Serveur d'exploration MERS

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Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection.

Identifieur interne : 001968 ( PubMed/Checkpoint ); précédent : 001967; suivant : 001969

Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection.

Auteurs : Yaseen M. Arabi ; Ahmed A. Arifi ; Hanan H. Balkhy ; Hani Najm ; Abdulaziz S. Aldawood ; Alaa Ghabashi ; Hassan Hawa ; Adel Alothman ; Abdulaziz Khaldi ; Basel Al Raiy

Source :

RBID : pubmed:24474051

Descripteurs français

English descriptors

Abstract

Since September 2012, 170 confirmed infections with Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization, including 72 deaths. Data on critically ill patients with MERS-CoV infection are limited.

DOI: 10.7326/M13-2486
PubMed: 24474051


Affiliations:


Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:24474051

Le document en format XML

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<div type="abstract" xml:lang="en">Since September 2012, 170 confirmed infections with Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization, including 72 deaths. Data on critically ill patients with MERS-CoV infection are limited.</div>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Since September 2012, 170 confirmed infections with Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization, including 72 deaths. Data on critically ill patients with MERS-CoV infection are limited.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To describe the critical illness associated with MERS-CoV.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Case series.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">3 intensive care units (ICUs) at 2 tertiary care hospitals in Saudi Arabia.</AbstractText>
<AbstractText Label="PATIENTS" NlmCategory="METHODS">12 patients with confirmed or probable MERS-CoV infection.</AbstractText>
<AbstractText Label="MEASUREMENTS" NlmCategory="METHODS">Presenting symptoms, comorbid conditions, pulmonary and extrapulmonary manifestations, measures of severity of illness and organ failure, ICU course, and outcome are described, as are the results of surveillance of health care workers (HCWs) and patients with potential exposure.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Between December 2012 and August 2013, 114 patients were tested for suspected MERS-CoV; of these, 11 ICU patients (10%) met the definition of confirmed or probable cases. Three of these patients were part of a health care-associated cluster that also included 3 HCWs. One HCW became critically ill and was the 12th patient in this case series. Median Acute Physiology and Chronic Health Evaluation II score was 28 (range, 16 to 36). All 12 patients had underlying comorbid conditions and presented with acute severe hypoxemic respiratory failure. Most patients (92%) had extrapulmonary manifestations, including shock, acute kidney injury, and thrombocytopenia. Five (42%) were alive at day 90. Of the 520 exposed HCWs, only 4 (1%) were positive.</AbstractText>
<AbstractText Label="LIMITATION" NlmCategory="CONCLUSIONS">The sample size was small.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">MERS-CoV causes severe acute hypoxemic respiratory failure and considerable extrapulmonary organ dysfunction and is associated with high mortality. Community-acquired and health care-associated MERS-CoV infection occurs in patients with chronic comorbid conditions. The health care-associated cluster suggests that human-to-human transmission does occur with unprotected exposure.</AbstractText>
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<ArticleId IdType="doi">10.7326/M13-2486</ArticleId>
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<name sortKey="Al Raiy, Basel" sort="Al Raiy, Basel" uniqKey="Al Raiy B" first="Basel" last="Al Raiy">Basel Al Raiy</name>
<name sortKey="Aldawood, Abdulaziz S" sort="Aldawood, Abdulaziz S" uniqKey="Aldawood A" first="Abdulaziz S" last="Aldawood">Abdulaziz S. Aldawood</name>
<name sortKey="Alothman, Adel" sort="Alothman, Adel" uniqKey="Alothman A" first="Adel" last="Alothman">Adel Alothman</name>
<name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name>
<name sortKey="Arifi, Ahmed A" sort="Arifi, Ahmed A" uniqKey="Arifi A" first="Ahmed A" last="Arifi">Ahmed A. Arifi</name>
<name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name>
<name sortKey="Ghabashi, Alaa" sort="Ghabashi, Alaa" uniqKey="Ghabashi A" first="Alaa" last="Ghabashi">Alaa Ghabashi</name>
<name sortKey="Hawa, Hassan" sort="Hawa, Hassan" uniqKey="Hawa H" first="Hassan" last="Hawa">Hassan Hawa</name>
<name sortKey="Khaldi, Abdulaziz" sort="Khaldi, Abdulaziz" uniqKey="Khaldi A" first="Abdulaziz" last="Khaldi">Abdulaziz Khaldi</name>
<name sortKey="Najm, Hani" sort="Najm, Hani" uniqKey="Najm H" first="Hani" last="Najm">Hani Najm</name>
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