Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity.
Identifieur interne : 000B35 ( PubMed/Checkpoint ); précédent : 000B34; suivant : 000B36Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity.
Auteurs : Jae-Hoon Ko [Corée du Sud] ; Marcel A. Müller [Allemagne] ; Hyeri Seok [Corée du Sud] ; Ga Eun Park [Corée du Sud] ; Ji Yeon Lee [Corée du Sud] ; Sun Young Cho [Corée du Sud] ; Young Eun Ha [Corée du Sud] ; Jin Yang Baek [Corée du Sud] ; So Hyun Kim [Corée du Sud] ; Ji-Man Kang [Corée du Sud] ; Yae-Jean Kim [Corée du Sud] ; Ik Joon Jo [Corée du Sud] ; Chi Ryang Chung [Corée du Sud] ; Myong-Joon Hahn [Corée du Sud] ; Christian Drosten [Allemagne] ; Cheol-In Kang [Corée du Sud] ; Doo Ryeon Chung [Corée du Sud] ; Jae-Hoon Song [Corée du Sud] ; Eun-Suk Kang [Corée du Sud] ; Kyong Ran Peck [Corée du Sud]Source :
- Diagnostic microbiology and infectious disease [ 1879-0070 ] ; 2017.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (sang), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Humains, Immunoglobuline A (immunologie), Immunoglobuline A (sang), Immunoglobuline G (immunologie), Immunoglobuline G (sang), Immunoglobuline M (immunologie), Immunoglobuline M (sang), Infections à coronavirus (immunologie), Infections à coronavirus (sang), Infections à coronavirus (virologie), Pneumopathie infectieuse (diagnostic), Pneumopathie infectieuse (sang), Pneumopathie infectieuse (virologie), RT-PCR, Séroconversion, Études rétrospectives.
- MESH :
- diagnostic : Pneumopathie infectieuse.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Immunoglobuline A, Immunoglobuline G, Immunoglobuline M, Infections à coronavirus.
- sang : Anticorps antiviraux, Immunoglobuline A, Immunoglobuline G, Immunoglobuline M, Infections à coronavirus, Pneumopathie infectieuse.
- virologie : Infections à coronavirus, Pneumopathie infectieuse.
- Humains, RT-PCR, Séroconversion, Études rétrospectives.
English descriptors
- KwdEn :
- Antibodies, Viral (blood), Coronavirus Infections (blood), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Immunoglobulin A (blood), Immunoglobulin A (immunology), Immunoglobulin G (blood), Immunoglobulin G (immunology), Immunoglobulin M (blood), Immunoglobulin M (immunology), Middle East Respiratory Syndrome Coronavirus (immunology), Pneumonia (blood), Pneumonia (diagnosis), Pneumonia (virology), Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Seroconversion.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M.
- blood : Coronavirus Infections, Pneumonia.
- diagnosis : Pneumonia.
- immunology : Coronavirus Infections, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Pneumonia.
- Humans, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Seroconversion.
Abstract
We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001). Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003).
DOI: 10.1016/j.diagmicrobio.2017.07.006
PubMed: 28821364
Affiliations:
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<author><name sortKey="Cho, Sun Young" sort="Cho, Sun Young" uniqKey="Cho S" first="Sun Young" last="Cho">Sun Young Cho</name>
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<author><name sortKey="Ha, Young Eun" sort="Ha, Young Eun" uniqKey="Ha Y" first="Young Eun" last="Ha">Young Eun Ha</name>
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<author><name sortKey="Baek, Jin Yang" sort="Baek, Jin Yang" uniqKey="Baek J" first="Jin Yang" last="Baek">Jin Yang Baek</name>
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<author><name sortKey="Kim, So Hyun" sort="Kim, So Hyun" uniqKey="Kim S" first="So Hyun" last="Kim">So Hyun Kim</name>
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<author><name sortKey="Jo, Ik Joon" sort="Jo, Ik Joon" uniqKey="Jo I" first="Ik Joon" last="Jo">Ik Joon Jo</name>
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<author><name sortKey="Hahn, Myong Joon" sort="Hahn, Myong Joon" uniqKey="Hahn M" first="Myong-Joon" last="Hahn">Myong-Joon Hahn</name>
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<wicri:regionArea>Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 16419</wicri:regionArea>
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<author><name sortKey="Chung, Doo Ryeon" sort="Chung, Doo Ryeon" uniqKey="Chung D" first="Doo Ryeon" last="Chung">Doo Ryeon Chung</name>
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<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Song, Jae Hoon" sort="Song, Jae Hoon" uniqKey="Song J" first="Jae-Hoon" last="Song">Jae-Hoon Song</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea; Asia Pacific Foundation for Infectious Diseases (APFID), Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Kang, Eun Suk" sort="Kang, Eun Suk" uniqKey="Kang E" first="Eun-Suk" last="Kang">Eun-Suk Kang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: eskang@skku.edu.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Peck, Kyong Ran" sort="Peck, Kyong Ran" uniqKey="Peck K" first="Kyong Ran" last="Peck">Kyong Ran Peck</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea. Electronic address: krpeck@skku.edu.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Seok, Hyeri" sort="Seok, Hyeri" uniqKey="Seok H" first="Hyeri" last="Seok">Hyeri Seok</name>
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<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Park, Ga Eun" sort="Park, Ga Eun" uniqKey="Park G" first="Ga Eun" last="Park">Ga Eun Park</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
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<author><name sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351</wicri:regionArea>
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<region type="capital">Région capitale de Séoul</region>
</placeName>
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<author><name sortKey="Cho, Sun Young" sort="Cho, Sun Young" uniqKey="Cho S" first="Sun Young" last="Cho">Sun Young Cho</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ha, Young Eun" sort="Ha, Young Eun" uniqKey="Ha Y" first="Young Eun" last="Ha">Young Eun Ha</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baek, Jin Yang" sort="Baek, Jin Yang" uniqKey="Baek J" first="Jin Yang" last="Baek">Jin Yang Baek</name>
<affiliation wicri:level="3"><nlm:affiliation>Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Asia Pacific Foundation for Infectious Diseases (APFID), Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
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<author><name sortKey="Kim, So Hyun" sort="Kim, So Hyun" uniqKey="Kim S" first="So Hyun" last="Kim">So Hyun Kim</name>
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<country xml:lang="fr">Corée du Sud</country>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Chung, Chi Ryang" sort="Chung, Chi Ryang" uniqKey="Chung C" first="Chi Ryang" last="Chung">Chi Ryang Chung</name>
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<country xml:lang="fr">Corée du Sud</country>
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<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Hahn, Myong Joon" sort="Hahn, Myong Joon" uniqKey="Hahn M" first="Myong-Joon" last="Hahn">Myong-Joon Hahn</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 16419</wicri:regionArea>
<wicri:noRegion>Suwon 16419</wicri:noRegion>
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<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
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<wicri:noRegion>Germany; German Centre for Infection Research</wicri:noRegion>
<wicri:noRegion>Germany; German Centre for Infection Research</wicri:noRegion>
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<author><name sortKey="Kang, Cheol In" sort="Kang, Cheol In" uniqKey="Kang C" first="Cheol-In" last="Kang">Cheol-In Kang</name>
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<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Chung, Doo Ryeon" sort="Chung, Doo Ryeon" uniqKey="Chung D" first="Doo Ryeon" last="Chung">Doo Ryeon Chung</name>
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<author><name sortKey="Song, Jae Hoon" sort="Song, Jae Hoon" uniqKey="Song J" first="Jae-Hoon" last="Song">Jae-Hoon Song</name>
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<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Kang, Eun Suk" sort="Kang, Eun Suk" uniqKey="Kang E" first="Eun-Suk" last="Kang">Eun-Suk Kang</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Peck, Kyong Ran" sort="Peck, Kyong Ran" uniqKey="Peck K" first="Kyong Ran" last="Peck">Kyong Ran Peck</name>
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<term>Coronavirus Infections (virology)</term>
<term>Humans</term>
<term>Immunoglobulin A (blood)</term>
<term>Immunoglobulin A (immunology)</term>
<term>Immunoglobulin G (blood)</term>
<term>Immunoglobulin G (immunology)</term>
<term>Immunoglobulin M (blood)</term>
<term>Immunoglobulin M (immunology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
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<term>Pneumonia (diagnosis)</term>
<term>Pneumonia (virology)</term>
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<front><div type="abstract" xml:lang="en">We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001). Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003).</div>
</front>
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<DateCompleted><Year>2018</Year>
<Month>05</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0070</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>89</Volume>
<Issue>2</Issue>
<PubDate><Year>2017</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Diagnostic microbiology and infectious disease</Title>
<ISOAbbreviation>Diagn. Microbiol. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity.</ArticleTitle>
<Pagination><MedlinePgn>106-111</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0732-8893(17)30221-3</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.diagmicrobio.2017.07.006</ELocationID>
<Abstract><AbstractText>We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001). Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003).</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ko</LastName>
<ForeName>Jae-Hoon</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Müller</LastName>
<ForeName>Marcel A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Centre for Infection Research, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seok</LastName>
<ForeName>Hyeri</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Ga Eun</ForeName>
<Initials>GE</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</Affiliation>
</AffiliationInfo>
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<ForeName>Ji Yeon</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cho</LastName>
<ForeName>Sun Young</ForeName>
<Initials>SY</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Young Eun</ForeName>
<Initials>YE</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Jin Yang</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>So Hyun</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Ji-Man</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Yae-Jean</ForeName>
<Initials>YJ</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jo</LastName>
<ForeName>Ik Joon</ForeName>
<Initials>IJ</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chung</LastName>
<ForeName>Chi Ryang</ForeName>
<Initials>CR</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hahn</LastName>
<ForeName>Myong-Joon</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.</Affiliation>
</AffiliationInfo>
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<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Centre for Infection Research, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Cheol-In</ForeName>
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<Author ValidYN="Y"><LastName>Chung</LastName>
<ForeName>Doo Ryeon</ForeName>
<Initials>DR</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea; Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Jae-Hoon</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea; Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Eun-Suk</ForeName>
<Initials>ES</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: eskang@skku.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peck</LastName>
<ForeName>Kyong Ran</ForeName>
<Initials>KR</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea. Electronic address: krpeck@skku.edu.</Affiliation>
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<Month>07</Month>
<Day>14</Day>
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