On the biased nucleotide composition of the human coronavirus RNA genome.
Identifieur interne : 001416 ( PubMed/Checkpoint ); précédent : 001415; suivant : 001417On the biased nucleotide composition of the human coronavirus RNA genome.
Auteurs : Ben Berkhout [Pays-Bas] ; Formijn Van Hemert [Pays-Bas]Source :
- Virus research [ 1872-7492 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Biosynthèse des protéines, Composition en bases nucléiques, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Génome viral, Humains, Nucléotides (génétique), Protéines virales (biosynthèse), Virus du SRAS (génétique), Virus du SRAS (physiologie).
- MESH :
- biosynthèse : Protéines virales.
- génétique : ARN viral, Coronavirus du syndrome respiratoire du Moyen-Orient, Nucléotides, Virus du SRAS.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- Biosynthèse des protéines, Composition en bases nucléiques, Génome viral, Humains.
English descriptors
- KwdEn :
- Base Composition, Genome, Viral, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Nucleotides (genetics), Protein Biosynthesis, RNA, Viral (genetics), SARS Virus (genetics), SARS Virus (physiology), Viral Proteins (biosynthesis).
- MESH :
- chemical , biosynthesis : Viral Proteins.
- chemical , genetics : Nucleotides, RNA, Viral.
- genetics : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- Base Composition, Genome, Viral, Humans, Protein Biosynthesis.
Abstract
We investigated the nucleotide composition of the RNA genome of the six human coronaviruses. Some general coronavirus characteristics were apparent (e.g. high U, low C count), but we also detected species-specific signatures. Most strikingly, the high U and low C proportions are quite variable and act like communicating vessels, C goes down when U goes up and vice versa. U ranges among virus isolates from 30.7% to 40.3%, and C makes the opposite movement from 20.0% to 12.9%, respectively. The nucleotide biases are more pronounced in the unpaired regions of the structured RNA genome, which may suggest a certain biological function for these distinctive sequence signatures. Coronaviruses have an atypical codon usage that has been linked to mutational events operating on the viral RNA genome on an evolutionary time scale. We suggest that the atypical nucleotide bias may serve a distinct biological function and that it is the direct cause of the characteristic codon usage in these viruses. The relevance for evolution of the novel human pathogens MERS and SARS is discussed.
DOI: 10.1016/j.virusres.2014.11.031
PubMed: 25656063
Affiliations:
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pubmed:25656063Le document en format XML
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<front><div type="abstract" xml:lang="en">We investigated the nucleotide composition of the RNA genome of the six human coronaviruses. Some general coronavirus characteristics were apparent (e.g. high U, low C count), but we also detected species-specific signatures. Most strikingly, the high U and low C proportions are quite variable and act like communicating vessels, C goes down when U goes up and vice versa. U ranges among virus isolates from 30.7% to 40.3%, and C makes the opposite movement from 20.0% to 12.9%, respectively. The nucleotide biases are more pronounced in the unpaired regions of the structured RNA genome, which may suggest a certain biological function for these distinctive sequence signatures. Coronaviruses have an atypical codon usage that has been linked to mutational events operating on the viral RNA genome on an evolutionary time scale. We suggest that the atypical nucleotide bias may serve a distinct biological function and that it is the direct cause of the characteristic codon usage in these viruses. The relevance for evolution of the novel human pathogens MERS and SARS is discussed. </div>
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<Abstract><AbstractText>We investigated the nucleotide composition of the RNA genome of the six human coronaviruses. Some general coronavirus characteristics were apparent (e.g. high U, low C count), but we also detected species-specific signatures. Most strikingly, the high U and low C proportions are quite variable and act like communicating vessels, C goes down when U goes up and vice versa. U ranges among virus isolates from 30.7% to 40.3%, and C makes the opposite movement from 20.0% to 12.9%, respectively. The nucleotide biases are more pronounced in the unpaired regions of the structured RNA genome, which may suggest a certain biological function for these distinctive sequence signatures. Coronaviruses have an atypical codon usage that has been linked to mutational events operating on the viral RNA genome on an evolutionary time scale. We suggest that the atypical nucleotide bias may serve a distinct biological function and that it is the direct cause of the characteristic codon usage in these viruses. The relevance for evolution of the novel human pathogens MERS and SARS is discussed. </AbstractText>
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<ReferenceList><Reference><Citation>Nucleic Acids Res. 1987 Feb 11;15(3):1281-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3547335</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nucleic Acids Res. 1994 May 11;22(9):1705-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8202375</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virol J. 2004 Nov 17;1:7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15548333</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2012;7(4):e33502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22529893</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Biol Evol. 2011 Oct;28(10):2731-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21546353</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Gene. 1990 Mar 1;87(1):23-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2110097</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>mBio. 2012 Nov 20;3(6):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23170002</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2003 May 15;423(6937):240</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12748632</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2004 May;101(2):155-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15041183</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Virol. 2011 Jan;156(1):153-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21069395</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2009 Aug 6;460(7256):711-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19661910</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Genes. 2013 Feb;46(1):10-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22996735</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Viruses. 2010 Aug;2(8):1804-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21994708</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nucleic Acids Res. 2000 Jan 1;28(1):292</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10592250</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Feb;14(2):140-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Retrovirology. 2012 Nov 06;9:92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23131071</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Opin Microbiol. 2014 Aug;20:69-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24908561</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1982 Mar 25;257(6):3026-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7037777</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Evol. 1995 Aug;41(2):132-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7666442</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nucleic Acids Res. 1998 May 15;26(10):2286-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9580676</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2013 Nov 26;8(11):e81469</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24303050</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 2004 Apr;10(4):368-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15034574</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Jan;79(2):884-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15613317</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>RNA Biol. 2013 Feb;10(2):211-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23235488</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2007 Apr;81(7):3051-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17079323</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Evol Biol. 2010 Aug 19;10:253</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20723216</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2003 Mar;92(1):1-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12606071</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2012;8(10):e1002950</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23055928</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Trends Genet. 2004 Mar;20(3):131-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15049309</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2014 Nov 26;193:16-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24675274</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biomed Res Int. 2013;2013:406342</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24199191</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2007 Dec 20;369(2):431-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17881030</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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<tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Berkhout, Ben" sort="Berkhout, Ben" uniqKey="Berkhout B" first="Ben" last="Berkhout">Ben Berkhout</name>
</region>
<name sortKey="Van Hemert, Formijn" sort="Van Hemert, Formijn" uniqKey="Van Hemert F" first="Formijn" last="Van Hemert">Formijn Van Hemert</name>
</country>
</tree>
</affiliations>
</record>
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Pour générer des pages wiki
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