MersV1, PubMed, Checkpoint, bibRecord, 001875

Infection with MERS-CoV causes lethal pneumonia in the common marmoset.

Identifieur interne : 001875 ( PubMed/Checkpoint ); précédent : 001874; suivant : 001876

Infection with MERS-CoV causes lethal pneumonia in the common marmoset.

Auteurs : Darryl Falzarano [États-Unis] ; Emmie De Wit [États-Unis] ; Friederike Feldmann [États-Unis] ; Angela L. Rasmussen [États-Unis] ; Atsushi Okumura [États-Unis] ; Xinxia Peng [États-Unis] ; Matthew J. Thomas [États-Unis] ; Neeltje Van Doremalen [États-Unis] ; Elaine Haddock [États-Unis] ; Lee Nagy [États-Unis] ; Rachel Lacasse [États-Unis] ; Tingting Liu [États-Unis] ; Jiang Zhu [États-Unis] ; Jason S. Mclellan [États-Unis] ; Dana P. Scott [États-Unis] ; Michael G. Katze [États-Unis] ; Heinz Feldmann [Canada] ; Vincent J. Munster [États-Unis]

Source :

PLoS pathogens [ 1553-7374 ] ; 2014.

RBID : pubmed:25144235

Descripteurs français

English descriptors

KwdEn :
- Animals, Callithrix, Coronavirus Infections (pathology), Coronavirus Infections (virology), Disease Models, Animal, Immunohistochemistry, Male, Middle East Respiratory Syndrome Coronavirus, Pneumonia, Viral (pathology), Pneumonia, Viral (virology), Real-Time Polymerase Chain Reaction.
MESH :
- pathology : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Animals, Callithrix, Disease Models, Animal, Immunohistochemistry, Male, Middle East Respiratory Syndrome Coronavirus, Real-Time Polymerase Chain Reaction.

Abstract

The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction between the MERS-CoV spike glycoprotein and its receptor dipeptidyl peptidase 4 predicted comparable interaction energies in common marmosets and humans. The suitability of the marmoset as a MERS-CoV model was tested by inoculation via combined intratracheal, intranasal, oral and ocular routes. Most of the marmosets developed a progressive severe pneumonia leading to euthanasia of some animals. Extensive lesions were evident in the lungs of all animals necropsied at different time points post inoculation. Some animals were also viremic; high viral loads were detected in the lungs of all infected animals, and total RNAseq demonstrated the induction of immune and inflammatory pathways. This is the first description of a severe, partially lethal, disease model of MERS-CoV, and as such will have a major impact on the ability to assess the efficacy of vaccines and treatment strategies as well as allowing more detailed pathogenesis studies.

DOI: 10.1371/journal.ppat.1004250
PubMed: 25144235

Affiliations:

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Infection with MERS-CoV causes lethal pneumonia in the common marmoset.</title>
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<author><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name>
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<author><name sortKey="Lacasse, Rachel" sort="Lacasse, Rachel" uniqKey="Lacasse R" first="Rachel" last="Lacasse">Rachel Lacasse</name>
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<author><name sortKey="Liu, Tingting" sort="Liu, Tingting" uniqKey="Liu T" first="Tingting" last="Liu">Tingting Liu</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Zhu, Jiang" sort="Zhu, Jiang" uniqKey="Zhu J" first="Jiang" last="Zhu">Jiang Zhu</name>
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<series><title level="j">PLoS pathogens</title>
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<term>Immunohistochemistry</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction between the MERS-CoV spike glycoprotein and its receptor dipeptidyl peptidase 4 predicted comparable interaction energies in common marmosets and humans. The suitability of the marmoset as a MERS-CoV model was tested by inoculation via combined intratracheal, intranasal, oral and ocular routes. Most of the marmosets developed a progressive severe pneumonia leading to euthanasia of some animals. Extensive lesions were evident in the lungs of all animals necropsied at different time points post inoculation. Some animals were also viremic; high viral loads were detected in the lungs of all infected animals, and total RNAseq demonstrated the induction of immune and inflammatory pathways. This is the first description of a severe, partially lethal, disease model of MERS-CoV, and as such will have a major impact on the ability to assess the efficacy of vaccines and treatment strategies as well as allowing more detailed pathogenesis studies. </div>
</front>
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<Month>12</Month>
<Day>21</Day>
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<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
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<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>8</Issue>
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<Month>Aug</Month>
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<Title>PLoS pathogens</Title>
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<ArticleTitle>Infection with MERS-CoV causes lethal pneumonia in the common marmoset.</ArticleTitle>
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<Abstract><AbstractText>The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction between the MERS-CoV spike glycoprotein and its receptor dipeptidyl peptidase 4 predicted comparable interaction energies in common marmosets and humans. The suitability of the marmoset as a MERS-CoV model was tested by inoculation via combined intratracheal, intranasal, oral and ocular routes. Most of the marmosets developed a progressive severe pneumonia leading to euthanasia of some animals. Extensive lesions were evident in the lungs of all animals necropsied at different time points post inoculation. Some animals were also viremic; high viral loads were detected in the lungs of all infected animals, and total RNAseq demonstrated the induction of immune and inflammatory pathways. This is the first description of a severe, partially lethal, disease model of MERS-CoV, and as such will have a major impact on the ability to assess the efficacy of vaccines and treatment strategies as well as allowing more detailed pathogenesis studies. </AbstractText>
</Abstract>
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<ForeName>Darryl</ForeName>
<Initials>D</Initials>
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</AffiliationInfo>
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<ForeName>Emmie</ForeName>
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<ForeName>Friederike</ForeName>
<Initials>F</Initials>
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<ForeName>Angela L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, University of Washington, Seattle, Washington, United States of America.</Affiliation>
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<ForeName>Atsushi</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, University of Washington, Seattle, Washington, United States of America.</Affiliation>
</AffiliationInfo>
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<ForeName>Xinxia</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, University of Washington, Seattle, Washington, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Matthew J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, University of Washington, Seattle, Washington, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Doremalen</LastName>
<ForeName>Neeltje</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</Affiliation>
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<ForeName>Elaine</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</Affiliation>
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<ForeName>Lee</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>LaCasse</LastName>
<ForeName>Rachel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Tingting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Immunology and Microbial Science, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Jiang</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Immunology and Microbial Science, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McLellan</LastName>
<ForeName>Jason S</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scott</LastName>
<ForeName>Dana P</ForeName>
<Initials>DP</Initials>
<AffiliationInfo><Affiliation>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Katze</LastName>
<ForeName>Michael G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, University of Washington, Seattle, Washington, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feldmann</LastName>
<ForeName>Heinz</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Munster</LastName>
<ForeName>Vincent J</ForeName>
<Initials>VJ</Initials>
<AffiliationInfo><Affiliation>Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America.</Affiliation>
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<Agency>NIH HHS</Agency>
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</Reference>
<Reference><Citation>Lancet Infect Dis. 2013 Oct;13(10):859-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23933067</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2013;18(36):pii=20574</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24079378</ArticleId>
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</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24043791</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2013 Oct;19(10):1313-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24013700</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16598-603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24062443</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Nov;87(22):12489-95</Citation>
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<li>New Hampshire</li>
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<settlement><li>Seattle</li>
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<orgName><li>Université de Washington</li>
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<tree><country name="États-Unis"><region name="Montana"><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name>
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<name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name>
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<name sortKey="Haddock, Elaine" sort="Haddock, Elaine" uniqKey="Haddock E" first="Elaine" last="Haddock">Elaine Haddock</name>
<name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
<name sortKey="Lacasse, Rachel" sort="Lacasse, Rachel" uniqKey="Lacasse R" first="Rachel" last="Lacasse">Rachel Lacasse</name>
<name sortKey="Liu, Tingting" sort="Liu, Tingting" uniqKey="Liu T" first="Tingting" last="Liu">Tingting Liu</name>
<name sortKey="Mclellan, Jason S" sort="Mclellan, Jason S" uniqKey="Mclellan J" first="Jason S" last="Mclellan">Jason S. Mclellan</name>
<name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name>
<name sortKey="Nagy, Lee" sort="Nagy, Lee" uniqKey="Nagy L" first="Lee" last="Nagy">Lee Nagy</name>
<name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name>
<name sortKey="Peng, Xinxia" sort="Peng, Xinxia" uniqKey="Peng X" first="Xinxia" last="Peng">Xinxia Peng</name>
<name sortKey="Rasmussen, Angela L" sort="Rasmussen, Angela L" uniqKey="Rasmussen A" first="Angela L" last="Rasmussen">Angela L. Rasmussen</name>
<name sortKey="Scott, Dana P" sort="Scott, Dana P" uniqKey="Scott D" first="Dana P" last="Scott">Dana P. Scott</name>
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<name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name>
<name sortKey="Zhu, Jiang" sort="Zhu, Jiang" uniqKey="Zhu J" first="Jiang" last="Zhu">Jiang Zhu</name>
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<country name="Canada"><region name="Manitoba"><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name>
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   |wiki=    Sante
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   |clé=     pubmed:25144235
   |texte=   Infection with MERS-CoV causes lethal pneumonia in the common marmoset.
}}

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	Serveur d'exploration MERS
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Serveur d'exploration MERS

Infection with MERS-CoV causes lethal pneumonia in the common marmoset.

Infection with MERS-CoV causes lethal pneumonia in the common marmoset.

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