Trichopoulos D" first="D" last="Trichopoulos">D. Trichopoulos</name></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C" last="La Vecchia">C. La Vecchia</name></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Confidence Intervals</term><term>Diet</term><term>Female</term><term>Flavonoids (administration & dosage)</term><term>Flavonoids (pharmacology)</term><term>Fruit</term><term>Humans</term><term>Italy</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Pancreatic Neoplasms (prevention & control)</term><term>Proanthocyanidins (administration & dosage)</term><term>Proanthocyanidins (pharmacology)</term><term>Risk</term><term>Surveys and Questionnaires</term><term>Vegetables</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Flavonoïdes (administration et posologie)</term><term>Flavonoïdes (pharmacologie)</term><term>Fruit</term><term>Humains</term><term>Intervalles de confiance</term><term>Italie</term><term>Légumes</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Proanthocyanidines (administration et posologie)</term><term>Proanthocyanidines (pharmacologie)</term><term>Risque</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du pancréas ()</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Flavonoids</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavonoids</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Flavonoïdes</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Flavonoïdes</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Confidence Intervals</term><term>Diet</term><term>Female</term><term>Fruit</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Risk</term><term>Surveys and Questionnaires</term><term>Vegetables</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Fruit</term><term>Humains</term><term>Intervalles de confiance</term><term>Italie</term><term>Légumes</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Risque</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du pancréas</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Four cohort studies have examined the relation between flavonoids and pancreatic cancer risk providing inconsistent results.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22052986</PMID><DateCompleted><Year>2012</Year><Month>09</Month><Day>20</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1569-8041</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>6</Issue><PubDate><Year>2012</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Annals of oncology : official journal of the European Society for Medical Oncology</Title><ISOAbbreviation>Ann. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy.</ArticleTitle><Pagination><MedlinePgn>1488-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/annonc/mdr475</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Four cohort studies have examined the relation between flavonoids and pancreatic cancer risk providing inconsistent results.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">We conducted a case-control study between 1991 and 2008 in Northern Italy. Subjects were 326 cases with incident pancreatic cancer and 652 frequency-matched controls (admitted to the same hospitals as cases for acute non-neoplastic conditions) who answered a reproducible and valid food-frequency questionnaire. We computed odds ratios (ORs) using logistic regression models conditioned on gender, age and study center, and adjusted for education, history of diabetes, tobacco smoking, alcohol drinking and energy intake.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Proanthocyanidins with three or more mers were inversely related to pancreatic cancer risk. The ORs were similar in all classes of polymers with three or more mers and in their combination (OR for the highest versus the lowest quintile of intake, 0.41; 95% confidence interval 0.24-0.69), and did not substantially change after adjustment for fruit and vegetable consumption, and for vitamin C and folate intakes. Eating an additional portion of fruits rich in proanthocyanidins every day reduced the risk of pancreatic cancer by 25%.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Dietary proanthocyanidins-mostly present in apples, pears and pulses-may convey some protection against pancreatic cancer risk.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rossi</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy. marta.rossi@marionegri.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lugo</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lagiou</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Zucchetto</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Polesel</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Serraino</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Negri</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Trichopoulos</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>La Vecchia</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>11</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Oncol</MedlineTA><NlmUniqueID>9007735</NlmUniqueID><ISSNLinking>0923-7534</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044945">Proanthocyanidins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016001" MajorTopicYN="N">Confidence Intervals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="N">Diet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010190" MajorTopicYN="N">Pancreatic Neoplasms</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044945" MajorTopicYN="N">Proanthocyanidins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014675" MajorTopicYN="N">Vegetables</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22052986</ArticleId><ArticleId IdType="pii">S0923-7534(19)38711-3</ArticleId><ArticleId IdType="doi">10.1093/annonc/mdr475</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C" last="La Vecchia">C. La Vecchia</name><name sortKey="Lagiou, P" sort="Lagiou, P" uniqKey="Lagiou P" first="P" last="Lagiou">P. Lagiou</name><name sortKey="Lugo, A" sort="Lugo, A" uniqKey="Lugo A" first="A" last="Lugo">A. Lugo</name><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E" last="Negri">E. Negri</name><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J" last="Polesel">J. Polesel</name><name sortKey="Serraino, D" sort="Serraino, D" uniqKey="Serraino D" first="D" last="Serraino">D. Serraino</name><name sortKey="Trichopoulos, D" sort="Trichopoulos, D" uniqKey="Trichopoulos D" first="D" last="Trichopoulos">D. Trichopoulos</name><name sortKey="Zucchetto, A" sort="Zucchetto, A" uniqKey="Zucchetto A" first="A" last="Zucchetto">A. Zucchetto</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Rossi, M" sort="Rossi, M" uniqKey="Rossi M" first="M" last="Rossi">M. 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