An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia, 2014.
Identifieur interne : 001640 ( PubMed/Checkpoint ); précédent : 001639; suivant : 001641An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia, 2014.
Auteurs : Christian Drosten [Allemagne] ; Doreen Muth ; Victor M. Corman [Allemagne] ; Raheela Hussain ; Malaki Al Masri ; Waleed Hajomar ; Olfert Landt [Allemagne] ; Abdullah Assiri ; Isabella Eckerle ; Ali Al Shangiti ; Jaffar A. Al-Tawfiq ; Ali Albarrak ; Alimuddin Zumla ; Andrew Rambaut [États-Unis] ; Ziad A. MemishSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- MESH :
- geographic : Saudi Arabia.
- epidemiology : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- Base Sequence, Cross Infection, Disease Outbreaks, Humans, Molecular Sequence Data, Polymorphism, Single Nucleotide.
Abstract
In spring 2014, a sudden rise in the number of notified Middle East respiratory syndrome coronavirus (MERS-CoV) infections occurred across Saudi Arabia with a focus in Jeddah. Hypotheses to explain the outbreak pattern include increased surveillance, increased zoonotic transmission, nosocomial transmission, and changes in viral transmissibility, as well as diagnostic laboratory artifacts.
DOI: 10.1093/cid/ciu812
PubMed: 25323704
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:25323704Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia, 2014.</title>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
<affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation>
<wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M" last="Corman">Victor M. Corman</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hussain, Raheela" sort="Hussain, Raheela" uniqKey="Hussain R" first="Raheela" last="Hussain">Raheela Hussain</name>
<affiliation><nlm:affiliation>Jeddah Regional Laboratory.</nlm:affiliation>
<wicri:noCountry code="no comma">Jeddah Regional Laboratory.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Al Masri, Malaki" sort="Al Masri, Malaki" uniqKey="Al Masri M" first="Malaki" last="Al Masri">Malaki Al Masri</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine.</nlm:affiliation>
<wicri:noCountry code="no comma">Global Centre for Mass Gatherings Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hajomar, Waleed" sort="Hajomar, Waleed" uniqKey="Hajomar W" first="Waleed" last="Hajomar">Waleed Hajomar</name>
<affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Landt, Olfert" sort="Landt, Olfert" uniqKey="Landt O" first="Olfert" last="Landt">Olfert Landt</name>
<affiliation wicri:level="3"><nlm:affiliation>Tib-Molbiol, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tib-Molbiol, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine.</nlm:affiliation>
<wicri:noCountry code="no comma">Global Centre for Mass Gatherings Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Eckerle, Isabella" sort="Eckerle, Isabella" uniqKey="Eckerle I" first="Isabella" last="Eckerle">Isabella Eckerle</name>
<affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation>
<wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Al Shangiti, Ali" sort="Al Shangiti, Ali" uniqKey="Al Shangiti A" first="Ali" last="Al Shangiti">Ali Al Shangiti</name>
<affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
<affiliation><nlm:affiliation>Johns Hopkins Aramco Healthcare, Saudi Aramco, Dhahran, Kingdom of Saudi Arabia Indiana University School of Medicine, Indianapolis.</nlm:affiliation>
<wicri:noCountry code="subField">Indianapolis</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Albarrak, Ali" sort="Albarrak, Ali" uniqKey="Albarrak A" first="Ali" last="Albarrak">Ali Albarrak</name>
<affiliation><nlm:affiliation>Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine Division of Infection and Immunity, University College London National Institute for Health Research Biomedical Research Centre, University College London Hospitals National Health Service Foundation Trust.</nlm:affiliation>
<wicri:noCountry code="subField">University College London Hospitals National Health Service Foundation Trust</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, University of Edinburgh, United Kingdom Fogarty International Center, National Institutes of Health, Bethesda, Maryland.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, University of Edinburgh, United Kingdom Fogarty International Center, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine Alfaisal University, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25323704</idno>
<idno type="pmid">25323704</idno>
<idno type="doi">10.1093/cid/ciu812</idno>
<idno type="wicri:Area/PubMed/Corpus">001812</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001812</idno>
<idno type="wicri:Area/PubMed/Curation">001812</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001812</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001640</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001640</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia, 2014.</title>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
<affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation>
<wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M" last="Corman">Victor M. Corman</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hussain, Raheela" sort="Hussain, Raheela" uniqKey="Hussain R" first="Raheela" last="Hussain">Raheela Hussain</name>
<affiliation><nlm:affiliation>Jeddah Regional Laboratory.</nlm:affiliation>
<wicri:noCountry code="no comma">Jeddah Regional Laboratory.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Al Masri, Malaki" sort="Al Masri, Malaki" uniqKey="Al Masri M" first="Malaki" last="Al Masri">Malaki Al Masri</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine.</nlm:affiliation>
<wicri:noCountry code="no comma">Global Centre for Mass Gatherings Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hajomar, Waleed" sort="Hajomar, Waleed" uniqKey="Hajomar W" first="Waleed" last="Hajomar">Waleed Hajomar</name>
<affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Landt, Olfert" sort="Landt, Olfert" uniqKey="Landt O" first="Olfert" last="Landt">Olfert Landt</name>
<affiliation wicri:level="3"><nlm:affiliation>Tib-Molbiol, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Tib-Molbiol, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine.</nlm:affiliation>
<wicri:noCountry code="no comma">Global Centre for Mass Gatherings Medicine.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Eckerle, Isabella" sort="Eckerle, Isabella" uniqKey="Eckerle I" first="Isabella" last="Eckerle">Isabella Eckerle</name>
<affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation>
<wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Al Shangiti, Ali" sort="Al Shangiti, Ali" uniqKey="Al Shangiti A" first="Ali" last="Al Shangiti">Ali Al Shangiti</name>
<affiliation><nlm:affiliation>Regional Laboratory, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
<affiliation><nlm:affiliation>Johns Hopkins Aramco Healthcare, Saudi Aramco, Dhahran, Kingdom of Saudi Arabia Indiana University School of Medicine, Indianapolis.</nlm:affiliation>
<wicri:noCountry code="subField">Indianapolis</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Albarrak, Ali" sort="Albarrak, Ali" uniqKey="Albarrak A" first="Ali" last="Albarrak">Ali Albarrak</name>
<affiliation><nlm:affiliation>Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine Division of Infection and Immunity, University College London National Institute for Health Research Biomedical Research Centre, University College London Hospitals National Health Service Foundation Trust.</nlm:affiliation>
<wicri:noCountry code="subField">University College London Hospitals National Health Service Foundation Trust</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, University of Edinburgh, United Kingdom Fogarty International Center, National Institutes of Health, Bethesda, Maryland.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, University of Edinburgh, United Kingdom Fogarty International Center, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name>
<affiliation><nlm:affiliation>Global Centre for Mass Gatherings Medicine Alfaisal University, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Cross Infection</term>
<term>Disease Outbreaks</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Arabie saoudite</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Infection croisée</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Séquence nucléotidique</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term>
<term>Cross Infection</term>
<term>Disease Outbreaks</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Arabie saoudite</term>
<term>Données de séquences moléculaires</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Infection croisée</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Séquence nucléotidique</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In spring 2014, a sudden rise in the number of notified Middle East respiratory syndrome coronavirus (MERS-CoV) infections occurred across Saudi Arabia with a focus in Jeddah. Hypotheses to explain the outbreak pattern include increased surveillance, increased zoonotic transmission, nosocomial transmission, and changes in viral transmissibility, as well as diagnostic laboratory artifacts.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25323704</PMID>
<DateCompleted><Year>2015</Year>
<Month>09</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>60</Volume>
<Issue>3</Issue>
<PubDate><Year>2015</Year>
<Month>Feb</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title>
<ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia, 2014.</ArticleTitle>
<Pagination><MedlinePgn>369-77</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciu812</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In spring 2014, a sudden rise in the number of notified Middle East respiratory syndrome coronavirus (MERS-CoV) infections occurred across Saudi Arabia with a focus in Jeddah. Hypotheses to explain the outbreak pattern include increased surveillance, increased zoonotic transmission, nosocomial transmission, and changes in viral transmissibility, as well as diagnostic laboratory artifacts.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Diagnostic results from Jeddah Regional Laboratory were analyzed. Viruses from the Jeddah outbreak and viruses occurring during the same time in Riyadh, Al-Kharj, and Madinah were fully or partially sequenced. A set of 4 single-nucleotide polymorphisms distinctive to the Jeddah outbreak were determined from additional viruses. Viruses from Riyadh and Jeddah were isolated and studied in cell culture.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Up to 481 samples were received per day for reverse transcription polymerase chain reaction (RT-PCR) testing. A laboratory proficiency assessment suggested positive and negative results to be reliable. Forty-nine percent of 168 positive-testing samples during the Jeddah outbreak stemmed from King Fahd Hospital. All viruses from Jeddah were monophyletic and similar, whereas viruses from Riyadh were paraphyletic and diverse. A hospital-associated transmission cluster, to which cases in Indiana (United States) and the Netherlands belonged, was discovered in Riyadh. One Jeddah-type virus was found in Riyadh, with matching travel history to Jeddah. Virus isolates representing outbreaks in Jeddah and Riyadh were not different from MERS-CoV EMC/2012 in replication, escape of interferon response, or serum neutralization.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Virus shedding and virus functions did not change significantly during the outbreak in Jeddah. These results suggest the outbreaks to have been caused by biologically unchanged viruses in connection with nosocomial transmission.</AbstractText>
<CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drosten</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muth</LastName>
<ForeName>Doreen</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Corman</LastName>
<ForeName>Victor M</ForeName>
<Initials>VM</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre German Centre for Infection Research, Hannover, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hussain</LastName>
<ForeName>Raheela</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Jeddah Regional Laboratory.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al Masri</LastName>
<ForeName>Malaki</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>HajOmar</LastName>
<ForeName>Waleed</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Regional Laboratory, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Landt</LastName>
<ForeName>Olfert</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Tib-Molbiol, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Assiri</LastName>
<ForeName>Abdullah</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eckerle</LastName>
<ForeName>Isabella</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al Shangiti</LastName>
<ForeName>Ali</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Regional Laboratory, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Tawfiq</LastName>
<ForeName>Jaffar A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Johns Hopkins Aramco Healthcare, Saudi Aramco, Dhahran, Kingdom of Saudi Arabia Indiana University School of Medicine, Indianapolis.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Albarrak</LastName>
<ForeName>Ali</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zumla</LastName>
<ForeName>Alimuddin</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine Division of Infection and Immunity, University College London National Institute for Health Research Biomedical Research Centre, University College London Hospitals National Health Service Foundation Trust.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rambaut</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Evolutionary Biology, University of Edinburgh, Centre for Infection, Immunity and Evolution, University of Edinburgh, United Kingdom Fogarty International Center, National Institutes of Health, Bethesda, Maryland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Memish</LastName>
<ForeName>Ziad A</ForeName>
<Initials>ZA</Initials>
<AffiliationInfo><Affiliation>Global Centre for Mass Gatherings Medicine Alfaisal University, Riyadh, Kingdom of Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName>
<AccessionNumberList><AccessionNumber>KM027260</AccessionNumber>
<AccessionNumber>KM027262</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>095831</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>10</Month>
<Day>16</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Clin Infect Dis</MedlineTA>
<NlmUniqueID>9203213</NlmUniqueID>
<ISSNLinking>1058-4838</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Clin Infect Dis. 2015 Feb 1;60(3):378-80</RefSource>
<PMID Version="1">25323703</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="Y">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012529" MajorTopicYN="N" Type="Geographic">Saudi Arabia</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MERS-coronavirus</Keyword>
<Keyword MajorTopicYN="N">nosocomial transmission</Keyword>
<Keyword MajorTopicYN="N">outbreak</Keyword>
<Keyword MajorTopicYN="N">transmission infection control</Keyword>
<Keyword MajorTopicYN="N">virus isolation</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>10</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>10</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>9</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25323704</ArticleId>
<ArticleId IdType="pii">ciu812</ArticleId>
<ArticleId IdType="doi">10.1093/cid/ciu812</ArticleId>
<ArticleId IdType="pmc">PMC4303774</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2014 Jun;20(6):1012-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24857749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2004 Nov 2;141(9):662-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15520422</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2014;19(21). pii: 20817</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24906375</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Aug;20(8):1339-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25075761</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Infect Dis. 2014 Jun;23:63-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24699184</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2006 Jan;129(1):95-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16424418</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virol J. 2008;5:138</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19014487</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Syst Biol. 2012 May;61(3):539-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22357727</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012;17(39). pii: 20285</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23041020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012;17(49). pii: 20334</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23231891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2012;3(6). pii: e00515-12. doi: 10.1128/mBio.00515-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23232719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2013 Aug 1;369(5):407-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23782161</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):745-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23782859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Apr;20(4):552-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24655412</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2014;5(3):e01146-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24781747</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2014 May 16;63(19):431-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24827411</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2014 Aug 28;371(9):828-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25162889</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>États-Unis</li>
</country>
<region><li>Basse-Saxe</li>
<li>Berlin</li>
<li>Maryland</li>
</region>
<settlement><li>Berlin</li>
<li>Hanovre</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Al Masri, Malaki" sort="Al Masri, Malaki" uniqKey="Al Masri M" first="Malaki" last="Al Masri">Malaki Al Masri</name>
<name sortKey="Al Shangiti, Ali" sort="Al Shangiti, Ali" uniqKey="Al Shangiti A" first="Ali" last="Al Shangiti">Ali Al Shangiti</name>
<name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
<name sortKey="Albarrak, Ali" sort="Albarrak, Ali" uniqKey="Albarrak A" first="Ali" last="Albarrak">Ali Albarrak</name>
<name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name>
<name sortKey="Eckerle, Isabella" sort="Eckerle, Isabella" uniqKey="Eckerle I" first="Isabella" last="Eckerle">Isabella Eckerle</name>
<name sortKey="Hajomar, Waleed" sort="Hajomar, Waleed" uniqKey="Hajomar W" first="Waleed" last="Hajomar">Waleed Hajomar</name>
<name sortKey="Hussain, Raheela" sort="Hussain, Raheela" uniqKey="Hussain R" first="Raheela" last="Hussain">Raheela Hussain</name>
<name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name>
<name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
<name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name>
</noCountry>
<country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
</region>
<name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M" last="Corman">Victor M. Corman</name>
<name sortKey="Landt, Olfert" sort="Landt, Olfert" uniqKey="Landt O" first="Olfert" last="Landt">Olfert Landt</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001640 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001640 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:25323704 |texte= An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia, 2014. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:25323704" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |