MersV1, PubMed, Checkpoint, bibRecord, 001096

Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.

Identifieur interne : 001096 ( PubMed/Checkpoint ); précédent : 001095; suivant : 001097

Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.

Auteurs : Yaseen M. Arabi [Arabie saoudite] ; Farhan Al-Enezi [Arabie saoudite] ; Kajsa-Stina Longuere [Royaume-Uni] ; Hanan H. Balkhy [Arabie saoudite] ; Mohamed Al-Sultan [Arabie saoudite] ; Awad Al-Omari [Arabie saoudite] ; Fahad M. Al-Hameed [Arabie saoudite] ; Gail Carson [Royaume-Uni] ; Nahoko Shindo [Suisse] ; Robert Fowler [Canada]

Source :

BMC anesthesiology [ 1471-2253 ] ; 2016.

RBID : pubmed:27405596

Descripteurs français

English descriptors

KwdEn :
- Attitude of Health Personnel, Coronavirus Infections (blood), Coronavirus Infections (therapy), Coronavirus Infections (virology), Critical Care (statistics & numerical data), Feasibility Studies, Humans, Middle East Respiratory Syndrome Coronavirus, Physicians (psychology), Plasma Exchange, Randomized Controlled Trials as Topic (methods), Saudi Arabia, Surveys and Questionnaires.
MESH :
- blood : Coronavirus Infections.
- methods : Randomized Controlled Trials as Topic.
- psychology : Physicians.
- statistics & numerical data : Critical Care.
- therapy : Coronavirus Infections.
- virology : Coronavirus Infections.
- Attitude of Health Personnel, Feasibility Studies, Humans, Middle East Respiratory Syndrome Coronavirus, Plasma Exchange, Saudi Arabia, Surveys and Questionnaires.

Abstract

The Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging respiratory pathogen with a high mortality rate and no specific treatments available to date. The purpose of this study was to determine the feasibility of conducting a randomized controlled trial (RCT) of convalescent plasma therapy for MERS-CoV-infected patients by using MERS-CoV-specific convalescent plasma obtained from previously recovered patients.

DOI: 10.1186/s12871-016-0198-x
PubMed: 27405596

Affiliations:

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Le document en format XML

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<series><title level="j">BMC anesthesiology</title>
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<term>Coronavirus Infections (blood)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Critical Care (statistics & numerical data)</term>
<term>Feasibility Studies</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Physicians (psychology)</term>
<term>Plasma Exchange</term>
<term>Randomized Controlled Trials as Topic (methods)</term>
<term>Saudi Arabia</term>
<term>Surveys and Questionnaires</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Arabie saoudite</term>
<term>Attitude du personnel soignant</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Enquêtes et questionnaires</term>
<term>Essais contrôlés randomisés comme sujet ()</term>
<term>Humains</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (sang)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Médecins (psychologie)</term>
<term>Soins de réanimation ()</term>
<term>Échange plasmatique</term>
<term>Études de faisabilité</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Attitude of Health Personnel</term>
<term>Feasibility Studies</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Plasma Exchange</term>
<term>Saudi Arabia</term>
<term>Surveys and Questionnaires</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Arabie saoudite</term>
<term>Attitude du personnel soignant</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Enquêtes et questionnaires</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
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<front><div type="abstract" xml:lang="en">The Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging respiratory pathogen with a high mortality rate and no specific treatments available to date. The purpose of this study was to determine the feasibility of conducting a randomized controlled trial (RCT) of convalescent plasma therapy for MERS-CoV-infected patients by using MERS-CoV-specific convalescent plasma obtained from previously recovered patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27405596</PMID>
<DateCompleted><Year>2017</Year>
<Month>10</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2253</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<Issue>1</Issue>
<PubDate><Year>2016</Year>
<Month>07</Month>
<Day>12</Day>
</PubDate>
</JournalIssue>
<Title>BMC anesthesiology</Title>
<ISOAbbreviation>BMC Anesthesiol</ISOAbbreviation>
</Journal>
<ArticleTitle>Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.</ArticleTitle>
<Pagination><MedlinePgn>36</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12871-016-0198-x</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">The Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging respiratory pathogen with a high mortality rate and no specific treatments available to date. The purpose of this study was to determine the feasibility of conducting a randomized controlled trial (RCT) of convalescent plasma therapy for MERS-CoV-infected patients by using MERS-CoV-specific convalescent plasma obtained from previously recovered patients.</AbstractText>
<AbstractText Label="METHODS">A survey was adapted from validated questionnaire originally aimed to measure network capacities and capabilities within the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC). The questionnaire was modified for this study to include 26 items that were divided into three main domains of interest: (1) the ability to care for critically ill MERS-CoV patients; (2) laboratory capacity to diagnose MERS-CoV and blood bank ability to prepare convalescent plasma; and (3), research capacity to conduct randomized controlled trials. The questionnaire was emailed to physicians.</AbstractText>
<AbstractText Label="RESULTS">Of 582 physicians who were invited to the survey, 327 responded (56.2 %). The professional focus of the majority of respondents was critical care (106/249 (43 %)), pediatrics (59/249, (24 %)) or internal medicine (52/249 (21 %)) but none was blood banking. Nearly all respondents (251/263 (95 %)) reported to have access to ICU facilities within their institutions. Most respondents (219/270 (81 %)) reported that intensivists were the most physician group responsible for treatment decisions about critically ill SARI patients. While 125/165 respondents (76 %) reported that they conduct research in ICUs, and 80/161 (49.7 %) had been involved in the conduct of RCTs, including using a placebo comparison (60/161 (37 %)), only 49/226 (21 %) of respondents regularly participated in research networks.</AbstractText>
<AbstractText Label="CONCLUSIONS">Our survey indicated that in the Kingdom of Saudi Arabia (KSA), ICUs are the most likely clinical locations for conducting a clinical trial of convalescent plasma therapy for MERS-CoV, and that most ICUs have experience with such research designs.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arabi</LastName>
<ForeName>Yaseen M</ForeName>
<Initials>YM</Initials>
<AffiliationInfo><Affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia. arabi@ngha.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Enezi</LastName>
<ForeName>Farhan</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, PO Box 22490, Riyadh, 11426, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Longuere</LastName>
<ForeName>Kajsa-Stina</ForeName>
<Initials>KS</Initials>
<AffiliationInfo><Affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>International Severe Acute Respiratory & emerging Infection Consortium (ISARIC), Old Road Campus, Headington, OX3 7FZ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Balkhy</LastName>
<ForeName>Hanan H</ForeName>
<Initials>HH</Initials>
<AffiliationInfo><Affiliation>Infection Control Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Sultan</LastName>
<ForeName>Mohamed</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Emergency & Critical Care Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Omari</LastName>
<ForeName>Awad</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>AlFaisal University, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Hameed</LastName>
<ForeName>Fahad M</ForeName>
<Initials>FM</Initials>
<AffiliationInfo><Affiliation>Critical Care & Pulmonary Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carson</LastName>
<ForeName>Gail</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>University of Oxford Centre for Tropical Medicine (CCVTM), Churchill Hospital Old Road, Headington, Oxford, OX3 7LE, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>International Severe Acute Respiratory & emerging Infection Consortium (ISARIC), Old Road Campus, Headington, OX3 7FZ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shindo</LastName>
<ForeName>Nahoko</ForeName>
<Initials>N</Initials>
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<ForeName>Robert</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada.</Affiliation>
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<Keyword MajorTopicYN="Y">Randomized controlled trial</Keyword>
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<ReferenceList><Reference><Citation>Ann Intern Med. 2006 Oct 17;145(8):599-609</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16940336</ArticleId>
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<Reference><Citation>N Engl J Med. 2012 Nov 8;367 (19):1814-20</Citation>
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<Reference><Citation>Hong Kong Med J. 2006 Dec;12(6):489</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17148811</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2011 Feb 15;52(4):447-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21248066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2013 Jun 27;368(26):2487-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23718156</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2014 May 16;63(19):431-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24827411</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2013 Aug;144(2):464-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23450336</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Clin Microbiol Infect Dis. 2005 Jan;24(1):44-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15616839</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Med. 2006 Sep;3(9):e343</Citation>
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</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2014 Mar 18;160(6):389-97</Citation>
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<orgName><li>Université de Toronto</li>
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<country name="Canada"><region name="Ontario"><name sortKey="Fowler, Robert" sort="Fowler, Robert" uniqKey="Fowler R" first="Robert" last="Fowler">Robert Fowler</name>
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Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.

Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians.

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