Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.
Identifieur interne : 000962 ( PubMed/Checkpoint ); précédent : 000961; suivant : 000963Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.
Auteurs : Yanqun Wang [République populaire de Chine] ; Jing Sun [République populaire de Chine] ; Airu Zhu [République populaire de Chine] ; Jingxian Zhao [République populaire de Chine] ; Jincun Zhao [République populaire de Chine]Source :
- Journal of thoracic disease [ 2072-1439 ] ; 2018.
Abstract
Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a novel betacoronavirus (MERS coronavirus, MERS-CoV). Since its first emergence in 2012, multiple transmission events of MERS-CoV (dromedary to human and human to human) have been reported, indicating that MERS-CoV has the potential to cause widespread outbreak. However, the epidemiology of MERS as well as immune responses against the virus in animal models and patients are still not well understood, hindering the vaccine and therapeutic developments. In this review, we summarize recent genetic and epidemic findings of MERS-CoV and the progress in animal model development, immune response studies in both animals and humans. At last, we discussed the breakthrough on vaccine and therapeutic development which are important against potential future MERS outbreak.
DOI: 10.21037/jtd.2018.03.80
PubMed: 30116605
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:30116605Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.</title><author><name sortKey="Wang, Yanqun" sort="Wang, Yanqun" uniqKey="Wang Y" first="Yanqun" last="Wang">Yanqun Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Sun, Jing" sort="Sun, Jing" uniqKey="Sun J" first="Jing" last="Sun">Jing Sun</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhu, Airu" sort="Zhu, Airu" uniqKey="Zhu A" first="Airu" last="Zhu">Airu Zhu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhao, Jingxian" sort="Zhao, Jingxian" uniqKey="Zhao J" first="Jingxian" last="Zhao">Jingxian Zhao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30116605</idno><idno type="pmid">30116605</idno><idno type="doi">10.21037/jtd.2018.03.80</idno><idno type="wicri:Area/PubMed/Corpus">000809</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000809</idno><idno type="wicri:Area/PubMed/Curation">000809</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000809</idno><idno type="wicri:Area/PubMed/Checkpoint">000962</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000962</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.</title><author><name sortKey="Wang, Yanqun" sort="Wang, Yanqun" uniqKey="Wang Y" first="Yanqun" last="Wang">Yanqun Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Sun, Jing" sort="Sun, Jing" uniqKey="Sun J" first="Jing" last="Sun">Jing Sun</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhu, Airu" sort="Zhu, Airu" uniqKey="Zhu A" first="Airu" last="Zhu">Airu Zhu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhao, Jingxian" sort="Zhao, Jingxian" uniqKey="Zhao J" first="Jingxian" last="Zhao">Jingxian Zhao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Journal of thoracic disease</title><idno type="ISSN">2072-1439</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a novel betacoronavirus (MERS coronavirus, MERS-CoV). Since its first emergence in 2012, multiple transmission events of MERS-CoV (dromedary to human and human to human) have been reported, indicating that MERS-CoV has the potential to cause widespread outbreak. However, the epidemiology of MERS as well as immune responses against the virus in animal models and patients are still not well understood, hindering the vaccine and therapeutic developments. In this review, we summarize recent genetic and epidemic findings of MERS-CoV and the progress in animal model development, immune response studies in both animals and humans. At last, we discussed the breakthrough on vaccine and therapeutic development which are important against potential future MERS outbreak.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30116605</PMID><DateRevised><Year>2019</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2072-1439</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>Suppl 19</Issue><PubDate><Year>2018</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of thoracic disease</Title><ISOAbbreviation>J Thorac Dis</ISOAbbreviation></Journal><ArticleTitle>Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.</ArticleTitle><Pagination><MedlinePgn>S2260-S2271</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.21037/jtd.2018.03.80</ELocationID><Abstract><AbstractText>Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a novel betacoronavirus (MERS coronavirus, MERS-CoV). Since its first emergence in 2012, multiple transmission events of MERS-CoV (dromedary to human and human to human) have been reported, indicating that MERS-CoV has the potential to cause widespread outbreak. However, the epidemiology of MERS as well as immune responses against the virus in animal models and patients are still not well understood, hindering the vaccine and therapeutic developments. In this review, we summarize recent genetic and epidemic findings of MERS-CoV and the progress in animal model development, immune response studies in both animals and humans. At last, we discussed the breakthrough on vaccine and therapeutic development which are important against potential future MERS outbreak.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yanqun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Airu</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jingxian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jincun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou 510120, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou 510120, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>J Thorac Dis</MedlineTA><NlmUniqueID>101533916</NlmUniqueID><ISSNLinking>2072-1439</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Middle East respiratory syndrome coronavirus (MERS-CoV)</Keyword><Keyword MajorTopicYN="N">animal model</Keyword><Keyword MajorTopicYN="N">antiviral therapy</Keyword><Keyword MajorTopicYN="N">epidemiology</Keyword><Keyword MajorTopicYN="N">immune response</Keyword></KeywordList><CoiStatement>Conflicts of Interest: The authors have no conflicts of interest to declare.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30116605</ArticleId><ArticleId IdType="doi">10.21037/jtd.2018.03.80</ArticleId><ArticleId IdType="pii">jtd-10-S19-S2260</ArticleId><ArticleId IdType="pmc">PMC6072923</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2017 Jun;23(6):985-988</Citation><ArticleIdList><ArticleId IdType="pubmed">28318484</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2006 Dec 15;364(5):964-73</Citation><ArticleIdList><ArticleId IdType="pubmed">17054987</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2011 Dec;121(12):4921-30</Citation><ArticleIdList><ArticleId IdType="pubmed">22105170</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 2005 Nov;150(11):2299-311</Citation><ArticleIdList><ArticleId IdType="pubmed">15986174</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Microbiol. 2016 Jun;24(6):490-502</Citation><ArticleIdList><ArticleId IdType="pubmed">27012512</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Apr;81(7):3051-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17079323</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4240-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15010527</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2017 Sep 12;91(19):</Citation><ArticleIdList><ArticleId IdType="pubmed">28747502</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Mol Biol. 2015;1282:1-23</Citation><ArticleIdList><ArticleId IdType="pubmed">25720466</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2015 Jun;89(11):6131-5</Citation><ArticleIdList><ArticleId IdType="pubmed">25810539</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Sep;81(18):9812-24</Citation><ArticleIdList><ArticleId IdType="pubmed">17596301</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2016 Aug;14(8):523-34</Citation><ArticleIdList><ArticleId IdType="pubmed">27344959</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Microbiol. 2016 Nov 28;2:16226</Citation><ArticleIdList><ArticleId IdType="pubmed">27892925</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2011 Jun 15;186(12):7264-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21576510</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Feb;79(4):2079-86</Citation><ArticleIdList><ArticleId IdType="pubmed">15681410</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2015 Nov;485:422-30</Citation><ArticleIdList><ArticleId IdType="pubmed">26342468</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2009 Mar;83(5):2368-73</Citation><ArticleIdList><ArticleId IdType="pubmed">19091867</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2016 Oct 26;12(10):e1005982</Citation><ArticleIdList><ArticleId IdType="pubmed">27783669</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2014 Feb 18;5(1):null</Citation><ArticleIdList><ArticleId IdType="pubmed">24549846</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2015 Sep;89(17):9119-23</Citation><ArticleIdList><ArticleId IdType="pubmed">26063432</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Transl Med. 2014 Apr 30;6(234):234ra59</Citation><ArticleIdList><ArticleId IdType="pubmed">24778414</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2014 May 1;209(9):1331-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24065148</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Feb;88(3):1834-8</Citation><ArticleIdList><ArticleId IdType="pubmed">24257613</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2017 Mar 23;7:44875</Citation><ArticleIdList><ArticleId IdType="pubmed">28332568</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2013 Oct;19(10):1697-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24050621</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2013 Aug 8;500(7461):227-31</Citation><ArticleIdList><ArticleId IdType="pubmed">23831647</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2018-26</Citation><ArticleIdList><ArticleId IdType="pubmed">24778221</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2013 Dec;11(12):836-48</Citation><ArticleIdList><ArticleId IdType="pubmed">24217413</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2016 Jun;22(6):1031-7</Citation><ArticleIdList><ArticleId IdType="pubmed">27070385</ArticleId></ArticleIdList></Reference><Reference><Citation>Transbound Emerg Dis. 2017 Apr;64(2):344-353</Citation><ArticleIdList><ArticleId IdType="pubmed">26256102</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2014 Jun 26;370(26):2499-505</Citation><ArticleIdList><ArticleId IdType="pubmed">24896817</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2014 Sep 10;16(3):328-37</Citation><ArticleIdList><ArticleId IdType="pubmed">25211075</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2017 Feb 9;376(6):584-594</Citation><ArticleIdList><ArticleId IdType="pubmed">28177862</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2014;5:3067</Citation><ArticleIdList><ArticleId IdType="pubmed">24473083</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2014 Jan 15;209(2):236-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24218506</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2013 Oct;100(1):286-95</Citation><ArticleIdList><ArticleId IdType="pubmed">24012996</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2015 Dec 23;10(12):e0145561</Citation><ArticleIdList><ArticleId IdType="pubmed">26701103</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2016 Jun 21;44(6):1379-91</Citation><ArticleIdList><ArticleId IdType="pubmed">27287409</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2013 Aug;67(2):130-40</Citation><ArticleIdList><ArticleId IdType="pubmed">23583636</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2015 Sep 08;6(5):e01280-15</Citation><ArticleIdList><ArticleId IdType="pubmed">26350969</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2016 Dec 16;91(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">27795425</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2006 Jul;78(7):938-49</Citation><ArticleIdList><ArticleId IdType="pubmed">16721849</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2014 Apr;454-455:197-205</Citation><ArticleIdList><ArticleId IdType="pubmed">24725946</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2015 Jul 28;6:7712</Citation><ArticleIdList><ArticleId IdType="pubmed">26218507</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Jul 16;290(3):367-73</Citation><ArticleIdList><ArticleId IdType="pubmed">12865378</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2016 Mar 15;213(6):904-14</Citation><ArticleIdList><ArticleId IdType="pubmed">26203058</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Apr;84(7):3542-51</Citation><ArticleIdList><ArticleId IdType="pubmed">20106914</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Microbes Infect. 2017 May 24;6(5):e37</Citation><ArticleIdList><ArticleId IdType="pubmed">28536429</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 Oct 25;362(9393):1353-8</Citation><ArticleIdList><ArticleId IdType="pubmed">14585636</ArticleId></ArticleIdList></Reference><Reference><Citation>J Antimicrob Chemother. 2015 Jul;70(7):2129-32</Citation><ArticleIdList><ArticleId IdType="pubmed">25900158</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 May;88(9):5195-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24574399</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Sep;84(18):9318-25</Citation><ArticleIdList><ArticleId IdType="pubmed">20610717</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2015 Dec 15;212(12):1904-13</Citation><ArticleIdList><ArticleId IdType="pubmed">26198719</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Opin Ther Targets. 2017 Feb;21(2):131-143</Citation><ArticleIdList><ArticleId IdType="pubmed">27936982</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Evol. 2002 Feb;54(2):156-65</Citation><ArticleIdList><ArticleId IdType="pubmed">11821909</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2014 Feb;95(Pt 2):408-12</Citation><ArticleIdList><ArticleId IdType="pubmed">24197535</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2016 Jan 1;351(6268):81-4</Citation><ArticleIdList><ArticleId IdType="pubmed">26678874</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2015 Jan;59(1):742-4</Citation><ArticleIdList><ArticleId IdType="pubmed">25331705</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2005 Aug;11(8):1225-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16102311</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 1967 Apr;1(2):175-8</Citation><ArticleIdList><ArticleId IdType="pubmed">4293939</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013 Jul 02;8(7):e69127</Citation><ArticleIdList><ArticleId IdType="pubmed">23844250</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Genet Evol. 2004 Mar;4(1):15-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15019585</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Res. 2015 Nov;25(11):1237-49</Citation><ArticleIdList><ArticleId IdType="pubmed">26391698</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pediatr Hematol Oncol. 2007 Jun;29(6):432-4</Citation><ArticleIdList><ArticleId IdType="pubmed">17551411</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2017 Aug 16;35(35 Pt A):4461-4464</Citation><ArticleIdList><ArticleId IdType="pubmed">28576573</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Rev. 2015 Apr;28(2):465-522</Citation><ArticleIdList><ArticleId IdType="pubmed">25810418</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Jul;87(14):7790-2</Citation><ArticleIdList><ArticleId IdType="pubmed">23678167</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hosp Infect. 2017 Feb;95(2):207-213</Citation><ArticleIdList><ArticleId IdType="pubmed">28153558</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Immunol. 2017 Aug 4;2(14):null</Citation><ArticleIdList><ArticleId IdType="pubmed">28778905</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2003 Oct 1;37(7):929-32</Citation><ArticleIdList><ArticleId IdType="pubmed">13130404</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43</Citation><ArticleIdList><ArticleId IdType="pubmed">26124093</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2015 Sep 5;386(9997):995-1007</Citation><ArticleIdList><ArticleId IdType="pubmed">26049252</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3119-E3128</Citation><ArticleIdList><ArticleId IdType="pubmed">28348219</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2016 Jun;22(6):1071-4</Citation><ArticleIdList><ArticleId IdType="pubmed">27070733</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2014 Aug 21;10(8):e1004250</Citation><ArticleIdList><ArticleId IdType="pubmed">25144235</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Transl Med. 2017 Jun 28;9(396):</Citation><ArticleIdList><ArticleId IdType="pubmed">28659436</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2016 Jun 3;34(26):2982-2987</Citation><ArticleIdList><ArticleId IdType="pubmed">27083424</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2016 Jan 1;351(6268):77-81</Citation><ArticleIdList><ArticleId IdType="pubmed">26678878</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2014 Apr 29;5(3):e01146-14</Citation><ArticleIdList><ArticleId IdType="pubmed">24781747</ArticleId></ArticleIdList></Reference><Reference><Citation>Protein Cell. 2013 Dec;4(12):951-61</Citation><ArticleIdList><ArticleId IdType="pubmed">24318862</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2011 Nov;85(21):11325-37</Citation><ArticleIdList><ArticleId IdType="pubmed">21849456</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2014 Sep;109:97-109</Citation><ArticleIdList><ArticleId IdType="pubmed">24995382</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Virol. 2015 Nov;2(1):573-97</Citation><ArticleIdList><ArticleId IdType="pubmed">26958929</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2017 Apr 11;35(16):2069-2075</Citation><ArticleIdList><ArticleId IdType="pubmed">28314561</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2014 Oct 14;32(45):5975-82</Citation><ArticleIdList><ArticleId IdType="pubmed">25192975</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2014 Mar 18;160(6):389-97</Citation><ArticleIdList><ArticleId IdType="pubmed">24474051</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2017 Jun 1;215(11):1702-1705</Citation><ArticleIdList><ArticleId IdType="pubmed">28387845</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5</Citation><ArticleIdList><ArticleId IdType="pubmed">24599590</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2013 Aug;94(Pt 8):1749-60</Citation><ArticleIdList><ArticleId IdType="pubmed">23620378</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2004 Dec;10(12 Suppl):S88-97</Citation><ArticleIdList><ArticleId IdType="pubmed">15577937</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2013 Oct;19(10):1313-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24013700</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2006 Mar 1;42(5):634-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16447108</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2015 Jun 22;5:11451</Citation><ArticleIdList><ArticleId IdType="pubmed">26099036</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10473-8</Citation><ArticleIdList><ArticleId IdType="pubmed">26216974</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Res. 2014 Aug;59(1-3):118-28</Citation><ArticleIdList><ArticleId IdType="pubmed">24845462</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Feb;81(3):1162-73</Citation><ArticleIdList><ArticleId IdType="pubmed">17108019</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Wang, Yanqun" sort="Wang, Yanqun" uniqKey="Wang Y" first="Yanqun" last="Wang">Yanqun Wang</name></region><name sortKey="Sun, Jing" sort="Sun, Jing" uniqKey="Sun J" first="Jing" last="Sun">Jing Sun</name><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><name sortKey="Zhao, Jingxian" sort="Zhao, Jingxian" uniqKey="Zhao J" first="Jingxian" last="Zhao">Jingxian Zhao</name><name sortKey="Zhu, Airu" sort="Zhu, Airu" uniqKey="Zhu A" first="Airu" last="Zhu">Airu Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000962 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000962 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:30116605
|texte= Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:30116605" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |