Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches.
Identifieur interne : 000C13 ( PubMed/Checkpoint ); précédent : 000C12; suivant : 000C14Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches.
Auteurs : Nisreen Ma Okba [Pays-Bas] ; V Stalin Raj [Pays-Bas] ; Bart L. Haagmans [Pays-Bas]Source :
- Current opinion in virology [ 1879-6265 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Vaccins antiviraux.
- isolement et purification : Vaccins antiviraux.
- médecine vétérinaire : Infections à coronavirus.
- Animaux, Chameaux, Découverte de médicament, Humains, Infections à coronavirus.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Viral Vaccines.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- chemical , isolation & purification : Viral Vaccines.
- methods : Drug Discovery.
- prevention & control : Coronavirus Infections.
- veterinary : Coronavirus Infections.
- Animals, Camelus, Humans.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. The re-emergence of lethal coronaviruses calls for international collaboration to produce coronavirus vaccines, which are still lacking to date. Ongoing efforts to develop MERS-CoV vaccines should consider the different target populations (dromedary camels and humans) and the correlates of protection. Extending on our current knowledge of MERS, vaccination of dromedary camels to induce mucosal immunity could be a promising approach to diminish MERS-CoV transmission to humans. In addition, it is equally important to develop vaccines for humans that induce broader reactivity against various coronaviruses to be prepared for a potential next CoV outbreak.
DOI: 10.1016/j.coviro.2017.03.007
PubMed: 28412285
Affiliations:
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The re-emergence of lethal coronaviruses calls for international collaboration to produce coronavirus vaccines, which are still lacking to date. Ongoing efforts to develop MERS-CoV vaccines should consider the different target populations (dromedary camels and humans) and the correlates of protection. Extending on our current knowledge of MERS, vaccination of dromedary camels to induce mucosal immunity could be a promising approach to diminish MERS-CoV transmission to humans. In addition, it is equally important to develop vaccines for humans that induce broader reactivity against various coronaviruses to be prepared for a potential next CoV outbreak.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28412285</PMID><DateCompleted><Year>2018</Year><Month>02</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-6265</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><PubDate><Year>2017</Year><Month>04</Month></PubDate></JournalIssue><Title>Current opinion in virology</Title><ISOAbbreviation>Curr Opin Virol</ISOAbbreviation></Journal><ArticleTitle>Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches.</ArticleTitle><Pagination><MedlinePgn>49-58</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1879-6257(16)30148-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.coviro.2017.03.007</ELocationID><Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. The re-emergence of lethal coronaviruses calls for international collaboration to produce coronavirus vaccines, which are still lacking to date. Ongoing efforts to develop MERS-CoV vaccines should consider the different target populations (dromedary camels and humans) and the correlates of protection. Extending on our current knowledge of MERS, vaccination of dromedary camels to induce mucosal immunity could be a promising approach to diminish MERS-CoV transmission to humans. In addition, it is equally important to develop vaccines for humans that induce broader reactivity against various coronaviruses to be prepared for a potential next CoV outbreak.</AbstractText><CopyrightInformation>Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Okba</LastName><ForeName>Nisreen Ma</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raj</LastName><ForeName>V Stalin</ForeName><Initials>VS</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haagmans</LastName><ForeName>Bart L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. 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