MersV1, PubMed, Checkpoint, bibRecord, 001416

On the biased nucleotide composition of the human coronavirus RNA genome.

Identifieur interne : 001416 ( PubMed/Checkpoint ); précédent : 001415; suivant : 001417

On the biased nucleotide composition of the human coronavirus RNA genome.

Auteurs : Ben Berkhout [Pays-Bas] ; Formijn Van Hemert [Pays-Bas]

Source :

Virus research [ 1872-7492 ] ; 2015.

RBID : pubmed:25656063

Descripteurs français

KwdFr :
- ARN viral (génétique), Biosynthèse des protéines, Composition en bases nucléiques, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Génome viral, Humains, Nucléotides (génétique), Protéines virales (biosynthèse), Virus du SRAS (génétique), Virus du SRAS (physiologie).
MESH :
- biosynthèse : Protéines virales.
- génétique : ARN viral, Coronavirus du syndrome respiratoire du Moyen-Orient, Nucléotides, Virus du SRAS.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- Biosynthèse des protéines, Composition en bases nucléiques, Génome viral, Humains.

English descriptors

KwdEn :
- Base Composition, Genome, Viral, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Nucleotides (genetics), Protein Biosynthesis, RNA, Viral (genetics), SARS Virus (genetics), SARS Virus (physiology), Viral Proteins (biosynthesis).
MESH :
- chemical , biosynthesis : Viral Proteins.
- chemical , genetics : Nucleotides, RNA, Viral.
- genetics : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- Base Composition, Genome, Viral, Humans, Protein Biosynthesis.

Abstract

We investigated the nucleotide composition of the RNA genome of the six human coronaviruses. Some general coronavirus characteristics were apparent (e.g. high U, low C count), but we also detected species-specific signatures. Most strikingly, the high U and low C proportions are quite variable and act like communicating vessels, C goes down when U goes up and vice versa. U ranges among virus isolates from 30.7% to 40.3%, and C makes the opposite movement from 20.0% to 12.9%, respectively. The nucleotide biases are more pronounced in the unpaired regions of the structured RNA genome, which may suggest a certain biological function for these distinctive sequence signatures. Coronaviruses have an atypical codon usage that has been linked to mutational events operating on the viral RNA genome on an evolutionary time scale. We suggest that the atypical nucleotide bias may serve a distinct biological function and that it is the direct cause of the characteristic codon usage in these viruses. The relevance for evolution of the novel human pathogens MERS and SARS is discussed.

DOI: 10.1016/j.virusres.2014.11.031
PubMed: 25656063

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We investigated the nucleotide composition of the RNA genome of the six human coronaviruses. Some general coronavirus characteristics were apparent (e.g. high U, low C count), but we also detected species-specific signatures. Most strikingly, the high U and low C proportions are quite variable and act like communicating vessels, C goes down when U goes up and vice versa. U ranges among virus isolates from 30.7% to 40.3%, and C makes the opposite movement from 20.0% to 12.9%, respectively. The nucleotide biases are more pronounced in the unpaired regions of the structured RNA genome, which may suggest a certain biological function for these distinctive sequence signatures. Coronaviruses have an atypical codon usage that has been linked to mutational events operating on the viral RNA genome on an evolutionary time scale. We suggest that the atypical nucleotide bias may serve a distinct biological function and that it is the direct cause of the characteristic codon usage in these viruses. The relevance for evolution of the novel human pathogens MERS and SARS is discussed. </div>
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<region><li>Hollande-Septentrionale</li>
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<settlement><li>Amsterdam</li>
</settlement>
<orgName><li>Université d'Amsterdam</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Berkhout, Ben" sort="Berkhout, Ben" uniqKey="Berkhout B" first="Ben" last="Berkhout">Ben Berkhout</name>
</region>
<name sortKey="Van Hemert, Formijn" sort="Van Hemert, Formijn" uniqKey="Van Hemert F" first="Formijn" last="Van Hemert">Formijn Van Hemert</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001416 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001416 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:25656063
   |texte=   On the biased nucleotide composition of the human coronavirus RNA genome.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:25656063" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

On the biased nucleotide composition of the human coronavirus RNA genome.

On the biased nucleotide composition of the human coronavirus RNA genome.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki