Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014.
Identifieur interne : 001426 ( PubMed/Checkpoint ); précédent : 001425; suivant : 001427Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014.
Auteurs : Shamsudeen F. Fagbo ; Leila Skakni ; Daniel K W. Chu ; Musa A. Garbati ; Mercy Joseph ; Malik Peiris ; Ahmed M. HakawiSource :
- Emerging infectious diseases [ 1080-6059 ] ; 2015.
Descripteurs français
- KwdFr :
- Arabie saoudite (épidémiologie), Flambées de maladies, Humains, Infections de l'appareil respiratoire (génétique), Infections de l'appareil respiratoire (transmission), Infections de l'appareil respiratoire (épidémiologie), Infections à coronavirus (génétique), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Maladie iatrogène (épidémiologie), Épidémiologie moléculaire ().
- MESH :
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Coronavirus Infections (epidemiology), Coronavirus Infections (genetics), Coronavirus Infections (transmission), Disease Outbreaks, Humans, Iatrogenic Disease (epidemiology), Molecular Epidemiology (methods), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (genetics), Respiratory Tract Infections (transmission), Saudi Arabia (epidemiology).
- MESH :
- geographic , epidemiology : Saudi Arabia.
- epidemiology : Coronavirus Infections, Iatrogenic Disease, Respiratory Tract Infections.
- genetics : Coronavirus Infections, Respiratory Tract Infections.
- methods : Molecular Epidemiology.
- transmission : Coronavirus Infections, Respiratory Tract Infections.
- Disease Outbreaks, Humans.
Abstract
We investigated an outbreak of Middle East respiratory syndrome (MERS) at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, during March 29-May 21, 2014. This outbreak involved 45 patients: 8 infected outside KFMC, 13 long-term patients at KFMC, 23 health care workers, and 1 who had an indeterminate source of infection. Sequences of full-length MERS coronavirus (MERS-CoV) from 10 patients and a partial sequence of MERS-CoV from another patient, when compared with other MERS-CoV sequences, demonstrated that this outbreak was part of a larger outbreak that affected multiple health care facilities in Riyadh and possibly arose from a single zoonotic transmission event that occurred in December 2013 (95% highest posterior density interval November 8, 2013-February 10, 2014). This finding suggested continued health care-associated transmission for 5 months. Molecular epidemiology documented multiple external introductions in a seemingly contiguous outbreak and helped support or refute transmission pathways suspected through epidemiologic investigation.
DOI: 10.3201/eid2111.150944
PubMed: 26484549
Affiliations:
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This outbreak involved 45 patients: 8 infected outside KFMC, 13 long-term patients at KFMC, 23 health care workers, and 1 who had an indeterminate source of infection. Sequences of full-length MERS coronavirus (MERS-CoV) from 10 patients and a partial sequence of MERS-CoV from another patient, when compared with other MERS-CoV sequences, demonstrated that this outbreak was part of a larger outbreak that affected multiple health care facilities in Riyadh and possibly arose from a single zoonotic transmission event that occurred in December 2013 (95% highest posterior density interval November 8, 2013-February 10, 2014). This finding suggested continued health care-associated transmission for 5 months. Molecular epidemiology documented multiple external introductions in a seemingly contiguous outbreak and helped support or refute transmission pathways suspected through epidemiologic investigation. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26484549</PMID><DateCompleted><Year>2016</Year><Month>05</Month><Day>17</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1080-6059</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>11</Issue><PubDate><Year>2015</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Emerging infectious diseases</Title><ISOAbbreviation>Emerging Infect. 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Sequences of full-length MERS coronavirus (MERS-CoV) from 10 patients and a partial sequence of MERS-CoV from another patient, when compared with other MERS-CoV sequences, demonstrated that this outbreak was part of a larger outbreak that affected multiple health care facilities in Riyadh and possibly arose from a single zoonotic transmission event that occurred in December 2013 (95% highest posterior density interval November 8, 2013-February 10, 2014). This finding suggested continued health care-associated transmission for 5 months. 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Chu</name><name sortKey="Fagbo, Shamsudeen F" sort="Fagbo, Shamsudeen F" uniqKey="Fagbo S" first="Shamsudeen F" last="Fagbo">Shamsudeen F. Fagbo</name><name sortKey="Garbati, Musa A" sort="Garbati, Musa A" uniqKey="Garbati M" first="Musa A" last="Garbati">Musa A. Garbati</name><name sortKey="Hakawi, Ahmed M" sort="Hakawi, Ahmed M" uniqKey="Hakawi A" first="Ahmed M" last="Hakawi">Ahmed M. Hakawi</name><name sortKey="Joseph, Mercy" sort="Joseph, Mercy" uniqKey="Joseph M" first="Mercy" last="Joseph">Mercy Joseph</name><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><name sortKey="Skakni, Leila" sort="Skakni, Leila" uniqKey="Skakni L" first="Leila" last="Skakni">Leila Skakni</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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