Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.
Identifieur interne : 001629 ( PubMed/Checkpoint ); précédent : 001628; suivant : 001630Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.
Auteurs : Bart L. Haagmans [Pays-Bas] ; Judith M A. Van Den Brand [Pays-Bas] ; Lisette B. Provacia [Pays-Bas] ; V Stalin Raj [Pays-Bas] ; Koert J. Stittelaar [Pays-Bas] ; Sarah Getu [Pays-Bas] ; Leon De Waal [Pays-Bas] ; Theo M. Bestebroer [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Georges M G M. Verjans [Pays-Bas] ; Ron A M. Fouchier [Pays-Bas] ; Saskia L. Smits [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; Albert D M E. Osterhaus [Pays-Bas]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Appareil respiratoire (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (croissance et développement), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Cricetinae, Excrétion virale, Femelle, Infections à coronavirus (anatomopathologie), Infections à coronavirus (virologie), Lapins, Maladies asymptomatiques, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Souris.
- MESH :
- anatomopathologie : Infections à coronavirus, Poumon.
- croissance et développement : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Appareil respiratoire, Infections à coronavirus, Poumon.
- Animaux, Cricetinae, Excrétion virale, Femelle, Lapins, Maladies asymptomatiques, Modèles animaux de maladie humaine, Souris.
English descriptors
- KwdEn :
- Animals, Asymptomatic Diseases, Coronavirus Infections (pathology), Coronavirus Infections (virology), Cricetinae, Disease Models, Animal, Female, Lung (pathology), Lung (virology), Mice, Middle East Respiratory Syndrome Coronavirus (growth & development), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Rabbits, Respiratory System (virology), Virus Shedding.
- MESH :
- growth & development : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections, Lung.
- virology : Coronavirus Infections, Lung, Respiratory System.
- Animals, Asymptomatic Diseases, Cricetinae, Disease Models, Animal, Female, Mice, Rabbits, Virus Shedding.
Abstract
The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.
DOI: 10.1128/JVI.00661-15
PubMed: 25810539
Affiliations:
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Bestebroer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Verjans, Georges M G M" sort="Verjans, Georges M G M" uniqKey="Verjans G" first="Georges M G M" last="Verjans">Georges M G M. Verjans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. 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Haagmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands b.haagmans@erasmusmc.nl.</nlm:affiliation><country wicri:rule="url">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M A" last="Van Den Brand">Judith M A. Van Den Brand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Provacia, Lisette B" sort="Provacia, Lisette B" uniqKey="Provacia L" first="Lisette B" last="Provacia">Lisette B. Provacia</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Stittelaar, Koert J" sort="Stittelaar, Koert J" uniqKey="Stittelaar K" first="Koert J" last="Stittelaar">Koert J. Stittelaar</name><affiliation wicri:level="3"><nlm:affiliation>Viroclinics Biosciences, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Viroclinics Biosciences, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Getu, Sarah" sort="Getu, Sarah" uniqKey="Getu S" first="Sarah" last="Getu">Sarah Getu</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Waal, Leon" sort="De Waal, Leon" uniqKey="De Waal L" first="Leon" last="De Waal">Leon De Waal</name><affiliation wicri:level="3"><nlm:affiliation>Viroclinics Biosciences, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Viroclinics Biosciences, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M" last="Bestebroer">Theo M. Bestebroer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Verjans, Georges M G M" sort="Verjans, Georges M G M" uniqKey="Verjans G" first="Georges M G M" last="Verjans">Georges M G M. Verjans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands Viroclinics Biosciences, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands Viroclinics Biosciences, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands Viroclinics Biosciences, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands Viroclinics Biosciences, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Asymptomatic Diseases</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Cricetinae</term><term>Disease Models, Animal</term><term>Female</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Mice</term><term>Middle East Respiratory Syndrome Coronavirus (growth & development)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Rabbits</term><term>Respiratory System (virology)</term><term>Virus Shedding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Appareil respiratoire (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (croissance et développement)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Cricetinae</term><term>Excrétion virale</term><term>Femelle</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (virologie)</term><term>Lapins</term><term>Maladies asymptomatiques</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Souris</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Asymptomatic Diseases</term><term>Cricetinae</term><term>Disease Models, Animal</term><term>Female</term><term>Mice</term><term>Rabbits</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cricetinae</term><term>Excrétion virale</term><term>Femelle</term><term>Lapins</term><term>Maladies asymptomatiques</term><term>Modèles animaux de maladie humaine</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25810539</PMID><DateCompleted><Year>2015</Year><Month>07</Month><Day>27</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>89</Volume><Issue>11</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.</ArticleTitle><Pagination><MedlinePgn>6131-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.00661-15</ELocationID><Abstract><AbstractText>The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species. </AbstractText><CopyrightInformation>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Haagmans</LastName><ForeName>Bart L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands b.haagmans@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van den Brand</LastName><ForeName>Judith M A</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Provacia</LastName><ForeName>Lisette B</ForeName><Initials>LB</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raj</LastName><ForeName>V Stalin</ForeName><Initials>VS</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stittelaar</LastName><ForeName>Koert J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>Viroclinics Biosciences, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Getu</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Waal</LastName><ForeName>Leon</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Viroclinics Biosciences, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bestebroer</LastName><ForeName>Theo M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Amerongen</LastName><ForeName>Geert</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verjans</LastName><ForeName>Georges M G M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fouchier</LastName><ForeName>Ron A M</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smits</LastName><ForeName>Saskia L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands Viroclinics Biosciences, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuiken</LastName><ForeName>Thijs</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osterhaus</LastName><ForeName>Albert D M E</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands Viroclinics Biosciences, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HHSN266200700010C</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN266200700010C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058070" MajorTopicYN="N">Asymptomatic Diseases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006224" MajorTopicYN="N">Cricetinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012137" MajorTopicYN="N">Respiratory System</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017201" MajorTopicYN="N">Virus Shedding</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>03</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25810539</ArticleId><ArticleId IdType="pii">JVI.00661-15</ArticleId><ArticleId IdType="doi">10.1128/JVI.00661-15</ArticleId><ArticleId IdType="pmc">PMC4442453</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>PLoS One. 2013;8(7):e69127</Citation><ArticleIdList><ArticleId IdType="pubmed">23844250</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2012;17(40):20290</Citation><ArticleIdList><ArticleId IdType="pubmed">23078800</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Feb;88(3):1834-8</Citation><ArticleIdList><ArticleId IdType="pubmed">24257613</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Curr. 2013 Nov 12;5:null</Citation><ArticleIdList><ArticleId 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IdType="pubmed">23232719</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. 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